Sonidegib_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sonidegib perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sonidegib_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial 0.306182
MYH9 myosin, heavy chain 9, non-muscle 0.27331
FN1 fibronectin 1 0.157519
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.100707
DST dystonin 0.0929669
TRIO trio Rho guanine nucleotide exchange factor 0.0897658
LDHA lactate dehydrogenase A 0.0836811
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0798492
CADM1 cell adhesion molecule 1 0.0783677
PGK1 phosphoglycerate kinase 1 0.0767727
NAMPT nicotinamide phosphoribosyltransferase 0.0764262
COL6A3 collagen, type VI, alpha 3 0.0755224
VCAN versican 0.0749519
FNDC3B fibronectin type III domain containing 3B 0.0732273
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0727514
EEF2 eukaryotic translation elongation factor 2 0.069106
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0690803
AHNAK AHNAK nucleoprotein 0.0598182
HLA-E major histocompatibility complex, class I, E 0.059311
FRMD4A FERM domain containing 4A 0.059184
EXT1 exostosin glycosyltransferase 1 0.0590216
CALR calreticulin 0.0577131
SMAD3 SMAD family member 3 0.0544268
TNIP1 TNFAIP3 interacting protein 1 0.0544116
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0520811
LOC112694756 uncharaterized LOC112694756 0.0506821
TNS3 tensin 3 0.0503704
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0503137
PDE10A phosphodiesterase 10A 0.0496432
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0492179
MYOF myoferlin 0.0491767
ZMYND8 zinc finger, MYND-type containing 8 0.0481417
UGCG UDP-glucose ceramide glucosyltransferase 0.0475231
ATXN1 ataxin 1 0.0471507
RNF213 ring finger protein 213 0.0456232
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0438383
MX1 MX dynamin-like GTPase 1 0.0438145
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0433854
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0427585
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0422696
COL8A1 collagen, type VIII, alpha 1 0.041772
MSN moesin 0.0415827
TRIP12 thyroid hormone receptor interactor 12 0.0413386
KYNU kynureninase 0.0410731
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0410508
USP9X ubiquitin specific peptidase 9, X-linked 0.0402059
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.0401741
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0393184
VEGFA vascular endothelial growth factor A 0.038677
FLNA filamin A, alpha 0.0375396
FBXO32 F-box protein 32 0.0366794
WTAP Wilms tumor 1 associated protein 0.0364569
CD44 CD44 molecule (Indian blood group) 0.0358578
CEP250 centrosomal protein 250kDa 0.0351447
RPL3 ribosomal protein L3 0.0350612
ARRDC3 arrestin domain containing 3 0.0350449
TENT5A terminal nucleotidyltransferase 5A 0.0345625
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0342737
FNIP1 folliculin interacting protein 1 0.0339752
LAMP2 lysosomal-associated membrane protein 2 0.0339614
APP amyloid beta (A4) precursor protein 0.0320697
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0317633
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0316234
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0315442
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0315417
SLC38A2 solute carrier family 38, member 2 0.0313143
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0309883
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0305045
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0303471
EGFR epidermal growth factor receptor 0.0303024
RAI14 retinoic acid induced 14 0.0301944
TGFBI transforming growth factor, beta-induced, 68kDa 0.0299234
NAV2 neuron navigator 2 0.0295408
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0290043
TMSB4X thymosin beta 4, X-linked 0.0289877
APLP2 amyloid beta (A4) precursor-like protein 2 0.0289151
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0288044
LOC102724023 ES1 protein homolog, mitochondrial 0.0287677
COL4A2 collagen, type IV, alpha 2 0.0285272
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0282548
SEPTIN9 septin 9 0.0282442
AKAP12 A kinase (PRKA) anchor protein 12 0.0282068
HDAC9 histone deacetylase 9 0.0280295
PRKCSH protein kinase C substrate 80K-H 0.027419
SDK1 sidekick cell adhesion molecule 1 0.0272725
ZHX2 zinc fingers and homeoboxes 2 0.0271249
TAPBP TAP binding protein (tapasin) 0.027029
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0269611
LOX lysyl oxidase 0.0268805
ADM adrenomedullin 0.0267439
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0267051
SPAG9 sperm associated antigen 9 0.0266195
ZNF292 zinc finger protein 292 0.0265263
OPTN optineurin 0.0264818
CTSB cathepsin B 0.0260477
IFI6 interferon, alpha-inducible protein 6 0.0259291
HLA-B major histocompatibility complex, class I, B 0.025876
UBC ubiquitin C 0.0258082
CSDE1 cold shock domain containing E1, RNA-binding 0.025696
ELL2 elongation factor, RNA polymerase II, 2 0.025541

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.108503
MT2A metallothionein 2A -0.107073
RPL35A ribosomal protein L35a -0.0729002
FTL ferritin, light polypeptide -0.0650338
RPS6 ribosomal protein S6 -0.0631286
RPLP1 ribosomal protein, large, P1 -0.0607812
RPS19 ribosomal protein S19 -0.0564466
RPS23 ribosomal protein S23 -0.0447272
EIF1 eukaryotic translation initiation factor 1 -0.0385391
TPT1 tumor protein, translationally-controlled 1 -0.0363355
RPL9 ribosomal protein L9 -0.0360263
NDRG1 N-myc downstream regulated 1 -0.0357813
RPL35 ribosomal protein L35 -0.0354596
PTMA prothymosin, alpha -0.0333112
RPS24 ribosomal protein S24 -0.0323488
RPL36 ribosomal protein L36 -0.0322485
RPL11 ribosomal protein L11 -0.0322251
RPS21 ribosomal protein S21 -0.0320758
RPS8 ribosomal protein S8 -0.0310866
RPL36A ribosomal protein L36a -0.0307863
RPL23 ribosomal protein L23 -0.0306352
HMGA1 high mobility group AT-hook 1 -0.0300406
KLF6 Kruppel-like factor 6 -0.0296144
RPLP2 ribosomal protein, large, P2 -0.0273522
RPL12 ribosomal protein L12 -0.0260944
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0259844
RPS14 ribosomal protein S14 -0.0258747
RPS10 ribosomal protein S10 -0.0249044
HMGB1 high mobility group box 1 -0.023803
RPL28 ribosomal protein L28 -0.023356
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0231031
EGR1 early growth response 1 -0.0229674
ACTG1 actin gamma 1 -0.0229586
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0226085
RPS13 ribosomal protein S13 -0.0219345
RPS20 ribosomal protein S20 -0.0217851
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0217593
HMGA2 high mobility group AT-hook 2 -0.021564
RPL26 ribosomal protein L26 -0.0210161
RPS27 ribosomal protein S27 -0.0204894
VDAC1 voltage-dependent anion channel 1 -0.0204476
RPS4X ribosomal protein S4, X-linked -0.0195002
RPL34 ribosomal protein L34 -0.0194482
RPL7A ribosomal protein L7a -0.0188461
RPS29 ribosomal protein S29 -0.018683
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0186279
RPLP0 ribosomal protein, large, P0 -0.0182932
RPS16 ribosomal protein S16 -0.0182322
NKTR natural killer cell triggering receptor -0.0179254
PHIP pleckstrin homology domain interacting protein -0.0176879
RPL31 ribosomal protein L31 -0.0176843
CBX3 chromobox homolog 3 -0.0176364
UBE2B ubiquitin-conjugating enzyme E2B -0.0175722
RPL32 ribosomal protein L32 -0.0172375
RPL27A ribosomal protein L27a -0.017231
EFNA5 ephrin-A5 -0.0171259
TBCA tubulin folding cofactor A -0.0168212
MT1X metallothionein 1X -0.0167839
COG5 component of oligomeric golgi complex 5 -0.016515
CDH13 cadherin 13 -0.0163422
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0162252
ATP5F1E ATP synthase F1 subunit epsilon -0.0162239
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0161543
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0159876
PCBP2 poly(rC) binding protein 2 -0.0157484
DEK DEK proto-oncogene -0.0157342
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0152712
MAP1B microtubule-associated protein 1B -0.0149668
SRSF11 serine/arginine-rich splicing factor 11 -0.0149038
ANKHD1 ankyrin repeat and KH domain containing 1 -0.014673
ATP11B ATPase, class VI, type 11B -0.0146313
CST3 cystatin C -0.0142277
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0141935
UBB ubiquitin B -0.0141154
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0139655
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.013961
RAN RAN, member RAS oncogene family -0.0136436
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0136421
S100A6 S100 calcium binding protein A6 -0.0135416
SOS1 son of sevenless homolog 1 (Drosophila) -0.0135113
PABPN1 poly(A) binding protein, nuclear 1 -0.013344
S100A9 S100 calcium binding protein A9 -0.0132843
RPL5 ribosomal protein L5 -0.0131655
SEC61G Sec61 gamma subunit -0.0131152
RPL39 ribosomal protein L39 -0.0130076
FUS FUS RNA binding protein -0.0127772
SMC4 structural maintenance of chromosomes 4 -0.0127603
RPL37A ribosomal protein L37a -0.012724
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0126753
RPL19 ribosomal protein L19 -0.0126246
TMEM41B transmembrane protein 41B -0.0125316
PFN1 profilin 1 -0.0125248
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0123796
LGALS1 lectin, galactoside-binding, soluble, 1 -0.012136
SHOC2 soc-2 suppressor of clear homolog (C. elegans) -0.0119496
RTN3 reticulon 3 -0.0119263
ATP5MK ATP synthase membrane subunit k -0.0119029
NUCB2 nucleobindin 2 -0.0118883
RPL30 ribosomal protein L30 -0.0117879
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0117585