| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sonidegib perturbation in CHP-212 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Sonidegib_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.236432 |
| IGF2 | insulin-like growth factor 2 | 0.160105 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.134803 |
| MEIS2 | Meis homeobox 2 | 0.114058 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0892931 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0883712 |
| SEPTIN9 | septin 9 | 0.0836297 |
| FAM13A | family with sequence similarity 13, member A | 0.0695645 |
| RPL19 | ribosomal protein L19 | 0.0644291 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0624784 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0589803 |
| MEF2A | myocyte enhancer factor 2A | 0.0541231 |
| RPS6 | ribosomal protein S6 | 0.0520334 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.051117 |
| RPS3 | ribosomal protein S3 | 0.0506133 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | 0.0496719 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0475784 |
| RPS12 | ribosomal protein S12 | 0.0474278 |
| RPS5 | ribosomal protein S5 | 0.046561 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0438237 |
| TLE4 | transducin-like enhancer of split 4 | 0.043127 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0430657 |
| RPL7A | ribosomal protein L7a | 0.0418041 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0412358 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0411029 |
| NDRG1 | N-myc downstream regulated 1 | 0.0406084 |
| FMN1 | formin 1 | 0.0396884 |
| PKM | pyruvate kinase, muscle | 0.0384619 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0383798 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.037971 |
| BPTF | bromodomain PHD finger transcription factor | 0.0379015 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0377011 |
| RACK1 | receptor for activated C kinase 1 | 0.0373014 |
| FAM162A | family with sequence similarity 162, member A | 0.0371789 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | 0.0370072 |
| RPLP0 | ribosomal protein, large, P0 | 0.0367378 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0366909 |
| DST | dystonin | 0.0365787 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0361089 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0360141 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0359818 |
| STC1 | stanniocalcin 1 | 0.0359718 |
| RPL3 | ribosomal protein L3 | 0.0355158 |
| RPL38 | ribosomal protein L38 | 0.0353681 |
| PCDH9 | protocadherin 9 | 0.0352477 |
| RPL37A | ribosomal protein L37a | 0.0351154 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0347546 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | 0.0344881 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | 0.0342925 |
| KAT6B | K(lysine) acetyltransferase 6B | 0.034273 |
| ANGPTL4 | angiopoietin-like 4 | 0.033152 |
| FERMT2 | fermitin family member 2 | 0.0327685 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0324281 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0320802 |
| VCL | vinculin | 0.0318763 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.0317335 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0315873 |
| ACTG1 | actin gamma 1 | 0.0310913 |
| NCAM2 | neural cell adhesion molecule 2 | 0.0310785 |
| TPI1 | triosephosphate isomerase 1 | 0.0310504 |
| KIAA1217 | KIAA1217 | 0.0305107 |
| SCFD1 | sec1 family domain containing 1 | 0.0299105 |
| CHD9 | chromodomain helicase DNA binding protein 9 | 0.0298719 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0292741 |
| RPS25 | ribosomal protein S25 | 0.0285592 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0281949 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0278349 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0274462 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0273351 |
| FRMD4A | FERM domain containing 4A | 0.0270434 |
| FNBP1 | formin binding protein 1 | 0.026986 |
| FUT11 | fucosyltransferase 11 (alpha (1,3) fucosyltransferase) | 0.0269427 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0267751 |
| SMARCE1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 | 0.0266647 |
| BRD2 | bromodomain containing 2 | 0.0265769 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0260242 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0260188 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0258693 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0257925 |
| WNT5A | wingless-type MMTV integration site family, member 5A | 0.025621 |
| RNF150 | ring finger protein 150 | 0.0256127 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0253099 |
| RALYL | RALY RNA binding protein-like | 0.0252996 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0249039 |
| ASPH | aspartate beta-hydroxylase | 0.0248216 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | 0.0248013 |
| SIK3 | SIK family kinase 3 | 0.0247145 |
| AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 | 0.0247144 |
| ZNF395 | zinc finger protein 395 | 0.0246981 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0246702 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0243482 |
| PFN1 | profilin 1 | 0.0242433 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.0242022 |
| PCDH15 | protocadherin-related 15 | 0.0241476 |
| RUNX1 | runt-related transcription factor 1 | 0.0240153 |
| VEGFA | vascular endothelial growth factor A | 0.0237882 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0235257 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | 0.0234217 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0232021 |
| WDR45B | WD repeat domain 45B | 0.0231807 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NRG1 | neuregulin 1 | -0.0811901 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0612887 |
| LPIN1 | lipin 1 | -0.0500625 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0476289 |
| HMGB2 | high mobility group box 2 | -0.0472583 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.045958 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0425844 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.040231 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.03959 |
| PCBP2 | poly(rC) binding protein 2 | -0.0394243 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0391901 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | -0.0388645 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0386864 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0386054 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.0377607 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0374286 |
| AHNAK | AHNAK nucleoprotein | -0.036816 |
| MED13L | mediator complex subunit 13-like | -0.03672 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0363546 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0361473 |
| THBS1 | thrombospondin 1 | -0.034595 |
| SEPTIN7 | septin 7 | -0.033373 |
| COL1A1 | collagen, type I, alpha 1 | -0.0333041 |
| PCNX1 | pecanex 1 | -0.0328946 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.032231 |
| NOP58 | NOP58 ribonucleoprotein | -0.0317616 |
| PTMA | prothymosin, alpha | -0.030673 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0301209 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.0297364 |
| TNRC6B | trinucleotide repeat containing 6B | -0.029272 |
| KPNB1 | karyopherin (importin) beta 1 | -0.029116 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0290302 |
| VIM | vimentin | -0.0285082 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0279806 |
| PARD3 | par-3 family cell polarity regulator | -0.0278496 |
| RPLP1 | ribosomal protein, large, P1 | -0.0274427 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0274397 |
| HIP1 | huntingtin interacting protein 1 | -0.0269368 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0261363 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | -0.0259411 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0258949 |
| KLHL13 | kelch-like family member 13 | -0.0256007 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.025454 |
| MATR3 | matrin 3 | -0.0252873 |
| CUX1 | cut-like homeobox 1 | -0.0252622 |
| SPAG9 | sperm associated antigen 9 | -0.0251425 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.025065 |
| UVRAG | UV radiation resistance associated | -0.024832 |
| AOPEP | aminopeptidase O (putative) | -0.0245478 |
| HELZ | helicase with zinc finger | -0.0243307 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | -0.0243262 |
| LPGAT1 | lysophosphatidylglycerol acyltransferase 1 | -0.0237465 |
| UBC | ubiquitin C | -0.0236578 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0235151 |
| FOXK2 | forkhead box K2 | -0.0233735 |
| NUMB | numb homolog (Drosophila) | -0.0233528 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0229318 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.0227068 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0226686 |
| WDR26 | WD repeat domain 26 | -0.0224389 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0224295 |
| RBM25 | RNA binding motif protein 25 | -0.0219634 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0217527 |
| TMSB10 | thymosin beta 10 | -0.0215729 |
| ZFR | zinc finger RNA binding protein | -0.0214549 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0214327 |
| CALU | calumenin | -0.0212834 |
| RC3H1 | ring finger and CCCH-type domains 1 | -0.0212819 |
| MSI2 | musashi RNA-binding protein 2 | -0.0209825 |
| TPM4 | tropomyosin 4 | -0.0209347 |
| PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | -0.0206104 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.020597 |
| RBM39 | RNA binding motif protein 39 | -0.0205191 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0205077 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.020396 |
| MYO9B | myosin IXB | -0.0203759 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.0202736 |
| KIDINS220 | kinase D-interacting substrate, 220kDa | -0.0202583 |
| RHEB | Ras homolog enriched in brain | -0.0202407 |
| ZNF292 | zinc finger protein 292 | -0.020222 |
| HERC1 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 | -0.0201554 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0201247 |
| CELF1 | CUGBP, Elav-like family member 1 | -0.0201226 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0200941 |
| ZNF207 | zinc finger protein 207 | -0.0200875 |
| SRPK2 | SRSF protein kinase 2 | -0.0200724 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | -0.0200454 |
| COL3A1 | collagen, type III, alpha 1 | -0.020021 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | -0.0197875 |
| LSAMP | limbic system-associated membrane protein | -0.0195879 |
| ZC3H15 | zinc finger CCCH-type containing 15 | -0.0195531 |
| CDC27 | cell division cycle 27 | -0.0195288 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0194919 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0194412 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0194383 |
| NUP214 | nucleoporin 214kDa | -0.0192508 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.0192038 |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase | -0.0192038 |
| KDM6A | lysine (K)-specific demethylase 6A | -0.0190715 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | -0.0190469 |
