Sodium Salicylate_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sodium Salicylate perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sodium Salicylate_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0674289
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0651546
LMO7 LIM domain 7 0.0537646
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0530415
MYO1E myosin IE 0.0464439
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0460527
INTS6 integrator complex subunit 6 0.0449564
THSD4 thrombospondin, type I, domain containing 4 0.0448787
ZSWIM6 zinc finger, SWIM-type containing 6 0.0419024
DSPP dentin sialophosphoprotein 0.0418995
CATSPERB catsper channel auxiliary subunit beta 0.0418552
MSI2 musashi RNA-binding protein 2 0.0410946
PDLIM5 PDZ and LIM domain 5 0.0379901
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0363357
RIMKLB ribosomal modification protein rimK-like family member B 0.0359478
KRT18 keratin 18, type I 0.0357186
PTPRB protein tyrosine phosphatase, receptor type, B 0.0356287
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0338923
GMDS GDP-mannose 4,6-dehydratase 0.0337875
MPRIP myosin phosphatase Rho interacting protein 0.0316628
FBXO11 F-box protein 11 0.0311575
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0307346
FRMD5 FERM domain containing 5 0.0291929
CTBP2 C-terminal binding protein 2 0.0291063
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0289715
SP100 SP100 nuclear antigen 0.0276169
NPSR1 neuropeptide S receptor 1 0.0274004
PSD3 pleckstrin and Sec7 domain containing 3 0.0271443
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.0264528
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 0.0264454
CUX1 cut-like homeobox 1 0.0260618
F3 coagulation factor III (thromboplastin, tissue factor) 0.0260235
LOC105378220 macrophage receptor MARCO-like 0.0254093
HSPA8 heat shock 70kDa protein 8 0.0251205
EZR ezrin 0.0247193
AOPEP aminopeptidase O (putative) 0.0245399
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0245346
LPP LIM domain containing preferred translocation partner in lipoma 0.0239883
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0239139
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 0.0236304
MYH14 myosin, heavy chain 14, non-muscle 0.0234645
SVIL supervillin 0.0232372
RCOR1 REST corepressor 1 0.0227498
OXSR1 oxidative stress responsive 1 0.0215507
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0211713
FMNL2 formin-like 2 0.0209611
ITPRID2 ITPR interacting domain containing 2 0.0208408
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0205032
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0204088
EGFR epidermal growth factor receptor 0.0200045
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0198482
MYO5B myosin VB 0.0196969
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0196147
NABP1 nucleic acid binding protein 1 0.0196081
STK39 serine threonine kinase 39 0.0194739
AHNAK AHNAK nucleoprotein 0.0192319
MCU mitochondrial calcium uniporter 0.0191753
DST dystonin 0.0190312
TRAPPC9 trafficking protein particle complex 9 0.0188324
DENND1A DENN/MADD domain containing 1A 0.0185532
DIAPH1 diaphanous-related formin 1 0.0184047
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.018311
IGF1R insulin-like growth factor 1 receptor 0.0181772
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0179903
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0178638
UBAP2 ubiquitin associated protein 2 0.0177897
PALLD palladin, cytoskeletal associated protein 0.0177382
P3H2 prolyl 3-hydroxylase 2 0.017738
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 0.0176081
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0175237
DSG2 desmoglein 2 0.0175013
LGALS12 lectin, galactoside-binding, soluble, 12 0.0170955
MTAP methylthioadenosine phosphorylase 0.017085
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0167767
SLTM SAFB-like, transcription modulator 0.0163238
AKAP13 A kinase (PRKA) anchor protein 13 0.0163026
COBL cordon-bleu WH2 repeat protein 0.0160761
MAML2 mastermind-like 2 (Drosophila) 0.0158746
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0158364
AEBP2 AE binding protein 2 0.0157496
SPON1 spondin 1, extracellular matrix protein 0.0156844
LRRC23 leucine rich repeat containing 23 0.0155618
OSBPL8 oxysterol binding protein-like 8 0.0155551
CEMIP cell migration inducing protein, hyaluronan binding 0.0155281
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 0.015528
MACF1 microtubule-actin crosslinking factor 1 0.0152767
RNF217 ring finger protein 217 0.015162
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0150824
PTK2 protein tyrosine kinase 2 0.0149252
PCSK6 proprotein convertase subtilisin/kexin type 6 0.0148504
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0147862
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0147636
RASAL2 RAS protein activator like 2 0.0147538
DIAPH2 diaphanous-related formin 2 0.0145621
CARMIL1 capping protein regulator and myosin 1 linker 1 0.0142965
SULF2 sulfatase 2 0.0142157
SLC38A2 solute carrier family 38, member 2 0.0140021
PTPRK protein tyrosine phosphatase, receptor type, K 0.0139864
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0139833
RABGAP1L RAB GTPase activating protein 1-like 0.0139403

decreased expression

Symbol Name Standardized Value
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.126266
RPLP1 ribosomal protein, large, P1 -0.124579
RPS6 ribosomal protein S6 -0.101926
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.096602
RPS12 ribosomal protein S12 -0.087768
TPT1 tumor protein, translationally-controlled 1 -0.0780475
TMSB10 thymosin beta 10 -0.0748224
RPS19 ribosomal protein S19 -0.0711163
RPS8 ribosomal protein S8 -0.0709201
TXNRD1 thioredoxin reductase 1 -0.0705021
RPLP0 ribosomal protein, large, P0 -0.0642392
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0635697
RPL35A ribosomal protein L35a -0.0635592
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0599385
RPL26 ribosomal protein L26 -0.0577127
RPL34 ribosomal protein L34 -0.0572554
RPL11 ribosomal protein L11 -0.0564748
RPL23 ribosomal protein L23 -0.0557973
GOLGA4 golgin A4 -0.0530305
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0509367
RPL37A ribosomal protein L37a -0.0492788
RPS3 ribosomal protein S3 -0.0484685
RPLP2 ribosomal protein, large, P2 -0.0480762
RPL13A ribosomal protein L13a -0.0480278
RPS23 ribosomal protein S23 -0.0477605
RPS13 ribosomal protein S13 -0.046056
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0460041
RPS17 ribosomal protein S17 -0.0453469
RPL12 ribosomal protein L12 -0.0452437
RPS21 ribosomal protein S21 -0.0441861
PTMA prothymosin, alpha -0.0437281
RPL9 ribosomal protein L9 -0.0434274
PRSS3 protease, serine, 3 -0.0425415
PKP2 plakophilin 2 -0.0422886
EIF1 eukaryotic translation initiation factor 1 -0.0419675
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.041689
GARS1 glycyl-tRNA synthetase 1 -0.0409813
RPL36 ribosomal protein L36 -0.0407662
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.038958
SHROOM3 shroom family member 3 -0.0379012
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0376409
RPL37 ribosomal protein L37 -0.0375986
RPS27A ribosomal protein S27a -0.0366694
PRELID2 PRELI domain containing 2 -0.0354841
GDF15 growth differentiation factor 15 -0.0353996
RPS27 ribosomal protein S27 -0.0339901
RPS29 ribosomal protein S29 -0.0339573
RPS16 ribosomal protein S16 -0.0336321
RPS24 ribosomal protein S24 -0.0335486
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0333798
EREG epiregulin -0.0321495
RACK1 receptor for activated C kinase 1 -0.0314071
RPS2 ribosomal protein S2 -0.0313758
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.0310708
RPL31 ribosomal protein L31 -0.0306293
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0304419
MON2 MON2 homolog (S. cerevisiae) -0.0303362
ABHD17C abhydrolase domain containing 17C -0.0300323
RPL19 ribosomal protein L19 -0.0299841
RPS14 ribosomal protein S14 -0.0296036
PLAC8 placenta-specific 8 -0.0295421
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0285299
RPL30 ribosomal protein L30 -0.0285015
RPS25 ribosomal protein S25 -0.028219
AKAP9 A kinase (PRKA) anchor protein 9 -0.0281196
RPS20 ribosomal protein S20 -0.0280885
NDRG1 N-myc downstream regulated 1 -0.0279983
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 -0.0278757
RPL27A ribosomal protein L27a -0.0278564
RPL5 ribosomal protein L5 -0.0275454
RPL32 ribosomal protein L32 -0.0273271
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0269852
RPS5 ribosomal protein S5 -0.0268502
RPL28 ribosomal protein L28 -0.0265969
HLA-B major histocompatibility complex, class I, B -0.0262824
BTBD9 BTB (POZ) domain containing 9 -0.0262198
RPL4 ribosomal protein L4 -0.0260407
RBM39 RNA binding motif protein 39 -0.0259944
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0259441
YBX3 Y box binding protein 3 -0.0252299
PLAUR plasminogen activator, urokinase receptor -0.0252215
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.0251411
S100P S100 calcium binding protein P -0.0250192
DSCAM Down syndrome cell adhesion molecule -0.0244913
PNISR PNN-interacting serine/arginine-rich protein -0.0243848
ZNF292 zinc finger protein 292 -0.0242903
TMEM45B transmembrane protein 45B -0.0235756
FOXO1 forkhead box O1 -0.0234765
TRIM2 tripartite motif containing 2 -0.0233229
CALU calumenin -0.0229065
RFX3 regulatory factor X, 3 (influences HLA class II expression) -0.022312
CXADR coxsackie virus and adenovirus receptor -0.0220328
ATXN1 ataxin 1 -0.0220228
FLNB filamin B, beta -0.0217925
WARS1 tryptophanyl-tRNA synthetase 1 -0.0216724
FHL2 four and a half LIM domains 2 -0.021438
AVL9 AVL9 homolog (S. cerevisiase) -0.0212027
ITGA6 integrin, alpha 6 -0.0209662
PCDHB16 protocadherin beta 16 -0.0209033
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0206997