| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sonidegib perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Sonidegib_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.136221 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0988851 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0825586 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0794518 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0725019 |
| AHNAK | AHNAK nucleoprotein | 0.0690708 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0634444 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0602647 |
| SMYD3 | SET and MYND domain containing 3 | 0.056934 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0563326 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0537151 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0516662 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0512299 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0507727 |
| AFF4 | AF4/FMR2 family, member 4 | 0.050197 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0501225 |
| CEP250 | centrosomal protein 250kDa | 0.048531 |
| ACIN1 | apoptotic chromatin condensation inducer 1 | 0.0477849 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0475089 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0474749 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0471077 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.047006 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0466788 |
| PKM | pyruvate kinase, muscle | 0.0462435 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0443654 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0439665 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0416426 |
| AHCTF1 | AT hook containing transcription factor 1 | 0.041154 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0411535 |
| SETD5 | SET domain containing 5 | 0.0405405 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0399883 |
| DERA | deoxyribose-phosphate aldolase (putative) | 0.0398002 |
| YAP1 | Yes-associated protein 1 | 0.0397602 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0394559 |
| FNIP1 | folliculin interacting protein 1 | 0.0387372 |
| PLEC | plectin | 0.0372129 |
| CUL5 | cullin 5 | 0.0368782 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0365231 |
| RPS3 | ribosomal protein S3 | 0.0361293 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.034902 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0345824 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0345604 |
| ZNF292 | zinc finger protein 292 | 0.034168 |
| GOLGB1 | golgin B1 | 0.0340869 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0340514 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | 0.0338835 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0336022 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0335252 |
| PRRC2B | proline-rich coiled-coil 2B | 0.0334348 |
| RBM39 | RNA binding motif protein 39 | 0.0331083 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0330952 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | 0.0328458 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | 0.0324686 |
| SQSTM1 | sequestosome 1 | 0.0323868 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0321874 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0321336 |
| RPS12 | ribosomal protein S12 | 0.032133 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0318859 |
| ASPH | aspartate beta-hydroxylase | 0.0318049 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0317205 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0316048 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.031061 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.030881 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0308374 |
| RPL3 | ribosomal protein L3 | 0.0306849 |
| COG5 | component of oligomeric golgi complex 5 | 0.0304353 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0303197 |
| ETNK1 | ethanolamine kinase 1 | 0.0301847 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0300837 |
| PRELID2 | PRELI domain containing 2 | 0.030029 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0299004 |
| CANX | calnexin | 0.0298245 |
| CPNE1 | copine I | 0.0297429 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0296649 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0287014 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.028701 |
| ANO6 | anoctamin 6 | 0.0286351 |
| CEP290 | centrosomal protein 290kDa | 0.0282931 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0278723 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0278075 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0276857 |
| AP3D1 | adaptor-related protein complex 3, delta 1 subunit | 0.027518 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0273527 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0272828 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.0272442 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0269852 |
| RAB10 | RAB10, member RAS oncogene family | 0.0269027 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0265151 |
| MCL1 | myeloid cell leukemia 1 | 0.0264869 |
| RPL37A | ribosomal protein L37a | 0.0262903 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0259832 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0259669 |
| SEPTIN9 | septin 9 | 0.0259341 |
| TMEM245 | transmembrane protein 245 | 0.025819 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0257366 |
| RAD50 | RAD50 homolog (S. cerevisiae) | 0.0256807 |
| VPS13A | vacuolar protein sorting 13 homolog A (S. cerevisiae) | 0.0256216 |
| ATXN1 | ataxin 1 | 0.0254075 |
| CCT7 | chaperonin containing TCP1, subunit 7 (eta) | 0.0253403 |
| CCDC91 | coiled-coil domain containing 91 | 0.0253027 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.123895 |
| VIM | vimentin | -0.121409 |
| RPL35A | ribosomal protein L35a | -0.0944108 |
| MT2A | metallothionein 2A | -0.0607224 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0553192 |
| POTEF | POTE ankyrin domain family, member F | -0.0502009 |
| RPL9 | ribosomal protein L9 | -0.044602 |
| PTMA | prothymosin, alpha | -0.0442729 |
| SEPTIN7 | septin 7 | -0.0441923 |
| S100A6 | S100 calcium binding protein A6 | -0.0434451 |
| HMGA2 | high mobility group AT-hook 2 | -0.0416615 |
| RAI14 | retinoic acid induced 14 | -0.0410991 |
| HMGB1 | high mobility group box 1 | -0.0399808 |
| RPLP1 | ribosomal protein, large, P1 | -0.0399086 |
| ANXA2 | annexin A2 | -0.0398396 |
| IGF2 | insulin-like growth factor 2 | -0.0394088 |
| TXNIP | thioredoxin interacting protein | -0.0379603 |
| PRR16 | proline rich 16 | -0.0376217 |
| RPL36 | ribosomal protein L36 | -0.0375448 |
| GNAS | GNAS complex locus | -0.0365847 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0360204 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0356636 |
| RPS21 | ribosomal protein S21 | -0.0345044 |
| LMO7 | LIM domain 7 | -0.0343292 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0343173 |
| RPS28 | ribosomal protein S28 | -0.0340283 |
| PARD3 | par-3 family cell polarity regulator | -0.0338394 |
| NALCN | sodium leak channel, non selective | -0.0333376 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0332231 |
| PRSS23 | protease, serine, 23 | -0.033072 |
| JMJD1C | jumonji domain containing 1C | -0.0318576 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0317073 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0316549 |
| RPS14 | ribosomal protein S14 | -0.0309387 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0305908 |
| CBX3 | chromobox homolog 3 | -0.0299194 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0293488 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0290806 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0287488 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0286466 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0279876 |
| RPL12 | ribosomal protein L12 | -0.0279496 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | -0.027736 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0271984 |
| RPS8 | ribosomal protein S8 | -0.0269638 |
| RBM25 | RNA binding motif protein 25 | -0.0269131 |
| SMAD3 | SMAD family member 3 | -0.0261345 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0258105 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0256921 |
| MMP24OS | MMP24 opposite strand | -0.0255326 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0252051 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0251539 |
| RPLP0 | ribosomal protein, large, P0 | -0.0249145 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0249141 |
| PODXL | podocalyxin-like | -0.0243186 |
| FUS | FUS RNA binding protein | -0.0243168 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0242807 |
| S100A9 | S100 calcium binding protein A9 | -0.0242797 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0242145 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0241824 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0239013 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0238476 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.023461 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0234341 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0234222 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0231972 |
| CEBPB | CCAAT/enhancer binding protein (C/EBP), beta | -0.0228441 |
| UQCRQ | ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa | -0.0228162 |
| FTL | ferritin, light polypeptide | -0.0228074 |
| RPL11 | ribosomal protein L11 | -0.0224476 |
| ZCRB1 | zinc finger CCHC-type and RNA binding motif 1 | -0.022087 |
| FMN1 | formin 1 | -0.0218119 |
| SNX14 | sorting nexin 14 | -0.0217195 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.0214956 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0213564 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0211037 |
| MPHOSPH8 | M-phase phosphoprotein 8 | -0.0210696 |
| ETV1 | ets variant 1 | -0.0210034 |
| ABI1 | abl-interactor 1 | -0.0209038 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.020771 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0206284 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0205655 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0204682 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0201592 |
| PRKCA | protein kinase C, alpha | -0.0201165 |
| BTN3A3 | butyrophilin, subfamily 3, member A3 | -0.0201086 |
| MYADM | myeloid-associated differentiation marker | -0.0198136 |
| NABP1 | nucleic acid binding protein 1 | -0.0198103 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0196598 |
| RPL27A | ribosomal protein L27a | -0.0196543 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0196459 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0196198 |
| CKLF | chemokine-like factor | -0.0194103 |
| SVIP | small VCP/p97-interacting protein | -0.0193935 |
| UBB | ubiquitin B | -0.0193687 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0193656 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | -0.0193248 |
| BSG | basigin (Ok blood group) | -0.0193203 |
| GATAD2B | GATA zinc finger domain containing 2B | -0.0192287 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0191483 |
