| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sonidegib perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Sonidegib_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LCN2 | lipocalin 2 | 0.135726 |
| EXT1 | exostosin glycosyltransferase 1 | 0.102132 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0938744 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0897173 |
| B2M | beta-2-microglobulin | 0.0896487 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0873365 |
| PHF3 | PHD finger protein 3 | 0.0768766 |
| IFNGR1 | interferon gamma receptor 1 | 0.07527 |
| RNF213 | ring finger protein 213 | 0.0697995 |
| MX1 | MX dynamin-like GTPase 1 | 0.0662272 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0631994 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.062994 |
| EPCAM | epithelial cell adhesion molecule | 0.0602228 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0589834 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0588479 |
| MX2 | MX dynamin-like GTPase 2 | 0.0502633 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0460912 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | 0.0457291 |
| LIMA1 | LIM domain and actin binding 1 | 0.0457259 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0455916 |
| UBAC2 | UBA domain containing 2 | 0.0452981 |
| SMAD3 | SMAD family member 3 | 0.0447382 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0447258 |
| LDHA | lactate dehydrogenase A | 0.0443341 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0429406 |
| DSPP | dentin sialophosphoprotein | 0.0429031 |
| FAT1 | FAT atypical cadherin 1 | 0.0427742 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0424889 |
| PKM | pyruvate kinase, muscle | 0.0422617 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0411574 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0406547 |
| ATP11A | ATPase, class VI, type 11A | 0.0405695 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0403093 |
| NCKAP5 | NCK-associated protein 5 | 0.0399445 |
| SP100 | SP100 nuclear antigen | 0.0398224 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0397166 |
| STK24 | serine/threonine kinase 24 | 0.0390074 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0383157 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0367316 |
| PRKCA | protein kinase C, alpha | 0.0366394 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0366036 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0362337 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.0360857 |
| ABLIM1 | actin binding LIM protein 1 | 0.0360478 |
| APP | amyloid beta (A4) precursor protein | 0.0353099 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 0.0350247 |
| ASPH | aspartate beta-hydroxylase | 0.0350199 |
| TMC5 | transmembrane channel-like 5 | 0.0348845 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0348698 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0345073 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0343397 |
| APOL1 | apolipoprotein L, 1 | 0.0341287 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0339531 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | 0.0338043 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0335707 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0334507 |
| MUC13 | mucin 13, cell surface associated | 0.0330687 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0329141 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0326255 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0324307 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | 0.0322021 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0319115 |
| OAS1 | 2'-5'-oligoadenylate synthetase 1, 40/46kDa | 0.0317218 |
| SFTPA2 | surfactant protein A2 | 0.0307379 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | 0.0306715 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0306383 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.0306252 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.0305798 |
| DUSP10 | dual specificity phosphatase 10 | 0.0305318 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0304623 |
| LYZ | lysozyme | 0.0304597 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0302851 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.03013 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.0300484 |
| MAP7 | microtubule-associated protein 7 | 0.0297935 |
| XAF1 | XIAP associated factor 1 | 0.0297334 |
| KIAA1217 | KIAA1217 | 0.0296519 |
| SET | SET nuclear proto-oncogene | 0.0294958 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0293877 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | 0.0293001 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0291949 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0288608 |
| ABHD2 | abhydrolase domain containing 2 | 0.0287407 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | 0.02861 |
| CUL3 | cullin 3 | 0.0285029 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0283965 |
| HKDC1 | hexokinase domain containing 1 | 0.0283672 |
| TRERF1 | transcriptional regulating factor 1 | 0.0282031 |
| DIAPH1 | diaphanous-related formin 1 | 0.0281104 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0278623 |
| HLA-A | major histocompatibility complex, class I, A | 0.0277556 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0274143 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0273503 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.027286 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0272353 |
| SERINC5 | serine incorporator 5 | 0.0271146 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0270906 |
| FAAH2 | fatty acid amide hydrolase 2 | 0.0270623 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.026883 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0267946 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EGR1 | early growth response 1 | -0.070718 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0562753 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.049874 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0376975 |
| VIM | vimentin | -0.0352962 |
| NDRG1 | N-myc downstream regulated 1 | -0.0334726 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0322068 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0316234 |
| EZR | ezrin | -0.0314014 |
| MT2A | metallothionein 2A | -0.0309498 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0296546 |
| S100P | S100 calcium binding protein P | -0.029189 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0285684 |
| RBM39 | RNA binding motif protein 39 | -0.028048 |
| RPS8 | ribosomal protein S8 | -0.0279914 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0276611 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0273523 |
| TMSB10 | thymosin beta 10 | -0.0267143 |
| CTBP2 | C-terminal binding protein 2 | -0.0265041 |
| EFNB2 | ephrin-B2 | -0.0263491 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0256987 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0256706 |
| SETD5 | SET domain containing 5 | -0.0247545 |
| RPL35A | ribosomal protein L35a | -0.0246887 |
| TNS4 | tensin 4 | -0.0244974 |
| RPL37A | ribosomal protein L37a | -0.0244422 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0243827 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0236925 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0236207 |
| MORF4L2 | mortality factor 4 like 2 | -0.0233803 |
| FOSL1 | FOS-like antigen 1 | -0.0229528 |
| CALR | calreticulin | -0.0229079 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.022273 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0219011 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.0214734 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.021427 |
| SQSTM1 | sequestosome 1 | -0.0213544 |
| WASF2 | WAS protein family, member 2 | -0.0213153 |
| TMEM263 | transmembrane protein 263 | -0.0210829 |
| RPL27A | ribosomal protein L27a | -0.0209484 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0203625 |
| FLNB | filamin B, beta | -0.0200062 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0191419 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0186709 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0186575 |
| SEC24A | SEC24 family member A | -0.0185448 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0184362 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0182246 |
| ACAP2 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 | -0.0182179 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0176469 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0175463 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0175389 |
| GOLGA4 | golgin A4 | -0.0174925 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0174439 |
| ESRP1 | epithelial splicing regulatory protein 1 | -0.0173227 |
| RPS27A | ribosomal protein S27a | -0.0172815 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0171639 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0171217 |
| GTF2B | general transcription factor IIB | -0.017006 |
| RPS25 | ribosomal protein S25 | -0.0168106 |
| MPRIP | myosin phosphatase Rho interacting protein | -0.0166805 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0166269 |
| ARF4 | ADP-ribosylation factor 4 | -0.0162941 |
| CANX | calnexin | -0.0162605 |
| MUC20 | mucin 20, cell surface associated | -0.0161383 |
| IRF1 | interferon regulatory factor 1 | -0.0160785 |
| CALU | calumenin | -0.0158589 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0157997 |
| AHI1 | Abelson helper integration site 1 | -0.0157541 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0157269 |
| BCL2L1 | BCL2-like 1 | -0.0157041 |
| FDPS | farnesyl diphosphate synthase | -0.0156825 |
| RPL36 | ribosomal protein L36 | -0.0155708 |
| RPS6 | ribosomal protein S6 | -0.0155357 |
| GPBP1 | GC-rich promoter binding protein 1 | -0.0154709 |
| MXD1 | MAX dimerization protein 1 | -0.0153947 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | -0.0151599 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0149028 |
| ITPKC | inositol-trisphosphate 3-kinase C | -0.0147527 |
| RPLP1 | ribosomal protein, large, P1 | -0.0147123 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0146627 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0146532 |
| VEGFA | vascular endothelial growth factor A | -0.0145962 |
| FN1 | fibronectin 1 | -0.0145365 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0144349 |
| GOLM2 | golgi membrane protein 2 | -0.0143808 |
| SEC61B | Sec61 beta subunit | -0.0143463 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0141698 |
| TES | testin LIM domain protein | -0.0141101 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | -0.0140997 |
| RPS17 | ribosomal protein S17 | -0.0140295 |
| HM13 | histocompatibility (minor) 13 | -0.0139321 |
| TOM1L2 | target of myb1-like 2 (chicken) | -0.0139242 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0138383 |
| MAGT1 | magnesium transporter 1 | -0.0138358 |
| RPS19 | ribosomal protein S19 | -0.0138038 |
| MANF | mesencephalic astrocyte-derived neurotrophic factor | -0.013734 |
| CDH13 | cadherin 13 | -0.013629 |
| DIS3 | DIS3 exosome endoribonuclease and 3'-5' exoribonuclease | -0.0135592 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.013469 |
