| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sonidegib perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Sonidegib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.160287 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.116497 |
| NDRG1 | N-myc downstream regulated 1 | 0.105473 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.103024 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0760844 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.075254 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0740125 |
| FAM13A | family with sequence similarity 13, member A | 0.0732805 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0720723 |
| ENO1 | enolase 1, (alpha) | 0.0716994 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.07103 |
| MSN | moesin | 0.0630321 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0621078 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0597289 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0575677 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0565923 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.05627 |
| PLEC | plectin | 0.0555036 |
| NAV2 | neuron navigator 2 | 0.0551708 |
| PTK2 | protein tyrosine kinase 2 | 0.0522277 |
| LDHA | lactate dehydrogenase A | 0.0508589 |
| ARRDC3 | arrestin domain containing 3 | 0.0506388 |
| PKM | pyruvate kinase, muscle | 0.0499164 |
| RCOR1 | REST corepressor 1 | 0.0493343 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0491731 |
| FLNB | filamin B, beta | 0.046524 |
| CALR | calreticulin | 0.0464999 |
| MX1 | MX dynamin-like GTPase 1 | 0.045174 |
| TPM3 | tropomyosin 3 | 0.043869 |
| VEGFA | vascular endothelial growth factor A | 0.0429503 |
| FHIT | fragile histidine triad | 0.0417631 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0413784 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0410846 |
| DSPP | dentin sialophosphoprotein | 0.0397557 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0396077 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0380877 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0365594 |
| MYO6 | myosin VI | 0.0362635 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.034441 |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 | 0.0342865 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0342384 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0332774 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0330828 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0328644 |
| HDGF | hepatoma-derived growth factor | 0.0327605 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0327528 |
| G0S2 | G0/G1 switch 2 | 0.0323549 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0321251 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0320743 |
| TMF1 | TATA element modulatory factor 1 | 0.0319961 |
| ADAR | adenosine deaminase, RNA-specific | 0.0318364 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0308376 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0306262 |
| RPL3 | ribosomal protein L3 | 0.0301681 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0299802 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0298592 |
| LAMB3 | laminin, beta 3 | 0.0297489 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0295771 |
| POTEF | POTE ankyrin domain family, member F | 0.0293951 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0292583 |
| BBX | bobby sox homolog (Drosophila) | 0.0292253 |
| PCBP2 | poly(rC) binding protein 2 | 0.0289871 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0286242 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0278496 |
| LMNA | lamin A/C | 0.0275143 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | 0.0274744 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0272839 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0272377 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.0272176 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0271379 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0271111 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.026945 |
| CCNY | cyclin Y | 0.0268452 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0266787 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0266726 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0263536 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 0.0260588 |
| MCL1 | myeloid cell leukemia 1 | 0.0259614 |
| LNPEP | leucyl/cystinyl aminopeptidase | 0.0258329 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.0254507 |
| EZR | ezrin | 0.0254075 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0253001 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0252005 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0249131 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0241364 |
| RHOA | ras homolog family member A | 0.0239588 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0239398 |
| RAD51B | RAD51 paralog B | 0.0239161 |
| WASF2 | WAS protein family, member 2 | 0.023244 |
| RAI14 | retinoic acid induced 14 | 0.0232334 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0230362 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | 0.0228501 |
| EGR1 | early growth response 1 | 0.0227933 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0226253 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0224247 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0222445 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0219051 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0218572 |
| KRT18 | keratin 18, type I | 0.0218145 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0217369 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.267393 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0944434 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0725864 |
| RPL35A | ribosomal protein L35a | -0.0691434 |
| LMO7 | LIM domain 7 | -0.0568908 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.049643 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0491689 |
| ACTG1 | actin gamma 1 | -0.0478552 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0462519 |
| RPL34 | ribosomal protein L34 | -0.0458819 |
| FTL | ferritin, light polypeptide | -0.0449454 |
| RPLP1 | ribosomal protein, large, P1 | -0.0398809 |
| ARF1 | ADP-ribosylation factor 1 | -0.0325939 |
| S100A6 | S100 calcium binding protein A6 | -0.03162 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0313724 |
| TMSB10 | thymosin beta 10 | -0.0303192 |
| RPL23 | ribosomal protein L23 | -0.0294147 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0286603 |
| SLC38A1 | solute carrier family 38, member 1 | -0.028506 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0264382 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0257795 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0252571 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0252527 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0249947 |
| RPS27A | ribosomal protein S27a | -0.0249923 |
| CRABP2 | cellular retinoic acid binding protein 2 | -0.0246728 |
| RPS6 | ribosomal protein S6 | -0.0245827 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.024563 |
| RPS24 | ribosomal protein S24 | -0.0243683 |
| RRAS2 | related RAS viral (r-ras) oncogene homolog 2 | -0.0239705 |
| HMGA1 | high mobility group AT-hook 1 | -0.0233027 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0231327 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.023107 |
| CANX | calnexin | -0.0223639 |
| RPL30 | ribosomal protein L30 | -0.0221444 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | -0.0218357 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0214973 |
| HMGB2 | high mobility group box 2 | -0.0214127 |
| FN1 | fibronectin 1 | -0.0210255 |
| SH3RF1 | SH3 domain containing ring finger 1 | -0.0207794 |
| RPS8 | ribosomal protein S8 | -0.020615 |
| RPS16 | ribosomal protein S16 | -0.0202134 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0201111 |
| RPS23 | ribosomal protein S23 | -0.0199938 |
| EGFR | epidermal growth factor receptor | -0.0198173 |
| VIM | vimentin | -0.0196516 |
| RPL27A | ribosomal protein L27a | -0.0195175 |
| SVIL | supervillin | -0.0194955 |
| RPLP2 | ribosomal protein, large, P2 | -0.0194449 |
| RPL11 | ribosomal protein L11 | -0.0193384 |
| RBM27 | RNA binding motif protein 27 | -0.0188969 |
| RPS13 | ribosomal protein S13 | -0.0187596 |
| TMEM263 | transmembrane protein 263 | -0.0187147 |
| RASA2 | RAS p21 protein activator 2 | -0.0187129 |
| NEMF | nuclear export mediator factor | -0.0186218 |
| RBM39 | RNA binding motif protein 39 | -0.0186206 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0185969 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0182155 |
| USP15 | ubiquitin specific peptidase 15 | -0.0181689 |
| H3-3B | H3.3 histone B | -0.0180557 |
| RPLP0 | ribosomal protein, large, P0 | -0.018026 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0180123 |
| RPL31 | ribosomal protein L31 | -0.0178239 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0174416 |
| RPS20 | ribosomal protein S20 | -0.0173912 |
| RPL26 | ribosomal protein L26 | -0.0171478 |
| GNAS | GNAS complex locus | -0.0171173 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0170584 |
| RPL37A | ribosomal protein L37a | -0.0170197 |
| RPL9 | ribosomal protein L9 | -0.0169962 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.016944 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0166161 |
| RACK1 | receptor for activated C kinase 1 | -0.016009 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0159835 |
| TCEA1 | transcription elongation factor A (SII), 1 | -0.0159531 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0159455 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0158834 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0158559 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0157644 |
| KPNA1 | karyopherin alpha 1 (importin alpha 5) | -0.0155091 |
| DHX36 | DEAH (Asp-Glu-Ala-His) box polypeptide 36 | -0.015266 |
| MORF4L1 | mortality factor 4 like 1 | -0.0150172 |
| HMBOX1 | homeobox containing 1 | -0.0147044 |
| RHEB | Ras homolog enriched in brain | -0.0146587 |
| NRP1 | neuropilin 1 | -0.0145832 |
| TARS1 | threonyl-tRNA synthetase 1 | -0.0145675 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0144375 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0143903 |
| FCHO2 | FCH domain only 2 | -0.0142138 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | -0.0141999 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0139741 |
| MAP4 | microtubule-associated protein 4 | -0.0139506 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0138029 |
| RAB1B | RAB1B, member RAS oncogene family | -0.0137446 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0137424 |
| RPS21 | ribosomal protein S21 | -0.013517 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0135167 |
| MT2A | metallothionein 2A | -0.0135051 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0134397 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | -0.013319 |
