Sodium Salicylate_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sodium Salicylate perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Sodium Salicylate_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SDK1 sidekick cell adhesion molecule 1 0.124943
GRB10 growth factor receptor-bound protein 10 0.107231
SMAD3 SMAD family member 3 0.0958938
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0866127
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0856875
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0823711
PCBP2 poly(rC) binding protein 2 0.080415
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0798267
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0678618
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0655658
TGM2 transglutaminase 2 0.0611867
NAV2 neuron navigator 2 0.0610213
KDM2A lysine (K)-specific demethylase 2A 0.0602445
ZSWIM6 zinc finger, SWIM-type containing 6 0.0585051
FNDC3B fibronectin type III domain containing 3B 0.0554419
SOD2 superoxide dismutase 2, mitochondrial 0.055282
RICTOR RPTOR independent companion of MTOR, complex 2 0.0552599
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0549535
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0522313
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0517838
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0513811
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0498871
PDLIM5 PDZ and LIM domain 5 0.0492716
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0485334
AADAC arylacetamide deacetylase 0.048303
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0474876
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0473624
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0463626
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0462289
EXT1 exostosin glycosyltransferase 1 0.046142
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0431203
SPAG9 sperm associated antigen 9 0.0429752
NDRG1 N-myc downstream regulated 1 0.0425532
INTS6 integrator complex subunit 6 0.042266
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0419631
ATXN1 ataxin 1 0.0418939
TRIO trio Rho guanine nucleotide exchange factor 0.0417644
LOXL2 lysyl oxidase-like 2 0.0415751
ELL2 elongation factor, RNA polymerase II, 2 0.0407336
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0394656
PTK2 protein tyrosine kinase 2 0.038623
MYH9 myosin, heavy chain 9, non-muscle 0.0386179
APLP2 amyloid beta (A4) precursor-like protein 2 0.0385458
EFNA5 ephrin-A5 0.0385415
NTN4 netrin 4 0.0384482
RUNX1 runt-related transcription factor 1 0.0370999
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0369257
HELZ helicase with zinc finger 0.036647
WAC WW domain containing adaptor with coiled-coil 0.0358083
SIK3 SIK family kinase 3 0.0351893
RAB1A RAB1A, member RAS oncogene family 0.0351045
RARB retinoic acid receptor, beta 0.0349957
EEF2 eukaryotic translation elongation factor 2 0.0348837
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0340776
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0337908
RBM39 RNA binding motif protein 39 0.0334359
VEGFA vascular endothelial growth factor A 0.0320867
GLS2 glutaminase 2 (liver, mitochondrial) 0.0320783
EPS8 epidermal growth factor receptor pathway substrate 8 0.0318249
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0317424
WLS wntless Wnt ligand secretion mediator 0.031037
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0308109
ANXA2 annexin A2 0.0307677
MARCKS myristoylated alanine-rich protein kinase C substrate 0.030764
MED13 mediator complex subunit 13 0.0307328
ECE1 endothelin converting enzyme 1 0.0305545
ZNF638 zinc finger protein 638 0.030452
PKM pyruvate kinase, muscle 0.0302445
DTNA dystrobrevin, alpha 0.0300451
TGFB1 transforming growth factor, beta 1 0.0299933
DOCK5 dedicator of cytokinesis 5 0.0296849
RAP1B RAP1B, member of RAS oncogene family 0.0296824
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0296422
ADD3 adducin 3 (gamma) 0.0296181
BIRC3 baculoviral IAP repeat containing 3 0.0294103
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0293338
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0289727
YBX1 Y box binding protein 1 0.0285282
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0284382
MYO10 myosin X 0.0283738
ASPH aspartate beta-hydroxylase 0.0279168
AKAP13 A kinase (PRKA) anchor protein 13 0.0276516
PIAS2 protein inhibitor of activated STAT, 2 0.0275965
MBNL1 muscleblind-like splicing regulator 1 0.027339
FAM107B family with sequence similarity 107, member B 0.0269845
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0261642
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0259757
FAM13A family with sequence similarity 13, member A 0.0255242
PARD3 par-3 family cell polarity regulator 0.0251472
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.0248832
RCOR1 REST corepressor 1 0.02474
HILPDA hypoxia inducible lipid droplet-associated 0.0247267
KTN1 kinectin 1 (kinesin receptor) 0.0245683
MACF1 microtubule-actin crosslinking factor 1 0.0243537
HMGA2 high mobility group AT-hook 2 0.0243247
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0243134
EZR ezrin 0.0240949
PARP8 poly (ADP-ribose) polymerase family, member 8 0.024041
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0240208
FAM20C family with sequence similarity 20, member C 0.0238961

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.128675
TMSB10 thymosin beta 10 -0.106577
NAMPT nicotinamide phosphoribosyltransferase -0.0586671
OSMR oncostatin M receptor -0.0572366
FN1 fibronectin 1 -0.0535267
RAB27B RAB27B, member RAS oncogene family -0.0532566
ZMYND8 zinc finger, MYND-type containing 8 -0.0518906
DPYD dihydropyrimidine dehydrogenase -0.0503852
LOX lysyl oxidase -0.0450576
TFPI2 tissue factor pathway inhibitor 2 -0.038961
CDH13 cadherin 13 -0.0383226
VIM vimentin -0.0378796
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0378489
NRG1 neuregulin 1 -0.0375391
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0369373
ENO1 enolase 1, (alpha) -0.0366582
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0358227
TPT1 tumor protein, translationally-controlled 1 -0.0353976
IFI6 interferon, alpha-inducible protein 6 -0.034579
GPC6 glypican 6 -0.034413
SYT1 synaptotagmin I -0.0334631
PTGIS prostaglandin I2 (prostacyclin) synthase -0.0321779
ETV6 ets variant 6 -0.0311891
GCC2 GRIP and coiled-coil domain containing 2 -0.0308816
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0301128
EXOC4 exocyst complex component 4 -0.0293531
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0291831
ZBTB20 zinc finger and BTB domain containing 20 -0.0289851
NPC1 Niemann-Pick disease, type C1 -0.0286019
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0281161
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 -0.0279663
S100A6 S100 calcium binding protein A6 -0.0278948
NAV3 neuron navigator 3 -0.0278717
TM4SF1 transmembrane 4 L six family member 1 -0.0268105
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0267467
PSD3 pleckstrin and Sec7 domain containing 3 -0.0259724
MYO9A myosin IXA -0.02501
MECOM MDS1 and EVI1 complex locus -0.025006
PID1 phosphotyrosine interaction domain containing 1 -0.0248896
CDCP1 CUB domain containing protein 1 -0.0248405
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0247353
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.0242241
ZNF804A zinc finger protein 804A -0.0242004
MAML3 mastermind-like 3 (Drosophila) -0.0237276
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0236208
PTPRK protein tyrosine phosphatase, receptor type, K -0.0232619
HEG1 heart development protein with EGF-like domains 1 -0.0229555
RPL37A ribosomal protein L37a -0.0224857
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0224517
GRIK5 glutamate receptor, ionotropic, kainate 5 -0.0221732
ANTXR2 anthrax toxin receptor 2 -0.0218462
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0216072
CLMP CXADR-like membrane protein -0.0211172
MON2 MON2 homolog (S. cerevisiae) -0.0210738
B2M beta-2-microglobulin -0.0209741
RPS19 ribosomal protein S19 -0.0205973
PGK1 phosphoglycerate kinase 1 -0.0205183
PRSS23 protease, serine, 23 -0.0200865
RPL36 ribosomal protein L36 -0.0199959
DST dystonin -0.0199069
NLRP1 NLR family, pyrin domain containing 1 -0.019881
IGFBP3 insulin-like growth factor binding protein 3 -0.0198593
MSRB3 methionine sulfoxide reductase B3 -0.0193186
HDLBP high density lipoprotein binding protein -0.01899
COL12A1 collagen, type XII, alpha 1 -0.018966
EIF1 eukaryotic translation initiation factor 1 -0.0186752
ATG7 autophagy related 7 -0.0185679
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0183654
LTBP1 latent transforming growth factor beta binding protein 1 -0.0183244
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 -0.0182047
ENO2 enolase 2 (gamma, neuronal) -0.0181834
TMTC1 transmembrane and tetratricopeptide repeat containing 1 -0.0180037
HLA-B major histocompatibility complex, class I, B -0.0179859
PTPRR protein tyrosine phosphatase, receptor type, R -0.0178451
TAS2R14 taste receptor, type 2, member 14 -0.0176884
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0176649
EHBP1 EH domain binding protein 1 -0.0176127
DCN decorin -0.0175332
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0171916
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0171352
BMAL2 basic helix-loop-helix ARNT like 2 -0.0170192
TTC3 tetratricopeptide repeat domain 3 -0.016928
ATM ATM serine/threonine kinase -0.0168506
CEMIP cell migration inducing protein, hyaluronan binding -0.016644
FAM114A1 family with sequence similarity 114, member A1 -0.0165475
PCNX4 pecanex 4 -0.0161518
RPL34 ribosomal protein L34 -0.0160672
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0160504
ADAM28 ADAM metallopeptidase domain 28 -0.0160479
WSB1 WD repeat and SOCS box containing 1 -0.0159034
IFITM3 interferon induced transmembrane protein 3 -0.0158389
AOPEP aminopeptidase O (putative) -0.0158049
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0157204
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.01571
IFI16 interferon, gamma-inducible protein 16 -0.0155923
LRRC49 leucine rich repeat containing 49 -0.0154919
PTPRF protein tyrosine phosphatase, receptor type, F -0.0154546
ENOSF1 enolase superfamily member 1 -0.0154381
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0153478
RPL37 ribosomal protein L37 -0.0152699