Sodium Salicylate_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sodium Salicylate perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sodium Salicylate_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.17072
INTS6 integrator complex subunit 6 0.0763964
FLNA filamin A, alpha 0.0667065
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0612482
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0521318
ZSWIM6 zinc finger, SWIM-type containing 6 0.0504473
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0470032
VEGFA vascular endothelial growth factor A 0.0447127
VCL vinculin 0.0411385
HILPDA hypoxia inducible lipid droplet-associated 0.0385095
PDLIM5 PDZ and LIM domain 5 0.0349709
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.0320699
TUFT1 tuftelin 1 0.0318156
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0311111
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0309522
PLEC plectin 0.0291597
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0291023
APLP2 amyloid beta (A4) precursor-like protein 2 0.0285863
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0281728
NTN4 netrin 4 0.0276273
PALLD palladin, cytoskeletal associated protein 0.0273733
ZFP36L1 ZFP36 ring finger protein-like 1 0.0271889
POTEF POTE ankyrin domain family, member F 0.0271735
PLIN2 perilipin 2 0.0269255
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0259104
AEBP2 AE binding protein 2 0.0257231
MYO1E myosin IE 0.0250088
GLUL glutamate-ammonia ligase 0.0249668
EEF2 eukaryotic translation elongation factor 2 0.0237189
STC2 stanniocalcin 2 0.0235283
SOX9 SRY (sex determining region Y)-box 9 0.0227042
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0224938
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0224742
ABLIM1 actin binding LIM protein 1 0.0222075
CLIP2 CAP-GLY domain containing linker protein 2 0.022136
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0221172
IGFBP3 insulin-like growth factor binding protein 3 0.0219894
EPAS1 endothelial PAS domain protein 1 0.0216044
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0210642
HOMER1 homer scaffolding protein 1 0.0208166
FERMT2 fermitin family member 2 0.0204269
TGM2 transglutaminase 2 0.0201344
RASAL2 RAS protein activator like 2 0.0199554
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0197484
DUSP16 dual specificity phosphatase 16 0.0197418
LHFPL2 lipoma HMGIC fusion partner-like 2 0.01969
TTC19 tetratricopeptide repeat domain 19 0.0196183
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.0195934
ZMIZ1 zinc finger, MIZ-type containing 1 0.0194494
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0190737
ATXN1 ataxin 1 0.0190708
POU2F2 POU class 2 homeobox 2 0.0185379
CEMIP2 cell migration inducing hyaluronidase 2 0.0185035
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0182501
LRRC23 leucine rich repeat containing 23 0.0180149
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0179428
NCOR2 nuclear receptor corepressor 2 0.0179381
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.017865
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0174845
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0173629
SHB Src homology 2 domain containing adaptor protein B 0.0171277
CEMIP cell migration inducing protein, hyaluronan binding 0.0169659
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0169386
EGFR epidermal growth factor receptor 0.0169257
LOC102724023 ES1 protein homolog, mitochondrial 0.0168521
AKAP12 A kinase (PRKA) anchor protein 12 0.0167148
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0167029
ITGB4 integrin, beta 4 0.0166
NAV1 neuron navigator 1 0.0164223
SOD2 superoxide dismutase 2, mitochondrial 0.0163896
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0163088
AHRR aryl-hydrocarbon receptor repressor 0.0162187
TGFB1 transforming growth factor, beta 1 0.0161916
RAB7A RAB7A, member RAS oncogene family 0.016029
PRELID2 PRELI domain containing 2 0.0158793
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0157246
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0155855
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0155796
FOSL1 FOS-like antigen 1 0.0154367
IRS2 insulin receptor substrate 2 0.0153311
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 0.0152777
NALF1 NALCN channel auxiliary factor 1 0.0151233
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0150236
MYOF myoferlin 0.0149263
PDE10A phosphodiesterase 10A 0.0149121
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0146894
MAML3 mastermind-like 3 (Drosophila) 0.014647
ENO2 enolase 2 (gamma, neuronal) 0.0146162
PCF11 PCF11 cleavage and polyadenylation factor subunit 0.0146057
SPDYA speedy/RINGO cell cycle regulator family member A 0.0145833
INTS1 integrator complex subunit 1 0.014566
UBAP2 ubiquitin associated protein 2 0.0144869
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0141824
LOC112694756 uncharaterized LOC112694756 0.0140636
KRT18 keratin 18, type I 0.0139918
FBXO11 F-box protein 11 0.0138326
TOB2 transducer of ERBB2, 2 0.0137827
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0137421
STC1 stanniocalcin 1 0.013642
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0136108

decreased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase -0.250445
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.138212
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.118506
TMEM156 transmembrane protein 156 -0.115778
FN1 fibronectin 1 -0.108538
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.102872
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.102328
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.09732
PRRC2C proline-rich coiled-coil 2C -0.0865232
MT2A metallothionein 2A -0.0857034
OSMR oncostatin M receptor -0.0843958
ITGA1 integrin, alpha 1 -0.0803821
PTMA prothymosin, alpha -0.0672256
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0664173
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0660023
TMEM165 transmembrane protein 165 -0.0649786
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0572825
CENPF centromere protein F, 350/400kDa -0.0569933
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0564638
NRG1 neuregulin 1 -0.0561894
AHR aryl hydrocarbon receptor -0.0555085
MCTP2 multiple C2 domains, transmembrane 2 -0.0551683
FNBP1 formin binding protein 1 -0.0544317
ELL2 elongation factor, RNA polymerase II, 2 -0.051288
RBM39 RNA binding motif protein 39 -0.0502264
CANX calnexin -0.0493366
CAB39 calcium binding protein 39 -0.0488933
KLHL5 kelch-like family member 5 -0.0486351
TMSB4X thymosin beta 4, X-linked -0.0475178
GLIS3 GLIS family zinc finger 3 -0.0460339
S100A6 S100 calcium binding protein A6 -0.0455623
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0455119
TAS2R14 taste receptor, type 2, member 14 -0.0441475
JMJD1C jumonji domain containing 1C -0.0439496
CLTC clathrin, heavy chain (Hc) -0.0437273
MKI67 marker of proliferation Ki-67 -0.0436463
TPR translocated promoter region, nuclear basket protein -0.0436103
B2M beta-2-microglobulin -0.0432751
FOXP1 forkhead box P1 -0.0428044
GCC2 GRIP and coiled-coil domain containing 2 -0.0426665
NEK7 NIMA-related kinase 7 -0.042275
DENND5B DENN/MADD domain containing 5B -0.0419701
ETV6 ets variant 6 -0.0419373
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0410689
NIPBL Nipped-B homolog (Drosophila) -0.0409308
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0405835
ETV1 ets variant 1 -0.0404348
CDCP1 CUB domain containing protein 1 -0.0401188
UBE2K ubiquitin-conjugating enzyme E2K -0.0400503
ZMYND8 zinc finger, MYND-type containing 8 -0.0395781
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0393099
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0386607
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0382401
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0379854
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0378025
EFNA5 ephrin-A5 -0.0374669
EREG epiregulin -0.0362099
NAP1L1 nucleosome assembly protein 1-like 1 -0.0360782
CDC73 cell division cycle 73 -0.0356936
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0356849
ETNK1 ethanolamine kinase 1 -0.0351612
GOLT1B golgi transport 1B -0.0345376
SMOX spermine oxidase -0.0343286
GOLGA4 golgin A4 -0.0340864
IFI27 interferon, alpha-inducible protein 27 -0.0339868
KMT2E lysine (K)-specific methyltransferase 2E -0.0336778
STAT1 signal transducer and activator of transcription 1, 91kDa -0.03349
SOS1 son of sevenless homolog 1 (Drosophila) -0.0333398
UGCG UDP-glucose ceramide glucosyltransferase -0.0327908
RUNX2 runt-related transcription factor 2 -0.0322951
ZFR zinc finger RNA binding protein -0.0318882
AOPEP aminopeptidase O (putative) -0.0318296
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.0316924
SUCO SUN domain containing ossification factor -0.0316576
RAB2A RAB2A, member RAS oncogene family -0.0315794
EIF1 eukaryotic translation initiation factor 1 -0.0314327
CD44 CD44 molecule (Indian blood group) -0.0312147
OGA O-GlcNAcase -0.0311508
LCORL ligand dependent nuclear receptor corepressor-like -0.0310869
IL6ST interleukin 6 signal transducer -0.0308609
TXNIP thioredoxin interacting protein -0.0304625
NRP1 neuropilin 1 -0.0304605
PTBP3 polypyrimidine tract binding protein 3 -0.0302285
ARHGAP35 Rho GTPase activating protein 35 -0.0301152
RPL26 ribosomal protein L26 -0.0300864
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0299005
APP amyloid beta (A4) precursor protein -0.0298512
SYT1 synaptotagmin I -0.0298505
KDM3A lysine (K)-specific demethylase 3A -0.0297921
TRIO trio Rho guanine nucleotide exchange factor -0.0296996
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0293907
RPS2 ribosomal protein S2 -0.0291568
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0291251
CEP350 centrosomal protein 350kDa -0.0290454
RNF115 ring finger protein 115 -0.0286948
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha -0.0286635
TXNRD1 thioredoxin reductase 1 -0.0285042
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.028455
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0282079
RAB1A RAB1A, member RAS oncogene family -0.0281874