Sodium Salicylate_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sodium Salicylate perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sodium Salicylate_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.151926
EZR ezrin 0.0821554
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0617705
TPT1 tumor protein, translationally-controlled 1 0.0567944
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0563871
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0530484
CDK13 cyclin-dependent kinase 13 0.0522329
KMT2C lysine (K)-specific methyltransferase 2C 0.0519153
IFRD1 interferon-related developmental regulator 1 0.0493611
HM13 histocompatibility (minor) 13 0.0484756
ANKHD1 ankyrin repeat and KH domain containing 1 0.0481346
ANKRD11 ankyrin repeat domain 11 0.0480623
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0468219
RPS6 ribosomal protein S6 0.0462962
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0457511
RBM39 RNA binding motif protein 39 0.0431194
FNDC3B fibronectin type III domain containing 3B 0.0427244
EEF2 eukaryotic translation elongation factor 2 0.0425508
EPS8 epidermal growth factor receptor pathway substrate 8 0.0395387
GMDS GDP-mannose 4,6-dehydratase 0.0394645
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0389472
NCEH1 neutral cholesterol ester hydrolase 1 0.0382885
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0380328
ZFAND3 zinc finger, AN1-type domain 3 0.0370661
FBXO11 F-box protein 11 0.0370546
WAC WW domain containing adaptor with coiled-coil 0.0366841
HLA-A major histocompatibility complex, class I, A 0.0362207
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0353554
CSNK1A1 casein kinase 1, alpha 1 0.0350861
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0348741
NDRG1 N-myc downstream regulated 1 0.034537
TMF1 TATA element modulatory factor 1 0.0344371
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0341848
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0340345
RHEB Ras homolog enriched in brain 0.034007
RAB7A RAB7A, member RAS oncogene family 0.0338678
CEMIP2 cell migration inducing hyaluronidase 2 0.0332184
SEC31A SEC31 homolog A (S. cerevisiae) 0.033086
PTMA prothymosin, alpha 0.0327431
MYH14 myosin, heavy chain 14, non-muscle 0.0326807
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0326187
KDM6A lysine (K)-specific demethylase 6A 0.0321855
SIK3 SIK family kinase 3 0.0319002
GOLGA4 golgin A4 0.0313429
PTK2 protein tyrosine kinase 2 0.031284
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0284045
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0282729
KMT2E lysine (K)-specific methyltransferase 2E 0.0281957
DIDO1 death inducer-obliterator 1 0.0281801
EPB41L5 erythrocyte membrane protein band 4.1 like 5 0.0281147
TMEM39A transmembrane protein 39A 0.0278592
ZNF292 zinc finger protein 292 0.0277873
KRT18 keratin 18, type I 0.0277817
SSBP3 single stranded DNA binding protein 3 0.0277421
EIF1 eukaryotic translation initiation factor 1 0.0276865
SQSTM1 sequestosome 1 0.027662
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0276481
MYO1E myosin IE 0.0270473
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0270436
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0267841
MACC1 metastasis associated in colon cancer 1 0.0267062
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0265351
RPL37A ribosomal protein L37a 0.0265228
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0264869
GTF2IRD1 GTF2I repeat domain containing 1 0.0262334
FUS FUS RNA binding protein 0.0261694
RPS27A ribosomal protein S27a 0.0258093
SET SET nuclear proto-oncogene 0.0257147
RPS13 ribosomal protein S13 0.0255208
TUFT1 tuftelin 1 0.025417
H2AC6 H2A clustered histone 6 0.025191
BIRC6 baculoviral IAP repeat containing 6 0.0249932
MON2 MON2 homolog (S. cerevisiae) 0.0247785
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0246981
HBP1 HMG-box transcription factor 1 0.0246262
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0242042
TJP1 tight junction protein 1 0.0241119
GNAS GNAS complex locus 0.0240668
CTBP2 C-terminal binding protein 2 0.0238198
ESYT2 extended synaptotagmin-like protein 2 0.023813
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0235949
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0235922
FAM107B family with sequence similarity 107, member B 0.0235765
RAB1A RAB1A, member RAS oncogene family 0.0235477
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0234702
TOP1 topoisomerase (DNA) I 0.0233915
HDGF hepatoma-derived growth factor 0.0231886
SPAG9 sperm associated antigen 9 0.0231642
RPL35A ribosomal protein L35a 0.0231507
KDM5B lysine (K)-specific demethylase 5B 0.0229668
KDM2A lysine (K)-specific demethylase 2A 0.0227794
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0225207
GPHN gephyrin 0.0224535
RBM33 RNA binding motif protein 33 0.0222768
MATR3 matrin 3 0.0222053
RPL13A ribosomal protein L13a 0.0220561
BRD2 bromodomain containing 2 0.021943
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.021933
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.021825
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0217666

decreased expression

Symbol Name Standardized Value
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.109243
TMSB10 thymosin beta 10 -0.0904927
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0736041
H1-0 H1.0 linker histone -0.0650519
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0529561
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0526747
MKI67 marker of proliferation Ki-67 -0.0524442
CENPF centromere protein F, 350/400kDa -0.0522645
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.051635
FRMD5 FERM domain containing 5 -0.0485143
CBX3 chromobox homolog 3 -0.0477499
RPS21 ribosomal protein S21 -0.0455247
B2M beta-2-microglobulin -0.0453645
TPX2 TPX2, microtubule-associated -0.0436726
RPL18 ribosomal protein L18 -0.0429206
RPL12 ribosomal protein L12 -0.0413199
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0408552
TMEM123 transmembrane protein 123 -0.0387456
RPS19 ribosomal protein S19 -0.0362394
ATP5F1E ATP synthase F1 subunit epsilon -0.0344699
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0335568
CST3 cystatin C -0.0332641
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0331387
RPLP1 ribosomal protein, large, P1 -0.0326957
PRELID2 PRELI domain containing 2 -0.0322992
XPO1 exportin 1 -0.0313055
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0306444
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0303172
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.0299458
GSTP1 glutathione S-transferase pi 1 -0.0298181
SMYD3 SET and MYND domain containing 3 -0.0297251
AHNAK AHNAK nucleoprotein -0.029325
MYOF myoferlin -0.0290907
RPL32 ribosomal protein L32 -0.0285983
FAM3C family with sequence similarity 3, member C -0.0283131
SEPTIN7 septin 7 -0.0280371
RPL23 ribosomal protein L23 -0.0272772
CD46 CD46 molecule, complement regulatory protein -0.0268901
FAT1 FAT atypical cadherin 1 -0.0267481
S100A10 S100 calcium binding protein A10 -0.0265696
RPL8 ribosomal protein L8 -0.0263033
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.0258644
SMC4 structural maintenance of chromosomes 4 -0.0256672
CKAP5 cytoskeleton associated protein 5 -0.0254515
RPLP2 ribosomal protein, large, P2 -0.0243387
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.0236629
SON SON DNA binding protein -0.0228227
DSPP dentin sialophosphoprotein -0.0213472
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0211914
PCLO piccolo presynaptic cytomatrix protein -0.0211069
FTL ferritin, light polypeptide -0.0208755
TXNIP thioredoxin interacting protein -0.0205572
IFITM1 interferon induced transmembrane protein 1 -0.0203201
RAD21 RAD21 homolog (S. pombe) -0.0201581
RPS5 ribosomal protein S5 -0.0197186
SDK1 sidekick cell adhesion molecule 1 -0.0194748
PTBP3 polypyrimidine tract binding protein 3 -0.0194507
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain -0.0192131
RPL28 ribosomal protein L28 -0.0190551
NHSL1 NHS-like 1 -0.0189752
KIF4A kinesin family member 4A -0.0187522
TMOD3 tropomodulin 3 (ubiquitous) -0.0187195
CDCP1 CUB domain containing protein 1 -0.01862
DSG2 desmoglein 2 -0.0183582
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa -0.0183343
UBE2C ubiquitin-conjugating enzyme E2C -0.018161
GPX4 glutathione peroxidase 4 -0.0181136
ENO1 enolase 1, (alpha) -0.0180721
RPLP0 ribosomal protein, large, P0 -0.0179767
PPP4R2 protein phosphatase 4, regulatory subunit 2 -0.0178319
ANLN anillin, actin binding protein -0.0177831
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.017557
WWOX WW domain containing oxidoreductase -0.0174228
KIF11 kinesin family member 11 -0.0173985
SEM1 SEM1 26S proteasome subunit -0.017383
HMGN2 high mobility group nucleosomal binding domain 2 -0.0173466
CXXC5 CXXC finger protein 5 -0.0173203
EPCAM epithelial cell adhesion molecule -0.0172026
IFI27 interferon, alpha-inducible protein 27 -0.0171327
RPL19 ribosomal protein L19 -0.01709
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0170883
HMGB2 high mobility group box 2 -0.0170084
ROMO1 reactive oxygen species modulator 1 -0.0169965
PFN1 profilin 1 -0.0169501
KMT2A lysine (K)-specific methyltransferase 2A -0.0169134
ATAD2 ATPase family, AAA domain containing 2 -0.0168745
SOX4 SRY (sex determining region Y)-box 4 -0.0168648
KLF6 Kruppel-like factor 6 -0.0168115
FOSL1 FOS-like antigen 1 -0.0165908
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.016516
DST dystonin -0.0164693
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0164105
NUSAP1 nucleolar and spindle associated protein 1 -0.0163844
ECT2 epithelial cell transforming 2 -0.0161558
ITGA6 integrin, alpha 6 -0.0160657
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0160484
CCNI cyclin I -0.0159045
PTMS parathymosin -0.0158973
HOXB9 homeobox B9 -0.0158048
CTTN cortactin -0.0157882