Spinocerebellar ataxia Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description A spinocerebellar degeneration that is characterized by degeneration of the cerebellum leading to loss of muscle coordination. (Human Disease Ontology, DOID_1441)
External Link https://www.kegg.jp/entry/hsa05017
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Genes

143 proteins participating in the Spinocerebellar ataxia pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ADRM1 adhesion regulating molecule 1
AFG3L2 AFG3-like AAA ATPase 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
AMBRA1 autophagy/beclin-1 regulator 1
ATG101 autophagy related 101
ATG13 autophagy related 13
ATG14 autophagy related 14
ATG2A autophagy related 2A
ATG2B autophagy related 2B
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATXN1 ataxin 1
ATXN10 ataxin 10
ATXN1L ataxin 1-like
ATXN2 ataxin 2
ATXN2L ataxin 2-like
ATXN3 ataxin 3
ATXN3L ataxin 3-like
BEAN1 brain expressed, associated with NEDD4, 1
BECN1 beclin 1, autophagy related
BECN2 beclin 2
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CIC capicua transcriptional repressor
CLSTN1 calsyntenin 1
CYCS cytochrome c, somatic
DAND5 DAN domain family member 5, BMP antagonist
DNAAF3 dynein, axonemal, assembly factor 3
ERN1 endoplasmic reticulum to nucleus signaling 1
FGF14 fibroblast growth factor 14
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GPRIN1 G protein regulated inducer of neurite outgrowth 1
GRIA1 glutamate receptor, ionotropic, AMPA 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRIA3 glutamate receptor, ionotropic, AMPA 3
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
GRM1 glutamate receptor, metabotropic 1
GTF2B general transcription factor IIB
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KAT5 K(lysine) acetyltransferase 5
KCNC3 potassium channel, voltage gated Shaw related subfamily C, member 3
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
LNCEGFL7OS lncRNA EGFL7 opposite strand
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK10 mitogen-activated protein kinase 10
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MCU mitochondrial calcium uniporter
MED12 mediator complex subunit 12
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYOD1 myogenic differentiation 1
NFYA nuclear transcription factor Y, alpha
NOP56 NOP56 ribonucleoprotein
NRBF2 nuclear receptor binding factor 2
OMA1 OMA1 zinc metallopeptidase
PDYN prodynorphin
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCB2 phospholipase C, beta 2
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCB4 phospholipase C, beta 4
PPIF peptidylprolyl isomerase F
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCG protein kinase C, gamma
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
PUM1 pumilio RNA-binding family member 1
PUM2 pumilio RNA-binding family member 2
RB1CC1 RB1-inducible coiled-coil 1
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like
RELN reelin
RORA RAR-related orphan receptor A
RYR1 ryanodine receptor 1 (skeletal)
SEM1 SEM1 26S proteasome subunit
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SPTBN2 spectrin, beta, non-erythrocytic 2
TANK TRAF family member-associated NFKB activator
TBP TATA box binding protein
TBPL1 TBP-like 1
TBPL2 TATA box binding protein like 2
TRPC3 transient receptor potential cation channel, subfamily C, member 3
TWNK twinkle mtDNA helicase
ULK1 unc-51 like autophagy activating kinase 1
ULK2 unc-51 like autophagy activating kinase 2
VDAC1 voltage-dependent anion channel 1
VDAC2 voltage-dependent anion channel 2
VDAC3 voltage-dependent anion channel 3
VLDLR very low density lipoprotein receptor
WIPI1 WD repeat domain, phosphoinositide interacting 1
WIPI2 WD repeat domain, phosphoinositide interacting 2
XBP1 X-box binding protein 1