Sodium Salicylate_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sodium Salicylate perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sodium Salicylate_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 0.259526
THSD4 thrombospondin, type I, domain containing 4 0.0911659
SLTM SAFB-like, transcription modulator 0.0568212
ASPH aspartate beta-hydroxylase 0.0543086
PTPRM protein tyrosine phosphatase, receptor type, M 0.0489375
EFNA5 ephrin-A5 0.0445637
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0442296
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.04383
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0434727
GRAMD1B GRAM domain containing 1B 0.0403494
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0384296
DOCK5 dedicator of cytokinesis 5 0.0377511
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0368434
SAMD4A sterile alpha motif domain containing 4A 0.0338755
PDLIM5 PDZ and LIM domain 5 0.0335107
CEMIP cell migration inducing protein, hyaluronan binding 0.0326478
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0305263
PDE4D phosphodiesterase 4D, cAMP-specific 0.0304908
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0303097
SMAD3 SMAD family member 3 0.0298896
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0290602
RNF213 ring finger protein 213 0.0288525
RAD51B RAD51 paralog B 0.0288328
FNDC3B fibronectin type III domain containing 3B 0.0283307
PLEC plectin 0.0277059
LPP LIM domain containing preferred translocation partner in lipoma 0.0257779
MCL1 myeloid cell leukemia 1 0.0250789
BCAR3 breast cancer anti-estrogen resistance 3 0.0241824
INTS6 integrator complex subunit 6 0.022765
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0216811
SUMF1 sulfatase modifying factor 1 0.020973
GRB10 growth factor receptor-bound protein 10 0.0208335
AKAP13 A kinase (PRKA) anchor protein 13 0.0207783
NPAS2 neuronal PAS domain protein 2 0.0207757
DOCK1 dedicator of cytokinesis 1 0.0207318
MACF1 microtubule-actin crosslinking factor 1 0.0205979
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0196438
LGALS12 lectin, galactoside-binding, soluble, 12 0.0196143
SCEL sciellin 0.0194426
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.019426
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0191696
MYO1E myosin IE 0.0188962
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0187043
TRAPPC9 trafficking protein particle complex 9 0.0183493
LAMC2 laminin, gamma 2 0.0182748
MYOF myoferlin 0.0180749
IGF1R insulin-like growth factor 1 receptor 0.0178779
SMYD3 SET and MYND domain containing 3 0.0175202
TBC1D22A TBC1 domain family, member 22A 0.0174318
VCL vinculin 0.0173162
CCSER1 coiled-coil serine-rich protein 1 0.0172656
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0171276
MYH9 myosin, heavy chain 9, non-muscle 0.0171244
PM20D1 peptidase M20 domain containing 1 0.0168434
ZNF638 zinc finger protein 638 0.0167465
MAML3 mastermind-like 3 (Drosophila) 0.016672
ATP11A ATPase, class VI, type 11A 0.0161694
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0156728
PRKCA protein kinase C, alpha 0.0154872
VEGFC vascular endothelial growth factor C 0.0153431
FOXP1 forkhead box P1 0.0153
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0151458
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0151207
SVIL supervillin 0.0150423
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0149804
OSMR oncostatin M receptor 0.0149684
NABP1 nucleic acid binding protein 1 0.0149638
ZSWIM6 zinc finger, SWIM-type containing 6 0.0149184
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0147534
CMIP c-Maf inducing protein 0.0146166
RABGAP1L RAB GTPase activating protein 1-like 0.0140463
EXT1 exostosin glycosyltransferase 1 0.0138394
AHNAK AHNAK nucleoprotein 0.0137368
TRIO trio Rho guanine nucleotide exchange factor 0.0134357
PATJ PATJ crumbs cell polarity complex component 0.0133089
PTK2 protein tyrosine kinase 2 0.0132974
RIMS2 regulating synaptic membrane exocytosis 2 0.0132418
MSN moesin 0.0130773
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0130567
DSPP dentin sialophosphoprotein 0.0129159
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 0.0128769
ERRFI1 ERBB receptor feedback inhibitor 1 0.012835
NRIP1 nuclear receptor interacting protein 1 0.0127032
MCTP1 multiple C2 domains, transmembrane 1 0.0126121
TNS3 tensin 3 0.0126051
EHBP1 EH domain binding protein 1 0.0125265
TBC1D5 TBC1 domain family, member 5 0.0124359
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0122978
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0122005
CUX1 cut-like homeobox 1 0.0121651
FLNA filamin A, alpha 0.0119931
FLNB filamin B, beta 0.0119154
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0118202
LRP12 low density lipoprotein receptor-related protein 12 0.0116719
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0116585
HDAC4 histone deacetylase 4 0.0116047
CTBP2 C-terminal binding protein 2 0.0115903
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0115532
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0114928
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0114113

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.349024
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.134452
TMSB10 thymosin beta 10 -0.102497
MT2A metallothionein 2A -0.0797925
FTL ferritin, light polypeptide -0.0761608
TPT1 tumor protein, translationally-controlled 1 -0.0721738
PTMA prothymosin, alpha -0.0598436
SEC61G Sec61 gamma subunit -0.051835
RPS3 ribosomal protein S3 -0.0510942
NDRG1 N-myc downstream regulated 1 -0.0490625
RPLP1 ribosomal protein, large, P1 -0.0468569
TXNRD1 thioredoxin reductase 1 -0.0467186
RPL35A ribosomal protein L35a -0.0430647
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0414902
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0399952
NAMPT nicotinamide phosphoribosyltransferase -0.0393852
EIF1 eukaryotic translation initiation factor 1 -0.0387483
RPS8 ribosomal protein S8 -0.0366643
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0360082
RPL37A ribosomal protein L37a -0.0350989
RPL34 ribosomal protein L34 -0.0347156
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0344361
S100A10 S100 calcium binding protein A10 -0.0344243
RPS24 ribosomal protein S24 -0.0343575
RPS25 ribosomal protein S25 -0.0337474
PRRC2C proline-rich coiled-coil 2C -0.0332185
H1-0 H1.0 linker histone -0.0327284
B2M beta-2-microglobulin -0.0321253
PGK1 phosphoglycerate kinase 1 -0.0317278
RPLP0 ribosomal protein, large, P0 -0.0316764
LDHA lactate dehydrogenase A -0.0314629
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0314255
UBC ubiquitin C -0.0301504
FTH1 ferritin, heavy polypeptide 1 -0.0298038
PKM pyruvate kinase, muscle -0.0285344
LOC112694756 uncharaterized LOC112694756 -0.0284204
RPL31 ribosomal protein L31 -0.0283569
RPS6 ribosomal protein S6 -0.02687
RPS23 ribosomal protein S23 -0.026727
ENO1 enolase 1, (alpha) -0.0265374
RPL11 ribosomal protein L11 -0.0265161
CST3 cystatin C -0.0262384
TMEM165 transmembrane protein 165 -0.0256077
RPL12 ribosomal protein L12 -0.0251254
RPS12 ribosomal protein S12 -0.0247294
WDR45B WD repeat domain 45B -0.024719
SLC38A1 solute carrier family 38, member 1 -0.024694
RPS27A ribosomal protein S27a -0.0244078
S100P S100 calcium binding protein P -0.0238276
RAB7A RAB7A, member RAS oncogene family -0.0233364
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0233238
WASF2 WAS protein family, member 2 -0.0226479
RACK1 receptor for activated C kinase 1 -0.0218271
RPS19 ribosomal protein S19 -0.0216314
RPL19 ribosomal protein L19 -0.0214453
RPL30 ribosomal protein L30 -0.0213668
ACTG1 actin gamma 1 -0.0212331
BTG1 B-cell translocation gene 1, anti-proliferative -0.0207597
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0205354
RPL8 ribosomal protein L8 -0.0202589
RPL37 ribosomal protein L37 -0.0201175
TOP1 topoisomerase (DNA) I -0.0199708
S100A9 S100 calcium binding protein A9 -0.0199321
KDM3A lysine (K)-specific demethylase 3A -0.0199224
UVRAG UV radiation resistance associated -0.0198824
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0198345
RPS29 ribosomal protein S29 -0.0195911
IER3 immediate early response 3 -0.0193506
MT1X metallothionein 1X -0.0190008
MORF4L2 mortality factor 4 like 2 -0.0189651
ARRDC3 arrestin domain containing 3 -0.0187946
CCNI cyclin I -0.0187849
AKR1C1 aldo-keto reductase family 1, member C1 -0.0187388
RPS14 ribosomal protein S14 -0.018281
RPL23 ribosomal protein L23 -0.0180043
RPS27 ribosomal protein S27 -0.01783
CSTB cystatin B (stefin B) -0.0178007
RPL7 ribosomal protein L7 -0.0176926
RNMT RNA (guanine-7-) methyltransferase -0.0173706
RPS17 ribosomal protein S17 -0.0170422
TPD52 tumor protein D52 -0.0168929
MKI67 marker of proliferation Ki-67 -0.016797
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0166192
RPS21 ribosomal protein S21 -0.0165773
RPL26 ribosomal protein L26 -0.0165034
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0164882
HILPDA hypoxia inducible lipid droplet-associated -0.0164881
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0164682
C15ORF48 chromosome 15 open reading frame 48 -0.0163492
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0163037
KCMF1 potassium channel modulatory factor 1 -0.0161332
S100A6 S100 calcium binding protein A6 -0.0159589
SPAG9 sperm associated antigen 9 -0.0159551
RPS16 ribosomal protein S16 -0.0159403
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.01591
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0158858
ABLIM1 actin binding LIM protein 1 -0.0158549
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0157558
RPLP2 ribosomal protein, large, P2 -0.0157208
MXI1 MAX interactor 1, dimerization protein -0.015702