Sphingolipid signaling pathway Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description Sphingomyelin (SM) and its metabolic products are now known to have second messenger functions in a variety of cellular signaling pathways. Particularly, the sphingolipid metabolites, ceramide (Cer) and sphingosine-1-phosphate (S1P), have emerged as a new class of potent bioactive molecules. Ceramide can be generated de novo or by hydrolysis of membrane sphingomyelin by sphingomyelinase (SMase). Ceramide is subsequently metabolized by ceramidase to generate sphingosine (Sph) which in turn produces S1P through phosphorylation by sphingosine kinases 1 and 2 (SphK1, 2). Both ceramide and S1P regulate cellular responses to stress, with generally opposing effects. S1P functions as a growth and survival factor, acting as a ligand for a family of G protein-coupled receptors, whereas ceramide activates intrinsic and extrinsic apoptotic pathways through receptor-independent mechanisms. (Kyoto Encyclopedia of Genes and Genomes, hsa04071)
External Link https://www.kegg.jp/entry/hsa04071
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123 proteins participating in the Sphingolipid signaling pathway pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ACER1 alkaline ceramidase 1
ACER2 alkaline ceramidase 2
ADORA1 adenosine A1 receptor
ADORA3 adenosine A3 receptor
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BDKRB2 bradykinin receptor B2
BID BH3 interacting domain death agonist
CERS1 ceramide synthase 1
CERS2 ceramide synthase 2
CERS3 ceramide synthase 3
CERS4 ceramide synthase 4
CERS6 ceramide synthase 6
CLSTN1 calsyntenin 1
CTSD cathepsin D
DEGS1 delta(4)-desaturase, sphingolipid 1
DEGS2 delta(4)-desaturase, sphingolipid 2
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FYN FYN proto-oncogene, Src family tyrosine kinase
GAB2 GRB2-associated binding protein 2
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
HRAS Harvey rat sarcoma viral oncogene homolog
KNG1 kininogen 1
LNCEGFL7OS lncRNA EGFL7 opposite strand
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK1 mitogen-activated protein kinase 1
MAPK10 mitogen-activated protein kinase 10
MAPK11 mitogen-activated protein kinase 11
MAPK12 mitogen-activated protein kinase 12
MAPK13 mitogen-activated protein kinase 13
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MS4A2 membrane-spanning 4-domains, subfamily A, member 2
NANOS3 nanos homolog 3 (Drosophila)
NCOA3 nuclear receptor coactivator 3
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
OPRD1 opioid receptor, delta 1
ORMDL1 ORMDL sphingolipid biosynthesis regulator 1
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2
ORMDL3 ORMDL sphingolipid biosynthesis regulator 3
PDPK1 3-phosphoinositide dependent protein kinase 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCB2 phospholipase C, beta 2
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCB4 phospholipase C, beta 4
PLD2 phospholipase D2
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma
PPP2R2D protein phosphatase 2, regulatory subunit B, delta
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PPP2R5D protein phosphatase 2, regulatory subunit B', delta
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCE protein kinase C, epsilon
PRKCG protein kinase C, gamma
PRKCSH protein kinase C substrate 80K-H
PRKCZ protein kinase C, zeta
PTEN phosphatase and tensin homolog
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RHOA ras homolog family member A
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE3 ribonuclease, RNase A family, 3
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
S1PR1 sphingosine-1-phosphate receptor 1
S1PR2 sphingosine-1-phosphate receptor 2
S1PR3 sphingosine-1-phosphate receptor 3
S1PR4 sphingosine-1-phosphate receptor 4
S1PR5 sphingosine-1-phosphate receptor 5
SGMS1 sphingomyelin synthase 1
SGMS2 sphingomyelin synthase 2
SGPL1 sphingosine-1-phosphate lyase 1
SGPP1 sphingosine-1-phosphate phosphatase 1
SGPP2 sphingosine-1-phosphate phosphatase 2
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SPHK1 sphingosine kinase 1
SPHK2 sphingosine kinase 2
SPTLC1 serine palmitoyltransferase, long chain base subunit 1
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SPTSSA serine palmitoyltransferase, small subunit A
SPTSSB serine palmitoyltransferase, small subunit B
TANK TRAF family member-associated NFKB activator
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TP53 tumor protein p53
TRADD TNFRSF1A-associated via death domain