Sodium Salicylate_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sodium Salicylate perturbation in RKO cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Sodium Salicylate_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
JMJD1C jumonji domain containing 1C 0.0502305
MCTP1 multiple C2 domains, transmembrane 1 0.0456407
EXT1 exostosin glycosyltransferase 1 0.0422797
IARS1 isoleucyl-tRNA synthetase 1 0.0380636
HDAC9 histone deacetylase 9 0.0348865
RAB7A RAB7A, member RAS oncogene family 0.0323377
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.0308217
ERBIN erbb2 interacting protein 0.0286548
UPP1 uridine phosphorylase 1 0.0284898
STC1 stanniocalcin 1 0.0262552
SFPQ splicing factor proline/glutamine-rich 0.025366
AGO2 argonaute RISC catalytic component 2 0.0252683
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0248431
ATP13A3 ATPase type 13A3 0.0244515
SGMS2 sphingomyelin synthase 2 0.0242356
ANKRD17 ankyrin repeat domain 17 0.0227347
RASA2 RAS p21 protein activator 2 0.0226142
NAV3 neuron navigator 3 0.0224323
PTK2 protein tyrosine kinase 2 0.0220877
RIGI RNA sensor RIG-I 0.0219793
MAST4 microtubule associated serine/threonine kinase family member 4 0.0218028
FLNA filamin A, alpha 0.0217716
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0214819
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0198735
MT2A metallothionein 2A 0.0189054
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0188846
RTN4 reticulon 4 0.0185881
RUNX1 runt-related transcription factor 1 0.0183668
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0183138
SMC4 structural maintenance of chromosomes 4 0.0182535
FNDC3B fibronectin type III domain containing 3B 0.0181322
RBM25 RNA binding motif protein 25 0.018034
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0178803
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0173777
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0172513
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.0168818
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0168569
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0168414
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0167146
ALCAM activated leukocyte cell adhesion molecule 0.0167013
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.016519
BHLHE40 basic helix-loop-helix family, member e40 0.0164823
FAF1 Fas (TNFRSF6) associated factor 1 0.0163171
ZFP36L1 ZFP36 ring finger protein-like 1 0.0160787
ZEB1 zinc finger E-box binding homeobox 1 0.0160508
ZSWIM6 zinc finger, SWIM-type containing 6 0.0156762
VMP1 vacuole membrane protein 1 0.0156118
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0155255
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.015413
TXNRD1 thioredoxin reductase 1 0.0153868
BRD2 bromodomain containing 2 0.0151457
RCOR1 REST corepressor 1 0.0150822
USP3 ubiquitin specific peptidase 3 0.0149808
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0149204
ZBTB38 zinc finger and BTB domain containing 38 0.0148774
ZNF644 zinc finger protein 644 0.0148255
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0147741
IFI16 interferon, gamma-inducible protein 16 0.0147095
RAP1B RAP1B, member of RAS oncogene family 0.0144971
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.014452
KPNB1 karyopherin (importin) beta 1 0.0143037
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0141867
AOPEP aminopeptidase O (putative) 0.0141672
KDM6A lysine (K)-specific demethylase 6A 0.0140144
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0139208
CCNY cyclin Y 0.0137852
CRY1 cryptochrome circadian clock 1 0.0137793
PA2G4 proliferation-associated 2G4, 38kDa 0.0136727
KDM5C lysine (K)-specific demethylase 5C 0.0136698
MTDH metadherin 0.0136572
ANXA5 annexin A5 0.0135648
WDR37 WD repeat domain 37 0.013529
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0134583
BLZF1 basic leucine zipper nuclear factor 1 0.0134221
EEF2 eukaryotic translation elongation factor 2 0.0133405
THOC2 THO complex 2 0.0133118
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0133093
TM4SF19 transmembrane 4 L six family member 19 0.0131817
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0130964
CCNL1 cyclin L1 0.0130955
DEK DEK proto-oncogene 0.0130906
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0129527
SMC5 structural maintenance of chromosomes 5 0.0129467
MCL1 myeloid cell leukemia 1 0.0127986
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0126399
TOP1 topoisomerase (DNA) I 0.0125631
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0125483
TUBB4B tubulin, beta 4B class IVb 0.0125033
WRN Werner syndrome, RecQ helicase-like 0.0124977
CREB5 cAMP responsive element binding protein 5 0.0124147
HMGA1 high mobility group AT-hook 1 0.0123905
ANKRD28 ankyrin repeat domain 28 0.0123628
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0122873
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0122844
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.012282
SRRM2 serine/arginine repetitive matrix 2 0.0122195
EFNB2 ephrin-B2 0.0121607
SPIDR scaffolding protein involved in DNA repair 0.0121244
SEC24A SEC24 family member A 0.0120879
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0120727

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.123678
RPS6 ribosomal protein S6 -0.0948855
RPL19 ribosomal protein L19 -0.0672718
DLC1 DLC1 Rho GTPase activating protein -0.056456
RPS12 ribosomal protein S12 -0.0512689
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0490837
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0475692
RPL12 ribosomal protein L12 -0.0435365
RPL23 ribosomal protein L23 -0.0432529
RPL34 ribosomal protein L34 -0.0388651
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.038234
RPS8 ribosomal protein S8 -0.0381217
TMSB10 thymosin beta 10 -0.036963
RPL8 ribosomal protein L8 -0.0361045
CANX calnexin -0.035001
ACTG1 actin gamma 1 -0.0342787
RPL7 ribosomal protein L7 -0.0335303
RPLP1 ribosomal protein, large, P1 -0.0316844
RPL35 ribosomal protein L35 -0.0316618
TTR transthyretin -0.0315657
RPS19 ribosomal protein S19 -0.0309294
RPL3 ribosomal protein L3 -0.0308729
AHNAK AHNAK nucleoprotein -0.0293001
RPLP2 ribosomal protein, large, P2 -0.0292227
RPL22L1 ribosomal protein L22-like 1 -0.0292166
RPS17 ribosomal protein S17 -0.0284507
RPS3 ribosomal protein S3 -0.0278311
RPL26 ribosomal protein L26 -0.0267551
RACK1 receptor for activated C kinase 1 -0.0261814
RPL5 ribosomal protein L5 -0.0261317
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0259871
RPL37A ribosomal protein L37a -0.0258142
RPS2 ribosomal protein S2 -0.0251977
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0251253
RPL4 ribosomal protein L4 -0.0246877
ENO1 enolase 1, (alpha) -0.0244896
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0243895
HMGA2 high mobility group AT-hook 2 -0.0243247
SLC38A2 solute carrier family 38, member 2 -0.0236356
RPL7A ribosomal protein L7a -0.0230519
FRMD4A FERM domain containing 4A -0.0228987
RPL9 ribosomal protein L9 -0.0227792
RPL30 ribosomal protein L30 -0.0227498
EIF1 eukaryotic translation initiation factor 1 -0.0225827
RPS4X ribosomal protein S4, X-linked -0.0224391
EEF1G eukaryotic translation elongation factor 1 gamma -0.0216029
RPL36 ribosomal protein L36 -0.0213271
CALD1 caldesmon 1 -0.0212769
RPS20 ribosomal protein S20 -0.0212713
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0210901
LDHA lactate dehydrogenase A -0.0205233
RPS27 ribosomal protein S27 -0.0201364
RPL32 ribosomal protein L32 -0.0200422
NACA nascent polypeptide-associated complex alpha subunit -0.0198739
RPL11 ribosomal protein L11 -0.0192728
LOC112694756 uncharaterized LOC112694756 -0.0190918
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0190626
RPS21 ribosomal protein S21 -0.0188155
RPL13A ribosomal protein L13a -0.0185593
RSL1D1 ribosomal L1 domain containing 1 -0.0182914
RPLP0 ribosomal protein, large, P0 -0.0180617
LPP LIM domain containing preferred translocation partner in lipoma -0.0180576
RPL18 ribosomal protein L18 -0.017077
PGK1 phosphoglycerate kinase 1 -0.0170091
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0166597
PDIA6 protein disulfide isomerase family A, member 6 -0.0166103
RPL37 ribosomal protein L37 -0.0163254
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0161478
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.0158847
MTAP methylthioadenosine phosphorylase -0.0157318
RPS10 ribosomal protein S10 -0.0155143
TRAM1 translocation associated membrane protein 1 -0.0150865
TPT1 tumor protein, translationally-controlled 1 -0.0148252
RPS25 ribosomal protein S25 -0.0147923
EIF3E eukaryotic translation initiation factor 3, subunit E -0.0145523
RPL38 ribosomal protein L38 -0.0144595
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0143028
RPS16 ribosomal protein S16 -0.0141195
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0138427
TMEM123 transmembrane protein 123 -0.0137617
PHF3 PHD finger protein 3 -0.0136745
PDIA3 protein disulfide isomerase family A, member 3 -0.0133838
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0130524
RPS14 ribosomal protein S14 -0.0130092
ZNF438 zinc finger protein 438 -0.0128675
RPS15A ribosomal protein S15a -0.0126843
RPS26 ribosomal protein S26 -0.0124778
CLTC clathrin, heavy chain (Hc) -0.0124242
FRMD6 FERM domain containing 6 -0.0123575
HSPA8 heat shock 70kDa protein 8 -0.0123479
RPS27A ribosomal protein S27a -0.0123474
RPL6 ribosomal protein L6 -0.0121025
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0120666
RPS5 ribosomal protein S5 -0.0120104
PTPN11 protein tyrosine phosphatase, non-receptor type 11 -0.011974
PCNX4 pecanex 4 -0.0119217
RPL27 ribosomal protein L27 -0.0117771
UBC ubiquitin C -0.0117027
RRBP1 ribosome binding protein 1 -0.0116125
GOLGA4 golgin A4 -0.011554