Spindle Gene Set

Dataset COMPARTMENTS Curated Protein Localization Evidence Scores 2025
Category structural or functional annotations
Type cellular component
Description The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. (Gene Ontology, GO_0005819)
External Link http://amigo.geneontology.org/amigo/term/GO:0005819
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Genes

332 proteins localized to the Spindle cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.

Symbol Name Standardized Value
FAM161A family with sequence similarity 161, member A 5.0
SPATA5L1 spermatogenesis associated 5-like 1 5.0
CEP104 centrosomal protein 104kDa 5.0
CDC16 cell division cycle 16 5.0
KLHL21 kelch-like family member 21 5.0
HMMR hyaluronan-mediated motility receptor (RHAMM) 5.0
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae) 5.0
VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae) 5.0
CEP95 centrosomal protein 95kDa 5.0
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 5.0
CDC27 cell division cycle 27 5.0
KIF14 kinesin family member 14 5.0
CETN1 centrin, EF-hand protein, 1 5.0
STAG2 stromal antigen 2 5.0
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 5.0
MAP9 microtubule-associated protein 9 5.0
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 5.0
TPR translocated promoter region, nuclear basket protein 5.0
CEP44 centrosomal protein 44kDa 5.0
JTB jumping translocation breakpoint 5.0
RACGAP1 Rac GTPase activating protein 1 5.0
ECT2 epithelial cell transforming 2 5.0
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 5.0
CCDC117 coiled-coil domain containing 117 5.0
OR2A4 olfactory receptor, family 2, subfamily A, member 4 5.0
CDC25B cell division cycle 25B 5.0
BOD1 biorientation of chromosomes in cell division 1 5.0
MAEA macrophage erythroblast attacher 5.0
RAB11A RAB11A, member RAS oncogene family 5.0
TBCK TBC1 domain containing kinase 5.0
PMEPA1 prostate transmembrane protein, androgen induced 1 5.0
MAD2L1BP MAD2L1 binding protein 5.0
HSF1 heat shock transcription factor 1 5.0
TBL1X transducin (beta)-like 1X-linked 5.0
CUL3 cullin 3 5.0
ANXA11 annexin A11 5.0
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 5.0
CSPP1 centrosome and spindle pole associated protein 1 5.0
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4 5.0
HAUS7 HAUS augmin-like complex, subunit 7 5.0
AGBL5 ATP/GTP binding protein-like 5 5.0
FLCN folliculin 5.0
RCC2 regulator of chromosome condensation 2 5.0
LIMK2 LIM domain kinase 2 5.0
AUNIP aurora kinase A and ninein interacting protein 5.0
PARP4 poly (ADP-ribose) polymerase family, member 4 5.0
CIAO1 cytosolic iron-sulfur assembly component 1 5.0
NCAPG non-SMC condensin I complex, subunit G 5.0
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 5.0
CCSAP centriole, cilia and spindle-associated protein 5.0
AFG2A AFG2 AAA ATPase homolog A 5.0
EML4 echinoderm microtubule associated protein like 4 5.0
BIRC6 baculoviral IAP repeat containing 6 5.0
NCOR1 nuclear receptor corepressor 1 5.0
KATNA1 katanin p60 (ATPase containing) subunit A 1 5.0
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 5.0
KIF20A kinesin family member 20A 5.0
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 5.0
KAT5 K(lysine) acetyltransferase 5 5.0
DCDC1 doublecortin domain containing 1 5.0
CSNK1D casein kinase 1, delta 5.0
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 5.0
DCUN1D5 DCN1, defective in cullin neddylation 1, domain containing 5 5.0
TTL tubulin tyrosine ligase 5.0
HAUS8 HAUS augmin-like complex, subunit 8 5.0
EML3 echinoderm microtubule associated protein like 3 5.0
WNK1 WNK lysine deficient protein kinase 1 5.0
CEP19 centrosomal protein 19kDa 5.0
CYLD cylindromatosis (turban tumor syndrome) 5.0
HAUS1 HAUS augmin-like complex, subunit 1 5.0
HAUS2 HAUS augmin-like complex, subunit 2 5.0
HAUS5 HAUS augmin-like complex, subunit 5 5.0
HAUS4 HAUS augmin-like complex, subunit 4 5.0
CDC42 cell division cycle 42 5.0
HAUS6 HAUS augmin-like complex, subunit 6 5.0
LATS1 large tumor suppressor kinase 1 5.0
LATS2 large tumor suppressor kinase 2 5.0
PKP4 plakophilin 4 5.0
MZT1 mitotic spindle organizing protein 1 5.0
MTCL1 microtubule crosslinking factor 1 5.0
LUZP1 leucine zipper protein 1 5.0
KATNB1 katanin p80 (WD repeat containing) subunit B 1 5.0
TPPP tubulin polymerization promoting protein 5.0
CFAP53 cilia and flagella associated protein 53 5.0
SPAG5 sperm associated antigen 5 5.0
CHAMP1 chromosome alignment maintaining phosphoprotein 1 5.0
CENPV centromere protein V 5.0
EVI5 ecotropic viral integration site 5 5.0
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 5.0
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 5.0
SMC1A structural maintenance of chromosomes 1A 5.0
KATNAL1 katanin p60 subunit A-like 1 5.0
KATNAL2 katanin p60 subunit A-like 2 5.0
PLK1 polo-like kinase 1 5.0
KIF22 kinesin family member 22 5.0
SPICE1 spindle and centriole associated protein 1 5.0
CCDC69 coiled-coil domain containing 69 5.0
UMOD uromodulin 5.0
GMNN geminin, DNA replication inhibitor 5.0
CEP295 centrosomal protein 295kDa 5.0
CENPF centromere protein F, 350/400kDa 5.0
BCCIP BRCA2 and CDKN1A interacting protein 5.0
TBCCD1 TBCC domain containing 1 5.0
KNTC1 kinetochore associated 1 5.0
FAM110A family with sequence similarity 110, member A 5.0
ARL3 ADP-ribosylation factor-like 3 5.0
ANKRD53 ankyrin repeat domain 53 5.0
TUBGCP3 tubulin, gamma complex associated protein 3 5.0
CEP162 centrosomal protein 162kDa 5.0
SPOUT1 SPOUT domain containing methyltransferase 1 5.0
SGO1 shugoshin 1 5.0
CIAO2B cytosolic iron-sulfur assembly component 2B 5.0
MAP4 microtubule-associated protein 4 5.0
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) 5.0
ALMS1 Alstrom syndrome protein 1 5.0
CAPN6 calpain 6 5.0
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1 5.0
MTUS1 microtubule associated tumor suppressor 1 5.0
RMDN1 regulator of microtubule dynamics 1 5.0
RMDN3 regulator of microtubule dynamics 3 5.0
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 5.0
KIF16B kinesin family member 16B 5.0
HASPIN histone H3 associated protein kinase 5.0
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 5.0
CEP128 centrosomal protein 128kDa 5.0
SPAST spastin 5.0
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1 5.0
NDEL1 nudE neurodevelopment protein 1-like 1 5.0
MAP10 microtubule-associated protein 10 5.0
TRAPPC14 trafficking protein particle complex subunit 14 5.0
BEX4 brain expressed, X-linked 4 5.0
SEPTIN12 septin 12 5.0
CALM1 calmodulin 1 (phosphorylase kinase, delta) 5.0
CALM3 calmodulin 3 (phosphorylase kinase, delta) 5.0
CALM2 calmodulin 2 (phosphorylase kinase, delta) 5.0
AAAS achalasia, adrenocortical insufficiency, alacrimia 5.0
SKA1 spindle and kinetochore associated complex subunit 1 5.0
RTRAF RNA transcription, translation and transport factor 5.0
NUP62 nucleoporin 62kDa 5.0
ANAPC7 anaphase promoting complex subunit 7 5.0
ANAPC5 anaphase promoting complex subunit 5 5.0
POC1B POC1 centriolar protein B 5.0
POC1A POC1 centriolar protein A 5.0
SPDL1 spindle apparatus coiled-coil protein 1 5.0
FBF1 Fas (TNFRSF6) binding factor 1 5.0
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) 5.0
ZW10 zw10 kinetochore protein 5.0
SKA2 spindle and kinetochore associated complex subunit 2 5.0
HDAC3 histone deacetylase 3 5.0
TPT1 tumor protein, translationally-controlled 1 5.0
CCDC57 coiled-coil domain containing 57 5.0
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 5.0
SMC3 structural maintenance of chromosomes 3 5.0
ARL8B ADP-ribosylation factor-like 8B 5.0
ARL8A ADP-ribosylation factor-like 8A 5.0
DAPK3 death-associated protein kinase 3 5.0
GPSM2 G-protein signaling modulator 2 5.0
MAPKBP1 mitogen-activated protein kinase binding protein 1 5.0
CLTCL1 clathrin, heavy chain-like 1 5.0
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 5.0
MZT2B mitotic spindle organizing protein 2B 5.0
SBDS Shwachman-Bodian-Diamond syndrome 5.0
CDK1 cyclin-dependent kinase 1 5.0
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 5.0
NEK6 NIMA-related kinase 6 5.0
ALPK3 alpha-kinase 3 5.0
ALPK1 alpha-kinase 1 5.0
EFHC1 EF-hand domain (C-terminal) containing 1 5.0
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1 5.0
ATAT1 alpha tubulin acetyltransferase 1 5.0
CSAG1 chondrosarcoma associated gene 1 5.0
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive) 5.0
ARL2BP ADP-ribosylation factor-like 2 binding protein 5.0
ERCC2 excision repair cross-complementation group 2 5.0
CBX3 chromobox homolog 3 5.0
CEP85 centrosomal protein 85kDa 5.0
CEP89 centrosomal protein 89kDa 5.0
CKAP5 cytoskeleton associated protein 5 5.0
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 5.0
CBX1 chromobox homolog 1 5.0
DYNLL1 dynein, light chain, LC8-type 1 5.0
UNC119 unc-119 homolog (C. elegans) 5.0
RPS3 ribosomal protein S3 5.0
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 5.0
CCAR2 cell cycle and apoptosis regulator 2 5.0
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 4.0
CEP63 centrosomal protein 63kDa 4.0
HNF4G hepatocyte nuclear factor 4, gamma 4.0
KAT14 lysine acetyltransferase 14 4.0
GOLGA2 golgin A2 4.0
TUBB8 tubulin, beta 8 class VIII 4.0
TUBB2B tubulin, beta 2B class IIb 4.0
NEXMIF neurite extension and migration factor 4.0
TUBB6 tubulin, beta 6 class V 4.0
TUBB2A tubulin, beta 2A class IIa 4.0
TUBB3 tubulin, beta 3 class III 4.0
TUBB8B tubulin beta 8B 4.0
RNF103-CHMP3 RNF103-CHMP3 readthrough 4.0
TTK TTK protein kinase 4.0
TMEM9 transmembrane protein 9 4.0
SACK1D scaffolding CK1 anchoring protein D 4.0
TUBB4B tubulin, beta 4B class IVb 4.0
CDC7 cell division cycle 7 4.0
MBIP MAP3K12 binding inhibitory protein 1 4.0
CLTC clathrin, heavy chain (Hc) 4.0
CDC6 cell division cycle 6 4.0
CCNB1 cyclin B1 4.0
PMF1-BGLAP PMF1-BGLAP readthrough 4.0
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 4.0
ZZZ3 zinc finger, ZZ-type containing 3 4.0
YPEL5 yippee-like 5 (Drosophila) 4.0
HSPA2 heat shock 70kDa protein 2 4.0
TUBB4A tubulin, beta 4A class IVa 4.0
INPPL1 inositol polyphosphate phosphatase-like 1 4.0
PYCR3 pyrroline-5-carboxylate reductase 3 4.0
WAPL WAPL cohesin release factor 4.0
DCDC2 doublecortin domain containing 2 4.0
EPB41 erythrocyte membrane protein band 4.1 4.0
GPX2 glutathione peroxidase 2 4.0
SGF29 SAGA complex associated factor 29 4.0
NGRN neugrin, neurite outgrowth associated 4.0
KIF15 kinesin family member 15 4.0
MYF6 myogenic factor 6 (herculin) 4.0
MZT2A mitotic spindle organizing protein 2A 4.0
RGS14 regulator of G-protein signaling 14 4.0
CHMP1B charged multivesicular body protein 1B 4.0
TUBB tubulin, beta class I 4.0
YEATS2 YEATS domain containing 2 4.0
DSN1 DSN1, MIS12 kinetochore complex component 4.0
CXCR2 chemokine (C-X-C motif) receptor 2 4.0
CHMP2B charged multivesicular body protein 2B 4.0
CHMP2A charged multivesicular body protein 2A 4.0
ODAM odontogenic, ameloblast asssociated 4.0
KLHL22 kelch-like family member 22 4.0
CKAP2L cytoskeleton associated protein 2-like 4.0
CDC20 cell division cycle 20 4.0
MIS12 MIS12 kinetochore complex component 4.0
CSNK1A1 casein kinase 1, alpha 1 4.0
PTPN7 protein tyrosine phosphatase, non-receptor type 7 4.0
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 4.0
KIF4A kinesin family member 4A 4.0
TADA2A transcriptional adaptor 2A 4.0
PRKD2 protein kinase D2 4.0
TADA3 transcriptional adaptor 3 4.0
CHMP6 charged multivesicular body protein 6 4.0
SKA3 spindle and kinetochore associated complex subunit 3 4.0
MAP1S microtubule-associated protein 1S 4.0
CHMP4C charged multivesicular body protein 4C 4.0
CHMP4B charged multivesicular body protein 4B 4.0
LRIF1 ligand dependent nuclear receptor interacting factor 1 4.0
CHMP5 charged multivesicular body protein 5 4.0
CHMP7 charged multivesicular body protein 7 4.0
BCL2L10 BCL2-like 10 (apoptosis facilitator) 4.0
KATNBL1 katanin p80 subunit B-like 1 4.0
NDE1 nudE neurodevelopment protein 1 4.0
CKAP2 cytoskeleton associated protein 2 4.0
DIAPH1 diaphanous-related formin 1 4.0
WDR5 WD repeat domain 5 4.0
CHMP1A charged multivesicular body protein 1A 4.0
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 4.0
MAPK1 mitogen-activated protein kinase 1 4.0
RMDN2 regulator of microtubule dynamics 2 4.0
NUDC nudC nuclear distribution protein 4.0
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 4.0
SHCBP1L SHC SH2-domain binding protein 1-like 4.0
NUDCD2 NudC domain containing 2 4.0
MISP mitotic spindle positioning 4.0
TPX2 TPX2, microtubule-associated 4.0
DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) 4.0
DCTN1 dynactin 1 4.0
CENPE centromere protein E, 312kDa 4.0
IQCB1 IQ motif containing B1 4.0
NUMA1 nuclear mitotic apparatus protein 1 4.0
RNASE7 ribonuclease, RNase A family, 7 4.0
KIF23 kinesin family member 23 4.0
KANSL1 KAT8 regulatory NSL complex subunit 1 4.0
SIRT2 sirtuin 2 4.0
FBXO5 F-box protein 5 4.0
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 4.0
TRAT1 T cell receptor associated transmembrane adaptor 1 4.0
KNSTRN kinetochore-localized astrin/SPAG5 binding protein 4.0
KIF20B kinesin family member 20B 4.0
TACC3 transforming, acidic coiled-coil containing protein 3 4.0
ZWILCH zwilch kinetochore protein 4.0
HEPACAM2 HEPACAM family member 2 4.0
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 4.0
CD180 CD180 molecule 4.0
KIF11 kinesin family member 11 4.0
KAT2A K(lysine) acetyltransferase 2A 4.0
KAT2B K(lysine) acetyltransferase 2B 4.0
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase 4.0
NIN ninein (GSK3B interacting protein) 3.0
CLASP1 cytoplasmic linker associated protein 1 3.0
NUSAP1 nucleolar and spindle associated protein 1 3.0
KIFC2 kinesin family member C2 3.0
KIFC1 kinesin family member C1 3.0
CDCA8 cell division cycle associated 8 3.0
KIF18B kinesin family member 18B 3.0
EMD emerin 3.0
CDC14C cell division cycle 14C 3.0
CDC14A cell division cycle 14A 3.0
CDK5RAP2 CDK5 regulatory subunit associated protein 2 3.0
HAUS3 HAUS augmin-like complex, subunit 3 3.0
KASH5 KASH domain containing 5 3.0
PRC1 protein regulator of cytokinesis 1 3.0
SAC3D1 SAC3 domain containing 1 3.0
BIRC5 baculoviral IAP repeat containing 5 3.0
CLASP2 cytoplasmic linker associated protein 2 3.0
SPATA17 spermatogenesis associated 17 3.0
PLK3 polo-like kinase 3 3.0
MAPRE2 microtubule-associated protein, RP/EB family, member 2 3.0
TUBG2 tubulin, gamma 2 3.0
UHRF1 ubiquitin-like with PHD and ring finger domains 1 3.0
TUBG1 tubulin, gamma 1 3.0
AURKC aurora kinase C 3.0
PLK2 polo-like kinase 2 3.0
AURKB aurora kinase B 3.0
AURKA aurora kinase A 3.0
KIF18A kinesin family member 18A 3.0
ZNF367 zinc finger protein 367 3.0
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae) 3.0
INCENP inner centromere protein antigens 135/155kDa 3.0
NEDD1 neural precursor cell expressed, developmentally down-regulated 1 3.0
ANKFN1 ankyrin-repeat and fibronectin type III domain containing 1 3.0
USP44 ubiquitin specific peptidase 44 3.0
KIF2B kinesin family member 2B 3.0
WDR62 WD repeat domain 62 3.0
KIF2C kinesin family member 2C 3.0
KIF2A kinesin heavy chain member 2A 3.0
MAPRE3 microtubule-associated protein, RP/EB family, member 3 3.0
MAPRE1 microtubule-associated protein, RP/EB family, member 1 3.0
PSRC1 proline/serine-rich coiled-coil 1 3.0