| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sonidegib perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Sonidegib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.353555 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.314344 |
| LOC112694756 | uncharaterized LOC112694756 | 0.122566 |
| TXNRD1 | thioredoxin reductase 1 | 0.10363 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.102138 |
| MKI67 | marker of proliferation Ki-67 | 0.0913934 |
| FAM13A | family with sequence similarity 13, member A | 0.0750409 |
| ARRDC3 | arrestin domain containing 3 | 0.0654979 |
| SLTM | SAFB-like, transcription modulator | 0.0638734 |
| PLEC | plectin | 0.0635194 |
| UBC | ubiquitin C | 0.0590887 |
| NGLY1 | N-glycanase 1 | 0.0556506 |
| LDHA | lactate dehydrogenase A | 0.0550912 |
| CES1 | carboxylesterase 1 | 0.0522728 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0515694 |
| PCBP2 | poly(rC) binding protein 2 | 0.0508842 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.04621 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.043975 |
| RPS3 | ribosomal protein S3 | 0.0436612 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.043023 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0423223 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0416317 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0415995 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0413805 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0407339 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0406131 |
| RPL3 | ribosomal protein L3 | 0.0400075 |
| SPAG9 | sperm associated antigen 9 | 0.0396679 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0394717 |
| RUNX1 | runt-related transcription factor 1 | 0.0388687 |
| NDRG1 | N-myc downstream regulated 1 | 0.0385652 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0382419 |
| ZNF292 | zinc finger protein 292 | 0.0369583 |
| CSNK1E | casein kinase 1, epsilon | 0.0364271 |
| MSN | moesin | 0.0357772 |
| CDCP1 | CUB domain containing protein 1 | 0.0355953 |
| XRN2 | 5'-3' exoribonuclease 2 | 0.0351313 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0346598 |
| OGA | O-GlcNAcase | 0.0345195 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | 0.0344897 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0343654 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0337252 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0337169 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0324858 |
| TPD52 | tumor protein D52 | 0.0323008 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0318393 |
| ENO1 | enolase 1, (alpha) | 0.0315003 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.031229 |
| HDLBP | high density lipoprotein binding protein | 0.0307204 |
| MYO1B | myosin IB | 0.0303663 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0300643 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0297925 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0295958 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0293003 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0292325 |
| TOP1 | topoisomerase (DNA) I | 0.0289578 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0289182 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0287081 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0285865 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0284275 |
| CKAP2 | cytoskeleton associated protein 2 | 0.0283024 |
| YBX3 | Y box binding protein 3 | 0.0280264 |
| LAMB3 | laminin, beta 3 | 0.0279627 |
| PGK1 | phosphoglycerate kinase 1 | 0.0278943 |
| CTTN | cortactin | 0.0277722 |
| ANGPTL4 | angiopoietin-like 4 | 0.0276693 |
| OSMR | oncostatin M receptor | 0.0274681 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0274082 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0273512 |
| EP300 | E1A binding protein p300 | 0.0272476 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0272145 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0272119 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0271306 |
| SON | SON DNA binding protein | 0.0271116 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0271057 |
| H1-0 | H1.0 linker histone | 0.0266839 |
| MT2A | metallothionein 2A | 0.0264095 |
| KLC1 | kinesin light chain 1 | 0.0261135 |
| HELZ | helicase with zinc finger | 0.0261034 |
| USP34 | ubiquitin specific peptidase 34 | 0.0260875 |
| SQOR | sulfide quinone oxidoreductase | 0.0259779 |
| RTN4 | reticulon 4 | 0.0256403 |
| TMEM165 | transmembrane protein 165 | 0.0253835 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0249127 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.02477 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0246252 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0244515 |
| CUL3 | cullin 3 | 0.024341 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.0243249 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0240673 |
| TPI1 | triosephosphate isomerase 1 | 0.0236261 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0233877 |
| ITSN2 | intersectin 2 | 0.023135 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0231285 |
| ANO6 | anoctamin 6 | 0.0230583 |
| SMAD3 | SMAD family member 3 | 0.0230529 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0229515 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | 0.0226965 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | 0.022532 |
| ATP13A3 | ATPase type 13A3 | 0.0224653 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.109624 |
| TMSB10 | thymosin beta 10 | -0.106029 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0947439 |
| ASPH | aspartate beta-hydroxylase | -0.0806661 |
| PTMA | prothymosin, alpha | -0.0787851 |
| EGFR | epidermal growth factor receptor | -0.0715758 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0667744 |
| ACTG1 | actin gamma 1 | -0.0657368 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0643336 |
| EGR1 | early growth response 1 | -0.0590966 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0573432 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0533106 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0530925 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0523581 |
| RPL35A | ribosomal protein L35a | -0.0521338 |
| INTS6 | integrator complex subunit 6 | -0.0518294 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0504464 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0497183 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0460221 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0439189 |
| CUX1 | cut-like homeobox 1 | -0.0426541 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0424355 |
| TPM4 | tropomyosin 4 | -0.0377013 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0374855 |
| HMGA1 | high mobility group AT-hook 1 | -0.0369301 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0355011 |
| PATJ | PATJ crumbs cell polarity complex component | -0.032237 |
| PRKCA | protein kinase C, alpha | -0.0319701 |
| VCL | vinculin | -0.030685 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0304824 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0289107 |
| RPLP1 | ribosomal protein, large, P1 | -0.0287499 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0283474 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0282944 |
| GNAS | GNAS complex locus | -0.0282087 |
| SVIL | supervillin | -0.0278559 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0276963 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0275041 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0270828 |
| FBXO11 | F-box protein 11 | -0.0270389 |
| HLA-B | major histocompatibility complex, class I, B | -0.0269652 |
| EHBP1 | EH domain binding protein 1 | -0.026942 |
| HOMER1 | homer scaffolding protein 1 | -0.026569 |
| EFNA5 | ephrin-A5 | -0.0261126 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0256647 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0248851 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0247995 |
| MYO1E | myosin IE | -0.0246914 |
| CMIP | c-Maf inducing protein | -0.0244116 |
| RPL31 | ribosomal protein L31 | -0.023943 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0237995 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0236956 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.023628 |
| CST3 | cystatin C | -0.0233516 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0229426 |
| RPS29 | ribosomal protein S29 | -0.0220174 |
| SMIM14 | small integral membrane protein 14 | -0.0216477 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0215692 |
| SCEL | sciellin | -0.021497 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0214196 |
| LARP1B | La ribonucleoprotein domain family, member 1B | -0.0214128 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.021385 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | -0.0213127 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0211856 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0211173 |
| GOSR2 | golgi SNAP receptor complex member 2 | -0.0201966 |
| BPTF | bromodomain PHD finger transcription factor | -0.0200747 |
| PCED1B | PC-esterase domain containing 1B | -0.0200091 |
| SP100 | SP100 nuclear antigen | -0.0199805 |
| TNS3 | tensin 3 | -0.0198959 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0197952 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0194909 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0193784 |
| ZNF609 | zinc finger protein 609 | -0.0191515 |
| FUS | FUS RNA binding protein | -0.0191436 |
| EXOC6B | exocyst complex component 6B | -0.0191052 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | -0.0189541 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0189393 |
| RIN2 | Ras and Rab interactor 2 | -0.0188094 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0187948 |
| HM13 | histocompatibility (minor) 13 | -0.0187534 |
| RPS25 | ribosomal protein S25 | -0.0186745 |
| LRRC23 | leucine rich repeat containing 23 | -0.0186138 |
| RPL9 | ribosomal protein L9 | -0.0185796 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0185669 |
| GOLGB1 | golgin B1 | -0.0182681 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0182601 |
| CTBP2 | C-terminal binding protein 2 | -0.0182506 |
| SH3D19 | SH3 domain containing 19 | -0.0181291 |
| RPLP2 | ribosomal protein, large, P2 | -0.0179871 |
| RPL37A | ribosomal protein L37a | -0.0179469 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0179097 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | -0.0178316 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0177669 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0176972 |
| AEBP2 | AE binding protein 2 | -0.0176336 |
| KAT6B | K(lysine) acetyltransferase 6B | -0.0176183 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0174937 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0174706 |
| SUMF1 | sulfatase modifying factor 1 | -0.0174651 |
