Sonidegib_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sonidegib perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sonidegib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.211567
RAD51B RAD51 paralog B 0.117903
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.106504
PDE4D phosphodiesterase 4D, cAMP-specific 0.10648
GRAMD1B GRAM domain containing 1B 0.0934474
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0903379
AKAP12 A kinase (PRKA) anchor protein 12 0.0885004
YBX3 Y box binding protein 3 0.0677919
PRELID2 PRELI domain containing 2 0.0665597
TPM3 tropomyosin 3 0.0663367
ATXN1 ataxin 1 0.0631808
EEF2 eukaryotic translation elongation factor 2 0.0629972
EXOC4 exocyst complex component 4 0.0620105
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0619147
ERRFI1 ERBB receptor feedback inhibitor 1 0.0605751
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0583241
WWOX WW domain containing oxidoreductase 0.0566248
CSDE1 cold shock domain containing E1, RNA-binding 0.0547059
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.053223
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.052073
ADAR adenosine deaminase, RNA-specific 0.0503278
MYH9 myosin, heavy chain 9, non-muscle 0.0487526
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0480117
USP34 ubiquitin specific peptidase 34 0.0473998
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0461574
ANKRD36 ankyrin repeat domain 36 0.0457533
PDE10A phosphodiesterase 10A 0.0449599
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0443603
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0432079
MACF1 microtubule-actin crosslinking factor 1 0.0431252
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0431202
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0429442
THSD4 thrombospondin, type I, domain containing 4 0.0408089
RPL3 ribosomal protein L3 0.0402863
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0401114
AFF3 AF4/FMR2 family, member 3 0.0395946
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0394708
TPI1 triosephosphate isomerase 1 0.0380848
PHF20 PHD finger protein 20 0.0378504
DST dystonin 0.037522
PRKCE protein kinase C, epsilon 0.036989
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0368599
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0363478
CTTN cortactin 0.0361805
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0342355
PLEC plectin 0.0339331
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0335785
DENND5B DENN/MADD domain containing 5B 0.033574
IGF1R insulin-like growth factor 1 receptor 0.0332749
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0331058
DSPP dentin sialophosphoprotein 0.0326209
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0323452
ANO6 anoctamin 6 0.0322263
AEBP2 AE binding protein 2 0.0322213
SMYD3 SET and MYND domain containing 3 0.0321556
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0319335
MCL1 myeloid cell leukemia 1 0.0317953
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0317779
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0312133
TBC1D5 TBC1 domain family, member 5 0.0309964
BABAM2 BRISC and BRCA1 A complex member 2 0.0308679
DOCK5 dedicator of cytokinesis 5 0.0300417
EML4 echinoderm microtubule associated protein like 4 0.0299889
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0299768
XPO1 exportin 1 0.0296029
SMAD3 SMAD family member 3 0.0292528
PTK2 protein tyrosine kinase 2 0.0291883
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0291206
SRSF1 serine/arginine-rich splicing factor 1 0.0290255
CEP250 centrosomal protein 250kDa 0.0289017
YAP1 Yes-associated protein 1 0.0288919
ENO1 enolase 1, (alpha) 0.0288554
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0287287
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0283697
AHNAK AHNAK nucleoprotein 0.0282297
KRT18 keratin 18, type I 0.0281609
TAS2R14 taste receptor, type 2, member 14 0.0280034
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0278523
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0272609
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0270077
SDK1 sidekick cell adhesion molecule 1 0.026625
BBX bobby sox homolog (Drosophila) 0.0261158
TRIO trio Rho guanine nucleotide exchange factor 0.0261058
UBE2H ubiquitin-conjugating enzyme E2H 0.0260481
MED13L mediator complex subunit 13-like 0.0259787
RPS3 ribosomal protein S3 0.0258404
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0257598
ZBTB20 zinc finger and BTB domain containing 20 0.0255293
HSPA8 heat shock 70kDa protein 8 0.0255288
RBM39 RNA binding motif protein 39 0.0253436
ATP11A ATPase, class VI, type 11A 0.0251257
SET SET nuclear proto-oncogene 0.0249976
FAM168A family with sequence similarity 168, member A 0.0249715
ZCCHC7 zinc finger, CCHC domain containing 7 0.0247348
MBD5 methyl-CpG binding domain protein 5 0.0246022
FMNL2 formin-like 2 0.0243305
LDHA lactate dehydrogenase A 0.0241592
PHF21A PHD finger protein 21A 0.0241111
KTN1 kinectin 1 (kinesin receptor) 0.0241013
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0236231

decreased expression

Symbol Name Standardized Value
TFPI2 tissue factor pathway inhibitor 2 -0.114897
RPL35A ribosomal protein L35a -0.0903888
TMSB10 thymosin beta 10 -0.0832469
EGR1 early growth response 1 -0.0706535
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0654256
RPLP1 ribosomal protein, large, P1 -0.0464119
RAB7A RAB7A, member RAS oncogene family -0.0424286
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0410813
EIF1 eukaryotic translation initiation factor 1 -0.0406318
RPS8 ribosomal protein S8 -0.0390365
FTL ferritin, light polypeptide -0.0386792
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.038584
TXNRD1 thioredoxin reductase 1 -0.0376804
RPL12 ribosomal protein L12 -0.0361346
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0338788
RPS27 ribosomal protein S27 -0.0333131
KPNB1 karyopherin (importin) beta 1 -0.0329207
RPS19 ribosomal protein S19 -0.0328444
RPS21 ribosomal protein S21 -0.0322927
VIM vimentin -0.032109
RPL37A ribosomal protein L37a -0.031842
ACTG1 actin gamma 1 -0.031516
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0314886
EXT1 exostosin glycosyltransferase 1 -0.0310128
RPL23 ribosomal protein L23 -0.0305123
PTMA prothymosin, alpha -0.030492
ELL2 elongation factor, RNA polymerase II, 2 -0.0290891
RTN4 reticulon 4 -0.0283302
TPT1 tumor protein, translationally-controlled 1 -0.0275489
RPL9 ribosomal protein L9 -0.0275069
MYL12B myosin, light chain 12B, regulatory -0.0274624
RPL34 ribosomal protein L34 -0.0274219
RPS6 ribosomal protein S6 -0.0273394
RPL26 ribosomal protein L26 -0.0265621
RPS29 ribosomal protein S29 -0.0264364
RPL31 ribosomal protein L31 -0.0262763
WSB1 WD repeat and SOCS box containing 1 -0.0251175
GOLGA4 golgin A4 -0.024428
HMGA1 high mobility group AT-hook 1 -0.02409
MT2A metallothionein 2A -0.0237346
TMEM41B transmembrane protein 41B -0.0231323
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0228871
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0224818
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0220131
IGF2 insulin-like growth factor 2 -0.0219559
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0217743
RPL36 ribosomal protein L36 -0.0214119
RPLP0 ribosomal protein, large, P0 -0.0212413
ATF6 activating transcription factor 6 -0.0208701
NABP1 nucleic acid binding protein 1 -0.0207324
RPS14 ribosomal protein S14 -0.0202732
RPS15 ribosomal protein S15 -0.0200977
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0200026
STC1 stanniocalcin 1 -0.0198048
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0196443
RPS27A ribosomal protein S27a -0.0195864
RPS24 ribosomal protein S24 -0.0195292
POTEF POTE ankyrin domain family, member F -0.0194937
VDAC1 voltage-dependent anion channel 1 -0.0194914
LMAN1 lectin, mannose-binding, 1 -0.0194863
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0190964
CDK17 cyclin-dependent kinase 17 -0.019005
LOC102724023 ES1 protein homolog, mitochondrial -0.018472
RPL38 ribosomal protein L38 -0.0182026
RPS20 ribosomal protein S20 -0.0179592
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0177835
RPL36A ribosomal protein L36a -0.0177754
SETX senataxin -0.0175985
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0174244
S100A6 S100 calcium binding protein A6 -0.0172101
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0170017
HLA-B major histocompatibility complex, class I, B -0.0166919
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0166384
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0165386
RPL13A ribosomal protein L13a -0.0165033
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0160706
RPS25 ribosomal protein S25 -0.0160478
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0160301
MARCHF4 membrane associated ring-CH-type finger 4 -0.0159102
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0156054
FHL2 four and a half LIM domains 2 -0.0155809
CD44 CD44 molecule (Indian blood group) -0.015297
ATP5F1B ATP synthase F1 subunit beta -0.0151901
AKIRIN1 akirin 1 -0.0149973
ATXN2 ataxin 2 -0.0149391
RECQL RecQ helicase-like -0.0149008
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0148723
SPAG9 sperm associated antigen 9 -0.0148546
ATP5F1E ATP synthase F1 subunit epsilon -0.0148148
RPLP2 ribosomal protein, large, P2 -0.0147736
ANXA5 annexin A5 -0.0146959
DUSP6 dual specificity phosphatase 6 -0.0146462
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0143137
ERLEC1 endoplasmic reticulum lectin 1 -0.0141248
KLF6 Kruppel-like factor 6 -0.014116
RPS23 ribosomal protein S23 -0.0139761
RPL30 ribosomal protein L30 -0.0139267
RBM25 RNA binding motif protein 25 -0.0139183
RPL35 ribosomal protein L35 -0.0139147
FBXO11 F-box protein 11 -0.0137916