Sotrastaurin Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/10296883
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Genes

199 proteins with high or low expression in Sotrastaurin relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
CCDC158 coiled-coil domain containing 158 3.4
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 2.91
MARCKSL1 MARCKS-like 1 1.33
RPS25 ribosomal protein S25 1.31
MARCKS myristoylated alanine-rich protein kinase C substrate 1.26
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 1.09
SP100 SP100 nuclear antigen 1.08
GREB1 growth regulation by estrogen in breast cancer 1 1.05
CD63 CD63 molecule 0.92
CEMIP cell migration inducing protein, hyaluronan binding 0.9
TTC14 tetratricopeptide repeat domain 14 0.89
GATA2 GATA binding protein 2 0.86
SYTL2 synaptotagmin-like 2 0.84
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.83
TSPAN3 tetraspanin 3 0.82
ZNF385A zinc finger protein 385A 0.81
ADGRL1 adhesion G protein-coupled receptor L1 0.81
CCN3 cellular communication network factor 3 0.79
RPL26 ribosomal protein L26 0.76
DDIT4 DNA-damage-inducible transcript 4 0.73
MZT2B mitotic spindle organizing protein 2B 0.73
CDK6 cyclin-dependent kinase 6 0.72
GLI2 GLI family zinc finger 2 0.71
MSX1 msh homeobox 1 0.71
ZNF503 zinc finger protein 503 0.7
KDF1 keratinocyte differentiation factor 1 0.7
S100A4 S100 calcium binding protein A4 0.69
GMCL2 germ cell-less 2, spermatogenesis associated 0.68
CBX3 chromobox homolog 3 0.67
ARID5B AT rich interactive domain 5B (MRF1-like) 0.65
S100A6 S100 calcium binding protein A6 0.62
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 0.62
CDC37 cell division cycle 37 0.61
L1CAM L1 cell adhesion molecule 0.61
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 0.6
TUBB tubulin, beta class I 0.58
NDRG2 NDRG family member 2 0.57
PCSK9 proprotein convertase subtilisin/kexin type 9 0.57
MAN1A1 mannosidase, alpha, class 1A, member 1 0.56
CCDC82 coiled-coil domain containing 82 0.56
FBXL6 F-box and leucine-rich repeat protein 6 0.56
CCNQ cyclin Q 0.55
AJUBA ajuba LIM protein 0.55
MLXIPL MLX interacting protein-like 0.53
AMOT angiomotin 0.53
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.52
CMTM4 CKLF-like MARVEL transmembrane domain containing 4 0.52
ATF3 activating transcription factor 3 0.51
CETN1 centrin, EF-hand protein, 1 0.51
MAST2 microtubule associated serine/threonine kinase 2 0.51
RBP1 retinol binding protein 1, cellular 0.51
DHFR dihydrofolate reductase 0.5
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.49
RPL27 ribosomal protein L27 0.49
NEBL nebulette 0.49
ORC1 origin recognition complex, subunit 1 0.48
MAST1 microtubule associated serine/threonine kinase 1 0.48
F2RL1 coagulation factor II (thrombin) receptor-like 1 0.48
PLPP2 phospholipid phosphatase 2 0.47
TRIML2 tripartite motif family-like 2 0.47
C7 complement component 7 0.46
WDR6 WD repeat domain 6 0.46
RASAL1 RAS protein activator like 1 (GAP1 like) 0.46
RHOA ras homolog family member A 0.45
EHF ets homologous factor 0.45
CLTCL1 clathrin, heavy chain-like 1 0.45
RETSAT retinol saturase (all-trans-retinol 13,14-reductase) 0.45
DHRS11 dehydrogenase/reductase (SDR family) member 11 0.43
ALG12 ALG12, alpha-1,6-mannosyltransferase 0.43
FTSJ1 FtsJ RNA methyltransferase homolog 1 (E. coli) 0.43
DUSP22 dual specificity phosphatase 22 0.43
NADSYN1 NAD synthetase 1 0.43
PTPRD protein tyrosine phosphatase, receptor type, D 0.42
PRELID1 PRELI domain containing 1 0.42
TTPA tocopherol (alpha) transfer protein 0.41
PCBP4 poly(rC) binding protein 4 0.41
EXD2 exonuclease 3'-5' domain containing 2 0.41
TRAF3IP2 TRAF3 interacting protein 2 0.41
MSX2 msh homeobox 2 0.41
ALK anaplastic lymphoma receptor tyrosine kinase 0.41
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.4
KLF3 Kruppel-like factor 3 (basic) 0.4
FAM133B family with sequence similarity 133, member B 0.4
CFL1 cofilin 1 (non-muscle) 0.4
PEBP1 phosphatidylethanolamine binding protein 1 0.4
SEC24D SEC24 family member D 0.4
RNF17 ring finger protein 17 0.4
DENND4A DENN/MADD domain containing 4A 0.4
PDE5A phosphodiesterase 5A, cGMP-specific 0.4
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 0.39
ZNF827 zinc finger protein 827 0.39
ZC4H2 zinc finger, C4H2 domain containing 0.39
TMC4 transmembrane channel-like 4 0.39
CCNE2 cyclin E2 0.39
TNS3 tensin 3 0.39
KLF13 Kruppel-like factor 13 0.39
ESPN espin 0.39
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 0.38
ASIC1 acid sensing (proton gated) ion channel 1 0.38

low expression

Symbol Name Standardized Value
PRKCD protein kinase C, delta -1.39
RIPK4 receptor-interacting serine-threonine kinase 4 -1.35
TPK1 thiamin pyrophosphokinase 1 -1.0
WNT16 wingless-type MMTV integration site family, member 16 -0.97
EID2 EP300 interacting inhibitor of differentiation 2 -0.91
ABHD4 abhydrolase domain containing 4 -0.84
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.84
PRKCQ protein kinase C, theta -0.82
AXL AXL receptor tyrosine kinase -0.8
LRP12 low density lipoprotein receptor-related protein 12 -0.78
PRKCE protein kinase C, epsilon -0.73
MT2A metallothionein 2A -0.72
AHR aryl hydrocarbon receptor -0.71
ONECUT3 one cut homeobox 3 -0.7
TACSTD2 tumor-associated calcium signal transducer 2 -0.69
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -0.69
BORA bora, aurora kinase A activator -0.68
GRAMD2A GRAM domain containing 2A -0.66
SPRY4 sprouty homolog 4 (Drosophila) -0.66
CLDN3 claudin 3 -0.64
GRB7 growth factor receptor-bound protein 7 -0.64
DUSP4 dual specificity phosphatase 4 -0.63
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.62
ZRANB1 zinc finger, RAN-binding domain containing 1 -0.62
JUNB jun B proto-oncogene -0.6
PRKCA protein kinase C, alpha -0.6
CALCOCO1 calcium binding and coiled-coil domain 1 -0.6
DUSP5 dual specificity phosphatase 5 -0.59
RTN2 reticulon 2 -0.59
DGKD diacylglycerol kinase, delta 130kDa -0.58
ZNF740 zinc finger protein 740 -0.57
SMG9 SMG9 nonsense mediated mRNA decay factor -0.57
UPP1 uridine phosphorylase 1 -0.57
MLPH melanophilin -0.57
FTL ferritin, light polypeptide -0.56
AMPD1 adenosine monophosphate deaminase 1 -0.56
SGMS2 sphingomyelin synthase 2 -0.56
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A -0.56
METTL6 methyltransferase like 6 -0.56
ARHGEF35 Rho guanine nucleotide exchange factor (GEF) 35 -0.55
ZMYND19 zinc finger, MYND-type containing 19 -0.55
ELFN1 extracellular leucine-rich repeat and fibronectin type III domain containing 1 -0.55
CORO2B coronin, actin binding protein, 2B -0.53
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B -0.53
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.52
PPP1R2B PPP1R2 family member B -0.51
RNF135 ring finger protein 135 -0.51
CENPO centromere protein O -0.51
DUOX1 dual oxidase 1 -0.51
NRP1 neuropilin 1 -0.51
PNPLA2 patatin-like phospholipase domain containing 2 -0.5
TRAK2 trafficking protein, kinesin binding 2 -0.5
TCAIM T cell activation inhibitor, mitochondrial -0.5
RYK receptor-like tyrosine kinase -0.5
CDC6 cell division cycle 6 -0.5
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.49
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.49
ITGA6 integrin, alpha 6 -0.49
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.49
ENC1 ectodermal-neural cortex 1 (with BTB domain) -0.48
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 -0.48
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 -0.48
WDR45 WD repeat domain 45 -0.47
F8 coagulation factor VIII, procoagulant component -0.47
CST6 cystatin E/M -0.47
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.47
STX1A syntaxin 1A (brain) -0.47
SYTL3 synaptotagmin-like 3 -0.46
SEC14L1 SEC14-like 1 (S. cerevisiae) -0.46
IKZF5 IKAROS family zinc finger 5 (Pegasus) -0.46
GJB3 gap junction protein, beta 3, 31kDa -0.46
DUSP6 dual specificity phosphatase 6 -0.46
CTSL cathepsin L -0.46
PHLDA2 pleckstrin homology-like domain, family A, member 2 -0.45
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 -0.45
ZNF12 zinc finger protein 12 -0.45
LINS1 lines homolog 1 -0.45
EGR1 early growth response 1 -0.45
CPTP ceramide-1-phosphate transfer protein -0.45
CNTNAP3 contactin associated protein-like 3 -0.45
ERRFI1 ERBB receptor feedback inhibitor 1 -0.45
BCAR3 breast cancer anti-estrogen resistance 3 -0.45
RPGR retinitis pigmentosa GTPase regulator -0.44
BRWD1 bromodomain and WD repeat domain containing 1 -0.44
PRKCB protein kinase C, beta -0.44
PTBP1 polypyrimidine tract binding protein 1 -0.44
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 -0.44
EPS8 epidermal growth factor receptor pathway substrate 8 -0.44
MEGF6 multiple EGF-like-domains 6 -0.43
SP110 SP110 nuclear body protein -0.43
TNS4 tensin 4 -0.43
CEP97 centrosomal protein 97kDa -0.43
NT5E 5'-nucleotidase, ecto (CD73) -0.43
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.43
IFITM3 interferon induced transmembrane protein 3 -0.42
COQ8A coenzyme Q8A -0.42
F3 coagulation factor III (thromboplastin, tissue factor) -0.42
EAPP E2F-associated phosphoprotein -0.42
MYT1L myelin transcription factor 1-like -0.42
C1ORF122 chromosome 1 open reading frame 122 -0.42