Sodium Salicylate_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sodium Salicylate perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sodium Salicylate_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor 0.0505904
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0477817
ANKRD33B ankyrin repeat domain 33B 0.0430923
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0412354
KMT2C lysine (K)-specific methyltransferase 2C 0.0378392
ADGRL3 adhesion G protein-coupled receptor L3 0.0343527
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0330951
UTRN utrophin 0.0329767
IGF1R insulin-like growth factor 1 receptor 0.0329694
TRA2A transformer 2 alpha homolog (Drosophila) 0.0326366
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0320778
MAML2 mastermind-like 2 (Drosophila) 0.0302201
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0295846
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.028326
SRPK2 SRSF protein kinase 2 0.0281984
QKI QKI, KH domain containing, RNA binding 0.0272591
FTH1 ferritin, heavy polypeptide 1 0.025606
MARCHF6 membrane associated ring-CH-type finger 6 0.0254485
CDC73 cell division cycle 73 0.0250127
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0247077
SHROOM3 shroom family member 3 0.0246651
FBXO11 F-box protein 11 0.024317
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0242068
DST dystonin 0.0239019
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 0.0232175
MED13L mediator complex subunit 13-like 0.0227963
SPTBN1 spectrin, beta, non-erythrocytic 1 0.022113
ECT2 epithelial cell transforming 2 0.0220087
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0213564
GOLGA4 golgin A4 0.020878
TMEM64 transmembrane protein 64 0.0205854
OSBPL8 oxysterol binding protein-like 8 0.0205689
FNDC3B fibronectin type III domain containing 3B 0.0205407
ZNF217 zinc finger protein 217 0.0204687
ADNP activity-dependent neuroprotector homeobox 0.0204287
CDC14A cell division cycle 14A 0.0202941
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0201037
OSBPL10 oxysterol binding protein-like 10 0.0199798
LHFPL6 LHFPL tetraspan subfamily member 6 0.0197202
SMG7 SMG7 nonsense mediated mRNA decay factor 0.019674
FMNL2 formin-like 2 0.0195302
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0193867
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0191084
ZNF292 zinc finger protein 292 0.0190475
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0190277
CPA6 carboxypeptidase A6 0.018957
INTS6 integrator complex subunit 6 0.0187271
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0185055
SFTPA2 surfactant protein A2 0.0179816
PDE4D phosphodiesterase 4D, cAMP-specific 0.017976
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0178491
HMGA2 high mobility group AT-hook 2 0.0178436
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0177456
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0176705
SPAG9 sperm associated antigen 9 0.0173249
KIAA1328 KIAA1328 0.0171795
SPRED2 sprouty-related, EVH1 domain containing 2 0.0170928
SOX5 SRY (sex determining region Y)-box 5 0.0170395
FNBP1L formin binding protein 1-like 0.0166859
NCOR1 nuclear receptor corepressor 1 0.0165006
FAF1 Fas (TNFRSF6) associated factor 1 0.0164625
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 0.016363
PARD3 par-3 family cell polarity regulator 0.0163404
ZEB2 zinc finger E-box binding homeobox 2 0.0161984
ZNF608 zinc finger protein 608 0.0161248
NUP98 nucleoporin 98kDa 0.0161097
ZNF385D zinc finger protein 385D 0.0160469
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.0160383
RAB2A RAB2A, member RAS oncogene family 0.0160155
PRKD1 protein kinase D1 0.0160112
FLNB filamin B, beta 0.0160084
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0159326
MYO9A myosin IXA 0.0158412
TMEM135 transmembrane protein 135 0.0157208
MSI2 musashi RNA-binding protein 2 0.0156969
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.015514
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0154816
LRRN3 leucine rich repeat neuronal 3 0.0154088
RREB1 ras responsive element binding protein 1 0.0151514
SGMS1 sphingomyelin synthase 1 0.0150713
UBAP2L ubiquitin associated protein 2-like 0.0150348
WWTR1 WW domain containing transcription regulator 1 0.0150072
VCL vinculin 0.014969
RLF rearranged L-myc fusion 0.014958
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0149226
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0148655
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0147176
CTNND1 catenin (cadherin-associated protein), delta 1 0.0147042
MEMO1 mediator of cell motility 1 0.0146671
CTNNBL1 catenin, beta like 1 0.0146456
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0145755
KDM6A lysine (K)-specific demethylase 6A 0.0145662
EVI5 ecotropic viral integration site 5 0.0145173
AKAP12 A kinase (PRKA) anchor protein 12 0.0144966
JAZF1 JAZF zinc finger 1 0.0144901
TPD52 tumor protein D52 0.0144717
GCC2 GRIP and coiled-coil domain containing 2 0.0143057
FIP1L1 factor interacting with PAPOLA and CPSF1 0.0142977
TENT2 terminal nucleotidyltransferase 2 0.0142323
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0141447

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.184474
COL11A1 collagen, type XI, alpha 1 -0.164916
TMSB10 thymosin beta 10 -0.134017
PHIP pleckstrin homology domain interacting protein -0.0921429
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.07408
ITGAV integrin, alpha V -0.0699214
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0678084
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0595249
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.0578641
PGK1 phosphoglycerate kinase 1 -0.0557958
POTEF POTE ankyrin domain family, member F -0.0557886
COL5A2 collagen, type V, alpha 2 -0.0532816
ACTG1 actin gamma 1 -0.0519556
PCDH9 protocadherin 9 -0.0513114
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0504805
PTMA prothymosin, alpha -0.0502403
UBC ubiquitin C -0.0488943
GPC3 glypican 3 -0.046585
RPS16 ribosomal protein S16 -0.0464539
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0451334
RPL5 ribosomal protein L5 -0.0446591
ENO1 enolase 1, (alpha) -0.0441183
PCLO piccolo presynaptic cytomatrix protein -0.0400824
CADM2 cell adhesion molecule 2 -0.0399124
RPS27A ribosomal protein S27a -0.0396412
CALR calreticulin -0.0394125
RPL35A ribosomal protein L35a -0.0389465
RPS8 ribosomal protein S8 -0.038871
RPS6 ribosomal protein S6 -0.038296
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0379057
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0378924
PDIA3 protein disulfide isomerase family A, member 3 -0.0376706
RPL23 ribosomal protein L23 -0.0363697
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.034917
KCTD16 potassium channel tetramerization domain containing 16 -0.033613
B2M beta-2-microglobulin -0.0318932
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0318792
XPO1 exportin 1 -0.0317294
UPP1 uridine phosphorylase 1 -0.031617
KPNB1 karyopherin (importin) beta 1 -0.0313589
HDAC9 histone deacetylase 9 -0.031244
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0299943
APOE apolipoprotein E -0.0297905
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0296594
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.029332
GSE1 Gse1 coiled-coil protein -0.0293289
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0290316
S100A10 S100 calcium binding protein A10 -0.0289895
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0289848
RBM25 RNA binding motif protein 25 -0.0289547
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0289063
RPL11 ribosomal protein L11 -0.0286951
SRRM2 serine/arginine repetitive matrix 2 -0.0283761
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0281567
COL1A2 collagen, type I, alpha 2 -0.0279544
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0271979
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0268155
RPS3 ribosomal protein S3 -0.0267019
SAMD4B sterile alpha motif domain containing 4B -0.026316
RPLP1 ribosomal protein, large, P1 -0.0262897
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0258807
TXNRD1 thioredoxin reductase 1 -0.0256047
RPS25 ribosomal protein S25 -0.0253403
RPLP0 ribosomal protein, large, P0 -0.0252822
DMD dystrophin -0.0250761
MRPS6 mitochondrial ribosomal protein S6 -0.024939
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0248739
FOXP2 forkhead box P2 -0.0241113
NAP1L1 nucleosome assembly protein 1-like 1 -0.0238912
USP9X ubiquitin specific peptidase 9, X-linked -0.0238625
MEIS2 Meis homeobox 2 -0.0236073
RPS21 ribosomal protein S21 -0.0235647
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0235232
EIF1 eukaryotic translation initiation factor 1 -0.0232781
GARRE1 granule associated Rac and RHOG effector 1 -0.0231299
BAZ1A bromodomain adjacent to zinc finger domain, 1A -0.0231279
RAI1 retinoic acid induced 1 -0.0231145
RPS12 ribosomal protein S12 -0.0230785
RPL36 ribosomal protein L36 -0.0230538
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0227377
HSPB1 heat shock 27kDa protein 1 -0.0223726
GARS1 glycyl-tRNA synthetase 1 -0.0223273
PA2G4 proliferation-associated 2G4, 38kDa -0.0222815
CDH4 cadherin 4, type 1, R-cadherin (retinal) -0.022272
RPL18 ribosomal protein L18 -0.0222701
PCBP2 poly(rC) binding protein 2 -0.0220977
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0220204
USH2A Usher syndrome 2A (autosomal recessive, mild) -0.0220154
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -0.0219906
PLS3 plastin 3 -0.0217707
PFN1 profilin 1 -0.0217608
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0216389
TUBA1B tubulin, alpha 1b -0.0215517
SBF2 SET binding factor 2 -0.0214347
ATXN2 ataxin 2 -0.0212269
PDGFC platelet derived growth factor C -0.0210667
CBX3 chromobox homolog 3 -0.0210082
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 -0.0207539
SFPQ splicing factor proline/glutamine-rich -0.020673
WSB1 WD repeat and SOCS box containing 1 -0.0205543