| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sonidegib perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Sonidegib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0917268 |
| DSPP | dentin sialophosphoprotein | 0.0909496 |
| LDHA | lactate dehydrogenase A | 0.0851038 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0738453 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0717045 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0686183 |
| PRELID2 | PRELI domain containing 2 | 0.0663009 |
| FAT1 | FAT atypical cadherin 1 | 0.0659178 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0653756 |
| RPL3 | ribosomal protein L3 | 0.0635446 |
| PIGR | polymeric immunoglobulin receptor | 0.0582129 |
| FAM13A | family with sequence similarity 13, member A | 0.0576172 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0531459 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0529086 |
| KRT18 | keratin 18, type I | 0.0527534 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0501898 |
| EREG | epiregulin | 0.0496267 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0485859 |
| H1-4 | H1.4 linker histone, cluster member | 0.0452755 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0450358 |
| EZR | ezrin | 0.0423962 |
| RPS12 | ribosomal protein S12 | 0.0412464 |
| RPS3 | ribosomal protein S3 | 0.0397908 |
| PLEC | plectin | 0.0372446 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0371078 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0354031 |
| PKM | pyruvate kinase, muscle | 0.0349876 |
| TPM3 | tropomyosin 3 | 0.0341353 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0340834 |
| CDH17 | cadherin 17, LI cadherin (liver-intestine) | 0.0339585 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0334418 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0330153 |
| AHNAK | AHNAK nucleoprotein | 0.0327801 |
| EHF | ets homologous factor | 0.0306218 |
| EPCAM | epithelial cell adhesion molecule | 0.0305504 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0291955 |
| RHOA | ras homolog family member A | 0.0286386 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0281912 |
| PDZD8 | PDZ domain containing 8 | 0.0281464 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.028074 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0278808 |
| TUBB4B | tubulin, beta 4B class IVb | 0.0278394 |
| ENO1 | enolase 1, (alpha) | 0.0274571 |
| CCNY | cyclin Y | 0.0271888 |
| CALR | calreticulin | 0.0269559 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.026456 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0256559 |
| CLTC | clathrin, heavy chain (Hc) | 0.0256164 |
| FLNB | filamin B, beta | 0.0254945 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.025147 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0249056 |
| KRT8 | keratin 8, type II | 0.0244981 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0243622 |
| RPS18 | ribosomal protein S18 | 0.0241713 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0239423 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0235653 |
| B2M | beta-2-microglobulin | 0.0234952 |
| PPIA | peptidylprolyl isomerase A (cyclophilin A) | 0.023337 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0231889 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.023152 |
| ATXN1 | ataxin 1 | 0.0229862 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0228496 |
| CDK19 | cyclin-dependent kinase 19 | 0.022757 |
| CCT7 | chaperonin containing TCP1, subunit 7 (eta) | 0.0223761 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.022313 |
| OGA | O-GlcNAcase | 0.0222224 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0221633 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0220463 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0218736 |
| MUC13 | mucin 13, cell surface associated | 0.0213128 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.020991 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0208358 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0206488 |
| MYO5B | myosin VB | 0.0205368 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0204505 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0203786 |
| PGK1 | phosphoglycerate kinase 1 | 0.0201125 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0198328 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0198234 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | 0.0193806 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0192349 |
| TPI1 | triosephosphate isomerase 1 | 0.018941 |
| ARFGEF3 | ARFGEF family member 3 | 0.0188555 |
| LMO7 | LIM domain 7 | 0.0187267 |
| GLCE | glucuronic acid epimerase | 0.0186604 |
| MYOF | myoferlin | 0.0185868 |
| SCFD1 | sec1 family domain containing 1 | 0.0184108 |
| SRSF1 | serine/arginine-rich splicing factor 1 | 0.0183853 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0182583 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0182211 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.0182116 |
| RACK1 | receptor for activated C kinase 1 | 0.0181853 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0180919 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0180267 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.0179759 |
| SUCO | SUN domain containing ossification factor | 0.0179037 |
| UBC | ubiquitin C | 0.0178744 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0178414 |
| EMP1 | epithelial membrane protein 1 | 0.0178116 |
| HDLBP | high density lipoprotein binding protein | 0.0177616 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.256139 |
| NPSR1 | neuropeptide S receptor 1 | -0.16028 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.148096 |
| PTMA | prothymosin, alpha | -0.127277 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | -0.123627 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.117865 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | -0.108804 |
| RPL35A | ribosomal protein L35a | -0.101115 |
| RPS6 | ribosomal protein S6 | -0.0969872 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0908239 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0866594 |
| GPHN | gephyrin | -0.0801891 |
| RPLP1 | ribosomal protein, large, P1 | -0.0750054 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0722353 |
| MYO1E | myosin IE | -0.0718984 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0628197 |
| RPL34 | ribosomal protein L34 | -0.0607689 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0578327 |
| ONECUT3 | one cut homeobox 3 | -0.0563589 |
| HMGA1 | high mobility group AT-hook 1 | -0.0561294 |
| S100A6 | S100 calcium binding protein A6 | -0.0553576 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0511492 |
| MT2A | metallothionein 2A | -0.0493039 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0492731 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0484395 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0475939 |
| S100P | S100 calcium binding protein P | -0.0469049 |
| RPS8 | ribosomal protein S8 | -0.0442203 |
| HMGB1 | high mobility group box 1 | -0.0433096 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | -0.0418831 |
| TFF3 | trefoil factor 3 (intestinal) | -0.0417242 |
| GDF15 | growth differentiation factor 15 | -0.0403988 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0400465 |
| RPS19 | ribosomal protein S19 | -0.0396362 |
| ATF4 | activating transcription factor 4 | -0.0378329 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.037113 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0368361 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.036759 |
| TFF1 | trefoil factor 1 | -0.0361919 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0352237 |
| KIF5B | kinesin family member 5B | -0.0344486 |
| RPS21 | ribosomal protein S21 | -0.0341952 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0322117 |
| GNAS | GNAS complex locus | -0.0314367 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.031251 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0312095 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.0303227 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0302812 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | -0.0302791 |
| MAP4 | microtubule-associated protein 4 | -0.0302243 |
| CCND1 | cyclin D1 | -0.0301496 |
| MGST1 | microsomal glutathione S-transferase 1 | -0.0300277 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | -0.0297275 |
| RPS25 | ribosomal protein S25 | -0.0296443 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0295424 |
| RPL27A | ribosomal protein L27a | -0.0294922 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0292546 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0288491 |
| SH3D19 | SH3 domain containing 19 | -0.0285069 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.0283312 |
| CUX1 | cut-like homeobox 1 | -0.0282341 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | -0.0281421 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0277571 |
| RPS27 | ribosomal protein S27 | -0.027738 |
| GTF2IRD1 | GTF2I repeat domain containing 1 | -0.0271431 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0269975 |
| FBXO11 | F-box protein 11 | -0.026993 |
| AGR2 | anterior gradient 2 | -0.0267637 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0261194 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0257983 |
| POTEF | POTE ankyrin domain family, member F | -0.0257081 |
| MUC2 | mucin 2, oligomeric mucus/gel-forming | -0.02562 |
| RPL23 | ribosomal protein L23 | -0.0254023 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0253088 |
| ERGIC1 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 | -0.0252659 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0246052 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0244048 |
| RPS14 | ribosomal protein S14 | -0.0241623 |
| CBX3 | chromobox homolog 3 | -0.0238049 |
| RPS29 | ribosomal protein S29 | -0.0236899 |
| FHIT | fragile histidine triad | -0.0234205 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0231214 |
| KLK10 | kallikrein-related peptidase 10 | -0.023107 |
| RPS16 | ribosomal protein S16 | -0.023086 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.0228706 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0227038 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0226067 |
| RPLP2 | ribosomal protein, large, P2 | -0.0225778 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0224051 |
| FOXO1 | forkhead box O1 | -0.0223488 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0216109 |
| MSI2 | musashi RNA-binding protein 2 | -0.0215502 |
| MT1E | metallothionein 1E | -0.0214359 |
| MECOM | MDS1 and EVI1 complex locus | -0.0213542 |
| EGR1 | early growth response 1 | -0.0208205 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0208195 |
| BSG | basigin (Ok blood group) | -0.0207882 |
| NOP58 | NOP58 ribonucleoprotein | -0.0207639 |
| RPL35 | ribosomal protein L35 | -0.0207309 |
| LSAMP | limbic system-associated membrane protein | -0.0206188 |
