| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sonidegib perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Sonidegib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.183501 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.183363 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.148506 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.111318 |
| APOB | apolipoprotein B | 0.109578 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.106833 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.089631 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0890402 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0855368 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0855265 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0823661 |
| AHSG | alpha-2-HS-glycoprotein | 0.0816553 |
| RPS12 | ribosomal protein S12 | 0.0733397 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0703574 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0696712 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.068117 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0666188 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0659617 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0657441 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0600245 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.059238 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0589587 |
| RPL3 | ribosomal protein L3 | 0.0587484 |
| AFDN | afadin, adherens junction formation factor | 0.0548854 |
| SVIL | supervillin | 0.0533817 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0533172 |
| TF | transferrin | 0.0525542 |
| DSPP | dentin sialophosphoprotein | 0.0519557 |
| C3 | complement component 3 | 0.051388 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.050137 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0498745 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0491702 |
| FAT1 | FAT atypical cadherin 1 | 0.048826 |
| RPL11 | ribosomal protein L11 | 0.0486564 |
| TNS1 | tensin 1 | 0.0483456 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0474875 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0472026 |
| CPE | carboxypeptidase E | 0.047102 |
| RPL37A | ribosomal protein L37a | 0.0461647 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.045983 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.0452689 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0449252 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0446968 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0445173 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0443225 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0439667 |
| FAM107B | family with sequence similarity 107, member B | 0.0438076 |
| CCNY | cyclin Y | 0.0421184 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0416334 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0412227 |
| VEGFA | vascular endothelial growth factor A | 0.0409943 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0397385 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0394861 |
| RPS3 | ribosomal protein S3 | 0.0394381 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0390899 |
| RPS17 | ribosomal protein S17 | 0.0390475 |
| KIF1B | kinesin family member 1B | 0.0375113 |
| SIK3 | SIK family kinase 3 | 0.0372493 |
| CFB | complement factor B | 0.0370344 |
| RPL7 | ribosomal protein L7 | 0.0365147 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0362114 |
| RACK1 | receptor for activated C kinase 1 | 0.0355911 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0354726 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | 0.0347637 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0345036 |
| B2M | beta-2-microglobulin | 0.0339245 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0331638 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | 0.0329986 |
| DSTN | destrin (actin depolymerizing factor) | 0.0328629 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0327963 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0326929 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0326747 |
| SDC4 | syndecan 4 | 0.0324935 |
| JAK1 | Janus kinase 1 | 0.032424 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0322498 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0320791 |
| SERTAD2 | SERTA domain containing 2 | 0.0320254 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0312088 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0310941 |
| SLC11A2 | solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 | 0.0306822 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0305742 |
| KYNU | kynureninase | 0.0303188 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | 0.0302826 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0296201 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0295216 |
| GDI2 | GDP dissociation inhibitor 2 | 0.0290519 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.028643 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0285158 |
| RPL19 | ribosomal protein L19 | 0.0285022 |
| INTS6 | integrator complex subunit 6 | 0.0283147 |
| SDC2 | syndecan 2 | 0.0282735 |
| APOA1 | apolipoprotein A-I | 0.0282257 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0279104 |
| HSPA1B | heat shock 70kDa protein 1B | 0.0279005 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0278056 |
| FLNB | filamin B, beta | 0.0277721 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0275104 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0269204 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0266838 |
| PCGF5 | polycomb group ring finger 5 | 0.0266404 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.234788 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.196815 |
| EHBP1 | EH domain binding protein 1 | -0.136054 |
| FRMD5 | FERM domain containing 5 | -0.0868648 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0682975 |
| APOA2 | apolipoprotein A-II | -0.0640954 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0630394 |
| HMGA1 | high mobility group AT-hook 1 | -0.0622791 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.060622 |
| GPC6 | glypican 6 | -0.0603228 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0590398 |
| H1-0 | H1.0 linker histone | -0.0546774 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0539666 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0483293 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0448341 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0429185 |
| RIGI | RNA sensor RIG-I | -0.0409946 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0405087 |
| KIAA1217 | KIAA1217 | -0.0398082 |
| DST | dystonin | -0.0393404 |
| FERMT1 | fermitin family member 1 | -0.0387255 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0384911 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0382472 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0375072 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0373326 |
| VIM | vimentin | -0.0371031 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0367676 |
| TMSB10 | thymosin beta 10 | -0.0343535 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0320105 |
| RUNX1 | runt-related transcription factor 1 | -0.0315645 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0314584 |
| VCL | vinculin | -0.0312948 |
| RPLP1 | ribosomal protein, large, P1 | -0.0302738 |
| EGR1 | early growth response 1 | -0.0300162 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0297738 |
| CP | ceruloplasmin (ferroxidase) | -0.0295491 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0292336 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -0.028539 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0280361 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0280346 |
| STK39 | serine threonine kinase 39 | -0.0279673 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.02767 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.0276387 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | -0.027529 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.027524 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0274628 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -0.0272051 |
| RPL35A | ribosomal protein L35a | -0.0269139 |
| PTCHD4 | patched domain containing 4 | -0.0267085 |
| PERP | PERP, TP53 apoptosis effector | -0.0263305 |
| CDK6 | cyclin-dependent kinase 6 | -0.0260349 |
| TPM4 | tropomyosin 4 | -0.0257099 |
| BPTF | bromodomain PHD finger transcription factor | -0.0257097 |
| ASPH | aspartate beta-hydroxylase | -0.0244051 |
| HMGA2 | high mobility group AT-hook 2 | -0.024366 |
| NHSL1 | NHS-like 1 | -0.024027 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0239839 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0239056 |
| RNF213 | ring finger protein 213 | -0.0237531 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0233143 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0230876 |
| MX2 | MX dynamin-like GTPase 2 | -0.0229147 |
| LAMA4 | laminin, alpha 4 | -0.0226049 |
| FN1 | fibronectin 1 | -0.0225632 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.022261 |
| NF1 | neurofibromin 1 | -0.0222551 |
| CHD6 | chromodomain helicase DNA binding protein 6 | -0.0220411 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0219972 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0215101 |
| GK | glycerol kinase | -0.0215092 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0214725 |
| GDF15 | growth differentiation factor 15 | -0.0210984 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0208652 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0208152 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.02078 |
| TMEM123 | transmembrane protein 123 | -0.0203843 |
| TMCC1 | transmembrane and coiled-coil domain family 1 | -0.0203302 |
| RHOB | ras homolog family member B | -0.0202977 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0202822 |
| FAM135A | family with sequence similarity 135, member A | -0.0200063 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0199711 |
| IL13RA1 | interleukin 13 receptor, alpha 1 | -0.0198505 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0196686 |
| RAI14 | retinoic acid induced 14 | -0.0196286 |
| UTRN | utrophin | -0.0194375 |
| MAP1B | microtubule-associated protein 1B | -0.019395 |
| ETV6 | ets variant 6 | -0.0188487 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | -0.0187651 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | -0.0185812 |
| METTL9 | methyltransferase like 9 | -0.0185477 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.018336 |
| ANXA7 | annexin A7 | -0.0183274 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0182887 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0180563 |
| DNAH5 | dynein, axonemal, heavy chain 5 | -0.0180102 |
| GLIS3 | GLIS family zinc finger 3 | -0.0179905 |
| RAD51B | RAD51 paralog B | -0.0179865 |
| ATXN1 | ataxin 1 | -0.0177142 |
| ANXA2 | annexin A2 | -0.0177093 |
| DNAH17 | dynein, axonemal, heavy chain 17 | -0.017669 |
