Sodium Salicylate_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sodium Salicylate perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sodium Salicylate_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.217038
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.185698
FN1 fibronectin 1 0.15558
PABPC1 poly(A) binding protein, cytoplasmic 1 0.114522
FNDC3B fibronectin type III domain containing 3B 0.0998071
TSC22D2 TSC22 domain family, member 2 0.0990526
MYH9 myosin, heavy chain 9, non-muscle 0.083794
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0749218
EEF2 eukaryotic translation elongation factor 2 0.0744375
FAM13A family with sequence similarity 13, member A 0.073632
PTK2 protein tyrosine kinase 2 0.0734375
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0718544
CANX calnexin 0.0650347
ELL2 elongation factor, RNA polymerase II, 2 0.0623229
NAMPT nicotinamide phosphoribosyltransferase 0.0573119
BHLHE40 basic helix-loop-helix family, member e40 0.0558048
NDRG1 N-myc downstream regulated 1 0.0523918
RNF145 ring finger protein 145 0.0523162
KDM3A lysine (K)-specific demethylase 3A 0.051869
PLEC plectin 0.051844
GOLGA4 golgin A4 0.0517385
MATR3 matrin 3 0.0510324
KMT2E lysine (K)-specific methyltransferase 2E 0.0506535
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0501061
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0484916
ZNF292 zinc finger protein 292 0.0482836
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0478158
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0466384
FXR1 fragile X mental retardation, autosomal homolog 1 0.046626
RLF rearranged L-myc fusion 0.0448592
MARCHF6 membrane associated ring-CH-type finger 6 0.0445221
KDM6A lysine (K)-specific demethylase 6A 0.0432776
WDFY3 WD repeat and FYVE domain containing 3 0.0431191
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0427941
IGFBP3 insulin-like growth factor binding protein 3 0.0424468
HSPA8 heat shock 70kDa protein 8 0.0424012
SPAG9 sperm associated antigen 9 0.0420328
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.041721
CDC73 cell division cycle 73 0.0416585
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0411996
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.039766
CCNL1 cyclin L1 0.0395416
PAPOLA poly(A) polymerase alpha 0.0390515
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0377752
VEGFA vascular endothelial growth factor A 0.0376761
ZFAND3 zinc finger, AN1-type domain 3 0.0376645
RYBP RING1 and YY1 binding protein 0.0371943
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0370049
HELZ helicase with zinc finger 0.0369007
COPA coatomer protein complex, subunit alpha 0.0362961
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0357041
RBM39 RNA binding motif protein 39 0.0350105
GARS1 glycyl-tRNA synthetase 1 0.0349241
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0345433
MEF2A myocyte enhancer factor 2A 0.0344825
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0343939
USP3 ubiquitin specific peptidase 3 0.0341271
TFG TRK-fused gene 0.0339317
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0338648
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0336659
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0333102
GRB10 growth factor receptor-bound protein 10 0.033011
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0328844
EPS8 epidermal growth factor receptor pathway substrate 8 0.0324644
EZR ezrin 0.0317042
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0314613
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0313501
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0310461
RHEB Ras homolog enriched in brain 0.0306961
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0306626
ADAM9 ADAM metallopeptidase domain 9 0.0306083
RAD21 RAD21 homolog (S. pombe) 0.0305344
RSRC2 arginine/serine-rich coiled-coil 2 0.0297498
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0296927
PUM2 pumilio RNA-binding family member 2 0.0292397
NCKAP1 NCK-associated protein 1 0.0291978
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0291906
PUM1 pumilio RNA-binding family member 1 0.0290711
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0290583
APLP2 amyloid beta (A4) precursor-like protein 2 0.0287158
HMGB2 high mobility group box 2 0.0286009
BRD2 bromodomain containing 2 0.0282718
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0281548
RBM33 RNA binding motif protein 33 0.027466
IQGAP1 IQ motif containing GTPase activating protein 1 0.0272489
WAC WW domain containing adaptor with coiled-coil 0.0271032
ZNF148 zinc finger protein 148 0.0270582
TXNRD1 thioredoxin reductase 1 0.0270086
RAD23B RAD23 homolog B (S. cerevisiae) 0.0268502
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0267223
ANXA5 annexin A5 0.02672
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0266036
CALR calreticulin 0.0265611
TPM3 tropomyosin 3 0.0265122
ASPH aspartate beta-hydroxylase 0.0265055
ANKRD11 ankyrin repeat domain 11 0.0262395
GPBP1 GC-rich promoter binding protein 1 0.0262237
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0261728
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.026069
UBA6 ubiquitin-like modifier activating enzyme 6 0.0260357

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.203048
FTL ferritin, light polypeptide -0.183812
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.176084
TMSB10 thymosin beta 10 -0.160438
ACTG1 actin gamma 1 -0.107866
IFI6 interferon, alpha-inducible protein 6 -0.0973487
IFI27 interferon, alpha-inducible protein 27 -0.0945911
TPT1 tumor protein, translationally-controlled 1 -0.069964
MT2A metallothionein 2A -0.068694
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.068202
PTMA prothymosin, alpha -0.0679224
ISG15 ISG15 ubiquitin-like modifier -0.063711
TM4SF1 transmembrane 4 L six family member 1 -0.0636572
FBXO32 F-box protein 32 -0.0607372
WSB1 WD repeat and SOCS box containing 1 -0.056674
S100A10 S100 calcium binding protein A10 -0.0562438
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0555617
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0550657
LAMB3 laminin, beta 3 -0.0540107
LPP LIM domain containing preferred translocation partner in lipoma -0.0533763
SOX4 SRY (sex determining region Y)-box 4 -0.0531171
IFITM1 interferon induced transmembrane protein 1 -0.0512996
S100A6 S100 calcium binding protein A6 -0.051086
KRT7 keratin 7, type II -0.0494887
CSTB cystatin B (stefin B) -0.0462156
IFITM3 interferon induced transmembrane protein 3 -0.0446491
HLA-B major histocompatibility complex, class I, B -0.0443833
EXT1 exostosin glycosyltransferase 1 -0.0440012
IFI16 interferon, gamma-inducible protein 16 -0.0436836
LDHA lactate dehydrogenase A -0.041414
HLA-A major histocompatibility complex, class I, A -0.0403303
LY6E lymphocyte antigen 6 complex, locus E -0.0395432
RPL23 ribosomal protein L23 -0.0392126
G0S2 G0/G1 switch 2 -0.0382198
RPS13 ribosomal protein S13 -0.0381479
RPL34 ribosomal protein L34 -0.0376993
RPS23 ribosomal protein S23 -0.0370898
RPLP2 ribosomal protein, large, P2 -0.0359588
CCND1 cyclin D1 -0.0358646
HMGA1 high mobility group AT-hook 1 -0.0351824
RPS3 ribosomal protein S3 -0.0345366
S100A9 S100 calcium binding protein A9 -0.0342434
RPS8 ribosomal protein S8 -0.033576
RPS19 ribosomal protein S19 -0.033572
LMO7 LIM domain 7 -0.0334072
ZBTB20 zinc finger and BTB domain containing 20 -0.0329035
RPL35A ribosomal protein L35a -0.0328271
HSPB1 heat shock 27kDa protein 1 -0.0323569
SAMD4A sterile alpha motif domain containing 4A -0.0321485
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0320579
MDK midkine (neurite growth-promoting factor 2) -0.0320133
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0311381
ENO1 enolase 1, (alpha) -0.0310926
RPL32 ribosomal protein L32 -0.0307853
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0299682
RRBP1 ribosome binding protein 1 -0.0297444
C15ORF48 chromosome 15 open reading frame 48 -0.0297235
RPL37A ribosomal protein L37a -0.0292563
RPL9 ribosomal protein L9 -0.029141
KRT19 keratin 19, type I -0.0290293
RPS21 ribosomal protein S21 -0.0288593
RPS29 ribosomal protein S29 -0.0286968
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0286063
RPS14 ribosomal protein S14 -0.0284883
FTH1 ferritin, heavy polypeptide 1 -0.0284332
CAB39 calcium binding protein 39 -0.0281696
S100A11 S100 calcium binding protein A11 -0.0278719
RPLP1 ribosomal protein, large, P1 -0.0274207
RIGI RNA sensor RIG-I -0.0272356
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0270054
ARHGAP5 Rho GTPase activating protein 5 -0.0265285
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0264402
CD63 CD63 molecule -0.0263238
RPS24 ribosomal protein S24 -0.0262663
RPL30 ribosomal protein L30 -0.0261712
PDLIM5 PDZ and LIM domain 5 -0.0261031
AREG amphiregulin -0.0260201
RPL28 ribosomal protein L28 -0.0260172
SQSTM1 sequestosome 1 -0.0257269
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0251386
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0249195
LAMC2 laminin, gamma 2 -0.0248928
RPL36 ribosomal protein L36 -0.0242805
RPL37 ribosomal protein L37 -0.0241662
RPL12 ribosomal protein L12 -0.0239984
F3 coagulation factor III (thromboplastin, tissue factor) -0.0239725
EGFR epidermal growth factor receptor -0.0239262
B2M beta-2-microglobulin -0.0230079
TPI1 triosephosphate isomerase 1 -0.022968
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0229258
ENO2 enolase 2 (gamma, neuronal) -0.0228688
ERBIN erbb2 interacting protein -0.0225133
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0222304
IFIH1 interferon induced with helicase C domain 1 -0.0221118
PGK1 phosphoglycerate kinase 1 -0.0220614
IFI44L interferon-induced protein 44-like -0.022042
EFNA5 ephrin-A5 -0.0217639
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0217523
UBC ubiquitin C -0.0216393
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0214894