Sodium Salicylate_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sodium Salicylate perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sodium Salicylate_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.122962
FTH1 ferritin, heavy polypeptide 1 0.108827
IGFBP3 insulin-like growth factor binding protein 3 0.0814468
TGFBI transforming growth factor, beta-induced, 68kDa 0.0661606
NRXN3 neurexin 3 0.0516932
EFNA5 ephrin-A5 0.0465582
MYH9 myosin, heavy chain 9, non-muscle 0.04647
VEGFA vascular endothelial growth factor A 0.0410856
KMT2C lysine (K)-specific methyltransferase 2C 0.0405193
PSD3 pleckstrin and Sec7 domain containing 3 0.0397217
CDH13 cadherin 13 0.0396482
STC1 stanniocalcin 1 0.0395602
HMGA2 high mobility group AT-hook 2 0.036801
TTC3 tetratricopeptide repeat domain 3 0.0361482
IGFBP7 insulin-like growth factor binding protein 7 0.0352855
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0313345
TM4SF1 transmembrane 4 L six family member 1 0.0289287
ALK anaplastic lymphoma receptor tyrosine kinase 0.0287656
F3 coagulation factor III (thromboplastin, tissue factor) 0.0283908
GOLGB1 golgin B1 0.0267921
VEGFC vascular endothelial growth factor C 0.0267165
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.026545
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0263881
SEC24A SEC24 family member A 0.0262454
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0259571
FNIP1 folliculin interacting protein 1 0.0255254
NDRG1 N-myc downstream regulated 1 0.0252416
FSCN1 fascin actin-bundling protein 1 0.0252106
NKTR natural killer cell triggering receptor 0.0242103
LAMB1 laminin, beta 1 0.0240589
EGFR epidermal growth factor receptor 0.023768
NCOR2 nuclear receptor corepressor 2 0.022935
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0223045
DMTF1 cyclin D binding myb-like transcription factor 1 0.0209479
SQSTM1 sequestosome 1 0.0206136
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.020599
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0205928
SLC38A2 solute carrier family 38, member 2 0.0205662
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.020463
COL6A1 collagen, type VI, alpha 1 0.020411
VCL vinculin 0.020291
ERBIN erbb2 interacting protein 0.0202627
SND1 staphylococcal nuclease and tudor domain containing 1 0.0201884
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.020188
SUCO SUN domain containing ossification factor 0.0201722
TMEM158 transmembrane protein 158 (gene/pseudogene) 0.0201156
PRSS23 protease, serine, 23 0.0199534
PYGL phosphorylase, glycogen, liver 0.0196418
TPM1 tropomyosin 1 (alpha) 0.0196356
HDAC9 histone deacetylase 9 0.0196101
RNF145 ring finger protein 145 0.0190082
JPH2 junctophilin 2 0.0189792
KLHDC10 kelch domain containing 10 0.0189356
FHIT fragile histidine triad 0.0185463
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0184084
RAD51B RAD51 paralog B 0.0183706
OXSR1 oxidative stress responsive 1 0.0183042
LPP LIM domain containing preferred translocation partner in lipoma 0.018141
CALU calumenin 0.018104
L1CAM L1 cell adhesion molecule 0.0179333
HLA-A major histocompatibility complex, class I, A 0.0179093
MAP1B microtubule-associated protein 1B 0.0178883
MORF4L2 mortality factor 4 like 2 0.0178415
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.0178187
RAB6A RAB6A, member RAS oncogene family 0.0176831
GLRX glutaredoxin (thioltransferase) 0.0175977
MARCHF7 membrane associated ring-CH-type finger 7 0.0175267
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0174248
ZBTB20 zinc finger and BTB domain containing 20 0.0173924
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 0.0172027
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0171635
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0170209
PRKCE protein kinase C, epsilon 0.0170045
NUMA1 nuclear mitotic apparatus protein 1 0.016829
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0167659
PARD3 par-3 family cell polarity regulator 0.0166802
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0166585
DIAPH3 diaphanous-related formin 3 0.0164256
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0163176
CA12 carbonic anhydrase XII 0.0163052
ZMYND8 zinc finger, MYND-type containing 8 0.0162055
GLUL glutamate-ammonia ligase 0.0161932
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 0.0160519
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0160433
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.0159939
WRN Werner syndrome, RecQ helicase-like 0.0158573
GTDC1 glycosyltransferase-like domain containing 1 0.0157662
TBC1D22A TBC1 domain family, member 22A 0.0156836
KAZN kazrin, periplakin interacting protein 0.0156754
SHISA5 shisa family member 5 0.0154992
DLG1 discs, large homolog 1 (Drosophila) 0.0154887
GLIS3 GLIS family zinc finger 3 0.0154721
CCNT2 cyclin T2 0.0153538
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0153526
ENO2 enolase 2 (gamma, neuronal) 0.015346
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 0.0152979
FAM120A family with sequence similarity 120A 0.0152406
ZSWIM6 zinc finger, SWIM-type containing 6 0.0151396
FER fer (fps/fes related) tyrosine kinase 0.0151377
LUC7L LUC7-like (S. cerevisiae) 0.0151334

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.204996
TMSB10 thymosin beta 10 -0.141743
UBC ubiquitin C -0.0952618
VIM vimentin -0.0886617
MT2A metallothionein 2A -0.0885728
SDC4 syndecan 4 -0.0884213
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0805219
PTMA prothymosin, alpha -0.0740769
ENO1 enolase 1, (alpha) -0.0696398
GRB10 growth factor receptor-bound protein 10 -0.060901
TXNIP thioredoxin interacting protein -0.0570602
PDIA3 protein disulfide isomerase family A, member 3 -0.0506566
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0491176
NAMPT nicotinamide phosphoribosyltransferase -0.0490053
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0441789
FNDC3B fibronectin type III domain containing 3B -0.0432872
RTN4 reticulon 4 -0.0432527
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0425695
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.040855
WAC WW domain containing adaptor with coiled-coil -0.040662
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0406571
COL1A2 collagen, type I, alpha 2 -0.0405801
ANXA5 annexin A5 -0.0398603
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0397074
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0393284
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0391335
COL1A1 collagen, type I, alpha 1 -0.0385379
WTAP Wilms tumor 1 associated protein -0.038199
HLA-B major histocompatibility complex, class I, B -0.0379666
LDHA lactate dehydrogenase A -0.0374506
SPAG9 sperm associated antigen 9 -0.0372884
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0347373
CCNI cyclin I -0.0339029
SMYD3 SET and MYND domain containing 3 -0.0338937
SRPK2 SRSF protein kinase 2 -0.0338853
MT1X metallothionein 1X -0.03338
QKI QKI, KH domain containing, RNA binding -0.0327391
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.032046
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0319108
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0318824
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0315601
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.031136
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.030875
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0304687
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0302906
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.029895
RPLP1 ribosomal protein, large, P1 -0.0297029
LONP2 lon peptidase 2, peroxisomal -0.0292919
SOS2 son of sevenless homolog 2 (Drosophila) -0.0291141
AHNAK AHNAK nucleoprotein -0.029043
RPL32 ribosomal protein L32 -0.0289987
MEF2A myocyte enhancer factor 2A -0.0289012
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) -0.0287923
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0280092
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.027533
H3-3B H3.3 histone B -0.0271583
TOP1 topoisomerase (DNA) I -0.0271133
RPS27A ribosomal protein S27a -0.0267247
FAM20C family with sequence similarity 20, member C -0.0264436
FTL ferritin, light polypeptide -0.0260532
RIGI RNA sensor RIG-I -0.0260356
HMGB2 high mobility group box 2 -0.0259291
RPL23 ribosomal protein L23 -0.0257837
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0257834
FAM3C family with sequence similarity 3, member C -0.025557
ZNF395 zinc finger protein 395 -0.0254158
JUN jun proto-oncogene -0.0251466
LCOR ligand dependent nuclear receptor corepressor -0.0251455
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0250764
SMAD3 SMAD family member 3 -0.0250313
SEC24D SEC24 family member D -0.0250195
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0248253
RPL37A ribosomal protein L37a -0.0244856
PCBP2 poly(rC) binding protein 2 -0.0244178
USP12 ubiquitin specific peptidase 12 -0.0241289
ACVR1 activin A receptor, type I -0.0239715
BOD1L1 biorientation of chromosomes in cell division 1-like 1 -0.0239628
PIAS1 protein inhibitor of activated STAT, 1 -0.0238997
B2M beta-2-microglobulin -0.0236211
ITM2B integral membrane protein 2B -0.0235835
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0235643
S100A9 S100 calcium binding protein A9 -0.0233577
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma -0.023333
MT1E metallothionein 1E -0.0232248
TPT1 tumor protein, translationally-controlled 1 -0.0231544
FAM13A family with sequence similarity 13, member A -0.0229412
FLNB filamin B, beta -0.0227257
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0227052
RPS25 ribosomal protein S25 -0.022645
TPR translocated promoter region, nuclear basket protein -0.0225073
RPS11 ribosomal protein S11 -0.0223535
KIRREL1 kirre like nephrin family adhesion molecule 1 -0.02212
CUL4B cullin 4B -0.0218597
GLS2 glutaminase 2 (liver, mitochondrial) -0.0218486
ARL8B ADP-ribosylation factor-like 8B -0.021833
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0217591
ZNF207 zinc finger protein 207 -0.021747
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0217094
JMJD1C jumonji domain containing 1C -0.021567
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0215619