Sodium Salicylate_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sodium Salicylate perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Sodium Salicylate_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.050154
ZBTB38 zinc finger and BTB domain containing 38 0.0347738
BCAR3 breast cancer anti-estrogen resistance 3 0.0337569
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0318935
AHNAK AHNAK nucleoprotein 0.0296106
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0294827
VCL vinculin 0.0284637
WWTR1 WW domain containing transcription regulator 1 0.0283829
KRT18 keratin 18, type I 0.0275526
TOP1 topoisomerase (DNA) I 0.0255539
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.025355
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0245062
LPP LIM domain containing preferred translocation partner in lipoma 0.0235618
DST dystonin 0.0231349
RUNX1 runt-related transcription factor 1 0.0224996
INTS6 integrator complex subunit 6 0.0224193
SQSTM1 sequestosome 1 0.0214174
FTH1 ferritin, heavy polypeptide 1 0.0213988
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0209507
AKAP9 A kinase (PRKA) anchor protein 9 0.0195147
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0194981
THSD4 thrombospondin, type I, domain containing 4 0.0194853
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 0.0194579
FMNL2 formin-like 2 0.018614
ENO2 enolase 2 (gamma, neuronal) 0.0186072
PRELID2 PRELI domain containing 2 0.0185582
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0182062
VEGFC vascular endothelial growth factor C 0.0180429
CENPF centromere protein F, 350/400kDa 0.0179372
FNIP1 folliculin interacting protein 1 0.0178624
ZSWIM6 zinc finger, SWIM-type containing 6 0.0172047
ANKRD12 ankyrin repeat domain 12 0.0170838
NEK10 NIMA-related kinase 10 0.0170535
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0169423
RPS4X ribosomal protein S4, X-linked 0.0168967
MB21D2 Mab-21 domain containing 2 0.0168697
MT1X metallothionein 1X 0.016815
CDK6 cyclin-dependent kinase 6 0.0167872
FN1 fibronectin 1 0.0167852
AKAP12 A kinase (PRKA) anchor protein 12 0.0166543
MACF1 microtubule-actin crosslinking factor 1 0.0165712
SON SON DNA binding protein 0.0162399
BCAS3 breast carcinoma amplified sequence 3 0.0156287
RTTN rotatin 0.0155191
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0155102
SDCCAG8 serologically defined colon cancer antigen 8 0.0154705
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0153738
PDE4D phosphodiesterase 4D, cAMP-specific 0.0152589
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0152153
RCOR1 REST corepressor 1 0.0151868
ASPH aspartate beta-hydroxylase 0.0151229
EMP1 epithelial membrane protein 1 0.0145812
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0145257
CUL4B cullin 4B 0.0144917
CAPRIN2 caprin family member 2 0.0144229
AKAP13 A kinase (PRKA) anchor protein 13 0.0144199
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0142829
MON2 MON2 homolog (S. cerevisiae) 0.0141712
PLK2 polo-like kinase 2 0.014121
TXNRD1 thioredoxin reductase 1 0.0140805
TMSB10 thymosin beta 10 0.0139623
STK17A serine/threonine kinase 17a 0.0138383
ANKRD50 ankyrin repeat domain 50 0.0136665
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0136467
UTRN utrophin 0.0135028
ADGRG6 adhesion G protein-coupled receptor G6 0.0131971
RPL11 ribosomal protein L11 0.0130665
GCLM glutamate-cysteine ligase, modifier subunit 0.0129648
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.0128008
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0127157
COL6A3 collagen, type VI, alpha 3 0.0123041
NCAPD2 non-SMC condensin I complex, subunit D2 0.0122341
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.012123
MAML2 mastermind-like 2 (Drosophila) 0.0120596
BPTF bromodomain PHD finger transcription factor 0.0120509
TRERF1 transcriptional regulating factor 1 0.01202
NCEH1 neutral cholesterol ester hydrolase 1 0.01195
LMO7 LIM domain 7 0.0119036
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0118855
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0118385
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0118175
MYH9 myosin, heavy chain 9, non-muscle 0.0118009
CCDC88A coiled-coil domain containing 88A 0.0117739
EXT1 exostosin glycosyltransferase 1 0.0116571
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0115892
ATG10 autophagy related 10 0.011572
TM4SF1 transmembrane 4 L six family member 1 0.0114014
TSC22D2 TSC22 domain family, member 2 0.0113439
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0112553
REST RE1-silencing transcription factor 0.011251
ARHGAP5 Rho GTPase activating protein 5 0.0112381
BMERB1 bMERB domain containing 1 0.0112146
PDHX pyruvate dehydrogenase complex, component X 0.0111475
ATXN7L1 ataxin 7-like 1 0.0111233
ATM ATM serine/threonine kinase 0.0110783
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.0110321
APLP2 amyloid beta (A4) precursor-like protein 2 0.0110102
TPRG1 tumor protein p63 regulated 1 0.0109946
ARHGAP29 Rho GTPase activating protein 29 0.0109939
ITGB4 integrin, beta 4 0.0108487

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.197104
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0861872
TP63 tumor protein p63 -0.0707256
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.067664
PTMA prothymosin, alpha -0.0640935
RPL35A ribosomal protein L35a -0.0607013
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.057694
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0536064
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0522039
RPS6 ribosomal protein S6 -0.0473838
SDK1 sidekick cell adhesion molecule 1 -0.0449044
CADM2 cell adhesion molecule 2 -0.0447295
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0429367
TMSB4X thymosin beta 4, X-linked -0.04203
ZMYND8 zinc finger, MYND-type containing 8 -0.0409617
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0406533
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0402559
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0394855
RPL36A ribosomal protein L36a -0.039094
WSB1 WD repeat and SOCS box containing 1 -0.0377243
TNS3 tensin 3 -0.0376884
EZR ezrin -0.037093
ENO1 enolase 1, (alpha) -0.0367612
KPNB1 karyopherin (importin) beta 1 -0.0365326
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0348818
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0342039
CD44 CD44 molecule (Indian blood group) -0.0339693
ESYT2 extended synaptotagmin-like protein 2 -0.0325389
RPLP1 ribosomal protein, large, P1 -0.0322491
RPS8 ribosomal protein S8 -0.0314548
RPL31 ribosomal protein L31 -0.0307295
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0305054
HLA-E major histocompatibility complex, class I, E -0.0303313
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0297819
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0294218
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0282264
NPEPPS aminopeptidase puromycin sensitive -0.0281339
IFIH1 interferon induced with helicase C domain 1 -0.0263825
APP amyloid beta (A4) precursor protein -0.0260594
YEATS2 YEATS domain containing 2 -0.0260405
TPM4 tropomyosin 4 -0.0257476
NAMPT nicotinamide phosphoribosyltransferase -0.0257002
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0255383
NIBAN2 niban apoptosis regulator 2 -0.0255137
ANKRD11 ankyrin repeat domain 11 -0.0254686
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0248795
ANGPTL4 angiopoietin-like 4 -0.024616
PYGL phosphorylase, glycogen, liver -0.0245007
KDM2A lysine (K)-specific demethylase 2A -0.0244453
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0243118
PIAS2 protein inhibitor of activated STAT, 2 -0.0242866
RPL37 ribosomal protein L37 -0.0235198
NDRG1 N-myc downstream regulated 1 -0.0231862
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0230405
TXNIP thioredoxin interacting protein -0.0228234
RPL39 ribosomal protein L39 -0.0227085
RPS28 ribosomal protein S28 -0.0226162
PRRC2B proline-rich coiled-coil 2B -0.0224966
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0219558
WNK1 WNK lysine deficient protein kinase 1 -0.0217306
MATR3 matrin 3 -0.0213024
DLG1 discs, large homolog 1 (Drosophila) -0.021243
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0212255
PCBP2 poly(rC) binding protein 2 -0.021112
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0209757
FBXO11 F-box protein 11 -0.0209191
RPS19 ribosomal protein S19 -0.0208044
MT1E metallothionein 1E -0.0207687
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0207153
RPL7A ribosomal protein L7a -0.0204653
HMGA1 high mobility group AT-hook 1 -0.0204379
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0203962
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0203358
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0202723
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.020248
HOOK2 hook microtubule-tethering protein 2 -0.0201498
CLIP2 CAP-GLY domain containing linker protein 2 -0.0201395
TRIM56 tripartite motif containing 56 -0.0200308
RPS16 ribosomal protein S16 -0.0199931
PTK2 protein tyrosine kinase 2 -0.019961
EGR1 early growth response 1 -0.019959
CAVIN1 caveolae associated protein 1 -0.0198916
WARS1 tryptophanyl-tRNA synthetase 1 -0.0196377
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0195469
IFI6 interferon, alpha-inducible protein 6 -0.0195394
FBXO17 F-box protein 17 -0.0195113
BAZ1B bromodomain adjacent to zinc finger domain, 1B -0.0194462
ARL4C ADP-ribosylation factor-like 4C -0.019262
RPL5 ribosomal protein L5 -0.0191563
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.019036
RPS27 ribosomal protein S27 -0.0190035
EPHA4 EPH receptor A4 -0.0189158
SOD2 superoxide dismutase 2, mitochondrial -0.018756
SLC38A1 solute carrier family 38, member 1 -0.0186593
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0185721
RNF213 ring finger protein 213 -0.0184304
AGTPBP1 ATP/GTP binding protein 1 -0.0183277
LOXL2 lysyl oxidase-like 2 -0.0182563
CUX1 cut-like homeobox 1 -0.0181473
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0181409