Sodium Salicylate_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sodium Salicylate perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sodium Salicylate_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NLGN1 neuroligin 1 0.146787
LSAMP limbic system-associated membrane protein 0.144554
FN1 fibronectin 1 0.114428
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.110204
AKAP12 A kinase (PRKA) anchor protein 12 0.110131
SLC39A11 solute carrier family 39, member 11 0.082381
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0818582
FNDC3B fibronectin type III domain containing 3B 0.0768032
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0705223
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0607125
FMNL2 formin-like 2 0.0594141
NRG3 neuregulin 3 0.0563089
IGFBP3 insulin-like growth factor binding protein 3 0.0550289
CFAP20DC CFAP20 domain containing 0.049457
MSI2 musashi RNA-binding protein 2 0.0478569
SMAD3 SMAD family member 3 0.0476242
FLNA filamin A, alpha 0.0468469
SFTPA2 surfactant protein A2 0.0466191
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0427078
RAD51B RAD51 paralog B 0.0426762
BACE2 beta-site APP-cleaving enzyme 2 0.0399786
ANGPTL4 angiopoietin-like 4 0.039731
FLNB filamin B, beta 0.0389714
RUNX1 runt-related transcription factor 1 0.0386103
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0385534
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0377636
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0371064
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0367934
NOTCH2 notch 2 0.0364787
PLEC plectin 0.0362623
CADM1 cell adhesion molecule 1 0.0361116
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0360844
LRMDA leucine rich melanocyte differentiation associated 0.0358317
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0339072
EEF2 eukaryotic translation elongation factor 2 0.0326371
SOD2 superoxide dismutase 2, mitochondrial 0.031766
AFF3 AF4/FMR2 family, member 3 0.0317447
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0314011
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 0.0313656
FAM13A family with sequence similarity 13, member A 0.0308897
DST dystonin 0.0305392
SEPTIN9 septin 9 0.0304554
CABIN1 calcineurin binding protein 1 0.0303062
TPM3 tropomyosin 3 0.0298444
TNS1 tensin 1 0.0298403
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0296711
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0285489
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0283135
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0281421
FTH1 ferritin, heavy polypeptide 1 0.0280946
ALCAM activated leukocyte cell adhesion molecule 0.0279697
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.027908
TMEM51 transmembrane protein 51 0.02774
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0276266
LEF1 lymphoid enhancer-binding factor 1 0.0268514
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.02663
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0265388
YEATS2 YEATS domain containing 2 0.0265161
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0264646
MATR3 matrin 3 0.0261345
PKM pyruvate kinase, muscle 0.0257538
MYH9 myosin, heavy chain 9, non-muscle 0.0253622
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0242338
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0240701
RNF213 ring finger protein 213 0.0238252
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0238115
VEGFA vascular endothelial growth factor A 0.0237484
HLA-A major histocompatibility complex, class I, A 0.0235154
JMJD1C jumonji domain containing 1C 0.0232977
TPD52 tumor protein D52 0.0228719
HPSE2 heparanase 2 (inactive) 0.0228018
SETD5 SET domain containing 5 0.0227742
PTPRM protein tyrosine phosphatase, receptor type, M 0.0225084
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0223814
MMP12 matrix metallopeptidase 12 0.0222393
ESYT2 extended synaptotagmin-like protein 2 0.0218948
BHLHE40 basic helix-loop-helix family, member e40 0.0217505
FAM120A family with sequence similarity 120A 0.0216722
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0214984
SEC24A SEC24 family member A 0.0213784
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0213662
ZNF121 zinc finger protein 121 0.0206775
CD109 CD109 molecule 0.0205177
ARFGEF3 ARFGEF family member 3 0.0203681
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.020349
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0201781
FOXP1 forkhead box P1 0.0201216
NGLY1 N-glycanase 1 0.0199595
SOX10 SRY (sex determining region Y)-box 10 0.0199522
KIAA1217 KIAA1217 0.0199179
HLA-E major histocompatibility complex, class I, E 0.0198217
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0195851
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0194915
PFKP phosphofructokinase, platelet 0.0194534
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0193802
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0193552
ATXN7 ataxin 7 0.0193291
CEP128 centrosomal protein 128kDa 0.0193216
KIF13A kinesin family member 13A 0.0192483
KMT2E lysine (K)-specific methyltransferase 2E 0.019209

decreased expression

Symbol Name Standardized Value
FMN1 formin 1 -0.14917
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.1479
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.131066
VIM vimentin -0.114516
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0934974
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0557629
TMSB10 thymosin beta 10 -0.0557356
RPLP1 ribosomal protein, large, P1 -0.0503772
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0484649
RPL35A ribosomal protein L35a -0.0454154
MT2A metallothionein 2A -0.0445434
ANKRD28 ankyrin repeat domain 28 -0.0428417
WWTR1 WW domain containing transcription regulator 1 -0.0413243
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0409046
FTL ferritin, light polypeptide -0.037339
PGK1 phosphoglycerate kinase 1 -0.0357339
RPS3 ribosomal protein S3 -0.0350387
CD44 CD44 molecule (Indian blood group) -0.0346693
PMEL premelanosome protein -0.0328191
RTN4 reticulon 4 -0.0310293
UBC ubiquitin C -0.0304689
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0302792
VDAC1 voltage-dependent anion channel 1 -0.0299077
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0296528
TP63 tumor protein p63 -0.0296171
EIF1 eukaryotic translation initiation factor 1 -0.0285154
PRELID2 PRELI domain containing 2 -0.0282218
RPL12 ribosomal protein L12 -0.0281371
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0280327
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0278184
TSC22D2 TSC22 domain family, member 2 -0.0278022
TXNRD1 thioredoxin reductase 1 -0.027055
PCNX4 pecanex 4 -0.0265297
ERBIN erbb2 interacting protein -0.0263902
TCF20 transcription factor 20 (AR1) -0.0261944
MAP4 microtubule-associated protein 4 -0.0260704
CANX calnexin -0.0258926
RACK1 receptor for activated C kinase 1 -0.0257778
LDHA lactate dehydrogenase A -0.0254853
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0254608
ACTG1 actin gamma 1 -0.0250795
ANLN anillin, actin binding protein -0.024786
RPLP2 ribosomal protein, large, P2 -0.0245479
ACTN1 actinin, alpha 1 -0.0244503
RPL32 ribosomal protein L32 -0.0240131
GLS2 glutaminase 2 (liver, mitochondrial) -0.0238356
FBXL2 F-box and leucine-rich repeat protein 2 -0.0235743
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0232546
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0231023
PUM2 pumilio RNA-binding family member 2 -0.0230293
MT1X metallothionein 1X -0.022935
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 -0.0228027
RHOBTB3 Rho-related BTB domain containing 3 -0.0227224
RRBP1 ribosome binding protein 1 -0.0226246
VCL vinculin -0.0219252
RPS6 ribosomal protein S6 -0.0218393
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0217886
STK10 serine/threonine kinase 10 -0.0217582
RPL23 ribosomal protein L23 -0.0216468
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0216384
RPS8 ribosomal protein S8 -0.0216085
ICAM1 intercellular adhesion molecule 1 -0.0214776
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0214691
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0213795
ANXA2 annexin A2 -0.0213388
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0212361
EXT1 exostosin glycosyltransferase 1 -0.020939
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.020785
RB1CC1 RB1-inducible coiled-coil 1 -0.0207778
AGO2 argonaute RISC catalytic component 2 -0.0206878
LMNA lamin A/C -0.020631
FNDC3A fibronectin type III domain containing 3A -0.0205011
LPP LIM domain containing preferred translocation partner in lipoma -0.020296
RPS16 ribosomal protein S16 -0.0202749
RPS24 ribosomal protein S24 -0.0201672
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0199271
RPL38 ribosomal protein L38 -0.0197981
TUBB tubulin, beta class I -0.0195135
SENP5 SUMO1/sentrin specific peptidase 5 -0.0194123
FRMD5 FERM domain containing 5 -0.0194109
TM4SF1 transmembrane 4 L six family member 1 -0.0193186
DNAH14 dynein, axonemal, heavy chain 14 -0.0192783
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0191928
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0189772
MORF4L2 mortality factor 4 like 2 -0.0189306
MACROD2 MACRO domain containing 2 -0.0185692
CTSD cathepsin D -0.0184731
RPL27A ribosomal protein L27a -0.0184643
FBXW11 F-box and WD repeat domain containing 11 -0.0184603
MYOF myoferlin -0.0177606
INTS6 integrator complex subunit 6 -0.0177542
STAU1 staufen double-stranded RNA binding protein 1 -0.017711
MOSMO modulator of smoothened -0.0175555
GARS1 glycyl-tRNA synthetase 1 -0.0175252
RPS5 ribosomal protein S5 -0.0174344
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0173035
ANKRD17 ankyrin repeat domain 17 -0.0172068
RPL28 ribosomal protein L28 -0.0171781
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0169963
RPS19 ribosomal protein S19 -0.0169225