Sonidegib_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sonidegib perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sonidegib_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.173814
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.10255
TIMP3 TIMP metallopeptidase inhibitor 3 0.100406
MYH9 myosin, heavy chain 9, non-muscle 0.0842728
TRIO trio Rho guanine nucleotide exchange factor 0.0841238
CD44 CD44 molecule (Indian blood group) 0.0817503
PLEC plectin 0.0793264
LMO7 LIM domain 7 0.0790441
MTSS1 metastasis suppressor 1 0.07742
ENO1 enolase 1, (alpha) 0.076788
LOC112694756 uncharaterized LOC112694756 0.0757392
S100A10 S100 calcium binding protein A10 0.0742049
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0738784
FLNB filamin B, beta 0.0729918
LDHA lactate dehydrogenase A 0.0717586
B2M beta-2-microglobulin 0.0715426
TMSB4X thymosin beta 4, X-linked 0.0699742
MSN moesin 0.0673302
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0630712
UBC ubiquitin C 0.0611781
PGK1 phosphoglycerate kinase 1 0.0596695
SAMD9 sterile alpha motif domain containing 9 0.059188
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0589619
FLNA filamin A, alpha 0.0544492
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0532903
IFITM1 interferon induced transmembrane protein 1 0.0520195
MEF2A myocyte enhancer factor 2A 0.0504058
IFI6 interferon, alpha-inducible protein 6 0.0496596
KRT17 keratin 17, type I 0.0496469
RPL5 ribosomal protein L5 0.0495815
EZR ezrin 0.0495288
NCOR2 nuclear receptor corepressor 2 0.0489703
LMNA lamin A/C 0.0484814
MYOF myoferlin 0.0481541
DOK5 docking protein 5 0.0476575
CLU clusterin 0.0476177
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0470244
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0465085
ESYT2 extended synaptotagmin-like protein 2 0.0464304
TGM2 transglutaminase 2 0.0461374
RPL37 ribosomal protein L37 0.0456597
IFITM3 interferon induced transmembrane protein 3 0.0451593
SRRM2 serine/arginine repetitive matrix 2 0.0448298
FAM107B family with sequence similarity 107, member B 0.0436499
ITGA6 integrin, alpha 6 0.0434353
MBNL2 muscleblind-like splicing regulator 2 0.0433252
MACF1 microtubule-actin crosslinking factor 1 0.0432023
NDRG1 N-myc downstream regulated 1 0.0431184
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0422371
KTN1 kinectin 1 (kinesin receptor) 0.0420619
PKM pyruvate kinase, muscle 0.0418538
CALR calreticulin 0.0413375
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0410415
EXT1 exostosin glycosyltransferase 1 0.0409317
DPYD dihydropyrimidine dehydrogenase 0.0402729
OSMR oncostatin M receptor 0.0402024
PSD3 pleckstrin and Sec7 domain containing 3 0.0400002
RPS6 ribosomal protein S6 0.039336
RAI14 retinoic acid induced 14 0.0388339
PTK2 protein tyrosine kinase 2 0.0388034
FNDC3B fibronectin type III domain containing 3B 0.038642
RPS3 ribosomal protein S3 0.0381374
RPL8 ribosomal protein L8 0.0380196
AHNAK AHNAK nucleoprotein 0.0379809
PRELID2 PRELI domain containing 2 0.0378185
CELF1 CUGBP, Elav-like family member 1 0.0375801
CAV1 caveolin 1, caveolae protein, 22kDa 0.0375704
MYO10 myosin X 0.0370942
FNIP1 folliculin interacting protein 1 0.0362016
RND3 Rho family GTPase 3 0.0358295
NRIP1 nuclear receptor interacting protein 1 0.0357648
KRT6A keratin 6A, type II 0.0353348
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0351497
ACTN4 actinin, alpha 4 0.0347507
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0345477
UTRN utrophin 0.0344417
RPL21 ribosomal protein L21 0.0341045
RPLP2 ribosomal protein, large, P2 0.0335622
KMT2A lysine (K)-specific methyltransferase 2A 0.0331022
KLF5 Kruppel-like factor 5 (intestinal) 0.0330492
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0329925
TXNIP thioredoxin interacting protein 0.0326931
SET SET nuclear proto-oncogene 0.0324093
PCDH1 protocadherin 1 0.0320594
GNAS GNAS complex locus 0.0319564
KMT2E lysine (K)-specific methyltransferase 2E 0.0311782
SULF1 sulfatase 1 0.0308495
POTEF POTE ankyrin domain family, member F 0.0308016
DSTN destrin (actin depolymerizing factor) 0.0303548
EHF ets homologous factor 0.0303455
KRT14 keratin 14, type I 0.0300521
PYGL phosphorylase, glycogen, liver 0.0298062
SPINK5 serine peptidase inhibitor, Kazal type 5 0.0297462
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0295515
TPM3 tropomyosin 3 0.0290693
LAMA5 laminin, alpha 5 0.0290466
AKAP13 A kinase (PRKA) anchor protein 13 0.0287882
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0287319
MT2A metallothionein 2A 0.0286407
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0285021

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.04128
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.032969
SPAG9 sperm associated antigen 9 -0.0328498
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0327526
NT5C2 5'-nucleotidase, cytosolic II -0.0316362
RIGI RNA sensor RIG-I -0.0304984
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0303488
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0279449
INTS6 integrator complex subunit 6 -0.0278881
FSCN1 fascin actin-bundling protein 1 -0.0264145
CCL5 chemokine (C-C motif) ligand 5 -0.0244919
STC1 stanniocalcin 1 -0.0242464
MARCHF6 membrane associated ring-CH-type finger 6 -0.0222269
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0214357
SLMAP sarcolemma associated protein -0.0213448
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0206585
RAP1B RAP1B, member of RAS oncogene family -0.0194978
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0194035
EGFR epidermal growth factor receptor -0.0185535
OGA O-GlcNAcase -0.0175385
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.0174915
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0173213
LUZP1 leucine zipper protein 1 -0.0173098
ALCAM activated leukocyte cell adhesion molecule -0.0166266
RAB7A RAB7A, member RAS oncogene family -0.0162731
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0161353
CARS1 cysteinyl-tRNA synthetase 1 -0.0160923
TPT1 tumor protein, translationally-controlled 1 -0.0160691
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 -0.0159247
WNT2B wingless-type MMTV integration site family, member 2B -0.0158862
ARF1 ADP-ribosylation factor 1 -0.0158283
EGR1 early growth response 1 -0.0156727
IRAK2 interleukin-1 receptor-associated kinase 2 -0.0154042
GARS1 glycyl-tRNA synthetase 1 -0.0153757
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0152869
HM13 histocompatibility (minor) 13 -0.0152532
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0152296
ARF4 ADP-ribosylation factor 4 -0.0151861
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.014942
QKI QKI, KH domain containing, RNA binding -0.0147294
VIM vimentin -0.0147002
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0144342
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.0143699
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0143379
UVRAG UV radiation resistance associated -0.0142851
RAB1A RAB1A, member RAS oncogene family -0.0139971
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) -0.0138945
ANKRD11 ankyrin repeat domain 11 -0.0138889
LIFR leukemia inhibitory factor receptor alpha -0.0138533
ZFAND3 zinc finger, AN1-type domain 3 -0.0138055
YME1L1 YME1-like 1 ATPase -0.0137461
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0133733
ZMIZ1 zinc finger, MIZ-type containing 1 -0.0133234
TJP1 tight junction protein 1 -0.0132441
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0132113
CSNK1E casein kinase 1, epsilon -0.0131498
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.0131281
NR2C2 nuclear receptor subfamily 2, group C, member 2 -0.0131058
PITPNB phosphatidylinositol transfer protein, beta -0.0130274
DENND2C DENN/MADD domain containing 2C -0.0129718
WWTR1 WW domain containing transcription regulator 1 -0.0129625
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0129109
AFG2A AFG2 AAA ATPase homolog A -0.0128524
UBE4A ubiquitination factor E4A -0.012488
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.012422
SAR1A secretion associated, Ras related GTPase 1A -0.0124103
RC3H1 ring finger and CCCH-type domains 1 -0.0123388
SOD2 superoxide dismutase 2, mitochondrial -0.0123364
C4BPB complement component 4 binding protein, beta -0.0123134
GM2A GM2 ganglioside activator -0.0122973
RAB10 RAB10, member RAS oncogene family -0.0122695
SPRY4 sprouty homolog 4 (Drosophila) -0.0122086
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.0120409
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0118757
MARF1 meiosis regulator and mRNA stability factor 1 -0.0118703
WSB1 WD repeat and SOCS box containing 1 -0.0118466
IKBIP IKBKB interacting protein -0.0118349
FOXK2 forkhead box K2 -0.0116756
RNF149 ring finger protein 149 -0.0116567
MPRIP myosin phosphatase Rho interacting protein -0.0116277
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0114924
TBCK TBC1 domain containing kinase -0.0113919
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0113401
CCDC47 coiled-coil domain containing 47 -0.0112578
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0112016
HMGB1 high mobility group box 1 -0.0111514
POU2F1 POU class 2 homeobox 1 -0.0111221
AK1 adenylate kinase 1 -0.0110485
CLTB clathrin, light chain B -0.0110413
ZFAND6 zinc finger, AN1-type domain 6 -0.0109883
INPP5F inositol polyphosphate-5-phosphatase F -0.0109267
NCOA7 nuclear receptor coactivator 7 -0.0108242
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0108157
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 -0.010759
BMERB1 bMERB domain containing 1 -0.0107185
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0106233
FBXO11 F-box protein 11 -0.0105734
NRCAM neuronal cell adhesion molecule -0.0104477
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0104082
SLC45A4 solute carrier family 45, member 4 -0.0104057