Sonidegib_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sonidegib perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sonidegib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.188886
TPT1 tumor protein, translationally-controlled 1 0.121699
RPS6 ribosomal protein S6 0.0905522
RPS12 ribosomal protein S12 0.0887818
RPL37A ribosomal protein L37a 0.0795021
PSD3 pleckstrin and Sec7 domain containing 3 0.0768808
RPS3 ribosomal protein S3 0.0742231
RPL7A ribosomal protein L7a 0.0620271
RPL19 ribosomal protein L19 0.0602939
RPL3 ribosomal protein L3 0.0548055
RACK1 receptor for activated C kinase 1 0.0545961
RPL31 ribosomal protein L31 0.054238
RPS19 ribosomal protein S19 0.0515775
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.05154
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.0496659
RPL37 ribosomal protein L37 0.0493436
NACA nascent polypeptide-associated complex alpha subunit 0.0482059
RPS23 ribosomal protein S23 0.047406
RPS17 ribosomal protein S17 0.0453573
DST dystonin 0.0431239
RPS8 ribosomal protein S8 0.042774
FTL ferritin, light polypeptide 0.042723
RPS25 ribosomal protein S25 0.0424731
LOC112694756 uncharaterized LOC112694756 0.0409268
RPL38 ribosomal protein L38 0.0404877
RPS13 ribosomal protein S13 0.0402854
RPS29 ribosomal protein S29 0.0402292
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0387234
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0381768
TBXT T-box transcription factor T 0.0374558
IGFBP3 insulin-like growth factor binding protein 3 0.0369911
RPLP0 ribosomal protein, large, P0 0.0358964
TPI1 triosephosphate isomerase 1 0.0358623
H1-4 H1.4 linker histone, cluster member 0.0347906
RPL36A ribosomal protein L36a 0.0343589
PYGL phosphorylase, glycogen, liver 0.0342199
RPL11 ribosomal protein L11 0.0341173
RPL26 ribosomal protein L26 0.0337524
SMOC1 SPARC related modular calcium binding 1 0.0328895
RPL13A ribosomal protein L13a 0.031352
NCOR2 nuclear receptor corepressor 2 0.0307681
RPL36 ribosomal protein L36 0.0306297
RPL8 ribosomal protein L8 0.0305014
RPLP2 ribosomal protein, large, P2 0.0304758
RPL5 ribosomal protein L5 0.0304172
LOC102724023 ES1 protein homolog, mitochondrial 0.0295613
NDRG1 N-myc downstream regulated 1 0.029555
RPS11 ribosomal protein S11 0.0294994
P3H2 prolyl 3-hydroxylase 2 0.0292033
WARS1 tryptophanyl-tRNA synthetase 1 0.0290675
RPS4X ribosomal protein S4, X-linked 0.0273929
EEF2 eukaryotic translation elongation factor 2 0.0263002
ASTN2 astrotactin 2 0.0262458
EZR ezrin 0.0261434
HDLBP high density lipoprotein binding protein 0.0256162
AKAP12 A kinase (PRKA) anchor protein 12 0.0254684
PKM pyruvate kinase, muscle 0.0247889
HLA-B major histocompatibility complex, class I, B 0.0240987
RAD51B RAD51 paralog B 0.0240813
RPL7 ribosomal protein L7 0.0238731
STC2 stanniocalcin 2 0.0237403
RPS5 ribosomal protein S5 0.0236593
PM20D1 peptidase M20 domain containing 1 0.0235182
SEPTIN9 septin 9 0.0235049
MYH9 myosin, heavy chain 9, non-muscle 0.0232939
MT2A metallothionein 2A 0.0230676
RPS24 ribosomal protein S24 0.0229125
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0227767
EIF4H eukaryotic translation initiation factor 4H 0.022735
RPL28 ribosomal protein L28 0.0221738
S100A10 S100 calcium binding protein A10 0.0219594
EFNA5 ephrin-A5 0.0217079
BZW1 basic leucine zipper and W2 domains 1 0.021583
RPL32 ribosomal protein L32 0.0211671
LMNA lamin A/C 0.0211584
SQSTM1 sequestosome 1 0.020984
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0209504
SLC38A2 solute carrier family 38, member 2 0.0205227
SRRM2 serine/arginine repetitive matrix 2 0.0203523
RPS27 ribosomal protein S27 0.0203081
RPS14 ribosomal protein S14 0.0198311
ESYT2 extended synaptotagmin-like protein 2 0.0196993
RPS10 ribosomal protein S10 0.0196924
MSN moesin 0.0193746
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0191041
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0190992
NHSL1 NHS-like 1 0.0190771
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0188599
SMAD2 SMAD family member 2 0.0184934
PLEC plectin 0.018449
RPL30 ribosomal protein L30 0.0182915
EGR1 early growth response 1 0.0181613
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 0.0180395
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0180004
ESM1 endothelial cell-specific molecule 1 0.0179319
CCT7 chaperonin containing TCP1, subunit 7 (eta) 0.0178536
HDAC4 histone deacetylase 4 0.0176901
RPL6 ribosomal protein L6 0.0176239
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.0171543
RPL18 ribosomal protein L18 0.0170642

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.143187
TXNRD1 thioredoxin reductase 1 -0.123255
TMSB10 thymosin beta 10 -0.119504
UBC ubiquitin C -0.118075
CXCL8 chemokine (C-X-C motif) ligand 8 -0.103737
GDA guanine deaminase -0.0991636
NAMPT nicotinamide phosphoribosyltransferase -0.0901159
ASPH aspartate beta-hydroxylase -0.0857033
PCBP2 poly(rC) binding protein 2 -0.0691514
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0642102
RPS27A ribosomal protein S27a -0.0621885
POTEF POTE ankyrin domain family, member F -0.0595878
CANX calnexin -0.0568172
FN1 fibronectin 1 -0.0555841
LIMCH1 LIM and calponin homology domains 1 -0.0555823
ENO1 enolase 1, (alpha) -0.052784
TM4SF1 transmembrane 4 L six family member 1 -0.0526774
TFPI2 tissue factor pathway inhibitor 2 -0.0470589
GRAMD1B GRAM domain containing 1B -0.0458084
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0453485
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.04441
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0435172
SRPK2 SRSF protein kinase 2 -0.0409523
RTN4 reticulon 4 -0.0400095
TGFBR1 transforming growth factor, beta receptor 1 -0.0398745
TNPO1 transportin 1 -0.0393719
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0390458
COL8A1 collagen, type VIII, alpha 1 -0.0390188
MYOF myoferlin -0.0388747
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0376826
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0359933
COL4A5 collagen, type IV, alpha 5 -0.0358205
PRRC2C proline-rich coiled-coil 2C -0.0352519
SFPQ splicing factor proline/glutamine-rich -0.0348167
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0347098
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0338505
NALF1 NALCN channel auxiliary factor 1 -0.0336493
OGA O-GlcNAcase -0.0335224
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0325181
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0314742
AHNAK AHNAK nucleoprotein -0.031302
PARD3 par-3 family cell polarity regulator -0.0310762
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0305777
ELL2 elongation factor, RNA polymerase II, 2 -0.0289858
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.028948
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0288845
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0287574
VMP1 vacuole membrane protein 1 -0.0284882
PTMA prothymosin, alpha -0.0284851
RBM39 RNA binding motif protein 39 -0.0279162
MATR3 matrin 3 -0.0276578
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0269279
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0268406
TUSC3 tumor suppressor candidate 3 -0.026809
ATP13A3 ATPase type 13A3 -0.0265318
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0259655
SPAG9 sperm associated antigen 9 -0.0256263
FTH1 ferritin, heavy polypeptide 1 -0.0256228
SMYD3 SET and MYND domain containing 3 -0.0253998
PDIA6 protein disulfide isomerase family A, member 6 -0.0251531
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0251372
AKR1C1 aldo-keto reductase family 1, member C1 -0.0251269
SOD2 superoxide dismutase 2, mitochondrial -0.0250397
NEK7 NIMA-related kinase 7 -0.0249945
PDIA3 protein disulfide isomerase family A, member 3 -0.024703
SAMD4A sterile alpha motif domain containing 4A -0.0245889
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0241515
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.023988
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0237547
NCOA7 nuclear receptor coactivator 7 -0.0234013
NF1 neurofibromin 1 -0.0233133
JMJD1C jumonji domain containing 1C -0.0232992
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -0.0232868
GSK3B glycogen synthase kinase 3 beta -0.0227627
KDM3A lysine (K)-specific demethylase 3A -0.0226049
ZFAND3 zinc finger, AN1-type domain 3 -0.0221494
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.0220736
MARCHF6 membrane associated ring-CH-type finger 6 -0.0220673
ANKRD28 ankyrin repeat domain 28 -0.0220638
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0219685
PLCB4 phospholipase C, beta 4 -0.0218825
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0217087
GIGYF2 GRB10 interacting GYF protein 2 -0.0215883
LMAN1 lectin, mannose-binding, 1 -0.0215882
CFLAR CASP8 and FADD-like apoptosis regulator -0.0215021
ZEB2 zinc finger E-box binding homeobox 2 -0.0214403
ZNF207 zinc finger protein 207 -0.0212925
PUM2 pumilio RNA-binding family member 2 -0.0210732
PHF20 PHD finger protein 20 -0.0210488
ANXA5 annexin A5 -0.02077
RBM25 RNA binding motif protein 25 -0.0207635
WDR43 WD repeat domain 43 -0.020762
ZFC3H1 zinc finger, C3H1-type containing -0.0207073
CARD16 caspase recruitment domain family, member 16 -0.0206299
MGST1 microsomal glutathione S-transferase 1 -0.0203535
XPO1 exportin 1 -0.0201461
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0199312
ENAH enabled homolog (Drosophila) -0.0198656
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0195193
CERS2 ceramide synthase 2 -0.0194924