| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sonidegib perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Sonidegib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.224744 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.094438 |
| HDAC9 | histone deacetylase 9 | 0.0908899 |
| PEG10 | paternally expressed 10 | 0.086702 |
| COL5A2 | collagen, type V, alpha 2 | 0.083074 |
| H1-4 | H1.4 linker histone, cluster member | 0.081118 |
| ZNF292 | zinc finger protein 292 | 0.0792398 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0720526 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.0708477 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0662522 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0651527 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0599588 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0571772 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0568498 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0564462 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0543436 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0538155 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0537613 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0507715 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0507636 |
| PGAP1 | post-GPI attachment to proteins 1 | 0.0496808 |
| SETD5 | SET domain containing 5 | 0.0474116 |
| CALR | calreticulin | 0.0470088 |
| TRPS1 | trichorhinophalangeal syndrome I | 0.0465342 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0458583 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0458194 |
| PDGFC | platelet derived growth factor C | 0.0455672 |
| NCKAP1 | NCK-associated protein 1 | 0.0454217 |
| RPL3 | ribosomal protein L3 | 0.0453976 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0450306 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0449915 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0444973 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0444381 |
| APP | amyloid beta (A4) precursor protein | 0.0435814 |
| MEMO1 | mediator of cell motility 1 | 0.0427687 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0413916 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0413757 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.040787 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0401486 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0398837 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0395136 |
| FOXP2 | forkhead box P2 | 0.0394782 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0388877 |
| SET | SET nuclear proto-oncogene | 0.0385683 |
| NTM | neurotrimin | 0.0384603 |
| PPIA | peptidylprolyl isomerase A (cyclophilin A) | 0.0381154 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0377211 |
| CDC73 | cell division cycle 73 | 0.0367565 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0366766 |
| PTK2 | protein tyrosine kinase 2 | 0.0366599 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0364382 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0361459 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0360781 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0347053 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0346416 |
| ARRDC3 | arrestin domain containing 3 | 0.03462 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | 0.0345961 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0344664 |
| PCBP2 | poly(rC) binding protein 2 | 0.0343607 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0343557 |
| OLA1 | Obg-like ATPase 1 | 0.0342255 |
| COL11A1 | collagen, type XI, alpha 1 | 0.0342072 |
| SCAF8 | SR-related CTD-associated factor 8 | 0.0339068 |
| ANXA1 | annexin A1 | 0.0338525 |
| RASAL2 | RAS protein activator like 2 | 0.0336431 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.033369 |
| PRPF8 | pre-mRNA processing factor 8 | 0.0327051 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0322673 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0319564 |
| ADNP | activity-dependent neuroprotector homeobox | 0.0317864 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0312759 |
| FBXO11 | F-box protein 11 | 0.0312231 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0306636 |
| MTF2 | metal response element binding transcription factor 2 | 0.0306196 |
| CORO1C | coronin, actin binding protein, 1C | 0.0305561 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | 0.0304933 |
| RLF | rearranged L-myc fusion | 0.0301387 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.029974 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.029951 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0295768 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0293302 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0289582 |
| RBM33 | RNA binding motif protein 33 | 0.0288953 |
| PUM2 | pumilio RNA-binding family member 2 | 0.028651 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0286018 |
| RPS3 | ribosomal protein S3 | 0.0282926 |
| MYO10 | myosin X | 0.0281813 |
| GPC4 | glypican 4 | 0.0281229 |
| CALCR | calcitonin receptor | 0.0272911 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0271347 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | 0.0271166 |
| ZNF608 | zinc finger protein 608 | 0.026903 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0268142 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | 0.0266748 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0266523 |
| RHOA | ras homolog family member A | 0.0266077 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | 0.0261468 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0260288 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0258159 |
| WDR43 | WD repeat domain 43 | 0.0257674 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.18097 |
| VIM | vimentin | -0.173379 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.106178 |
| PTMA | prothymosin, alpha | -0.105443 |
| CADM2 | cell adhesion molecule 2 | -0.0924172 |
| RPL35A | ribosomal protein L35a | -0.0856129 |
| RPLP1 | ribosomal protein, large, P1 | -0.0719717 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0672415 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.064754 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0554627 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0505851 |
| SNX6 | sorting nexin 6 | -0.0490316 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0486487 |
| RPS16 | ribosomal protein S16 | -0.0479649 |
| HMGB1 | high mobility group box 1 | -0.0476666 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0431435 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.039867 |
| CDH4 | cadherin 4, type 1, R-cadherin (retinal) | -0.0389636 |
| RPL34 | ribosomal protein L34 | -0.0348941 |
| NEBL | nebulette | -0.0333827 |
| RPS21 | ribosomal protein S21 | -0.0316507 |
| GALNTL6 | polypeptide N-acetylgalactosaminyltransferase-like 6 | -0.0313265 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0304567 |
| XIAP | X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase | -0.0303132 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0301433 |
| COL1A2 | collagen, type I, alpha 2 | -0.0300504 |
| CENPF | centromere protein F, 350/400kDa | -0.0296111 |
| HMCN1 | hemicentin 1 | -0.0290738 |
| PLPP1 | phospholipid phosphatase 1 | -0.0281197 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0273358 |
| RPL12 | ribosomal protein L12 | -0.0266284 |
| NXN | nucleoredoxin | -0.0265823 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0262609 |
| JMJD1C | jumonji domain containing 1C | -0.0257707 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0256733 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0250557 |
| SGO2 | shugoshin 2 | -0.0250242 |
| RAB31 | RAB31, member RAS oncogene family | -0.0249209 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0247727 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | -0.0247711 |
| PRELID2 | PRELI domain containing 2 | -0.0246347 |
| TBL1X | transducin (beta)-like 1X-linked | -0.0245836 |
| CAVIN1 | caveolae associated protein 1 | -0.0239019 |
| RPS27 | ribosomal protein S27 | -0.0235953 |
| KLHL5 | kelch-like family member 5 | -0.0232765 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0231961 |
| PDS5A | PDS5 cohesin associated factor A | -0.0229386 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0227861 |
| FAM177A1 | family with sequence similarity 177, member A1 | -0.0226526 |
| ATF4 | activating transcription factor 4 | -0.0226153 |
| ZC3H12B | zinc finger CCCH-type containing 12B | -0.0224921 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0224054 |
| S100A6 | S100 calcium binding protein A6 | -0.0223315 |
| B2M | beta-2-microglobulin | -0.0222941 |
| HMGA1 | high mobility group AT-hook 1 | -0.0221279 |
| MEIS2 | Meis homeobox 2 | -0.0218649 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0218533 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0214115 |
| SOX2 | SRY (sex determining region Y)-box 2 | -0.0213696 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0211936 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0209879 |
| WASF2 | WAS protein family, member 2 | -0.0208246 |
| RAD51B | RAD51 paralog B | -0.0207004 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | -0.0206961 |
| CBX3 | chromobox homolog 3 | -0.0206874 |
| THOC2 | THO complex 2 | -0.0206089 |
| HSPB1 | heat shock 27kDa protein 1 | -0.020313 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0201241 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0201117 |
| FSCN1 | fascin actin-bundling protein 1 | -0.0200123 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0199771 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.019903 |
| RNF149 | ring finger protein 149 | -0.0198258 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0197433 |
| LPGAT1 | lysophosphatidylglycerol acyltransferase 1 | -0.0194489 |
| URI1 | URI1, prefoldin-like chaperone | -0.0194094 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0193823 |
| PALLD | palladin, cytoskeletal associated protein | -0.0191762 |
| RPL9 | ribosomal protein L9 | -0.0191194 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.0189631 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0189219 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0188138 |
| MAP4 | microtubule-associated protein 4 | -0.0187763 |
| FBXO27 | F-box protein 27 | -0.0185772 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0185089 |
| MAP1B | microtubule-associated protein 1B | -0.0182307 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.0181349 |
| GRK3 | G protein-coupled receptor kinase 3 | -0.0180735 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0180382 |
| EXOC6B | exocyst complex component 6B | -0.0178424 |
| TBC1D32 | TBC1 domain family, member 32 | -0.017678 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.017517 |
| CENPE | centromere protein E, 312kDa | -0.0174431 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0174359 |
| ZNF217 | zinc finger protein 217 | -0.0173893 |
| FOXK1 | forkhead box K1 | -0.0173576 |
| ULK4 | unc-51 like kinase 4 | -0.017321 |
| RPLP2 | ribosomal protein, large, P2 | -0.0173179 |
| CDK13 | cyclin-dependent kinase 13 | -0.0172929 |
| TXNRD1 | thioredoxin reductase 1 | -0.0172604 |
