Sonidegib_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sonidegib perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sonidegib_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TGFBI transforming growth factor, beta-induced, 68kDa 0.179543
COL6A3 collagen, type VI, alpha 3 0.171924
MYH9 myosin, heavy chain 9, non-muscle 0.15587
TIMP3 TIMP metallopeptidase inhibitor 3 0.114459
EGFR epidermal growth factor receptor 0.111771
COL5A1 collagen, type V, alpha 1 0.0983262
CALR calreticulin 0.0943306
NRXN3 neurexin 3 0.093879
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0816098
FAM13A family with sequence similarity 13, member A 0.0729561
CALD1 caldesmon 1 0.0667895
ARRDC3 arrestin domain containing 3 0.0647353
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0585254
TENT5A terminal nucleotidyltransferase 5A 0.0572901
VEGFA vascular endothelial growth factor A 0.0554766
NDRG1 N-myc downstream regulated 1 0.055095
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0548984
B2M beta-2-microglobulin 0.0518398
ZMYND8 zinc finger, MYND-type containing 8 0.0513587
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0509126
TNIP1 TNFAIP3 interacting protein 1 0.0475027
AHNAK AHNAK nucleoprotein 0.0473506
NCOR2 nuclear receptor corepressor 2 0.0443216
IGFBP3 insulin-like growth factor binding protein 3 0.0441815
PSD3 pleckstrin and Sec7 domain containing 3 0.0438179
NBAS neuroblastoma amplified sequence 0.0427829
MSN moesin 0.0425441
IL6 interleukin 6 0.0415401
EEF2 eukaryotic translation elongation factor 2 0.0415046
RUNX1 runt-related transcription factor 1 0.0410802
ATXN1 ataxin 1 0.0408059
CYLD cylindromatosis (turban tumor syndrome) 0.0407267
PLEC plectin 0.0406004
ENO1 enolase 1, (alpha) 0.0403354
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0396586
PGK1 phosphoglycerate kinase 1 0.0387761
USP34 ubiquitin specific peptidase 34 0.0386592
MACF1 microtubule-actin crosslinking factor 1 0.0386304
FLNA filamin A, alpha 0.038484
SMAD3 SMAD family member 3 0.0378675
COL6A1 collagen, type VI, alpha 1 0.0374194
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0370479
CD44 CD44 molecule (Indian blood group) 0.0369544
HDAC9 histone deacetylase 9 0.0369177
FNDC3B fibronectin type III domain containing 3B 0.036861
SNX13 sorting nexin 13 0.0363619
NAV2 neuron navigator 2 0.0362632
TNS3 tensin 3 0.0350523
GSE1 Gse1 coiled-coil protein 0.0346721
ZCCHC7 zinc finger, CCHC domain containing 7 0.0343731
TTC3 tetratricopeptide repeat domain 3 0.0339496
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0337149
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0333738
TPM3 tropomyosin 3 0.0324931
FNIP1 folliculin interacting protein 1 0.0324276
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0318224
CA12 carbonic anhydrase XII 0.0315628
LMNA lamin A/C 0.0312001
GOLGB1 golgin B1 0.0306109
VCAN versican 0.0305703
PRELID2 PRELI domain containing 2 0.0298467
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0298344
SND1 staphylococcal nuclease and tudor domain containing 1 0.0293436
FTL ferritin, light polypeptide 0.0291156
ZSWIM6 zinc finger, SWIM-type containing 6 0.0288613
ATP13A3 ATPase type 13A3 0.0287595
EXT1 exostosin glycosyltransferase 1 0.0287148
ZNF638 zinc finger protein 638 0.0285932
SEPTIN9 septin 9 0.028351
MYLK myosin light chain kinase 0.0281989
COG6 component of oligomeric golgi complex 6 0.0281275
SCFD1 sec1 family domain containing 1 0.028028
EXOC4 exocyst complex component 4 0.0276893
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0275047
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0274179
AUTS2 autism susceptibility candidate 2 0.0272718
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0272151
COL6A2 collagen, type VI, alpha 2 0.0272047
FBN1 fibrillin 1 0.0268391
MAML2 mastermind-like 2 (Drosophila) 0.0267247
TRIP12 thyroid hormone receptor interactor 12 0.0267134
DNAH11 dynein, axonemal, heavy chain 11 0.026393
YEATS2 YEATS domain containing 2 0.0261312
CSNK1A1 casein kinase 1, alpha 1 0.0261244
SDC2 syndecan 2 0.0258232
GRIK5 glutamate receptor, ionotropic, kainate 5 0.0257661
ARHGAP32 Rho GTPase activating protein 32 0.0256535
ERRFI1 ERBB receptor feedback inhibitor 1 0.0255597
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.0255185
RPL37 ribosomal protein L37 0.0255144
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0251094
CCND1 cyclin D1 0.0250817
VEGFC vascular endothelial growth factor C 0.0249215
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0248823
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0247805
SMYD3 SET and MYND domain containing 3 0.0247034
ZNF395 zinc finger protein 395 0.0245999
TPI1 triosephosphate isomerase 1 0.0245637
LOC102724023 ES1 protein homolog, mitochondrial 0.0245283
MBD5 methyl-CpG binding domain protein 5 0.0245125

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.15721
FN1 fibronectin 1 -0.101982
PTMA prothymosin, alpha -0.0630364
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0537577
FTH1 ferritin, heavy polypeptide 1 -0.0526405
ELL2 elongation factor, RNA polymerase II, 2 -0.0518032
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.047547
STC1 stanniocalcin 1 -0.0455829
ARF1 ADP-ribosylation factor 1 -0.0429314
EIF1 eukaryotic translation initiation factor 1 -0.0421436
LMAN1 lectin, mannose-binding, 1 -0.0418643
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0417216
TMSB10 thymosin beta 10 -0.0415864
OGA O-GlcNAcase -0.0394732
CANX calnexin -0.0374281
NALF1 NALCN channel auxiliary factor 1 -0.0373622
RPLP1 ribosomal protein, large, P1 -0.0373426
KMT2E lysine (K)-specific methyltransferase 2E -0.0361613
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0356878
DDIT4 DNA-damage-inducible transcript 4 -0.0350727
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.033927
SEPTIN7 septin 7 -0.0315811
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.03156
HMGB1 high mobility group box 1 -0.0312765
RPL34 ribosomal protein L34 -0.0306326
ZNF217 zinc finger protein 217 -0.0299403
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0297036
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0282501
GPC6 glypican 6 -0.0280944
RHEB Ras homolog enriched in brain -0.0279592
THY1 Thy-1 cell surface antigen -0.0279087
SRP54 signal recognition particle 54kDa -0.0278747
PRSS23 protease, serine, 23 -0.0276215
TFPI2 tissue factor pathway inhibitor 2 -0.0275626
COL1A2 collagen, type I, alpha 2 -0.0267306
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0254764
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0251827
YBX3 Y box binding protein 3 -0.0251047
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0246485
TPX2 TPX2, microtubule-associated -0.0246114
RSRC2 arginine/serine-rich coiled-coil 2 -0.0239251
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0238863
EMP1 epithelial membrane protein 1 -0.0237664
PDE10A phosphodiesterase 10A -0.0237109
MIMS1 mitochondrial inner membrane scaffold 1 -0.0232827
KLHDC10 kelch domain containing 10 -0.0231735
NT5C2 5'-nucleotidase, cytosolic II -0.0227978
RPS6 ribosomal protein S6 -0.0223704
OSBPL8 oxysterol binding protein-like 8 -0.0223501
COL1A1 collagen, type I, alpha 1 -0.0222507
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.0218862
UBE2C ubiquitin-conjugating enzyme E2C -0.0216612
ANXA2 annexin A2 -0.021637
LIFR leukemia inhibitory factor receptor alpha -0.0214775
ANO6 anoctamin 6 -0.0213386
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0210465
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.0205236
SMOX spermine oxidase -0.020516
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 -0.020494
CNOT6L CCR4-NOT transcription complex, subunit 6-like -0.0204817
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0200574
KDM2A lysine (K)-specific demethylase 2A -0.0200214
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0199161
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0197355
DLG1 discs, large homolog 1 (Drosophila) -0.0197267
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0197186
RAD21 RAD21 homolog (S. pombe) -0.0196142
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 -0.0193406
HIP1 huntingtin interacting protein 1 -0.0193346
CERT1 ceramide transporter 1 -0.0192711
PAIP2 poly(A) binding protein interacting protein 2 -0.0190924
INSIG1 insulin induced gene 1 -0.0190633
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.019053
ZC3H13 zinc finger CCCH-type containing 13 -0.0189382
SAR1A secretion associated, Ras related GTPase 1A -0.0189221
RSAD2 radical S-adenosyl methionine domain containing 2 -0.018921
TM4SF1 transmembrane 4 L six family member 1 -0.0188724
RPL12 ribosomal protein L12 -0.0188265
UBE2Z ubiquitin-conjugating enzyme E2Z -0.0186876
SRGN serglycin -0.0185946
SQSTM1 sequestosome 1 -0.0185885
RPL28 ribosomal protein L28 -0.0185858
LAPTM4A lysosomal protein transmembrane 4 alpha -0.0184934
FUS FUS RNA binding protein -0.0184384
GPX8 glutathione peroxidase 8 (putative) -0.0182869
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0181826
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0180819
HLA-A major histocompatibility complex, class I, A -0.0180755
HBP1 HMG-box transcription factor 1 -0.0180629
HILPDA hypoxia inducible lipid droplet-associated -0.0179814
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0179697
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0179317
WTAP Wilms tumor 1 associated protein -0.0179249
CLIC4 chloride intracellular channel 4 -0.0178763
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0178697
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.017862
TAS2R14 taste receptor, type 2, member 14 -0.01784
BIRC2 baculoviral IAP repeat containing 2 -0.0177944
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -0.0176759
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0176145