| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sonidegib perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Sonidegib_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIO | trio Rho guanine nucleotide exchange factor | 0.106132 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.105909 |
| STC2 | stanniocalcin 2 | 0.0981798 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0951983 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0886694 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0878005 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0773907 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0732044 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0667288 |
| SFTPA2 | surfactant protein A2 | 0.066719 |
| CALR | calreticulin | 0.0655423 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0652367 |
| PKM | pyruvate kinase, muscle | 0.0590429 |
| CD109 | CD109 molecule | 0.0578162 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0546345 |
| SQSTM1 | sequestosome 1 | 0.0538077 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0530501 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0528872 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0523321 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0512853 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0509621 |
| FLNA | filamin A, alpha | 0.0500835 |
| AHR | aryl hydrocarbon receptor | 0.0498256 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0472055 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0461165 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0452549 |
| FAT1 | FAT atypical cadherin 1 | 0.0439465 |
| UBC | ubiquitin C | 0.0427242 |
| ENO1 | enolase 1, (alpha) | 0.0414536 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0414158 |
| DST | dystonin | 0.0413854 |
| CTBP2 | C-terminal binding protein 2 | 0.0413482 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0410312 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0408378 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0406052 |
| RPS12 | ribosomal protein S12 | 0.0404784 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0400084 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0400083 |
| HDLBP | high density lipoprotein binding protein | 0.0399181 |
| FAM13A | family with sequence similarity 13, member A | 0.0398062 |
| EFNA5 | ephrin-A5 | 0.0396115 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0390378 |
| PLEC | plectin | 0.038694 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0384521 |
| COPA | coatomer protein complex, subunit alpha | 0.0384257 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0383834 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0377956 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0376201 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0368805 |
| HPS3 | Hermansky-Pudlak syndrome 3 | 0.0366187 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0363811 |
| RACK1 | receptor for activated C kinase 1 | 0.0363796 |
| HMGA2 | high mobility group AT-hook 2 | 0.0360014 |
| CANX | calnexin | 0.0357426 |
| TPM3 | tropomyosin 3 | 0.0357349 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0353476 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0349539 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0340697 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0340369 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0339499 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0337338 |
| PTK2 | protein tyrosine kinase 2 | 0.0334522 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0331524 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0329757 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0329215 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0327934 |
| TOP1 | topoisomerase (DNA) I | 0.032355 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0322634 |
| ARRDC3 | arrestin domain containing 3 | 0.0320819 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0320157 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.031971 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0317081 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0314934 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0309391 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0309268 |
| WDR45B | WD repeat domain 45B | 0.0308278 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0307767 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0306057 |
| TBC1D22A | TBC1 domain family, member 22A | 0.030393 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0302797 |
| EGFR | epidermal growth factor receptor | 0.0299292 |
| VEGFA | vascular endothelial growth factor A | 0.0299033 |
| NDRG1 | N-myc downstream regulated 1 | 0.0298728 |
| INSIG2 | insulin induced gene 2 | 0.0290852 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0290396 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0290165 |
| KLC1 | kinesin light chain 1 | 0.0283162 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0283126 |
| RPL3 | ribosomal protein L3 | 0.0278995 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0278526 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0278265 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0277069 |
| USP34 | ubiquitin specific peptidase 34 | 0.0273915 |
| ACTN4 | actinin, alpha 4 | 0.0273579 |
| GPC6 | glypican 6 | 0.0272826 |
| SUCO | SUN domain containing ossification factor | 0.0271208 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0267042 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0266884 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0265352 |
| AHNAK | AHNAK nucleoprotein | 0.026208 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.171478 |
| TMSB10 | thymosin beta 10 | -0.112294 |
| MT2A | metallothionein 2A | -0.111071 |
| RPL35A | ribosomal protein L35a | -0.0662859 |
| PTMA | prothymosin, alpha | -0.0583645 |
| S100A6 | S100 calcium binding protein A6 | -0.0563094 |
| RPLP1 | ribosomal protein, large, P1 | -0.0458239 |
| HMGA1 | high mobility group AT-hook 1 | -0.0421142 |
| RPL34 | ribosomal protein L34 | -0.0366831 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0362448 |
| RPL9 | ribosomal protein L9 | -0.0316934 |
| TMEM263 | transmembrane protein 263 | -0.0311158 |
| RPS21 | ribosomal protein S21 | -0.0309727 |
| EGR1 | early growth response 1 | -0.0304675 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0300365 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0281577 |
| HLA-B | major histocompatibility complex, class I, B | -0.0272157 |
| HMGB1 | high mobility group box 1 | -0.0270912 |
| IER3 | immediate early response 3 | -0.0260052 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0259995 |
| RPS24 | ribosomal protein S24 | -0.0254936 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0250739 |
| RPS19 | ribosomal protein S19 | -0.0249938 |
| VIM | vimentin | -0.0245969 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0240371 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0238834 |
| RPL12 | ribosomal protein L12 | -0.023412 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0223674 |
| RPS28 | ribosomal protein S28 | -0.0218779 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0208745 |
| ACTG1 | actin gamma 1 | -0.0203688 |
| RPS20 | ribosomal protein S20 | -0.0203662 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0202607 |
| MT1X | metallothionein 1X | -0.0200618 |
| POTEF | POTE ankyrin domain family, member F | -0.0195401 |
| S100A9 | S100 calcium binding protein A9 | -0.0191975 |
| RPL11 | ribosomal protein L11 | -0.0189482 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.018894 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0182 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0179436 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.017889 |
| KLHL5 | kelch-like family member 5 | -0.0178567 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0177385 |
| RPL23 | ribosomal protein L23 | -0.0173678 |
| PIM3 | Pim-3 proto-oncogene, serine/threonine kinase | -0.0170708 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0169792 |
| CBX3 | chromobox homolog 3 | -0.0169183 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0166851 |
| TOMM7 | translocase of outer mitochondrial membrane 7 homolog (yeast) | -0.0162426 |
| TXNDC17 | thioredoxin domain containing 17 | -0.015788 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0155949 |
| B2M | beta-2-microglobulin | -0.0152115 |
| VCL | vinculin | -0.0146133 |
| RPLP0 | ribosomal protein, large, P0 | -0.0146109 |
| GNAS | GNAS complex locus | -0.0145829 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0144621 |
| TUBB | tubulin, beta class I | -0.0144564 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0144264 |
| SERF2 | small EDRK-rich factor 2 | -0.014338 |
| FTL | ferritin, light polypeptide | -0.0143051 |
| RPL28 | ribosomal protein L28 | -0.0142814 |
| NRG1 | neuregulin 1 | -0.0142255 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.0141126 |
| RIGI | RNA sensor RIG-I | -0.0138379 |
| ATP5MK | ATP synthase membrane subunit k | -0.0137466 |
| RNASEH2A | ribonuclease H2, subunit A | -0.0136728 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0136552 |
| RPL38 | ribosomal protein L38 | -0.0135103 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0132657 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.0132436 |
| RPS6 | ribosomal protein S6 | -0.0132415 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0131387 |
| NDUFA4 | NDUFA4, mitochondrial complex associated | -0.013053 |
| CENPF | centromere protein F, 350/400kDa | -0.0127274 |
| LAMTOR5 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 | -0.0126778 |
| NTN4 | netrin 4 | -0.0125775 |
| GTSE1 | G-2 and S-phase expressed 1 | -0.0124755 |
| RPL31 | ribosomal protein L31 | -0.0124365 |
| RPS14 | ribosomal protein S14 | -0.0124069 |
| PELO | pelota homolog (Drosophila) | -0.012383 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0119572 |
| SYF2 | SYF2 pre-mRNA-splicing factor | -0.0118606 |
| SP100 | SP100 nuclear antigen | -0.0115971 |
| CENPE | centromere protein E, 312kDa | -0.011587 |
| RPS16 | ribosomal protein S16 | -0.0115512 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0114988 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0114844 |
| RPL36A | ribosomal protein L36a | -0.0113839 |
| RPL27A | ribosomal protein L27a | -0.0113338 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0112869 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0111957 |
| UBL5 | ubiquitin-like 5 | -0.01119 |
| SEPTIN7 | septin 7 | -0.0111534 |
| RAD21 | RAD21 homolog (S. pombe) | -0.011081 |
| ARPC5 | actin related protein 2/3 complex, subunit 5, 16kDa | -0.0108532 |
| GNB2 | guanine nucleotide binding protein (G protein), beta polypeptide 2 | -0.0108095 |
| ANKUB1 | ankyrin repeat and ubiquitin domain containing 1 | -0.0107662 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0107543 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0107401 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0106583 |
