| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sonidegib perturbation in SNU-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Sonidegib_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.192521 |
| RPL3 | ribosomal protein L3 | 0.121371 |
| HDAC9 | histone deacetylase 9 | 0.119161 |
| AHNAK | AHNAK nucleoprotein | 0.115633 |
| PKM | pyruvate kinase, muscle | 0.10295 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0971588 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0925133 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0909616 |
| FOXP1 | forkhead box P1 | 0.0852452 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | 0.0808741 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0785883 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0783097 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0779784 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0756036 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0711672 |
| RPS3 | ribosomal protein S3 | 0.0699171 |
| VCL | vinculin | 0.0638099 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0620265 |
| SOX6 | SRY (sex determining region Y)-box 6 | 0.0614692 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0592902 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0578296 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0528716 |
| H1-4 | H1.4 linker histone, cluster member | 0.0524503 |
| RHOA | ras homolog family member A | 0.0507259 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0502349 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0500688 |
| TGFBR3 | transforming growth factor, beta receptor III | 0.0494944 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0492148 |
| FLNB | filamin B, beta | 0.0476058 |
| RPL19 | ribosomal protein L19 | 0.0472836 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0450138 |
| NFIA | nuclear factor I/A | 0.0437187 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0435363 |
| SMYD3 | SET and MYND domain containing 3 | 0.0432617 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0425392 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0422288 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | 0.0421966 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0412731 |
| APP | amyloid beta (A4) precursor protein | 0.0410146 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.04101 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0409749 |
| PDGFC | platelet derived growth factor C | 0.0409382 |
| RPL8 | ribosomal protein L8 | 0.0397907 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0395975 |
| EZR | ezrin | 0.0392289 |
| AHCYL2 | adenosylhomocysteinase-like 2 | 0.0388432 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0387282 |
| AMOTL2 | angiomotin like 2 | 0.0383684 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0382822 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0375756 |
| RPL4 | ribosomal protein L4 | 0.0375218 |
| PRELID2 | PRELI domain containing 2 | 0.0373847 |
| HDLBP | high density lipoprotein binding protein | 0.036974 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0368838 |
| ANXA1 | annexin A1 | 0.0366306 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0364128 |
| FHIT | fragile histidine triad | 0.03601 |
| GLI2 | GLI family zinc finger 2 | 0.0358242 |
| FHAD1 | forkhead-associated (FHA) phosphopeptide binding domain 1 | 0.0358026 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0356749 |
| TACC2 | transforming, acidic coiled-coil containing protein 2 | 0.0353643 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0349809 |
| ZNF608 | zinc finger protein 608 | 0.0349722 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0343269 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0341458 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0341138 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0337689 |
| RPS18 | ribosomal protein S18 | 0.0337233 |
| RPL7A | ribosomal protein L7a | 0.0336195 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | 0.0331794 |
| TPI1 | triosephosphate isomerase 1 | 0.0326145 |
| BPTF | bromodomain PHD finger transcription factor | 0.0322276 |
| RPL32 | ribosomal protein L32 | 0.0319423 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0318324 |
| MKI67 | marker of proliferation Ki-67 | 0.0317962 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0313274 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0313011 |
| CORO1C | coronin, actin binding protein, 1C | 0.0311574 |
| MACROD2 | MACRO domain containing 2 | 0.0310811 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0310388 |
| PRRC2B | proline-rich coiled-coil 2B | 0.0309578 |
| LDHB | lactate dehydrogenase B | 0.0307784 |
| ECT2 | epithelial cell transforming 2 | 0.0307744 |
| TRERF1 | transcriptional regulating factor 1 | 0.0303329 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0303015 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0301293 |
| LDHA | lactate dehydrogenase A | 0.0301222 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0298613 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0297129 |
| TCF12 | transcription factor 12 | 0.0297125 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0289981 |
| RPS4X | ribosomal protein S4, X-linked | 0.0284419 |
| RPS12 | ribosomal protein S12 | 0.0284385 |
| RPL26 | ribosomal protein L26 | 0.0283587 |
| PPIA | peptidylprolyl isomerase A (cyclophilin A) | 0.0283369 |
| CACNB4 | calcium channel, voltage-dependent, beta 4 subunit | 0.0281704 |
| GSE1 | Gse1 coiled-coil protein | 0.0277949 |
| ENO1 | enolase 1, (alpha) | 0.0277914 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0275932 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0275913 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0691337 |
| RPL35A | ribosomal protein L35a | -0.0666102 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.065644 |
| TMSB10 | thymosin beta 10 | -0.0530816 |
| S100A6 | S100 calcium binding protein A6 | -0.0480209 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0445004 |
| RTN4 | reticulon 4 | -0.0384668 |
| TXNRD1 | thioredoxin reductase 1 | -0.0356699 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0353011 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0339903 |
| MT2A | metallothionein 2A | -0.0315177 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0289519 |
| RPLP1 | ribosomal protein, large, P1 | -0.0287127 |
| RPL34 | ribosomal protein L34 | -0.0261396 |
| RPS6 | ribosomal protein S6 | -0.0247882 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0247369 |
| HMGA1 | high mobility group AT-hook 1 | -0.0245493 |
| S100A4 | S100 calcium binding protein A4 | -0.023967 |
| RPS14 | ribosomal protein S14 | -0.023785 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0221411 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.021029 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0198961 |
| VIM | vimentin | -0.0198003 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0195497 |
| BMP10 | bone morphogenetic protein 10 | -0.0192449 |
| HLA-A | major histocompatibility complex, class I, A | -0.0190486 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0189644 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0186932 |
| SEC61G | Sec61 gamma subunit | -0.0184786 |
| S100A11 | S100 calcium binding protein A11 | -0.0180948 |
| TXNIP | thioredoxin interacting protein | -0.0178136 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0168255 |
| NDRG1 | N-myc downstream regulated 1 | -0.0164914 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0163251 |
| HMGB1 | high mobility group box 1 | -0.0160117 |
| RPS28 | ribosomal protein S28 | -0.0156392 |
| ZNF217 | zinc finger protein 217 | -0.015632 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0155824 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0148124 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.014728 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0147041 |
| WBP11 | WW domain binding protein 11 | -0.0144951 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.014121 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.014029 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0138781 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0136398 |
| CBX3 | chromobox homolog 3 | -0.0135922 |
| ATF4 | activating transcription factor 4 | -0.0134138 |
| FTL | ferritin, light polypeptide | -0.0133048 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | -0.0132749 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0132688 |
| ZDHHC20 | zinc finger, DHHC-type containing 20 | -0.0132022 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0130171 |
| TMEM123 | transmembrane protein 123 | -0.0127726 |
| FN1 | fibronectin 1 | -0.0126825 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0126307 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0125073 |
| FUS | FUS RNA binding protein | -0.0122971 |
| RPL9 | ribosomal protein L9 | -0.0122965 |
| TMEM41B | transmembrane protein 41B | -0.0120305 |
| MORF4L1 | mortality factor 4 like 1 | -0.0119604 |
| TNFRSF11B | tumor necrosis factor receptor superfamily, member 11b | -0.0119366 |
| G3BP2 | GTPase activating protein (SH3 domain) binding protein 2 | -0.0116766 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0116562 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0114791 |
| FGFR2 | fibroblast growth factor receptor 2 | -0.0114657 |
| DUSP6 | dual specificity phosphatase 6 | -0.0114531 |
| SESN2 | sestrin 2 | -0.0113659 |
| RPS20 | ribosomal protein S20 | -0.0112468 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0112394 |
| TDRD3 | tudor domain containing 3 | -0.0111757 |
| GGNBP2 | gametogenetin binding protein 2 | -0.011148 |
| ATP9B | ATPase, class II, type 9B | -0.0110088 |
| S100A9 | S100 calcium binding protein A9 | -0.0109584 |
| OLA1 | Obg-like ATPase 1 | -0.0108668 |
| COX5B | cytochrome c oxidase subunit Vb | -0.0108026 |
| CFDP1 | craniofacial development protein 1 | -0.0106538 |
| ATN1 | atrophin 1 | -0.0106477 |
| MNT | MAX network transcriptional repressor | -0.0106306 |
| ERLEC1 | endoplasmic reticulum lectin 1 | -0.0106125 |
| SPRY2 | sprouty homolog 2 (Drosophila) | -0.0105582 |
| SPIRE1 | spire-type actin nucleation factor 1 | -0.0105099 |
| TRIM33 | tripartite motif containing 33 | -0.0105047 |
| SMNDC1 | survival motor neuron domain containing 1 | -0.0105028 |
| SLC41A1 | solute carrier family 41 (magnesium transporter), member 1 | -0.0104955 |
| DIAPH2 | diaphanous-related formin 2 | -0.0104492 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0103657 |
| MT1X | metallothionein 1X | -0.0103012 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | -0.0102783 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0102691 |
| PTMA | prothymosin, alpha | -0.0102312 |
| MYADM | myeloid-associated differentiation marker | -0.0100667 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0100364 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | -0.00993387 |
| ARID3A | AT rich interactive domain 3A (BRIGHT-like) | -0.00988347 |
| RPS21 | ribosomal protein S21 | -0.00987765 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | -0.00985933 |
| IER2 | immediate early response 2 | -0.0098416 |
| PRRC2C | proline-rich coiled-coil 2C | -0.00983284 |
| GAPVD1 | GTPase activating protein and VPS9 domains 1 | -0.00983247 |
