Sodium Salicylate_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sodium Salicylate perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sodium Salicylate_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SOX6 SRY (sex determining region Y)-box 6 0.0689133
EZR ezrin 0.0654674
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0498614
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0456295
HDAC9 histone deacetylase 9 0.0443047
PDGFC platelet derived growth factor C 0.0441064
ZEB1 zinc finger E-box binding homeobox 1 0.0408266
ZNF292 zinc finger protein 292 0.0389938
ZNF608 zinc finger protein 608 0.0387024
PDE4D phosphodiesterase 4D, cAMP-specific 0.0380599
ECT2 epithelial cell transforming 2 0.0376747
PFN1 profilin 1 0.037484
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0366614
EML4 echinoderm microtubule associated protein like 4 0.03614
TJP1 tight junction protein 1 0.0348242
EVI5 ecotropic viral integration site 5 0.0345149
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0338969
DPYD dihydropyrimidine dehydrogenase 0.0336763
ARL4C ADP-ribosylation factor-like 4C 0.0335815
FLNB filamin B, beta 0.0323467
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0323176
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0321259
ADAM10 ADAM metallopeptidase domain 10 0.0318302
BMP2K BMP2 inducible kinase 0.0310388
SSBP2 single-stranded DNA binding protein 2 0.0308151
PRELID2 PRELI domain containing 2 0.0302906
NUP58 nucleoporin 58 0.0297646
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0293345
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0288966
LOC112694756 uncharaterized LOC112694756 0.0284464
TXNRD1 thioredoxin reductase 1 0.0279352
GLS2 glutaminase 2 (liver, mitochondrial) 0.027315
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0255345
FAT1 FAT atypical cadherin 1 0.0252825
UBA6 ubiquitin-like modifier activating enzyme 6 0.0252305
TMEM65 transmembrane protein 65 0.0252119
AHNAK AHNAK nucleoprotein 0.0243899
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0243639
ZFR zinc finger RNA binding protein 0.0243581
RHOA ras homolog family member A 0.0242512
FAM13A family with sequence similarity 13, member A 0.0240215
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0234699
EEF2 eukaryotic translation elongation factor 2 0.0233259
RNF145 ring finger protein 145 0.0232892
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0232532
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0229655
NPAS2 neuronal PAS domain protein 2 0.0226432
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0224602
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0221549
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0221284
SEPTIN11 septin 11 0.022077
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0216499
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0213404
MATR3 matrin 3 0.0209611
MIS18BP1 MIS18 binding protein 1 0.0208831
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.02087
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.0207388
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0205887
SYNE2 spectrin repeat containing, nuclear envelope 2 0.020464
ZMYM2 zinc finger, MYM-type 2 0.0204408
CDC73 cell division cycle 73 0.0203597
ITCH itchy E3 ubiquitin protein ligase 0.0202933
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0201234
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0201129
PKM pyruvate kinase, muscle 0.0201029
TXNIP thioredoxin interacting protein 0.0200738
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0195893
ZFAND3 zinc finger, AN1-type domain 3 0.0191329
ADAM9 ADAM metallopeptidase domain 9 0.0188886
NCKAP1 NCK-associated protein 1 0.018807
CCNL1 cyclin L1 0.018428
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 0.0184272
PCGF5 polycomb group ring finger 5 0.0180335
MYO5C myosin VC 0.0180064
ANXA1 annexin A1 0.0177556
ZBTB38 zinc finger and BTB domain containing 38 0.0177024
PDE4B phosphodiesterase 4B, cAMP-specific 0.0176467
GLI2 GLI family zinc finger 2 0.0176101
POTEF POTE ankyrin domain family, member F 0.0173882
HJURP Holliday junction recognition protein 0.0173001
MKI67 marker of proliferation Ki-67 0.0172426
AFF4 AF4/FMR2 family, member 4 0.0170944
BRWD1 bromodomain and WD repeat domain containing 1 0.0170068
MEF2A myocyte enhancer factor 2A 0.016926
ERBIN erbb2 interacting protein 0.0168356
MYOF myoferlin 0.0167389
QKI QKI, KH domain containing, RNA binding 0.0166778
LOXL3 lysyl oxidase-like 3 0.0166415
USP24 ubiquitin specific peptidase 24 0.0165254
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0163592
XPO1 exportin 1 0.0162813
GSPT1 G1 to S phase transition 1 0.0162221
KDM4C lysine (K)-specific demethylase 4C 0.0162203
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0161709
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0161657
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0161537
TOB1 transducer of ERBB2, 1 0.0161495
PIAS2 protein inhibitor of activated STAT, 2 0.0161145
PHIP pleckstrin homology domain interacting protein 0.0160741
NAMPT nicotinamide phosphoribosyltransferase 0.0159224

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.225803
TPT1 tumor protein, translationally-controlled 1 -0.0842552
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0786234
RPS6 ribosomal protein S6 -0.0687194
RPL31 ribosomal protein L31 -0.0548794
RPS3 ribosomal protein S3 -0.0521962
RPS8 ribosomal protein S8 -0.0496539
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0474746
RPS13 ribosomal protein S13 -0.0439811
RPL19 ribosomal protein L19 -0.0432329
RPS27A ribosomal protein S27a -0.0424378
RPL35A ribosomal protein L35a -0.0406618
RPL9 ribosomal protein L9 -0.0391486
RPS24 ribosomal protein S24 -0.0388059
RPL34 ribosomal protein L34 -0.0387103
RPS25 ribosomal protein S25 -0.0368522
RPL26 ribosomal protein L26 -0.0360319
RPS23 ribosomal protein S23 -0.0354087
RPLP1 ribosomal protein, large, P1 -0.0338153
RPS12 ribosomal protein S12 -0.0331299
RPL37A ribosomal protein L37a -0.0321541
HLA-B major histocompatibility complex, class I, B -0.0280517
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0264846
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0259733
TM4SF1 transmembrane 4 L six family member 1 -0.025865
RPL11 ribosomal protein L11 -0.0256666
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0254989
RPL30 ribosomal protein L30 -0.0253648
FTL ferritin, light polypeptide -0.0247849
WSB1 WD repeat and SOCS box containing 1 -0.0245181
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0243837
TUBB4B tubulin, beta 4B class IVb -0.0242969
VIM vimentin -0.0236466
PSD3 pleckstrin and Sec7 domain containing 3 -0.0235438
RPL23 ribosomal protein L23 -0.0229793
RPL38 ribosomal protein L38 -0.0225423
ASPH aspartate beta-hydroxylase -0.0223981
RPS2 ribosomal protein S2 -0.0219363
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.02177
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0216914
ENO2 enolase 2 (gamma, neuronal) -0.0215895
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0214584
AKAP12 A kinase (PRKA) anchor protein 12 -0.021456
ACTG1 actin gamma 1 -0.0213644
RPS29 ribosomal protein S29 -0.0213264
BCOR BCL6 corepressor -0.021019
KPNB1 karyopherin (importin) beta 1 -0.020935
EIF1 eukaryotic translation initiation factor 1 -0.0206978
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.02064
RPL37 ribosomal protein L37 -0.0197186
MYL12B myosin, light chain 12B, regulatory -0.0196757
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0195152
RPS27 ribosomal protein S27 -0.0194151
RPS21 ribosomal protein S21 -0.0193407
S100A9 S100 calcium binding protein A9 -0.019311
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0191648
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0187225
ANXA2 annexin A2 -0.0185426
SCMH1 sex comb on midleg homolog 1 (Drosophila) -0.0185228
S100A10 S100 calcium binding protein A10 -0.0183894
MCTP1 multiple C2 domains, transmembrane 1 -0.0182059
RPL13A ribosomal protein L13a -0.0179612
RPL36 ribosomal protein L36 -0.0177896
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0176053
RPL15 ribosomal protein L15 -0.0173221
HSPB1 heat shock 27kDa protein 1 -0.0171895
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0171886
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0171244
TBCA tubulin folding cofactor A -0.0169857
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0167822
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0166883
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0166517
NOP56 NOP56 ribonucleoprotein -0.0164065
PHF14 PHD finger protein 14 -0.016301
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.016037
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0160119
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0159867
IFITM3 interferon induced transmembrane protein 3 -0.015971
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0159191
NAP1L1 nucleosome assembly protein 1-like 1 -0.0156409
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0155968
ZMYND8 zinc finger, MYND-type containing 8 -0.0155686
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0154344
RPLP2 ribosomal protein, large, P2 -0.0153825
RPS28 ribosomal protein S28 -0.0151664
RPS17 ribosomal protein S17 -0.015104
RPS5 ribosomal protein S5 -0.0149888
FNDC3B fibronectin type III domain containing 3B -0.0148216
RACK1 receptor for activated C kinase 1 -0.014771
RPL8 ribosomal protein L8 -0.0146526
HMGB1 high mobility group box 1 -0.0145155
CLTA clathrin, light chain A -0.0144875
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0142981
TUBA1B tubulin, alpha 1b -0.0142901
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0141741
FN1 fibronectin 1 -0.0140495
PATJ PATJ crumbs cell polarity complex component -0.0140064
FTH1 ferritin, heavy polypeptide 1 -0.0140029
NCOA3 nuclear receptor coactivator 3 -0.0139799
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0138949