| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sonidegib perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Sonidegib_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIO | trio Rho guanine nucleotide exchange factor | 0.131553 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.125314 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.107969 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.106934 |
| FAM13A | family with sequence similarity 13, member A | 0.101812 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0973437 |
| FAM20C | family with sequence similarity 20, member C | 0.0971203 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0906902 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0855302 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0842284 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0802113 |
| GPC6 | glypican 6 | 0.0733463 |
| LOX | lysyl oxidase | 0.0731855 |
| PRELID2 | PRELI domain containing 2 | 0.0729837 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.0665591 |
| ADD3 | adducin 3 (gamma) | 0.0656029 |
| RAD51B | RAD51 paralog B | 0.0646968 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0644593 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0601253 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0600802 |
| NGLY1 | N-glycanase 1 | 0.0582797 |
| MYOF | myoferlin | 0.0581675 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.0564087 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0543133 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0539061 |
| RUNX2 | runt-related transcription factor 2 | 0.0537359 |
| PFKP | phosphofructokinase, platelet | 0.0526701 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0521072 |
| NCOA7 | nuclear receptor coactivator 7 | 0.0509292 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0500925 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0489875 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0469387 |
| EGFR | epidermal growth factor receptor | 0.0462693 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0455182 |
| CA12 | carbonic anhydrase XII | 0.0450837 |
| LDHA | lactate dehydrogenase A | 0.044096 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0438791 |
| ANGPTL4 | angiopoietin-like 4 | 0.0435887 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0432696 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0421191 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0416159 |
| ADAMTS14 | ADAM metallopeptidase with thrombospondin type 1 motif, 14 | 0.0408438 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0389809 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0386444 |
| SMAD3 | SMAD family member 3 | 0.0384821 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0384504 |
| NAV2 | neuron navigator 2 | 0.0383996 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | 0.0379275 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0372444 |
| GYS1 | glycogen synthase 1 (muscle) | 0.0368503 |
| ETV6 | ets variant 6 | 0.0363639 |
| ARF4 | ADP-ribosylation factor 4 | 0.0354752 |
| EZR | ezrin | 0.0349832 |
| MCL1 | myeloid cell leukemia 1 | 0.0346758 |
| CD109 | CD109 molecule | 0.0345587 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | 0.0340114 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0339354 |
| YEATS2 | YEATS domain containing 2 | 0.0334345 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.033205 |
| TNNC1 | troponin C type 1 (slow) | 0.0325836 |
| CEP250 | centrosomal protein 250kDa | 0.032574 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0324363 |
| LOXL2 | lysyl oxidase-like 2 | 0.0318493 |
| EXOC4 | exocyst complex component 4 | 0.0318177 |
| PRKCSH | protein kinase C substrate 80K-H | 0.0318122 |
| ZNF292 | zinc finger protein 292 | 0.0311629 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0309847 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0305633 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0303833 |
| FBXO32 | F-box protein 32 | 0.0301015 |
| RPL3 | ribosomal protein L3 | 0.0300657 |
| FLNB | filamin B, beta | 0.0299214 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0299032 |
| ANXA2 | annexin A2 | 0.0297597 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0292755 |
| EHBP1 | EH domain binding protein 1 | 0.0289887 |
| PDGFC | platelet derived growth factor C | 0.0288898 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0288202 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0287684 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0287266 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0278994 |
| AOPEP | aminopeptidase O (putative) | 0.0277894 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0277023 |
| PRKAR1B | protein kinase, cAMP-dependent, regulatory, type I, beta | 0.0276809 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | 0.0275934 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | 0.0275313 |
| ENO1 | enolase 1, (alpha) | 0.0272678 |
| RUNX1 | runt-related transcription factor 1 | 0.0272285 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0271558 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0270089 |
| TP53BP1 | tumor protein p53 binding protein 1 | 0.0269143 |
| RARB | retinoic acid receptor, beta | 0.0267268 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0264047 |
| HDAC9 | histone deacetylase 9 | 0.026192 |
| OSMR | oncostatin M receptor | 0.0259548 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0258375 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0252442 |
| AHNAK | AHNAK nucleoprotein | 0.0248413 |
| BLZF1 | basic leucine zipper nuclear factor 1 | 0.024451 |
| CYP26B1 | cytochrome P450, family 26, subfamily B, polypeptide 1 | 0.0243871 |
| Symbol | Name | Standardized Value |
|---|---|---|
| STC1 | stanniocalcin 1 | -0.110193 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.108152 |
| TMSB10 | thymosin beta 10 | -0.102225 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0993567 |
| CDH13 | cadherin 13 | -0.0974192 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0949722 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.093095 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0929871 |
| GLCCI1 | glucocorticoid induced 1 | -0.090579 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.088066 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0795317 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0726749 |
| MT2A | metallothionein 2A | -0.0691701 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0690097 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0687902 |
| MTSS1 | metastasis suppressor 1 | -0.0684423 |
| CD44 | CD44 molecule (Indian blood group) | -0.0674202 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.064713 |
| JMJD1C | jumonji domain containing 1C | -0.0578116 |
| NRP1 | neuropilin 1 | -0.0576931 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0573803 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0571649 |
| NDRG1 | N-myc downstream regulated 1 | -0.0557212 |
| RPS2 | ribosomal protein S2 | -0.0552512 |
| HMGA1 | high mobility group AT-hook 1 | -0.0540019 |
| HMGA2 | high mobility group AT-hook 2 | -0.0516441 |
| NUMB | numb homolog (Drosophila) | -0.0513173 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0499011 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0491579 |
| POTEF | POTE ankyrin domain family, member F | -0.0478273 |
| PARD3 | par-3 family cell polarity regulator | -0.0458514 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0457016 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0453117 |
| NRG1 | neuregulin 1 | -0.0451017 |
| RPLP1 | ribosomal protein, large, P1 | -0.0448579 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0432109 |
| PTMA | prothymosin, alpha | -0.0427042 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0420568 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0412482 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.040825 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0406712 |
| RPL35A | ribosomal protein L35a | -0.0403184 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0393581 |
| RPS6 | ribosomal protein S6 | -0.0393412 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0385949 |
| OSBPL8 | oxysterol binding protein-like 8 | -0.0385782 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.038 |
| S100A6 | S100 calcium binding protein A6 | -0.0371005 |
| RPS21 | ribosomal protein S21 | -0.0367623 |
| GNA12 | guanine nucleotide binding protein (G protein) alpha 12 | -0.03675 |
| SNX9 | sorting nexin 9 | -0.0366358 |
| DTNA | dystrobrevin, alpha | -0.0359755 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0358141 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0356391 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0353816 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0346409 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.034354 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0340708 |
| TMSB4X | thymosin beta 4, X-linked | -0.0340008 |
| CLMP | CXADR-like membrane protein | -0.0339074 |
| CDCP1 | CUB domain containing protein 1 | -0.0338206 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0330695 |
| GOLGA4 | golgin A4 | -0.0323351 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0322238 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0317875 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0310183 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | -0.0303567 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0295387 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.029109 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.0286656 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0286623 |
| KIF5B | kinesin family member 5B | -0.0285761 |
| HAS2 | hyaluronan synthase 2 | -0.0285595 |
| PRRX1 | paired related homeobox 1 | -0.028469 |
| FNBP1 | formin binding protein 1 | -0.0284655 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0284579 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.0283706 |
| PDGFA | platelet-derived growth factor alpha polypeptide | -0.0278978 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.026678 |
| BMERB1 | bMERB domain containing 1 | -0.026542 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0262782 |
| ITGAV | integrin, alpha V | -0.0261647 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0261388 |
| CLTC | clathrin, heavy chain (Hc) | -0.0257435 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.025638 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0255935 |
| PCNX1 | pecanex 1 | -0.0255371 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0253456 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0252679 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0252228 |
| WWC2 | WW and C2 domain containing 2 | -0.0251873 |
| RBM25 | RNA binding motif protein 25 | -0.0248601 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0245443 |
| RPS19 | ribosomal protein S19 | -0.0245112 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | -0.0242769 |
| TJP1 | tight junction protein 1 | -0.0241491 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0241009 |
| ANXA10 | annexin A10 | -0.0240044 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0238788 |
| ITGB5 | integrin, beta 5 | -0.0237792 |
