Sonidegib_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sonidegib perturbation in KATO III cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Sonidegib_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FGFR2 fibroblast growth factor receptor 2 0.398471
DSPP dentin sialophosphoprotein 0.0968739
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0782828
MYH9 myosin, heavy chain 9, non-muscle 0.0781809
EZR ezrin 0.0721041
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0626578
LOC112694756 uncharaterized LOC112694756 0.0597021
SPTBN1 spectrin, beta, non-erythrocytic 1 0.052789
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.052018
MBNL2 muscleblind-like splicing regulator 2 0.0516933
MACC1 metastasis associated in colon cancer 1 0.0515769
RPS3 ribosomal protein S3 0.0492878
KLF5 Kruppel-like factor 5 (intestinal) 0.0477551
LOC102724023 ES1 protein homolog, mitochondrial 0.0475144
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.046085
PLEC plectin 0.0397543
MYOF myoferlin 0.0393089
AHNAK AHNAK nucleoprotein 0.0364071
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0358874
EXT1 exostosin glycosyltransferase 1 0.0355908
AKAP9 A kinase (PRKA) anchor protein 9 0.0351431
MGAM2 maltase-glucoamylase 2 (putative) 0.0346218
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0345712
RPL19 ribosomal protein L19 0.032956
PRELID2 PRELI domain containing 2 0.0306353
TMC5 transmembrane channel-like 5 0.0305697
DSCAM Down syndrome cell adhesion molecule 0.0304634
ZNF292 zinc finger protein 292 0.0296505
DSTN destrin (actin depolymerizing factor) 0.0290054
PTPRK protein tyrosine phosphatase, receptor type, K 0.0287965
CLMN calmin (calponin-like, transmembrane) 0.0287679
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0282047
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0279573
TPI1 triosephosphate isomerase 1 0.0277538
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0274102
TM4SF1 transmembrane 4 L six family member 1 0.0272182
EEF2 eukaryotic translation elongation factor 2 0.026885
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0268227
TMEM45B transmembrane protein 45B 0.0266786
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.02667
ADGRF1 adhesion G protein-coupled receptor F1 0.0266005
KDM3A lysine (K)-specific demethylase 3A 0.0265363
APLP2 amyloid beta (A4) precursor-like protein 2 0.0263444
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0259606
EPCAM epithelial cell adhesion molecule 0.0258918
LDHA lactate dehydrogenase A 0.0257425
PDIA4 protein disulfide isomerase family A, member 4 0.0256342
HDLBP high density lipoprotein binding protein 0.0248674
TMF1 TATA element modulatory factor 1 0.0248074
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.0246577
UBC ubiquitin C 0.0245067
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0235083
RPS12 ribosomal protein S12 0.023139
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0227598
CDK19 cyclin-dependent kinase 19 0.022707
RPL18 ribosomal protein L18 0.0224605
FNIP1 folliculin interacting protein 1 0.0223363
COG6 component of oligomeric golgi complex 6 0.022264
KIDINS220 kinase D-interacting substrate, 220kDa 0.022217
H1-0 H1.0 linker histone 0.0220812
TMSB4X thymosin beta 4, X-linked 0.0220793
SSR1 signal sequence receptor, alpha 0.021935
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.0218227
PGK1 phosphoglycerate kinase 1 0.0217734
KIF16B kinesin family member 16B 0.0217662
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0213639
TRIM2 tripartite motif containing 2 0.0212937
RPL3 ribosomal protein L3 0.020974
FTL ferritin, light polypeptide 0.020851
EIF4H eukaryotic translation initiation factor 4H 0.0208056
RACK1 receptor for activated C kinase 1 0.0206759
FAM13A family with sequence similarity 13, member A 0.0204812
ANXA11 annexin A11 0.0204737
CNKSR3 CNKSR family member 3 0.0203315
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0202536
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.020181
GOLGB1 golgin B1 0.0200467
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0200262
PNRC1 proline-rich nuclear receptor coactivator 1 0.020003
H1-10 H1.10 linker histone 0.0199451
RRBP1 ribosome binding protein 1 0.0198337
RNF213 ring finger protein 213 0.019764
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0196382
HSPA8 heat shock 70kDa protein 8 0.0191313
PHF3 PHD finger protein 3 0.019096
HKDC1 hexokinase domain containing 1 0.0190559
TXNIP thioredoxin interacting protein 0.0188666
RPS27A ribosomal protein S27a 0.0186861
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0186433
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0185774
EEF1G eukaryotic translation elongation factor 1 gamma 0.0185616
ALPK1 alpha-kinase 1 0.0185612
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0185548
COPG1 coatomer protein complex, subunit gamma 1 0.018531
TMEM123 transmembrane protein 123 0.0183879
AGR3 anterior gradient 3 0.0183101
RPL13A ribosomal protein L13a 0.0183074
SEPTIN9 septin 9 0.0182995
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0181706
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0181695

decreased expression

Symbol Name Standardized Value
GMDS GDP-mannose 4,6-dehydratase -0.193263
NPSR1 neuropeptide S receptor 1 -0.17169
CEMIP cell migration inducing protein, hyaluronan binding -0.145837
TMSB10 thymosin beta 10 -0.12333
MAML2 mastermind-like 2 (Drosophila) -0.0972526
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0830297
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0642639
PTMA prothymosin, alpha -0.0623455
FLNB filamin B, beta -0.0615188
EHBP1 EH domain binding protein 1 -0.0613035
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0603633
RPL35A ribosomal protein L35a -0.0538784
BCL2L1 BCL2-like 1 -0.0529275
S100A6 S100 calcium binding protein A6 -0.0518922
TNIK TRAF2 and NCK interacting kinase -0.0478373
PRKCA protein kinase C, alpha -0.0455541
FAT1 FAT atypical cadherin 1 -0.0448324
ITGA6 integrin, alpha 6 -0.0439736
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0414729
CUX1 cut-like homeobox 1 -0.0395729
ACACA acetyl-CoA carboxylase alpha -0.0381305
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0381222
ASPH aspartate beta-hydroxylase -0.037423
PDIA3 protein disulfide isomerase family A, member 3 -0.0371533
WWC1 WW and C2 domain containing 1 -0.0370824
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0363107
CD46 CD46 molecule, complement regulatory protein -0.0359725
INSIG1 insulin induced gene 1 -0.0335277
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0332246
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0324102
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0305684
PTPRG protein tyrosine phosphatase, receptor type, G -0.0296836
UBASH3B ubiquitin associated and SH3 domain containing B -0.0291563
POTEF POTE ankyrin domain family, member F -0.0288704
DLG1 discs, large homolog 1 (Drosophila) -0.0286769
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0285285
SULF2 sulfatase 2 -0.0277659
HMGB1 high mobility group box 1 -0.027683
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0275745
GPX2 glutathione peroxidase 2 -0.0271345
TRPS1 trichorhinophalangeal syndrome I -0.0271275
HMGA1 high mobility group AT-hook 1 -0.0270901
FAF1 Fas (TNFRSF6) associated factor 1 -0.0268713
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -0.0268388
NHSL1 NHS-like 1 -0.0266447
SRPK2 SRSF protein kinase 2 -0.0265466
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0263007
NF1 neurofibromin 1 -0.0259257
CCND1 cyclin D1 -0.0259047
ANO1 anoctamin 1, calcium activated chloride channel -0.0254543
MSI2 musashi RNA-binding protein 2 -0.0250672
TMCC1 transmembrane and coiled-coil domain family 1 -0.0250629
KPNB1 karyopherin (importin) beta 1 -0.0245732
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0245235
DENND1A DENN/MADD domain containing 1A -0.0242478
RPLP1 ribosomal protein, large, P1 -0.0241799
TFRC transferrin receptor -0.0237812
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0237766
YAP1 Yes-associated protein 1 -0.0237243
TNS4 tensin 4 -0.0236757
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0236392
FMNL2 formin-like 2 -0.0235774
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.022856
DIAPH2 diaphanous-related formin 2 -0.0224101
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.0221446
PHF14 PHD finger protein 14 -0.0219737
DYNLT3 dynein, light chain, Tctex-type 3 -0.0219619
BAZ1B bromodomain adjacent to zinc finger domain, 1B -0.0219469
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0218553
CAMKMT calmodulin-lysine N-methyltransferase -0.0217652
SKAP1 src kinase associated phosphoprotein 1 -0.0217062
S100A9 S100 calcium binding protein A9 -0.0216199
MYO1E myosin IE -0.0213607
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.0212695
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0210706
AUTS2 autism susceptibility candidate 2 -0.0210005
TPM4 tropomyosin 4 -0.0209586
WARS1 tryptophanyl-tRNA synthetase 1 -0.0209459
PKP4 plakophilin 4 -0.0208861
SMC4 structural maintenance of chromosomes 4 -0.0208731
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) -0.0207001
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0206916
RASAL2 RAS protein activator like 2 -0.0206811
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0205501
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0204117
CBX3 chromobox homolog 3 -0.0203553
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0203446
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0202227
ZFP36L2 ZFP36 ring finger protein-like 2 -0.0200683
EGR1 early growth response 1 -0.0199935
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0198887
KLK10 kallikrein-related peptidase 10 -0.0196454
DLC1 DLC1 Rho GTPase activating protein -0.0192063
RRM2 ribonucleotide reductase M2 -0.019168
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0191604
UBE3C ubiquitin protein ligase E3C -0.0191225
RAB7A RAB7A, member RAS oncogene family -0.0191085
MED13 mediator complex subunit 13 -0.0187922
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0187616
TCF12 transcription factor 12 -0.0186741