Sonidegib_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sonidegib perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sonidegib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KRT17 keratin 17, type I 0.189228
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.14101
AKAP13 A kinase (PRKA) anchor protein 13 0.112716
DSCAM Down syndrome cell adhesion molecule 0.108592
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.10501
BZW1 basic leucine zipper and W2 domains 1 0.100851
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0992727
MYO1E myosin IE 0.0903928
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0758414
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0714569
RIGI RNA sensor RIG-I 0.067181
VIM vimentin 0.0654569
FTL ferritin, light polypeptide 0.0652434
EEF2 eukaryotic translation elongation factor 2 0.0603658
RPL37 ribosomal protein L37 0.0600179
OSBPL10 oxysterol binding protein-like 10 0.0598199
RNF149 ring finger protein 149 0.0597659
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0569399
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0565709
TNIP1 TNFAIP3 interacting protein 1 0.0556648
S100A10 S100 calcium binding protein A10 0.0555943
ANXA2 annexin A2 0.0546245
TOP1 topoisomerase (DNA) I 0.0535308
SET SET nuclear proto-oncogene 0.049447
MT2A metallothionein 2A 0.0489074
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0482659
RAD51B RAD51 paralog B 0.0480089
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0477057
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0476622
MYH9 myosin, heavy chain 9, non-muscle 0.0463931
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0459565
ANKRD17 ankyrin repeat domain 17 0.0450031
RPL7A ribosomal protein L7a 0.0444737
UBC ubiquitin C 0.0441162
PTMA prothymosin, alpha 0.0429471
IFIH1 interferon induced with helicase C domain 1 0.0428085
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 0.0422694
RAB10 RAB10, member RAS oncogene family 0.041991
APLP2 amyloid beta (A4) precursor-like protein 2 0.0418905
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0418471
CSNK1A1 casein kinase 1, alpha 1 0.0417071
PKM pyruvate kinase, muscle 0.0412731
RPL23 ribosomal protein L23 0.0411973
KDM3A lysine (K)-specific demethylase 3A 0.0410324
BACE2 beta-site APP-cleaving enzyme 2 0.0406424
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.04054
SMOC1 SPARC related modular calcium binding 1 0.0404456
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0399216
ARHGAP21 Rho GTPase activating protein 21 0.0399193
HDLBP high density lipoprotein binding protein 0.039586
KMT2E lysine (K)-specific methyltransferase 2E 0.0393831
LOC112694756 uncharaterized LOC112694756 0.0387528
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.038315
HOOK2 hook microtubule-tethering protein 2 0.0381124
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0379186
STC1 stanniocalcin 1 0.0376809
ZNF292 zinc finger protein 292 0.0376698
ACTN4 actinin, alpha 4 0.0369067
RPS23 ribosomal protein S23 0.0368937
TCF12 transcription factor 12 0.0365015
EZR ezrin 0.0362812
LAMB3 laminin, beta 3 0.0359905
ITPRID2 ITPR interacting domain containing 2 0.035763
ABLIM1 actin binding LIM protein 1 0.0351234
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0348689
NECTIN4 nectin cell adhesion molecule 4 0.0346213
RPLP1 ribosomal protein, large, P1 0.0344979
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0343333
CANX calnexin 0.0339988
NIPBL Nipped-B homolog (Drosophila) 0.0336617
SVIL supervillin 0.0335862
RPL26 ribosomal protein L26 0.0335286
FOXO3 forkhead box O3 0.0335054
NDRG1 N-myc downstream regulated 1 0.0330473
UBE2K ubiquitin-conjugating enzyme E2K 0.0328738
RBM25 RNA binding motif protein 25 0.0326258
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0324582
EIF1 eukaryotic translation initiation factor 1 0.0324245
NEBL nebulette 0.0321503
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0318918
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0313451
RPLP2 ribosomal protein, large, P2 0.0309548
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0307862
CDC73 cell division cycle 73 0.0306117
NCOA3 nuclear receptor coactivator 3 0.0305442
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0303385
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0301645
PHF20L1 PHD finger protein 20-like 1 0.0298647
SMAD3 SMAD family member 3 0.0297907
ATP11A ATPase, class VI, type 11A 0.0295104
S100P S100 calcium binding protein P 0.0294167
NCOR2 nuclear receptor corepressor 2 0.0291839
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0290143
CCNI cyclin I 0.0288195
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.0288112
BRD2 bromodomain containing 2 0.028646
KYNU kynureninase 0.0286425
PIAS1 protein inhibitor of activated STAT, 1 0.0285353
RPL7 ribosomal protein L7 0.028477
WAC WW domain containing adaptor with coiled-coil 0.0280484

decreased expression

Symbol Name Standardized Value
NALF1 NALCN channel auxiliary factor 1 -0.108002
COL6A3 collagen, type VI, alpha 3 -0.107429
CEMIP cell migration inducing protein, hyaluronan binding -0.105389
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.087338
ADGRB3 adhesion G protein-coupled receptor B3 -0.0873087
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0767048
ARHGAP32 Rho GTPase activating protein 32 -0.0737794
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced -0.0724451
FN1 fibronectin 1 -0.0717529
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0716344
MUC16 mucin 16, cell surface associated -0.070103
TAS2R14 taste receptor, type 2, member 14 -0.0691999
AKAP12 A kinase (PRKA) anchor protein 12 -0.0690605
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0687689
ABI3BP ABI family, member 3 (NESH) binding protein -0.0687618
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0675646
MMP1 matrix metallopeptidase 1 -0.0673483
WARS1 tryptophanyl-tRNA synthetase 1 -0.0623187
HOMER1 homer scaffolding protein 1 -0.0620426
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0619242
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0595724
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0589782
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0565813
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0557769
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0552761
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0543618
DENND4A DENN/MADD domain containing 4A -0.054015
RUNX1 runt-related transcription factor 1 -0.0539439
FRMD5 FERM domain containing 5 -0.0539303
NABP1 nucleic acid binding protein 1 -0.0528539
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0523519
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0519965
TPM4 tropomyosin 4 -0.051849
GLIS3 GLIS family zinc finger 3 -0.0492545
GRB10 growth factor receptor-bound protein 10 -0.0486902
ATP13A3 ATPase type 13A3 -0.0479493
PTPRM protein tyrosine phosphatase, receptor type, M -0.0476612
HDAC9 histone deacetylase 9 -0.0473883
DIAPH2 diaphanous-related formin 2 -0.0468638
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0465687
SHB Src homology 2 domain containing adaptor protein B -0.0456613
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.044988
HIPK2 homeodomain interacting protein kinase 2 -0.0447138
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0443721
MED13L mediator complex subunit 13-like -0.0437415
PARD3 par-3 family cell polarity regulator -0.0436133
ANTXR2 anthrax toxin receptor 2 -0.0431429
PLAUR plasminogen activator, urokinase receptor -0.0430463
RORA RAR-related orphan receptor A -0.0425077
PSD3 pleckstrin and Sec7 domain containing 3 -0.041995
NAMPT nicotinamide phosphoribosyltransferase -0.0414984
PRKCA protein kinase C, alpha -0.0411722
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0410176
KDM4C lysine (K)-specific demethylase 4C -0.0402365
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0402175
KATNBL1 katanin p80 subunit B-like 1 -0.0393075
HMGA2 high mobility group AT-hook 2 -0.0390156
TRIO trio Rho guanine nucleotide exchange factor -0.0387986
MAML3 mastermind-like 3 (Drosophila) -0.0386137
ANKRD11 ankyrin repeat domain 11 -0.0379647
EFNA5 ephrin-A5 -0.0379206
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0376126
FNDC3A fibronectin type III domain containing 3A -0.0372281
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0371667
WASF2 WAS protein family, member 2 -0.0366301
IGFBP3 insulin-like growth factor binding protein 3 -0.0362705
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0360283
RRBP1 ribosome binding protein 1 -0.0352806
BCAR3 breast cancer anti-estrogen resistance 3 -0.0350278
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0345989
INTS6 integrator complex subunit 6 -0.0337642
PRELID2 PRELI domain containing 2 -0.0337472
ABHD17C abhydrolase domain containing 17C -0.0336258
LIMCH1 LIM and calponin homology domains 1 -0.0334905
EHBP1 EH domain binding protein 1 -0.0333172
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.03315
CD44 CD44 molecule (Indian blood group) -0.0331276
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0326876
AK1 adenylate kinase 1 -0.0324637
INHBA inhibin, beta A -0.0321497
IL4R interleukin 4 receptor -0.0317769
NPTN neuroplastin -0.0316818
MAP4 microtubule-associated protein 4 -0.0316365
ANXA1 annexin A1 -0.0316362
FER fer (fps/fes related) tyrosine kinase -0.0315839
GATAD2B GATA zinc finger domain containing 2B -0.0314352
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0311966
PAIP2 poly(A) binding protein interacting protein 2 -0.0311363
S100A6 S100 calcium binding protein A6 -0.0309098
UBE3C ubiquitin protein ligase E3C -0.0307801
CFDP1 craniofacial development protein 1 -0.0304736
LPP LIM domain containing preferred translocation partner in lipoma -0.02998
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0298776
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) -0.029744
PDE10A phosphodiesterase 10A -0.029525
SEPTIN10 septin 10 -0.0294357
MAML2 mastermind-like 2 (Drosophila) -0.0294187
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0292179
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.029187
ALCAM activated leukocyte cell adhesion molecule -0.0291864