| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sonidegib perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Sonidegib_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.152974 |
| DST | dystonin | 0.11842 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.095848 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.088117 |
| RPL3 | ribosomal protein L3 | 0.0611273 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0599636 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0598508 |
| RPS12 | ribosomal protein S12 | 0.0591543 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0587259 |
| RUNX1 | runt-related transcription factor 1 | 0.0583495 |
| SET | SET nuclear proto-oncogene | 0.0560974 |
| PKM | pyruvate kinase, muscle | 0.0553089 |
| EZR | ezrin | 0.0552004 |
| POTEF | POTE ankyrin domain family, member F | 0.0533949 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.051823 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0514413 |
| FNIP1 | folliculin interacting protein 1 | 0.0512794 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.050568 |
| YEATS2 | YEATS domain containing 2 | 0.0494816 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0494516 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0490071 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0489462 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0488081 |
| ADAR | adenosine deaminase, RNA-specific | 0.0487013 |
| ENO1 | enolase 1, (alpha) | 0.0461782 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0460747 |
| LDHA | lactate dehydrogenase A | 0.0460055 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0438371 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0437574 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0425407 |
| RPS3 | ribosomal protein S3 | 0.0424302 |
| AHNAK | AHNAK nucleoprotein | 0.0417774 |
| BRD2 | bromodomain containing 2 | 0.0417739 |
| PLEC | plectin | 0.0417262 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0417078 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0410267 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0408247 |
| PPIA | peptidylprolyl isomerase A (cyclophilin A) | 0.0407343 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0404153 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0394957 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0394463 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.039422 |
| XPO1 | exportin 1 | 0.0388366 |
| PCDH1 | protocadherin 1 | 0.038737 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0385409 |
| TAPBP | TAP binding protein (tapasin) | 0.0365392 |
| CALR | calreticulin | 0.036349 |
| DDX41 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 | 0.0362249 |
| PLK2 | polo-like kinase 2 | 0.0357539 |
| PCBP2 | poly(rC) binding protein 2 | 0.0355396 |
| TPM3 | tropomyosin 3 | 0.0354294 |
| RPS18 | ribosomal protein S18 | 0.0353603 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0352265 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0349194 |
| ZNF148 | zinc finger protein 148 | 0.0348555 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.034524 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0342414 |
| ARRDC3 | arrestin domain containing 3 | 0.0341688 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0332786 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0332488 |
| HDLBP | high density lipoprotein binding protein | 0.032797 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0326911 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0326854 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0326364 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0323346 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0323121 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.031658 |
| MSN | moesin | 0.0316389 |
| EXOC4 | exocyst complex component 4 | 0.0307306 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0305088 |
| HDAC9 | histone deacetylase 9 | 0.0305044 |
| TNS3 | tensin 3 | 0.0302479 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0301544 |
| CAPRIN2 | caprin family member 2 | 0.029956 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | 0.0298787 |
| SLK | STE20-like kinase | 0.0297431 |
| GTF2I | general transcription factor IIi | 0.0296498 |
| UBC | ubiquitin C | 0.0294643 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0292641 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0292633 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0292442 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0291574 |
| RPL37A | ribosomal protein L37a | 0.0290563 |
| RAD51B | RAD51 paralog B | 0.0289988 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0288441 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0287213 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0286478 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0285367 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.028249 |
| COL5A2 | collagen, type V, alpha 2 | 0.0282313 |
| UBE2E3 | ubiquitin-conjugating enzyme E2E 3 | 0.0281588 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0281405 |
| SMYD3 | SET and MYND domain containing 3 | 0.0280376 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.027639 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.027505 |
| CDK19 | cyclin-dependent kinase 19 | 0.0272732 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0270482 |
| MOK | MOK protein kinase | 0.02676 |
| RNF213 | ring finger protein 213 | 0.0263523 |
| HELZ | helicase with zinc finger | 0.0261642 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.284235 |
| TMSB10 | thymosin beta 10 | -0.213642 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.135102 |
| RPL35A | ribosomal protein L35a | -0.103123 |
| MT1X | metallothionein 1X | -0.087222 |
| VIM | vimentin | -0.0860639 |
| PTMA | prothymosin, alpha | -0.0701645 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0694659 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0607214 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0540528 |
| ACTG1 | actin gamma 1 | -0.0528553 |
| MT1E | metallothionein 1E | -0.0508525 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0488743 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0432297 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0430594 |
| RPLP1 | ribosomal protein, large, P1 | -0.040605 |
| ZNF217 | zinc finger protein 217 | -0.0377778 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0352349 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0351475 |
| TMEM41B | transmembrane protein 41B | -0.0350216 |
| RPL34 | ribosomal protein L34 | -0.0348868 |
| RPLP0 | ribosomal protein, large, P0 | -0.0338487 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0335105 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0334438 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0321512 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0318554 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0318013 |
| S100A6 | S100 calcium binding protein A6 | -0.0313503 |
| EGR1 | early growth response 1 | -0.0304083 |
| RPS24 | ribosomal protein S24 | -0.0297288 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | -0.0292754 |
| SRGN | serglycin | -0.0281098 |
| HMGB1 | high mobility group box 1 | -0.0279936 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0272058 |
| PDE10A | phosphodiesterase 10A | -0.0260716 |
| RIGI | RNA sensor RIG-I | -0.0257917 |
| EMP1 | epithelial membrane protein 1 | -0.0257248 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0256995 |
| HMGA1 | high mobility group AT-hook 1 | -0.0253598 |
| RPS19 | ribosomal protein S19 | -0.0244313 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0241394 |
| ERCC1 | excision repair cross-complementation group 1 | -0.0238719 |
| RPS28 | ribosomal protein S28 | -0.0238059 |
| TP63 | tumor protein p63 | -0.0237468 |
| FBXO11 | F-box protein 11 | -0.0236976 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0235172 |
| FERMT1 | fermitin family member 1 | -0.0227551 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0227212 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0225808 |
| NAV2 | neuron navigator 2 | -0.0220666 |
| RPS21 | ribosomal protein S21 | -0.0220302 |
| RPL12 | ribosomal protein L12 | -0.0219214 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0218432 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0214844 |
| IER3 | immediate early response 3 | -0.0213512 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0212034 |
| BMERB1 | bMERB domain containing 1 | -0.0210969 |
| GCLM | glutamate-cysteine ligase, modifier subunit | -0.0210193 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0208339 |
| PRDX1 | peroxiredoxin 1 | -0.0206368 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0205213 |
| RAP2B | RAP2B, member of RAS oncogene family | -0.0204932 |
| TMSB4X | thymosin beta 4, X-linked | -0.0204242 |
| EHBP1 | EH domain binding protein 1 | -0.0204161 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.0203816 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0202545 |
| NEK10 | NIMA-related kinase 10 | -0.0202197 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0202001 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0199384 |
| MYL12B | myosin, light chain 12B, regulatory | -0.019861 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0196502 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0194392 |
| S100A10 | S100 calcium binding protein A10 | -0.0191545 |
| UPP1 | uridine phosphorylase 1 | -0.0189728 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0186644 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0183969 |
| RPL9 | ribosomal protein L9 | -0.0182329 |
| KLF6 | Kruppel-like factor 6 | -0.0179786 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0178966 |
| RPL35 | ribosomal protein L35 | -0.0178607 |
| BCKDHB | branched chain keto acid dehydrogenase E1, beta polypeptide | -0.0177235 |
| SEC61G | Sec61 gamma subunit | -0.0177161 |
| PYGL | phosphorylase, glycogen, liver | -0.0176645 |
| DNTTIP1 | deoxynucleotidyltransferase, terminal, interacting protein 1 | -0.0172043 |
| RPL26 | ribosomal protein L26 | -0.0170858 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0170342 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0170277 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0169654 |
| PLSCR1 | phospholipid scramblase 1 | -0.0169637 |
| GNAS | GNAS complex locus | -0.0168215 |
| RRM2 | ribonucleotide reductase M2 | -0.0166905 |
| WFDC10B | WAP four-disulfide core domain 10B | -0.0166245 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.0165901 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0164897 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0163032 |
| S100A9 | S100 calcium binding protein A9 | -0.0162371 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0162039 |
| ZNF267 | zinc finger protein 267 | -0.0161009 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0159433 |
| RAI1 | retinoic acid induced 1 | -0.0158955 |
