Sodium Salicylate_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sodium Salicylate perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sodium Salicylate_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.152947
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.134873
FTH1 ferritin, heavy polypeptide 1 0.124502
EXT1 exostosin glycosyltransferase 1 0.122883
PDE10A phosphodiesterase 10A 0.0984941
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0956969
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0895274
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0821163
PKM pyruvate kinase, muscle 0.0799572
FTL ferritin, light polypeptide 0.0793941
SND1 staphylococcal nuclease and tudor domain containing 1 0.0775624
DST dystonin 0.0768972
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0766573
NAP1L1 nucleosome assembly protein 1-like 1 0.0750583
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0743771
EPS8 epidermal growth factor receptor pathway substrate 8 0.0687557
RPS12 ribosomal protein S12 0.0677639
ERBIN erbb2 interacting protein 0.065025
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0633339
RPL35A ribosomal protein L35a 0.0612795
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0601536
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0598314
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0593504
IGFBP3 insulin-like growth factor binding protein 3 0.0576494
SBF2 SET binding factor 2 0.0557818
NCOA3 nuclear receptor coactivator 3 0.0546807
PGK1 phosphoglycerate kinase 1 0.0541179
SCFD1 sec1 family domain containing 1 0.0524545
EIF1 eukaryotic translation initiation factor 1 0.051593
RPS11 ribosomal protein S11 0.0502593
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0497207
PSD3 pleckstrin and Sec7 domain containing 3 0.0495515
POTEF POTE ankyrin domain family, member F 0.0487978
SLC38A2 solute carrier family 38, member 2 0.0485228
PTK2 protein tyrosine kinase 2 0.0484165
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0473037
RUNX1 runt-related transcription factor 1 0.0468882
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0466916
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0454508
SRRM2 serine/arginine repetitive matrix 2 0.0454303
BIRC6 baculoviral IAP repeat containing 6 0.0454213
CSNK1A1 casein kinase 1, alpha 1 0.0449743
SAMD4A sterile alpha motif domain containing 4A 0.0440909
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0430903
PLEC plectin 0.0423042
EFNA5 ephrin-A5 0.0419715
ASPH aspartate beta-hydroxylase 0.0415278
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.0414715
GLS2 glutaminase 2 (liver, mitochondrial) 0.0411912
GPC6 glypican 6 0.0392587
INTS6 integrator complex subunit 6 0.0386266
GNAS GNAS complex locus 0.0385529
ALCAM activated leukocyte cell adhesion molecule 0.0373456
RORA RAR-related orphan receptor A 0.0372252
TRIO trio Rho guanine nucleotide exchange factor 0.0368872
FMN1 formin 1 0.0366414
TCF12 transcription factor 12 0.0363916
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0360316
PRKN parkin RBR E3 ubiquitin protein ligase 0.0357539
OGA O-GlcNAcase 0.0357022
CDK6 cyclin-dependent kinase 6 0.0351041
KDM6A lysine (K)-specific demethylase 6A 0.0349497
TXNRD1 thioredoxin reductase 1 0.0345171
OSBPL8 oxysterol binding protein-like 8 0.0343618
LDHA lactate dehydrogenase A 0.0340932
ARHGAP32 Rho GTPase activating protein 32 0.0337327
TPT1 tumor protein, translationally-controlled 1 0.0333519
ZNF292 zinc finger protein 292 0.0333167
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0328584
ERRFI1 ERBB receptor feedback inhibitor 1 0.03279
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0327732
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0325461
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0321919
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0320114
PRRC2C proline-rich coiled-coil 2C 0.0317272
SPAG9 sperm associated antigen 9 0.0299889
VCL vinculin 0.0294894
MED13 mediator complex subunit 13 0.0290745
FAM13A family with sequence similarity 13, member A 0.0290334
RASA2 RAS p21 protein activator 2 0.0273341
NKD1 naked cuticle homolog 1 (Drosophila) 0.026962
CTBP2 C-terminal binding protein 2 0.0269215
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0266223
DSCAM Down syndrome cell adhesion molecule 0.0255209
STC1 stanniocalcin 1 0.0255026
AKAP9 A kinase (PRKA) anchor protein 9 0.0254587
NDRG1 N-myc downstream regulated 1 0.0254024
FNDC3A fibronectin type III domain containing 3A 0.0242047
MAP1B microtubule-associated protein 1B 0.0237771
RERE arginine-glutamic acid dipeptide (RE) repeats 0.023251
CANX calnexin 0.0231473
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0227667
USP34 ubiquitin specific peptidase 34 0.0227524
ARB2A ARB2 cotranscriptional regulator A 0.0225172
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0218815
VMP1 vacuole membrane protein 1 0.0217415
CMIP c-Maf inducing protein 0.0209765
RPL19 ribosomal protein L19 0.020199
TOP1 topoisomerase (DNA) I 0.0197899
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0196192

decreased expression

Symbol Name Standardized Value
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.156826
FN1 fibronectin 1 -0.138825
HMGA2 high mobility group AT-hook 2 -0.121908
TMSB10 thymosin beta 10 -0.116882
PCBP2 poly(rC) binding protein 2 -0.107478
THSD4 thrombospondin, type I, domain containing 4 -0.104468
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0986589
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0921344
ANKRD12 ankyrin repeat domain 12 -0.0918825
CD44 CD44 molecule (Indian blood group) -0.0914934
ATP11A ATPase, class VI, type 11A -0.0820542
RTN4 reticulon 4 -0.0759776
EGFR epidermal growth factor receptor -0.0754485
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0745909
MYO10 myosin X -0.0745036
RPS27A ribosomal protein S27a -0.0744503
VIM vimentin -0.0731167
PTMA prothymosin, alpha -0.0714747
ENO1 enolase 1, (alpha) -0.068256
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0675298
RPLP1 ribosomal protein, large, P1 -0.0665033
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.065746
OSMR oncostatin M receptor -0.0650326
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0575261
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0572729
PRKCA protein kinase C, alpha -0.0569526
SLTM SAFB-like, transcription modulator -0.0566441
ARHGAP5 Rho GTPase activating protein 5 -0.0564343
COL1A1 collagen, type I, alpha 1 -0.0558515
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0555399
B2M beta-2-microglobulin -0.0550662
EMP1 epithelial membrane protein 1 -0.0539826
RNF213 ring finger protein 213 -0.0522229
SEC31A SEC31 homolog A (S. cerevisiae) -0.0512836
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0511263
TXNIP thioredoxin interacting protein -0.0509604
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0486495
LPP LIM domain containing preferred translocation partner in lipoma -0.0474499
NAV1 neuron navigator 1 -0.0472599
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0469402
ITGA6 integrin, alpha 6 -0.0466016
KTN1 kinectin 1 (kinesin receptor) -0.046569
MMP1 matrix metallopeptidase 1 -0.0461653
IGF1R insulin-like growth factor 1 receptor -0.0461047
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0435414
RPL34 ribosomal protein L34 -0.0427916
PDE8A phosphodiesterase 8A -0.0422612
RBM25 RNA binding motif protein 25 -0.0411518
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.040282
SLC38A1 solute carrier family 38, member 1 -0.0400891
PATJ PATJ crumbs cell polarity complex component -0.0391243
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0377162
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0376434
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.0371064
INHBA inhibin, beta A -0.0365607
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0361235
PTPRM protein tyrosine phosphatase, receptor type, M -0.0357204
TBC1D5 TBC1 domain family, member 5 -0.0350137
RPL23 ribosomal protein L23 -0.0348617
UBAC2 UBA domain containing 2 -0.0345189
NHSL1 NHS-like 1 -0.0335459
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0329492
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0319252
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0315014
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0311008
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.030184
SMYD3 SET and MYND domain containing 3 -0.0298002
RAD51B RAD51 paralog B -0.0294935
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0294755
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0292523
RCOR1 REST corepressor 1 -0.0284106
GMDS GDP-mannose 4,6-dehydratase -0.0282499
FOXP1 forkhead box P1 -0.0275805
RASAL2 RAS protein activator like 2 -0.0263368
RAB7A RAB7A, member RAS oncogene family -0.0261506
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0258311
LAMB3 laminin, beta 3 -0.0256058
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0255943
ANXA2 annexin A2 -0.025587
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.025186
GSK3B glycogen synthase kinase 3 beta -0.0250905
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0247875
MCL1 myeloid cell leukemia 1 -0.0246956
SIK3 SIK family kinase 3 -0.0238897
ESYT2 extended synaptotagmin-like protein 2 -0.0235683
GOLGB1 golgin B1 -0.0228955
RPS6 ribosomal protein S6 -0.0227824
LAMA4 laminin, alpha 4 -0.0224936
TJP1 tight junction protein 1 -0.0224789
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0224287
JARID2 jumonji, AT rich interactive domain 2 -0.0219481
MACF1 microtubule-actin crosslinking factor 1 -0.0218079
MT2A metallothionein 2A -0.0217613
FNDC3B fibronectin type III domain containing 3B -0.0217152
RPL31 ribosomal protein L31 -0.0215309
CCND1 cyclin D1 -0.0210391
RSF1 remodeling and spacing factor 1 -0.0193488
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0188432
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0187582
MYH9 myosin, heavy chain 9, non-muscle -0.0183129