Sonidegib_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sonidegib perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sonidegib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.23045
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.162205
TRIO trio Rho guanine nucleotide exchange factor 0.125815
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.120365
LDHA lactate dehydrogenase A 0.0986143
DST dystonin 0.0859988
S100A10 S100 calcium binding protein A10 0.0788121
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0763158
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0760245
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0745966
ZBTB20 zinc finger and BTB domain containing 20 0.0735949
MBNL2 muscleblind-like splicing regulator 2 0.0683896
MYH9 myosin, heavy chain 9, non-muscle 0.0677144
LOC112694756 uncharaterized LOC112694756 0.0668222
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0661394
COL5A1 collagen, type V, alpha 1 0.0650924
CALR calreticulin 0.0648373
COL3A1 collagen, type III, alpha 1 0.06418
AHNAK AHNAK nucleoprotein 0.0622127
COL8A1 collagen, type VIII, alpha 1 0.0569142
MAP1B microtubule-associated protein 1B 0.0568636
ARL15 ADP-ribosylation factor-like 15 0.0563446
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.050666
FSTL1 follistatin-like 1 0.0497798
PKM pyruvate kinase, muscle 0.0496085
SEPTIN9 septin 9 0.0492087
NAV1 neuron navigator 1 0.0473977
SRRM2 serine/arginine repetitive matrix 2 0.0473461
TPM4 tropomyosin 4 0.046576
COL5A2 collagen, type V, alpha 2 0.0460159
EGFR epidermal growth factor receptor 0.0444179
EEF2 eukaryotic translation elongation factor 2 0.0443353
HDAC9 histone deacetylase 9 0.0438544
MSN moesin 0.0435019
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0426811
ADAR adenosine deaminase, RNA-specific 0.0420943
PDE4D phosphodiesterase 4D, cAMP-specific 0.0417791
ENO1 enolase 1, (alpha) 0.0413399
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0413051
DLG1 discs, large homolog 1 (Drosophila) 0.0406644
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0406273
TENM3 teneurin transmembrane protein 3 0.03932
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0389437
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0373192
MB21D2 Mab-21 domain containing 2 0.0362629
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0359017
DSPP dentin sialophosphoprotein 0.0351814
LAMB1 laminin, beta 1 0.0351522
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0350129
POTEF POTE ankyrin domain family, member F 0.0349882
B2M beta-2-microglobulin 0.0347398
VCL vinculin 0.0340584
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0337115
PDIA3 protein disulfide isomerase family A, member 3 0.0335018
MX2 MX dynamin-like GTPase 2 0.0335012
TIMP2 TIMP metallopeptidase inhibitor 2 0.0332144
EIF4A1 eukaryotic translation initiation factor 4A1 0.0331692
IQGAP1 IQ motif containing GTPase activating protein 1 0.0329996
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0323391
TNIP1 TNFAIP3 interacting protein 1 0.0322798
PPIB peptidylprolyl isomerase B (cyclophilin B) 0.0319121
TPM3 tropomyosin 3 0.0317584
PRELID2 PRELI domain containing 2 0.0315159
SET SET nuclear proto-oncogene 0.0311766
ERCC6L2 excision repair cross-complementation group 6-like 2 0.031077
GDI2 GDP dissociation inhibitor 2 0.0310389
RNF213 ring finger protein 213 0.0301689
CCT7 chaperonin containing TCP1, subunit 7 (eta) 0.0294701
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0293466
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.0288429
RRBP1 ribosome binding protein 1 0.0283157
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0280953
RHOA ras homolog family member A 0.0278928
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.0275515
SOD2 superoxide dismutase 2, mitochondrial 0.0273698
SPDL1 spindle apparatus coiled-coil protein 1 0.0272878
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0272202
RPL19 ribosomal protein L19 0.0271144
RTN4 reticulon 4 0.026953
CD44 CD44 molecule (Indian blood group) 0.0268472
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0267649
DDR2 discoidin domain receptor tyrosine kinase 2 0.0266277
DCLK2 doublecortin-like kinase 2 0.0264822
ADAM9 ADAM metallopeptidase domain 9 0.0260004
CALD1 caldesmon 1 0.0259054
LMNA lamin A/C 0.0258868
MSI2 musashi RNA-binding protein 2 0.0258396
MYOF myoferlin 0.0257714
FLNA filamin A, alpha 0.0255787
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0254076
ACTN4 actinin, alpha 4 0.0251581
CANX calnexin 0.0250032
IFI6 interferon, alpha-inducible protein 6 0.0249055
ANKRD11 ankyrin repeat domain 11 0.0244872
LIMA1 LIM domain and actin binding 1 0.0242725
CDK6 cyclin-dependent kinase 6 0.0240721
TMSB4X thymosin beta 4, X-linked 0.0239987
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0239714
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0239437
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.0234466

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0668371
MT2A metallothionein 2A -0.0606295
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0496222
CDH13 cadherin 13 -0.0483248
TMSB10 thymosin beta 10 -0.0422182
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0420487
STC1 stanniocalcin 1 -0.0390815
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0360591
S100A6 S100 calcium binding protein A6 -0.0357725
NDRG1 N-myc downstream regulated 1 -0.0349696
PODXL podocalyxin-like -0.0342736
PLAT plasminogen activator, tissue -0.0328307
CCND1 cyclin D1 -0.03258
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0293815
IGFBP3 insulin-like growth factor binding protein 3 -0.0285208
HIP1 huntingtin interacting protein 1 -0.0272428
ZEB1 zinc finger E-box binding homeobox 1 -0.0267005
FTH1 ferritin, heavy polypeptide 1 -0.0263914
EFNA5 ephrin-A5 -0.0255251
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0251175
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0236167
MT1X metallothionein 1X -0.023443
LOX lysyl oxidase -0.0196164
PBX3 pre-B-cell leukemia homeobox 3 -0.01908
UBC ubiquitin C -0.0189511
THBS2 thrombospondin 2 -0.0188938
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0188895
PARD3 par-3 family cell polarity regulator -0.0186196
RPL34 ribosomal protein L34 -0.018335
MARCKS myristoylated alanine-rich protein kinase C substrate -0.018141
SPAG9 sperm associated antigen 9 -0.0177407
PLAUR plasminogen activator, urokinase receptor -0.0177371
COL1A2 collagen, type I, alpha 2 -0.0172936
MYADM myeloid-associated differentiation marker -0.0172087
WWTR1 WW domain containing transcription regulator 1 -0.0171816
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0168806
RBM25 RNA binding motif protein 25 -0.0167729
KPNB1 karyopherin (importin) beta 1 -0.0166946
ARHGAP5 Rho GTPase activating protein 5 -0.0166681
SVIL supervillin -0.0166135
SLC38A1 solute carrier family 38, member 1 -0.0162878
PXDN peroxidasin -0.0162558
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0161523
MARCHF6 membrane associated ring-CH-type finger 6 -0.0159896
BACE2 beta-site APP-cleaving enzyme 2 -0.015811
ABTB3 ankyrin repeat and BTB domain containing 3 -0.015644
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) -0.0155525
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0154767
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0153039
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0151888
INSIG1 insulin induced gene 1 -0.0151841
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0148622
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0148057
RPL35A ribosomal protein L35a -0.0147852
KDM3A lysine (K)-specific demethylase 3A -0.014669
ULK1 unc-51 like autophagy activating kinase 1 -0.0145455
RASA2 RAS p21 protein activator 2 -0.014436
ARL4C ADP-ribosylation factor-like 4C -0.0142721
ZNF207 zinc finger protein 207 -0.0141574
LMAN1 lectin, mannose-binding, 1 -0.0141098
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0139948
ATF4 activating transcription factor 4 -0.0139715
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -0.0139593
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0138798
GDF15 growth differentiation factor 15 -0.01377
NAV2 neuron navigator 2 -0.0137467
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.0137372
FNBP4 formin binding protein 4 -0.0136624
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0136617
TM4SF1 transmembrane 4 L six family member 1 -0.0135811
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0133833
UBE2B ubiquitin-conjugating enzyme E2B -0.0132366
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0131297
NALF1 NALCN channel auxiliary factor 1 -0.0131093
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0130545
SDK1 sidekick cell adhesion molecule 1 -0.0129399
NUMB numb homolog (Drosophila) -0.0129121
ADM adrenomedullin -0.012872
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0128119
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0126955
GGNBP2 gametogenetin binding protein 2 -0.0126749
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0122726
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 -0.0120282
TUT4 terminal uridylyl transferase 4 -0.0120031
VDAC1 voltage-dependent anion channel 1 -0.0120012
KCMF1 potassium channel modulatory factor 1 -0.0119746
BTG1 B-cell translocation gene 1, anti-proliferative -0.0119472
AFF3 AF4/FMR2 family, member 3 -0.0119236
USP3 ubiquitin specific peptidase 3 -0.0119127
TJP1 tight junction protein 1 -0.0118489
ANKRD33B ankyrin repeat domain 33B -0.0118344
RPS16 ribosomal protein S16 -0.0118175
FRMD4A FERM domain containing 4A -0.0117534
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0117175
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0116225
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0116146
NSD2 nuclear receptor binding SET domain protein 2 -0.0115655
PRKCE protein kinase C, epsilon -0.0115562
BHLHE40 basic helix-loop-helix family, member e40 -0.0115423
IARS1 isoleucyl-tRNA synthetase 1 -0.0115241