Sodium Salicylate_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sodium Salicylate perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sodium Salicylate_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.0937811
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.063968
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0563569
DNER delta/notch-like EGF repeat containing 0.0441892
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0414966
IGFBP3 insulin-like growth factor binding protein 3 0.0396278
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0376473
EEF2 eukaryotic translation elongation factor 2 0.0373959
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0369045
GLS2 glutaminase 2 (liver, mitochondrial) 0.035956
PBX3 pre-B-cell leukemia homeobox 3 0.0353744
MYH9 myosin, heavy chain 9, non-muscle 0.0344439
EPAS1 endothelial PAS domain protein 1 0.0328522
SMAD3 SMAD family member 3 0.0318568
APLP2 amyloid beta (A4) precursor-like protein 2 0.0302513
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0300734
MBNL2 muscleblind-like splicing regulator 2 0.0282553
PLEC plectin 0.0281519
ATP13A3 ATPase type 13A3 0.0279344
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0276691
RAD51B RAD51 paralog B 0.0275021
CEP250 centrosomal protein 250kDa 0.0274374
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0269375
ANXA1 annexin A1 0.0267002
MSN moesin 0.0266645
FNIP1 folliculin interacting protein 1 0.0265518
TPST1 tyrosylprotein sulfotransferase 1 0.0264753
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0263148
VEGFA vascular endothelial growth factor A 0.0262481
CCDC88A coiled-coil domain containing 88A 0.0256591
SCAPER S-phase cyclin A-associated protein in the ER 0.0249503
ZFR zinc finger RNA binding protein 0.0248225
LOC112694756 uncharaterized LOC112694756 0.0242287
MACF1 microtubule-actin crosslinking factor 1 0.0241983
NSD2 nuclear receptor binding SET domain protein 2 0.023866
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0232613
SQSTM1 sequestosome 1 0.0230167
FAM13A family with sequence similarity 13, member A 0.0228277
ITGA6 integrin, alpha 6 0.0225512
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0224681
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.022301
CEP295 centrosomal protein 295kDa 0.0219172
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0218784
BIRC2 baculoviral IAP repeat containing 2 0.0217992
SFSWAP splicing factor, suppressor of white-apricot family 0.0217375
CENPP centromere protein P 0.0216847
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0212768
AKAP9 A kinase (PRKA) anchor protein 9 0.0210509
HSPA8 heat shock 70kDa protein 8 0.0210313
CLASP2 cytoplasmic linker associated protein 2 0.0210185
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0210162
ERCC6L2 excision repair cross-complementation group 6-like 2 0.0208922
AVL9 AVL9 homolog (S. cerevisiase) 0.020661
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0206475
RAD23B RAD23 homolog B (S. cerevisiae) 0.0202353
CKAP5 cytoskeleton associated protein 5 0.0201528
ARCN1 archain 1 0.0200284
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0200188
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 0.0198759
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0197697
SON SON DNA binding protein 0.0197262
PTK2 protein tyrosine kinase 2 0.0193397
NAMPT nicotinamide phosphoribosyltransferase 0.019283
NT5DC3 5'-nucleotidase domain containing 3 0.0191675
SRP54 signal recognition particle 54kDa 0.0191129
CLTC clathrin, heavy chain (Hc) 0.0190448
TFG TRK-fused gene 0.0189726
ANO6 anoctamin 6 0.018937
DNM2 dynamin 2 0.0189114
IL6ST interleukin 6 signal transducer 0.0188692
PTPRS protein tyrosine phosphatase, receptor type, S 0.0187601
SSH2 slingshot protein phosphatase 2 0.0186442
LOC102724023 ES1 protein homolog, mitochondrial 0.0185385
GOLGB1 golgin B1 0.0183594
NAV2 neuron navigator 2 0.0182057
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0181367
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.0180287
PTPRM protein tyrosine phosphatase, receptor type, M 0.0180253
MFAP3 microfibrillar-associated protein 3 0.0179998
RAB5A RAB5A, member RAS oncogene family 0.0179023
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0177695
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0176387
LRRC59 leucine rich repeat containing 59 0.0175697
ZNF721 zinc finger protein 721 0.0174394
LARP1 La ribonucleoprotein domain family, member 1 0.0172865
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0172173
CCDC91 coiled-coil domain containing 91 0.0172052
HELZ helicase with zinc finger 0.0171495
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0170904
TJP1 tight junction protein 1 0.0170464
DDHD1 DDHD domain containing 1 0.0170327
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0169252
PRRC2B proline-rich coiled-coil 2B 0.0168485
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) 0.0168003
NUMA1 nuclear mitotic apparatus protein 1 0.0167529
FBXL20 F-box and leucine-rich repeat protein 20 0.0167232
GIGYF2 GRB10 interacting GYF protein 2 0.0166931
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0166225
CPNE1 copine I 0.0165765
NCAPD2 non-SMC condensin I complex, subunit D2 0.0164991

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.27761
VIM vimentin -0.174598
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.132474
TMSB10 thymosin beta 10 -0.127984
PTMA prothymosin, alpha -0.103021
TPT1 tumor protein, translationally-controlled 1 -0.0929938
LDHA lactate dehydrogenase A -0.0681016
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0597099
MT2A metallothionein 2A -0.0553019
ACTG1 actin gamma 1 -0.0545768
RIGI RNA sensor RIG-I -0.0528961
ANGPTL4 angiopoietin-like 4 -0.0502303
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0499255
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0493014
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0482503
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.044937
SDC4 syndecan 4 -0.043049
RPL35A ribosomal protein L35a -0.0424233
PARD3 par-3 family cell polarity regulator -0.0414013
TM4SF1 transmembrane 4 L six family member 1 -0.0412679
RDX radixin -0.0404077
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0397144
THSD4 thrombospondin, type I, domain containing 4 -0.0394026
GNAS GNAS complex locus -0.0387353
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0385193
FMN1 formin 1 -0.0383506
S100A10 S100 calcium binding protein A10 -0.0383468
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0374921
RAI14 retinoic acid induced 14 -0.0374793
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0371592
ERBIN erbb2 interacting protein -0.0362641
SLC38A2 solute carrier family 38, member 2 -0.0359333
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0359128
ANKRD28 ankyrin repeat domain 28 -0.0353927
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0353304
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0345969
TPI1 triosephosphate isomerase 1 -0.0345426
ANXA2 annexin A2 -0.0342509
CELF1 CUGBP, Elav-like family member 1 -0.0340577
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0338632
RPS6 ribosomal protein S6 -0.0335365
CD44 CD44 molecule (Indian blood group) -0.0334866
B2M beta-2-microglobulin -0.0333521
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0323726
PDE8A phosphodiesterase 8A -0.0316541
NALCN sodium leak channel, non selective -0.031541
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0310946
NDRG1 N-myc downstream regulated 1 -0.0309554
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0308026
DST dystonin -0.0302571
PODXL podocalyxin-like -0.0301379
ARHGAP5 Rho GTPase activating protein 5 -0.0301325
FNDC3A fibronectin type III domain containing 3A -0.0299904
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.029952
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.029911
ENO2 enolase 2 (gamma, neuronal) -0.0298305
POTEF POTE ankyrin domain family, member F -0.0293237
MCTP1 multiple C2 domains, transmembrane 1 -0.0289684
BIRC6 baculoviral IAP repeat containing 6 -0.028902
OSMR oncostatin M receptor -0.0286394
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0284702
ARMH4 armadillo like helical domain containing 4 -0.0282423
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0279499
CDK13 cyclin-dependent kinase 13 -0.0278595
WARS1 tryptophanyl-tRNA synthetase 1 -0.0277676
WSB1 WD repeat and SOCS box containing 1 -0.0277666
MEF2A myocyte enhancer factor 2A -0.0277276
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0276083
GSK3B glycogen synthase kinase 3 beta -0.0273313
FTL ferritin, light polypeptide -0.0272534
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0272348
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0271032
RPS23 ribosomal protein S23 -0.0269262
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0268587
JMJD1C jumonji domain containing 1C -0.0268237
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0267973
TTC14 tetratricopeptide repeat domain 14 -0.0267545
ZBTB35 zinc finger and BTB domain containing 35 -0.0264805
RACK1 receptor for activated C kinase 1 -0.0264175
NPEPPS aminopeptidase puromycin sensitive -0.0263995
LMO7 LIM domain 7 -0.0263191
ENO1 enolase 1, (alpha) -0.0260878
RPS21 ribosomal protein S21 -0.0260652
PGK1 phosphoglycerate kinase 1 -0.0259326
GPC6 glypican 6 -0.0259035
ZBTB7A zinc finger and BTB domain containing 7A -0.0258556
RPL37 ribosomal protein L37 -0.0256894
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0255407
RPL15 ribosomal protein L15 -0.0253052
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 -0.025218
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.0251571
RPLP0 ribosomal protein, large, P0 -0.0249324
RPS13 ribosomal protein S13 -0.0248062
XPOT exportin, tRNA -0.0247939
IFI44 interferon-induced protein 44 -0.0245531
FBXO11 F-box protein 11 -0.024519
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0244998
ANKRD12 ankyrin repeat domain 12 -0.0244931
WASF2 WAS protein family, member 2 -0.0243635
PURA purine-rich element binding protein A -0.0242473