| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sonidegib perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Sonidegib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.195985 |
| PM20D1 | peptidase M20 domain containing 1 | 0.172202 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.169988 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.126218 |
| FTL | ferritin, light polypeptide | 0.104191 |
| RPL3 | ribosomal protein L3 | 0.0981201 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0892985 |
| TXNRD1 | thioredoxin reductase 1 | 0.0849057 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0838295 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0831477 |
| RPL19 | ribosomal protein L19 | 0.078341 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0772437 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0679333 |
| FGB | fibrinogen beta chain | 0.0668931 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0657712 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.064629 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0626982 |
| RHOA | ras homolog family member A | 0.0615008 |
| TPI1 | triosephosphate isomerase 1 | 0.060704 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0590726 |
| AHNAK | AHNAK nucleoprotein | 0.0558115 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0556011 |
| APP | amyloid beta (A4) precursor protein | 0.0549461 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0547323 |
| MYOF | myoferlin | 0.0528452 |
| RPL4 | ribosomal protein L4 | 0.0512869 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0512001 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0505544 |
| FGG | fibrinogen gamma chain | 0.0497301 |
| GRAMD1B | GRAM domain containing 1B | 0.0489781 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0467238 |
| PPIA | peptidylprolyl isomerase A (cyclophilin A) | 0.0452836 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0449402 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0439886 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0431241 |
| TPD52 | tumor protein D52 | 0.0423483 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 0.0419425 |
| BRD2 | bromodomain containing 2 | 0.0411999 |
| RPS18 | ribosomal protein S18 | 0.0411387 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0411353 |
| RPS5 | ribosomal protein S5 | 0.0410387 |
| WDR43 | WD repeat domain 43 | 0.0409126 |
| TPX2 | TPX2, microtubule-associated | 0.0406065 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.040167 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0386505 |
| RBM25 | RNA binding motif protein 25 | 0.0385664 |
| RPL7 | ribosomal protein L7 | 0.0378248 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0375978 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0371726 |
| YBX1 | Y box binding protein 1 | 0.0369771 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0367261 |
| RPL23 | ribosomal protein L23 | 0.0362919 |
| RBM39 | RNA binding motif protein 39 | 0.0362149 |
| RPS12 | ribosomal protein S12 | 0.0354262 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0351382 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0350467 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0349012 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0346012 |
| SPAG5 | sperm associated antigen 5 | 0.034389 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0343107 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0342036 |
| SIK3 | SIK family kinase 3 | 0.0341104 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0340775 |
| RPL18 | ribosomal protein L18 | 0.0333786 |
| FGA | fibrinogen alpha chain | 0.0332174 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0327855 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.032741 |
| NUP153 | nucleoporin 153kDa | 0.032636 |
| RPS3 | ribosomal protein S3 | 0.0324575 |
| H1-4 | H1.4 linker histone, cluster member | 0.0322831 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.032269 |
| FAT1 | FAT atypical cadherin 1 | 0.0322272 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.031945 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0315717 |
| CHN1 | chimerin 1 | 0.0313579 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0312368 |
| MRTFA | myocardin related transcription factor A | 0.0311222 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0307816 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | 0.0307329 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0305879 |
| RPS11 | ribosomal protein S11 | 0.0305824 |
| PKM | pyruvate kinase, muscle | 0.0304379 |
| YBX3 | Y box binding protein 3 | 0.0304162 |
| NCKAP1 | NCK-associated protein 1 | 0.0301573 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0299697 |
| ENO1 | enolase 1, (alpha) | 0.0299313 |
| CASC3 | cancer susceptibility candidate 3 | 0.0298454 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0297771 |
| HDLBP | high density lipoprotein binding protein | 0.0292857 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0291317 |
| TPM3 | tropomyosin 3 | 0.0290549 |
| RRM2 | ribonucleotide reductase M2 | 0.0289765 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | 0.0287995 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0287453 |
| H1-0 | H1.0 linker histone | 0.028739 |
| ACACA | acetyl-CoA carboxylase alpha | 0.0286491 |
| RPL8 | ribosomal protein L8 | 0.02863 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0282997 |
| EIF3B | eukaryotic translation initiation factor 3, subunit B | 0.0281598 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0280718 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.17752 |
| VIM | vimentin | -0.116492 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.114683 |
| IGF2 | insulin-like growth factor 2 | -0.103247 |
| TMSB10 | thymosin beta 10 | -0.0950535 |
| POTEF | POTE ankyrin domain family, member F | -0.0853203 |
| MT2A | metallothionein 2A | -0.0851907 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0836822 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0715261 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0622789 |
| RPL35A | ribosomal protein L35a | -0.0619439 |
| EGR1 | early growth response 1 | -0.0609842 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.057534 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0545496 |
| ACTG1 | actin gamma 1 | -0.0520612 |
| EGFR | epidermal growth factor receptor | -0.0491924 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0481912 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0473096 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0470994 |
| IER3 | immediate early response 3 | -0.046541 |
| NRG1 | neuregulin 1 | -0.0452537 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0450999 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0442961 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0437057 |
| ATXN1 | ataxin 1 | -0.0432036 |
| S100A6 | S100 calcium binding protein A6 | -0.0424457 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0415463 |
| PYGL | phosphorylase, glycogen, liver | -0.0386009 |
| RPLP1 | ribosomal protein, large, P1 | -0.0382055 |
| HMGA1 | high mobility group AT-hook 1 | -0.0379392 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0373562 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0371844 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0370145 |
| CMIP | c-Maf inducing protein | -0.0365211 |
| ANGPTL4 | angiopoietin-like 4 | -0.0363767 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0359703 |
| NDRG1 | N-myc downstream regulated 1 | -0.0353889 |
| FLNB | filamin B, beta | -0.0353656 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0349616 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0341744 |
| TPM1 | tropomyosin 1 (alpha) | -0.0340283 |
| NAV3 | neuron navigator 3 | -0.032797 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0323316 |
| RPL9 | ribosomal protein L9 | -0.0314315 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0311259 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0306508 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0302253 |
| RPS8 | ribosomal protein S8 | -0.0300023 |
| RAD51B | RAD51 paralog B | -0.029327 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0291158 |
| CD99 | CD99 molecule | -0.0289208 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0281993 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0280957 |
| ATG7 | autophagy related 7 | -0.0279956 |
| NUMB | numb homolog (Drosophila) | -0.0272133 |
| MAP1B | microtubule-associated protein 1B | -0.0270586 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0269694 |
| CD44 | CD44 molecule (Indian blood group) | -0.0265419 |
| MCL1 | myeloid cell leukemia 1 | -0.0252565 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | -0.0251465 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0247831 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0245906 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0238579 |
| GLIS3 | GLIS family zinc finger 3 | -0.023535 |
| VEGFA | vascular endothelial growth factor A | -0.0235054 |
| SVIL | supervillin | -0.0234079 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0232641 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0230425 |
| TGM2 | transglutaminase 2 | -0.0229225 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0227137 |
| FOXP1 | forkhead box P1 | -0.0226847 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0225818 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0224429 |
| NHSL1 | NHS-like 1 | -0.0222602 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0222494 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0221416 |
| EFNA5 | ephrin-A5 | -0.0220783 |
| NEMF | nuclear export mediator factor | -0.0220322 |
| NBEAL1 | neurobeachin-like 1 | -0.0216456 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0215575 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0214385 |
| FMNL2 | formin-like 2 | -0.021092 |
| MYO1E | myosin IE | -0.021087 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0210347 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0208193 |
| CUX1 | cut-like homeobox 1 | -0.0207735 |
| LAMA5 | laminin, alpha 5 | -0.0207715 |
| CDH4 | cadherin 4, type 1, R-cadherin (retinal) | -0.0206927 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0206337 |
| SQSTM1 | sequestosome 1 | -0.0205141 |
| USP34 | ubiquitin specific peptidase 34 | -0.0204689 |
| SNX6 | sorting nexin 6 | -0.0204302 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0201908 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0199201 |
| CYP20A1 | cytochrome P450, family 20, subfamily A, polypeptide 1 | -0.0197397 |
| HMOX1 | heme oxygenase 1 | -0.0195697 |
| RPS6 | ribosomal protein S6 | -0.0192169 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0191556 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0190439 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0189939 |
