| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sonidegib perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Sonidegib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.276327 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0975305 |
| AREG | amphiregulin | 0.0904923 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0815189 |
| TENM3 | teneurin transmembrane protein 3 | 0.0680485 |
| RPL3 | ribosomal protein L3 | 0.0655067 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | 0.0560193 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0541751 |
| CPOX | coproporphyrinogen oxidase | 0.0514277 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0512067 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0509794 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.050848 |
| ANXA1 | annexin A1 | 0.0506964 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0502261 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0493873 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0489724 |
| RPS12 | ribosomal protein S12 | 0.0486396 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0476932 |
| DST | dystonin | 0.0475895 |
| EPHA6 | EPH receptor A6 | 0.0445087 |
| CALR | calreticulin | 0.0439092 |
| PPIA | peptidylprolyl isomerase A (cyclophilin A) | 0.0435481 |
| RPS3 | ribosomal protein S3 | 0.0433719 |
| ZNF292 | zinc finger protein 292 | 0.0432793 |
| CCT7 | chaperonin containing TCP1, subunit 7 (eta) | 0.042277 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.0408806 |
| MGAT4C | MGAT4 family, member C | 0.0402322 |
| MED13L | mediator complex subunit 13-like | 0.040175 |
| EZR | ezrin | 0.0393455 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0382063 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0368323 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0366153 |
| RPL19 | ribosomal protein L19 | 0.036359 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.0356175 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0356048 |
| ATP11A | ATPase, class VI, type 11A | 0.0339844 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0335671 |
| SET | SET nuclear proto-oncogene | 0.0334939 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0329935 |
| TXNRD1 | thioredoxin reductase 1 | 0.0318306 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0318257 |
| USP34 | ubiquitin specific peptidase 34 | 0.0318179 |
| CDK6 | cyclin-dependent kinase 6 | 0.0308729 |
| ARRDC3 | arrestin domain containing 3 | 0.0308057 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0307822 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0303458 |
| CXADR | coxsackie virus and adenovirus receptor | 0.0286098 |
| BRD2 | bromodomain containing 2 | 0.0278996 |
| RHOA | ras homolog family member A | 0.0276188 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0273483 |
| RPL5 | ribosomal protein L5 | 0.0273103 |
| PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | 0.0271318 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0270117 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 0.0267922 |
| TPM3 | tropomyosin 3 | 0.0265267 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0264491 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0263085 |
| ETNK1 | ethanolamine kinase 1 | 0.0260597 |
| H1-4 | H1.4 linker histone, cluster member | 0.025597 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0253314 |
| NRXN3 | neurexin 3 | 0.0252241 |
| MPG | N-methylpurine-DNA glycosylase | 0.0252059 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0251957 |
| PDGFC | platelet derived growth factor C | 0.0249579 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0248724 |
| AP2M1 | adaptor-related protein complex 2, mu 1 subunit | 0.0240115 |
| FLNA | filamin A, alpha | 0.0240033 |
| SETD5 | SET domain containing 5 | 0.0237902 |
| PTMS | parathymosin | 0.0235843 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0234873 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0234527 |
| EPHA5 | EPH receptor A5 | 0.0234511 |
| RPL8 | ribosomal protein L8 | 0.0234204 |
| PKM | pyruvate kinase, muscle | 0.0232265 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0231857 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0229424 |
| NCKAP1 | NCK-associated protein 1 | 0.0228373 |
| RPL7A | ribosomal protein L7a | 0.0228272 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0226948 |
| PHF21A | PHD finger protein 21A | 0.0224664 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0224418 |
| VPS72 | vacuolar protein sorting 72 homolog (S. cerevisiae) | 0.0223701 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0223542 |
| SMYD3 | SET and MYND domain containing 3 | 0.022271 |
| YEATS2 | YEATS domain containing 2 | 0.0221936 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.0218332 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0217181 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0215831 |
| THOC1 | THO complex 1 | 0.0213413 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0212237 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.021066 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0208389 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0208271 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.020826 |
| EXOC6B | exocyst complex component 6B | 0.0205198 |
| CAMKMT | calmodulin-lysine N-methyltransferase | 0.0205116 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0204478 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.020412 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0203481 |
| HDAC9 | histone deacetylase 9 | 0.020297 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.151302 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.103505 |
| RPL35A | ribosomal protein L35a | -0.0965118 |
| ACTG1 | actin gamma 1 | -0.0931561 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0917971 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0850604 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0799156 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0789744 |
| NLGN1 | neuroligin 1 | -0.0731847 |
| EGR1 | early growth response 1 | -0.0721293 |
| HMGA2 | high mobility group AT-hook 2 | -0.0693875 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.065752 |
| HMGA1 | high mobility group AT-hook 1 | -0.0652058 |
| BCHE | butyrylcholinesterase | -0.0592721 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0572653 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0551806 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0541484 |
| ZNF804A | zinc finger protein 804A | -0.0491027 |
| PCDH7 | protocadherin 7 | -0.0481956 |
| RASAL2 | RAS protein activator like 2 | -0.0469086 |
| MMP12 | matrix metallopeptidase 12 | -0.0463736 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0450408 |
| EHBP1 | EH domain binding protein 1 | -0.0438697 |
| PTMA | prothymosin, alpha | -0.0426467 |
| RPLP1 | ribosomal protein, large, P1 | -0.0422157 |
| MAP1B | microtubule-associated protein 1B | -0.0402486 |
| CENPF | centromere protein F, 350/400kDa | -0.0382823 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0379102 |
| JMJD1C | jumonji domain containing 1C | -0.0373476 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0370555 |
| RPL34 | ribosomal protein L34 | -0.036768 |
| RPS24 | ribosomal protein S24 | -0.0362288 |
| TPM4 | tropomyosin 4 | -0.0351183 |
| RPS21 | ribosomal protein S21 | -0.0343479 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0338318 |
| NHSL1 | NHS-like 1 | -0.0328868 |
| ASPH | aspartate beta-hydroxylase | -0.0324823 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0323567 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0314056 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0307731 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0307698 |
| NAV3 | neuron navigator 3 | -0.0304726 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0303594 |
| NABP1 | nucleic acid binding protein 1 | -0.030348 |
| EDARADD | EDAR-associated death domain | -0.0302396 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0301796 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0293934 |
| TUBA1C | tubulin, alpha 1c | -0.0292463 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0289532 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0289283 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0287405 |
| CLDN1 | claudin 1 | -0.028358 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0281766 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0273559 |
| TMEM41B | transmembrane protein 41B | -0.0272395 |
| HMGB1 | high mobility group box 1 | -0.0263635 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0263591 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0260018 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0254217 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | -0.0247704 |
| GNAS | GNAS complex locus | -0.0240537 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0240334 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0240014 |
| MTAP | methylthioadenosine phosphorylase | -0.0238474 |
| KIF18B | kinesin family member 18B | -0.0238231 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.023566 |
| ATF4 | activating transcription factor 4 | -0.023515 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0234876 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0230048 |
| MAP4 | microtubule-associated protein 4 | -0.0227943 |
| SGO2 | shugoshin 2 | -0.0222536 |
| RPS6 | ribosomal protein S6 | -0.0220101 |
| DIAPH3 | diaphanous-related formin 3 | -0.0219571 |
| FUS | FUS RNA binding protein | -0.0219465 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0209928 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0207039 |
| SETX | senataxin | -0.0206944 |
| MKI67 | marker of proliferation Ki-67 | -0.0206385 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0206148 |
| TPX2 | TPX2, microtubule-associated | -0.0204438 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0204238 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.020186 |
| CBX3 | chromobox homolog 3 | -0.0201368 |
| CDV3 | CDV3 homolog (mouse) | -0.0199371 |
| PARK7 | parkinson protein 7 | -0.0198602 |
| CENPE | centromere protein E, 312kDa | -0.0194486 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.019347 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0192928 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0192786 |
| RPL9 | ribosomal protein L9 | -0.0189257 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0187006 |
| RPS14 | ribosomal protein S14 | -0.0186238 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0185561 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.018123 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0179359 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0179187 |
| IMMT | inner membrane protein, mitochondrial | -0.0176111 |
| TUBB | tubulin, beta class I | -0.0174687 |
| TMEM123 | transmembrane protein 123 | -0.0174045 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0172645 |
