Sodium Salicylate_RPMI-7951 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sodium Salicylate perturbation in RPMI-7951 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sodium Salicylate_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.132926
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0609211
VEGFA vascular endothelial growth factor A 0.0602221
BHLHE40 basic helix-loop-helix family, member e40 0.0591658
COL6A1 collagen, type VI, alpha 1 0.0589793
ANXA2 annexin A2 0.0483044
PLEC plectin 0.0413284
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0400006
GNAS GNAS complex locus 0.0351359
FTL ferritin, light polypeptide 0.0343141
ZBTB38 zinc finger and BTB domain containing 38 0.0343021
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0339946
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0336935
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0309876
ZNF292 zinc finger protein 292 0.0302449
CAVIN1 caveolae associated protein 1 0.0295373
LOC102724023 ES1 protein homolog, mitochondrial 0.0288512
FTH1 ferritin, heavy polypeptide 1 0.028177
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0280653
COL6A2 collagen, type VI, alpha 2 0.0278455
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0256285
TGFB1 transforming growth factor, beta 1 0.0249153
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0245835
CXCL8 chemokine (C-X-C motif) ligand 8 0.0245264
USP3 ubiquitin specific peptidase 3 0.0230546
RPL35A ribosomal protein L35a 0.0228555
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0219172
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0218736
IER3 immediate early response 3 0.0215677
KDM5B lysine (K)-specific demethylase 5B 0.0214804
ICAM1 intercellular adhesion molecule 1 0.0213987
ARHGAP35 Rho GTPase activating protein 35 0.0213139
FAM162A family with sequence similarity 162, member A 0.0211415
LGALS1 lectin, galactoside-binding, soluble, 1 0.0207181
QKI QKI, KH domain containing, RNA binding 0.0203888
WSB1 WD repeat and SOCS box containing 1 0.0203775
RAB7A RAB7A, member RAS oncogene family 0.0201282
EPAS1 endothelial PAS domain protein 1 0.0201126
TGM2 transglutaminase 2 0.0200227
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0197146
MORF4L2 mortality factor 4 like 2 0.0194365
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0192833
LMNA lamin A/C 0.0192514
AKAP12 A kinase (PRKA) anchor protein 12 0.018638
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit 0.0183444
COL5A1 collagen, type V, alpha 1 0.0181283
NOP58 NOP58 ribonucleoprotein 0.0180106
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0178902
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0178598
ANKRD11 ankyrin repeat domain 11 0.0175941
HDAC9 histone deacetylase 9 0.0172607
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0172568
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0171429
RLF rearranged L-myc fusion 0.0170016
TRA2A transformer 2 alpha homolog (Drosophila) 0.016834
RPLP1 ribosomal protein, large, P1 0.0165739
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.016379
SCAF11 SR-related CTD-associated factor 11 0.0163419
COL4A2 collagen, type IV, alpha 2 0.0161704
ECE1 endothelin converting enzyme 1 0.0160193
SPRED2 sprouty-related, EVH1 domain containing 2 0.0159274
HILPDA hypoxia inducible lipid droplet-associated 0.0157993
GOLGB1 golgin B1 0.0156092
IER2 immediate early response 2 0.0155756
IGFBP3 insulin-like growth factor binding protein 3 0.0152724
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.015244
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0151666
RNF145 ring finger protein 145 0.0150914
BSG basigin (Ok blood group) 0.0150259
SSBP2 single-stranded DNA binding protein 2 0.0149516
NRIP1 nuclear receptor interacting protein 1 0.0148871
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0148219
H1-0 H1.0 linker histone 0.0147929
RND3 Rho family GTPase 3 0.0147836
INSIG1 insulin induced gene 1 0.0146494
CTSB cathepsin B 0.0146006
LRRC23 leucine rich repeat containing 23 0.014582
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0145714
ERRFI1 ERBB receptor feedback inhibitor 1 0.0145704
DENND4C DENN/MADD domain containing 4C 0.0144829
PUM3 pumilio RNA binding family member 3 0.0144417
NCOA3 nuclear receptor coactivator 3 0.0143172
FBXO11 F-box protein 11 0.01424
KPNB1 karyopherin (importin) beta 1 0.0142169
MXI1 MAX interactor 1, dimerization protein 0.0141868
ADM adrenomedullin 0.0140909
MEIS2 Meis homeobox 2 0.0140163
TSC22D2 TSC22 domain family, member 2 0.0140114
PXDN peroxidasin 0.0139271
TPT1 tumor protein, translationally-controlled 1 0.0139222
CSNK1A1 casein kinase 1, alpha 1 0.0138114
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0138045
CCDC88A coiled-coil domain containing 88A 0.0138009
CLINT1 clathrin interactor 1 0.0137774
FGFR1 fibroblast growth factor receptor 1 0.0137247
TPD52 tumor protein D52 0.0137115
FSTL1 follistatin-like 1 0.0136524
CD109 CD109 molecule 0.0136099
KLHDC10 kelch domain containing 10 0.0135255
IRS2 insulin receptor substrate 2 0.0134927

decreased expression

Symbol Name Standardized Value
UBC ubiquitin C -0.0980212
VIM vimentin -0.0967892
ENO1 enolase 1, (alpha) -0.0917445
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0880612
FNDC3B fibronectin type III domain containing 3B -0.0820867
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0792935
CDH13 cadherin 13 -0.0783251
ASPH aspartate beta-hydroxylase -0.070084
RPS27A ribosomal protein S27a -0.0584
COL1A1 collagen, type I, alpha 1 -0.0573691
CD44 CD44 molecule (Indian blood group) -0.0569701
TMSB10 thymosin beta 10 -0.0529062
GLIS3 GLIS family zinc finger 3 -0.0499842
B2M beta-2-microglobulin -0.0484432
STC1 stanniocalcin 1 -0.0482458
CEMIP cell migration inducing protein, hyaluronan binding -0.0457661
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0457588
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0454573
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0429957
FRMD4A FERM domain containing 4A -0.0426452
JARID2 jumonji, AT rich interactive domain 2 -0.0426172
MCTP2 multiple C2 domains, transmembrane 2 -0.0417903
IFI6 interferon, alpha-inducible protein 6 -0.0411833
LDHA lactate dehydrogenase A -0.0407403
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0387493
CALU calumenin -0.0385706
FAM20C family with sequence similarity 20, member C -0.0371627
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0366033
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0360588
PDE4D phosphodiesterase 4D, cAMP-specific -0.0352105
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0346252
ITGA1 integrin, alpha 1 -0.0344545
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0330937
IFI44L interferon-induced protein 44-like -0.032236
ADAM12 ADAM metallopeptidase domain 12 -0.0322138
ZC3H12C zinc finger CCCH-type containing 12C -0.0309181
PDE10A phosphodiesterase 10A -0.0307604
ANKRD12 ankyrin repeat domain 12 -0.0303405
PALM2AKAP2 PALM2 and AKAP2 fusion -0.030191
MT2A metallothionein 2A -0.0296992
FNDC3A fibronectin type III domain containing 3A -0.0295268
NPAS2 neuronal PAS domain protein 2 -0.0295058
PCBP2 poly(rC) binding protein 2 -0.0294823
COLEC10 collectin sub-family member 10 (C-type lectin) -0.0288924
PLSCR1 phospholipid scramblase 1 -0.0286454
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0277255
COL1A2 collagen, type I, alpha 2 -0.0275875
INHBA inhibin, beta A -0.0273171
SSH1 slingshot protein phosphatase 1 -0.0269925
HLA-B major histocompatibility complex, class I, B -0.0265723
OGT O-linked N-acetylglucosamine (GlcNAc) transferase -0.0263139
TFPI2 tissue factor pathway inhibitor 2 -0.0262908
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0261946
SPDYA speedy/RINGO cell cycle regulator family member A -0.0260083
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.025851
CALR calreticulin -0.0257083
PDIA3 protein disulfide isomerase family A, member 3 -0.0254382
MMP12 matrix metallopeptidase 12 -0.025195
NBAS neuroblastoma amplified sequence -0.0249338
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0247084
PCBP3 poly(rC) binding protein 3 -0.0241402
MCL1 myeloid cell leukemia 1 -0.0232786
AHNAK AHNAK nucleoprotein -0.0232703
ZMYND8 zinc finger, MYND-type containing 8 -0.0232288
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like -0.0226509
CADM1 cell adhesion molecule 1 -0.0224023
ZBTB20 zinc finger and BTB domain containing 20 -0.0220613
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0219376
SET SET nuclear proto-oncogene -0.0217549
CDCP1 CUB domain containing protein 1 -0.021598
GIGYF2 GRB10 interacting GYF protein 2 -0.0210279
NAMPT nicotinamide phosphoribosyltransferase -0.0207459
DNER delta/notch-like EGF repeat containing -0.0206645
OXR1 oxidation resistance 1 -0.0206465
PSD3 pleckstrin and Sec7 domain containing 3 -0.0206384
RIGI RNA sensor RIG-I -0.0201346
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0200799
CENPF centromere protein F, 350/400kDa -0.0199761
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0199514
RPS17 ribosomal protein S17 -0.0199184
PTPRG protein tyrosine phosphatase, receptor type, G -0.0199036
SOD2 superoxide dismutase 2, mitochondrial -0.019897
S100A6 S100 calcium binding protein A6 -0.019775
IFI44 interferon-induced protein 44 -0.0195951
NKTR natural killer cell triggering receptor -0.0193917
USP34 ubiquitin specific peptidase 34 -0.0190421
TNS3 tensin 3 -0.0188729
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0188568
HLA-A major histocompatibility complex, class I, A -0.0187219
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0186738
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0186139
CCDC91 coiled-coil domain containing 91 -0.0185849
MAP2K1 mitogen-activated protein kinase kinase 1 -0.0185065
IL1B interleukin 1, beta -0.0182182
DST dystonin -0.0181104
XRN2 5'-3' exoribonuclease 2 -0.0179432
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.0178103
WNT5A wingless-type MMTV integration site family, member 5A -0.0177314
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0176588
RANBP2 RAN binding protein 2 -0.0176541