Sodium Salicylate_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sodium Salicylate perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sodium Salicylate_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 0.0972915
EEF2 eukaryotic translation elongation factor 2 0.0842393
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0763148
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0591775
FLNA filamin A, alpha 0.0569815
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0568971
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0563039
YAP1 Yes-associated protein 1 0.0533593
CENPF centromere protein F, 350/400kDa 0.0499578
ATXN1 ataxin 1 0.0483965
MACF1 microtubule-actin crosslinking factor 1 0.0458541
MYH9 myosin, heavy chain 9, non-muscle 0.0437958
CPOX coproporphyrinogen oxidase 0.0416549
FAT1 FAT atypical cadherin 1 0.0413787
ITGA6 integrin, alpha 6 0.040244
RNF43 ring finger protein 43 0.0376739
KIAA0040 KIAA0040 0.0371619
NAV2 neuron navigator 2 0.0341063
FNDC3B fibronectin type III domain containing 3B 0.0333175
APLP2 amyloid beta (A4) precursor-like protein 2 0.0332091
CD44 CD44 molecule (Indian blood group) 0.0329826
POTEF POTE ankyrin domain family, member F 0.0325245
TJP1 tight junction protein 1 0.0321529
PDE4B phosphodiesterase 4B, cAMP-specific 0.031516
SEPTIN9 septin 9 0.0312764
PKM pyruvate kinase, muscle 0.0307644
RPS4X ribosomal protein S4, X-linked 0.0307486
KRT18 keratin 18, type I 0.0305249
PDE4D phosphodiesterase 4D, cAMP-specific 0.0294851
GCLC glutamate-cysteine ligase, catalytic subunit 0.0289464
FTH1 ferritin, heavy polypeptide 1 0.0289443
ASPH aspartate beta-hydroxylase 0.0268752
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0257836
PLEC plectin 0.0255784
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0250516
CCNL1 cyclin L1 0.0249265
SMAD3 SMAD family member 3 0.0248051
USP6NL USP6 N-terminal like 0.0247661
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0246831
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0245613
FN1 fibronectin 1 0.0233672
VEGFA vascular endothelial growth factor A 0.0223912
CENPE centromere protein E, 312kDa 0.0221234
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0217265
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0215548
IGSF9B immunoglobulin superfamily, member 9B 0.0214649
TPM3 tropomyosin 3 0.0213362
BLTP1 bridge-like lipid transfer protein family member 1 0.0210488
EFNB2 ephrin-B2 0.020792
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.020081
DST dystonin 0.0200511
NT5E 5'-nucleotidase, ecto (CD73) 0.0197941
BRD2 bromodomain containing 2 0.0197117
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0193508
SLC30A10 solute carrier family 30, member 10 0.0191382
KDM6B lysine (K)-specific demethylase 6B 0.0190642
RNPS1 RNA binding protein S1, serine-rich domain 0.0189968
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0188951
CHD4 chromodomain helicase DNA binding protein 4 0.0188926
SMC1A structural maintenance of chromosomes 1A 0.0188838
PCBP2 poly(rC) binding protein 2 0.0186583
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 0.0186143
FAM120A family with sequence similarity 120A 0.0185227
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.018059
BCL2L1 BCL2-like 1 0.0179958
SLTM SAFB-like, transcription modulator 0.0179659
ZFP36L1 ZFP36 ring finger protein-like 1 0.0178499
SRRM2 serine/arginine repetitive matrix 2 0.017749
RUNX1 runt-related transcription factor 1 0.0174928
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0173819
SF3A1 splicing factor 3a, subunit 1, 120kDa 0.0173701
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0173144
ANKRD12 ankyrin repeat domain 12 0.0169941
EIF4A2 eukaryotic translation initiation factor 4A2 0.0169021
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0168199
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0165928
COPA coatomer protein complex, subunit alpha 0.016511
TGFB2 transforming growth factor, beta 2 0.016477
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0163398
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0161905
ACTN1 actinin, alpha 1 0.0161853
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0160836
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0157763
SAMD5 sterile alpha motif domain containing 5 0.0157582
MED13L mediator complex subunit 13-like 0.0157351
MIDEAS mitotic deacetylase associated SANT domain protein 0.0157292
EIF5 eukaryotic translation initiation factor 5 0.0156924
RPL3 ribosomal protein L3 0.015588
NCAPG2 non-SMC condensin II complex, subunit G2 0.0155455
USP8 ubiquitin specific peptidase 8 0.0155348
F2RL1 coagulation factor II (thrombin) receptor-like 1 0.015459
ZNF638 zinc finger protein 638 0.0154581
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0153356
UBA6 ubiquitin-like modifier activating enzyme 6 0.0153215
HOXB6 homeobox B6 0.0152362
PPARD peroxisome proliferator-activated receptor delta 0.0151794
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.0151725
PRPF8 pre-mRNA processing factor 8 0.0151549
NCKAP1 NCK-associated protein 1 0.0151492
LENG8 leukocyte receptor cluster (LRC) member 8 0.0150954

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.322745
PTMA prothymosin, alpha -0.177902
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.137731
TMSB10 thymosin beta 10 -0.135669
IER3 immediate early response 3 -0.135593
RPL35A ribosomal protein L35a -0.096019
ACTG1 actin gamma 1 -0.093017
RPL34 ribosomal protein L34 -0.0880867
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0798927
FHIT fragile histidine triad -0.0796815
RPS24 ribosomal protein S24 -0.0790491
RPS6 ribosomal protein S6 -0.0788407
TPT1 tumor protein, translationally-controlled 1 -0.0775834
VCL vinculin -0.0743604
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0739775
LAMB3 laminin, beta 3 -0.0728476
FLOT1 flotillin 1 -0.0683466
KLF5 Kruppel-like factor 5 (intestinal) -0.0654461
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0643271
GPC5 glypican 5 -0.0635837
RPL26 ribosomal protein L26 -0.062776
RPS8 ribosomal protein S8 -0.0583054
HDAC2 histone deacetylase 2 -0.0546353
LMO7 LIM domain 7 -0.0510172
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0506512
JARID2 jumonji, AT rich interactive domain 2 -0.0505132
RPLP1 ribosomal protein, large, P1 -0.0493101
RPL12 ribosomal protein L12 -0.0484085
RPS3 ribosomal protein S3 -0.0480867
RAD51B RAD51 paralog B -0.045773
RPL23 ribosomal protein L23 -0.0454667
RSL1D1 ribosomal L1 domain containing 1 -0.0447926
RPL19 ribosomal protein L19 -0.0445315
CUX1 cut-like homeobox 1 -0.0422445
RPS29 ribosomal protein S29 -0.0412939
RPS25 ribosomal protein S25 -0.0410607
SERINC5 serine incorporator 5 -0.0403274
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0403235
RPL37A ribosomal protein L37a -0.0399955
S100A6 S100 calcium binding protein A6 -0.0389202
OSBPL3 oxysterol binding protein-like 3 -0.0373514
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.037192
RPS27A ribosomal protein S27a -0.0370659
RPS13 ribosomal protein S13 -0.0370594
RPL31 ribosomal protein L31 -0.0368234
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0364407
RPL5 ribosomal protein L5 -0.0363269
RPS5 ribosomal protein S5 -0.0356138
UBC ubiquitin C -0.0344079
MTDH metadherin -0.0342248
RPL32 ribosomal protein L32 -0.0341618
RPL4 ribosomal protein L4 -0.0340808
RPS17 ribosomal protein S17 -0.0336568
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0333022
RPS12 ribosomal protein S12 -0.0328175
RPLP0 ribosomal protein, large, P0 -0.0328085
NDRG1 N-myc downstream regulated 1 -0.0318732
SMYD3 SET and MYND domain containing 3 -0.0318137
RPL37 ribosomal protein L37 -0.0316323
SQSTM1 sequestosome 1 -0.0312814
MTAP methylthioadenosine phosphorylase -0.0310143
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0309602
RPS23 ribosomal protein S23 -0.0308989
ITPKC inositol-trisphosphate 3-kinase C -0.0308752
RPL11 ribosomal protein L11 -0.0308411
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor -0.0308021
RAB1A RAB1A, member RAS oncogene family -0.0307644
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0307221
GPHN gephyrin -0.0305328
RPLP2 ribosomal protein, large, P2 -0.030495
CANX calnexin -0.0302769
MBNL1 muscleblind-like splicing regulator 1 -0.0289722
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0289535
RACK1 receptor for activated C kinase 1 -0.0287327
OSBPL10 oxysterol binding protein-like 10 -0.02868
EPCAM epithelial cell adhesion molecule -0.0286596
RPS19 ribosomal protein S19 -0.0286121
VDAC1 voltage-dependent anion channel 1 -0.0284549
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0283056
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0282351
RPL36 ribosomal protein L36 -0.0277268
MAML3 mastermind-like 3 (Drosophila) -0.0276946
RPS16 ribosomal protein S16 -0.0274036
CCND1 cyclin D1 -0.0273311
KLK10 kallikrein-related peptidase 10 -0.0272676
RPS15 ribosomal protein S15 -0.0272386
RPL36A ribosomal protein L36a -0.0272195
EIF1 eukaryotic translation initiation factor 1 -0.0271898
RPS27 ribosomal protein S27 -0.0271859
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0270896
CDK13 cyclin-dependent kinase 13 -0.0270301
RPS20 ribosomal protein S20 -0.0266311
RPL8 ribosomal protein L8 -0.0263261
RPL30 ribosomal protein L30 -0.0262317
MAP4 microtubule-associated protein 4 -0.0260973
NAP1L1 nucleosome assembly protein 1-like 1 -0.0257511
BMP2K BMP2 inducible kinase -0.0257491
IARS1 isoleucyl-tRNA synthetase 1 -0.0256656
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A -0.025606
RPS21 ribosomal protein S21 -0.0254922