| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sonidegib perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Sonidegib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.237149 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.184706 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.137636 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.13162 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.104109 |
| IER3 | immediate early response 3 | 0.0979699 |
| VIM | vimentin | 0.0977618 |
| LDHA | lactate dehydrogenase A | 0.0964039 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0849032 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0827014 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0822857 |
| CADM1 | cell adhesion molecule 1 | 0.0730926 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0678567 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0655814 |
| CALR | calreticulin | 0.059262 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0583723 |
| ARRDC3 | arrestin domain containing 3 | 0.0565994 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.055742 |
| CD44 | CD44 molecule (Indian blood group) | 0.0552609 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0546815 |
| LOX | lysyl oxidase | 0.0535992 |
| ENO1 | enolase 1, (alpha) | 0.0530177 |
| TMSB10 | thymosin beta 10 | 0.0523111 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0522666 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0508746 |
| VCAN | versican | 0.0501986 |
| INHBA | inhibin, beta A | 0.0483663 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0475175 |
| ATP13A3 | ATPase type 13A3 | 0.0473548 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0472611 |
| COL1A2 | collagen, type I, alpha 2 | 0.0471676 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.0471502 |
| PGK1 | phosphoglycerate kinase 1 | 0.0458844 |
| CALU | calumenin | 0.044021 |
| YBX1 | Y box binding protein 1 | 0.0409957 |
| STC1 | stanniocalcin 1 | 0.0401052 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0389052 |
| ANXA2 | annexin A2 | 0.0386933 |
| PTK2 | protein tyrosine kinase 2 | 0.0373694 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | 0.0368553 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0364893 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0361911 |
| TPM4 | tropomyosin 4 | 0.0347215 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0346511 |
| IRF1 | interferon regulatory factor 1 | 0.0337372 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0335602 |
| RUNX1 | runt-related transcription factor 1 | 0.0332391 |
| PFN1 | profilin 1 | 0.0331189 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0328119 |
| MAP1B | microtubule-associated protein 1B | 0.0323263 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0320184 |
| FAT1 | FAT atypical cadherin 1 | 0.0313576 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0312129 |
| PLEC | plectin | 0.0310569 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0309148 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0304953 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0298594 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.0294612 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0292451 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0290612 |
| PRELID2 | PRELI domain containing 2 | 0.0289449 |
| RARB | retinoic acid receptor, beta | 0.0285159 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0283766 |
| TFG | TRK-fused gene | 0.0283622 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0282609 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.02683 |
| RPL8 | ribosomal protein L8 | 0.0267415 |
| RPL32 | ribosomal protein L32 | 0.0267149 |
| ANGPTL4 | angiopoietin-like 4 | 0.0266248 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0264569 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0259982 |
| S100A10 | S100 calcium binding protein A10 | 0.025714 |
| ZNF292 | zinc finger protein 292 | 0.0253598 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0253083 |
| FAM162A | family with sequence similarity 162, member A | 0.0250694 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0249235 |
| MYO10 | myosin X | 0.0240971 |
| RPS5 | ribosomal protein S5 | 0.0240242 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0239146 |
| PKM | pyruvate kinase, muscle | 0.0234755 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0233998 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0231223 |
| ZNF148 | zinc finger protein 148 | 0.0229167 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0226684 |
| S100A9 | S100 calcium binding protein A9 | 0.0226163 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0226089 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0222745 |
| RHOA | ras homolog family member A | 0.0222532 |
| CCND1 | cyclin D1 | 0.0221702 |
| TUBB | tubulin, beta class I | 0.0219966 |
| SMAD3 | SMAD family member 3 | 0.0219311 |
| KLF6 | Kruppel-like factor 6 | 0.0216373 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0213831 |
| IL6 | interleukin 6 | 0.0213165 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0209913 |
| RPLP0 | ribosomal protein, large, P0 | 0.0209365 |
| SEPTIN9 | septin 9 | 0.0208402 |
| RPL3 | ribosomal protein L3 | 0.0208032 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0206898 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.020553 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0747246 |
| CDH13 | cadherin 13 | -0.064088 |
| NDRG1 | N-myc downstream regulated 1 | -0.0602048 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0523597 |
| SQSTM1 | sequestosome 1 | -0.0514119 |
| MT2A | metallothionein 2A | -0.0470935 |
| PTMA | prothymosin, alpha | -0.0440293 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0399934 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0379247 |
| ACTG1 | actin gamma 1 | -0.0342569 |
| HMGA2 | high mobility group AT-hook 2 | -0.0295138 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0288033 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0260805 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.025465 |
| COG5 | component of oligomeric golgi complex 5 | -0.0253651 |
| VEGFA | vascular endothelial growth factor A | -0.0244679 |
| RPS6 | ribosomal protein S6 | -0.0234717 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0230796 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0229928 |
| TGFB1 | transforming growth factor, beta 1 | -0.0228951 |
| RPS27A | ribosomal protein S27a | -0.0204979 |
| INTS6 | integrator complex subunit 6 | -0.0200415 |
| RPL9 | ribosomal protein L9 | -0.0200098 |
| HLA-B | major histocompatibility complex, class I, B | -0.0198153 |
| HMOX1 | heme oxygenase 1 | -0.0191834 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0188835 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0173787 |
| COL1A1 | collagen, type I, alpha 1 | -0.0173718 |
| H3-3B | H3.3 histone B | -0.0172484 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0171684 |
| FTL | ferritin, light polypeptide | -0.0170263 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0168349 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0168092 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.016707 |
| RPS2 | ribosomal protein S2 | -0.0166658 |
| CDK13 | cyclin-dependent kinase 13 | -0.0165317 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0164693 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0162868 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0162692 |
| RPL37 | ribosomal protein L37 | -0.0162657 |
| MED13 | mediator complex subunit 13 | -0.015993 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0159863 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0159698 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | -0.0157676 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0157053 |
| DST | dystonin | -0.0156918 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.01551 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0154989 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0154383 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0153693 |
| RPS29 | ribosomal protein S29 | -0.0153564 |
| GOLGA3 | golgin A3 | -0.0152241 |
| SRSF4 | serine/arginine-rich splicing factor 4 | -0.0151542 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0149956 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0149189 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0147371 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0146302 |
| COL5A1 | collagen, type V, alpha 1 | -0.0142455 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0140987 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0139068 |
| NABP1 | nucleic acid binding protein 1 | -0.0138662 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0137497 |
| STK40 | serine/threonine kinase 40 | -0.0136697 |
| AGRN | agrin | -0.0136426 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0135861 |
| RPL38 | ribosomal protein L38 | -0.0135675 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | -0.0135644 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0134373 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.013386 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0133709 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.013354 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0132987 |
| NECTIN3 | nectin cell adhesion molecule 3 | -0.0132586 |
| EXOC4 | exocyst complex component 4 | -0.0132457 |
| KAT6A | K(lysine) acetyltransferase 6A | -0.0131179 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0128781 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.012783 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0127808 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0127603 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0127532 |
| RPL31 | ribosomal protein L31 | -0.0127407 |
| LSM14A | LSM14A, SCD6 homolog A (S. cerevisiae) | -0.0127161 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0127065 |
| RTN3 | reticulon 3 | -0.0126314 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0125966 |
| MYO9A | myosin IXA | -0.0125723 |
| AHNAK | AHNAK nucleoprotein | -0.0125639 |
| TAPBP | TAP binding protein (tapasin) | -0.0123298 |
| RPS3 | ribosomal protein S3 | -0.0122679 |
| BBS9 | Bardet-Biedl syndrome 9 | -0.0121356 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0121162 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.012097 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0120879 |
| SET | SET nuclear proto-oncogene | -0.0120842 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0120501 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | -0.0119946 |
| ATM | ATM serine/threonine kinase | -0.0119723 |
| RAB10 | RAB10, member RAS oncogene family | -0.0119642 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0118219 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0117942 |
