| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7. (Chemical Entities of Biological Interest Ontology, CHEBI_9241) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/5833 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Spironolactone relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 2.7 |
| LTN1 | listerin E3 ubiquitin protein ligase 1 | 1.67 |
| CREBZF | CREB/ATF bZIP transcription factor | 0.99 |
| LRRC58 | leucine rich repeat containing 58 | 0.8 |
| H3C1 | H3 clustered histone 1 | 0.68 |
| SCLT1 | sodium channel and clathrin linker 1 | 0.66 |
| CCDC66 | coiled-coil domain containing 66 | 0.56 |
| PRR36 | proline rich 36 | 0.55 |
| ZNF518A | zinc finger protein 518A | 0.54 |
| ZNHIT6 | zinc finger, HIT-type containing 6 | 0.51 |
| MYH16 | myosin, heavy chain 16 pseudogene | 0.51 |
| TEN1 | TEN1 CST complex subunit | 0.51 |
| ZSWIM7 | zinc finger, SWIM-type containing 7 | 0.5 |
| TRIM15 | tripartite motif containing 15 | 0.49 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | 0.49 |
| FAM135A | family with sequence similarity 135, member A | 0.48 |
| HMCES | 5-hydroxymethylcytosine (hmC) binding, ES cell-specific | 0.47 |
| CCDC57 | coiled-coil domain containing 57 | 0.47 |
| ELF4 | E74-like factor 4 (ets domain transcription factor) | 0.46 |
| KIAA1586 | KIAA1586 | 0.46 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.45 |
| SPICE1 | spindle and centriole associated protein 1 | 0.44 |
| DUSP22 | dual specificity phosphatase 22 | 0.44 |
| FRMPD3 | FERM and PDZ domain containing 3 | 0.42 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) | 0.42 |
| CDC25C | cell division cycle 25C | 0.42 |
| HPSE | heparanase | 0.42 |
| HIVEP1 | human immunodeficiency virus type I enhancer binding protein 1 | 0.41 |
| BLOC1S5 | biogenesis of lysosomal organelles complex-1, subunit 5, muted | 0.41 |
| CCDC85C | coiled-coil domain containing 85C | 0.41 |
| ZIC5 | Zic family member 5 | 0.41 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.4 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | 0.4 |
| PLCB4 | phospholipase C, beta 4 | 0.4 |
| DOCK10 | dedicator of cytokinesis 10 | 0.39 |
| PPT1 | palmitoyl-protein thioesterase 1 | 0.39 |
| MADD | MAP-kinase activating death domain | 0.39 |
| CAPN6 | calpain 6 | 0.39 |
| GLCCI1 | glucocorticoid induced 1 | 0.39 |
| ANTXR1 | anthrax toxin receptor 1 | 0.38 |
| CD320 | CD320 molecule | 0.38 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | 0.38 |
| LMO7 | LIM domain 7 | 0.37 |
| MYO15A | myosin XVA | 0.37 |
| GLUL | glutamate-ammonia ligase | 0.37 |
| CEP63 | centrosomal protein 63kDa | 0.37 |
| KAZN | kazrin, periplakin interacting protein | 0.36 |
| CCNB2 | cyclin B2 | 0.36 |
| LRRC45 | leucine rich repeat containing 45 | 0.36 |
| DENND3 | DENN/MADD domain containing 3 | 0.36 |
| POMT1 | protein-O-mannosyltransferase 1 | 0.35 |
| FAM102B | family with sequence similarity 102, member B | 0.35 |
| MTM1 | myotubularin 1 | 0.35 |
| ASTE1 | asteroid homolog 1 (Drosophila) | 0.35 |
| TTN | titin | 0.35 |
| KPTN | kaptin (actin binding protein) | 0.34 |
| ZBTB9 | zinc finger and BTB domain containing 9 | 0.34 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.34 |
| ZNF76 | zinc finger protein 76 | 0.34 |
| ENDOG | endonuclease G | 0.34 |
| ARHGEF10L | Rho guanine nucleotide exchange factor (GEF) 10-like | 0.34 |
| GALNT11 | polypeptide N-acetylgalactosaminyltransferase 11 | 0.34 |
| KIAA0825 | KIAA0825 | 0.34 |
| CLNS1A | chloride channel, nucleotide-sensitive, 1A | 0.33 |
| ZNF480 | zinc finger protein 480 | 0.33 |
| CCN1 | cellular communication network factor 1 | 0.33 |
| ENTPD7 | ectonucleoside triphosphate diphosphohydrolase 7 | 0.33 |
| SP4 | Sp4 transcription factor | 0.33 |
| CEP55 | centrosomal protein 55kDa | 0.33 |
| ASIC1 | acid sensing (proton gated) ion channel 1 | 0.33 |
| NES | nestin | 0.33 |
| NFIB | nuclear factor I/B | 0.33 |
| WDR34 | WD repeat domain 34 | 0.33 |
| PRR11 | proline rich 11 | 0.32 |
| CIP2A | cellular inhibitor of PP2A | 0.32 |
| TMEM131L | transmembrane 131 like | 0.32 |
| GTF3C6 | general transcription factor IIIC, polypeptide 6, alpha 35kDa | 0.32 |
| TPM2 | tropomyosin 2 (beta) | 0.32 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | 0.32 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.32 |
| WEE1 | WEE1 G2 checkpoint kinase | 0.32 |
| TRIB1 | tribbles pseudokinase 1 | 0.32 |
| IER5L | immediate early response 5-like | 0.31 |
| PROSER3 | proline and serine rich 3 | 0.31 |
| ZUP1 | zinc finger containing ubiquitin peptidase 1 | 0.31 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.31 |
| ROGDI | rogdi homolog (Drosophila) | 0.31 |
| ZNF618 | zinc finger protein 618 | 0.31 |
| SH3YL1 | SH3 and SYLF domain containing 1 | 0.31 |
| SPC24 | SPC24, NDC80 kinetochore complex component | 0.31 |
| IFFO1 | intermediate filament family orphan 1 | 0.3 |
| CBX5 | chromobox homolog 5 | 0.3 |
| FANCL | Fanconi anemia, complementation group L | 0.3 |
| B2M | beta-2-microglobulin | 0.3 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.3 |
| FZD7 | frizzled class receptor 7 | 0.3 |
| LRFN1 | leucine rich repeat and fibronectin type III domain containing 1 | 0.3 |
| ARID3A | AT rich interactive domain 3A (BRIGHT-like) | 0.3 |
| ICE1 | interactor of little elongation complex ELL subunit 1 | 0.3 |
| ANAPC16 | anaphase promoting complex subunit 16 | 0.3 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ITGAM | integrin, alpha M (complement component 3 receptor 3 subunit) | -2.55 |
| ERCC3 | excision repair cross-complementation group 3 | -2.27 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | -1.51 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -1.36 |
| PIP | prolactin-induced protein | -1.28 |
| GTF2H4 | general transcription factor IIH, polypeptide 4, 52kDa | -0.93 |
| TSPAN3 | tetraspanin 3 | -0.84 |
| ZNF525 | zinc finger protein 525 | -0.81 |
| LMO4 | LIM domain only 4 | -0.7 |
| ZNF451 | zinc finger protein 451 | -0.65 |
| FGFBP1 | fibroblast growth factor binding protein 1 | -0.6 |
| GTF2H1 | general transcription factor IIH, polypeptide 1, 62kDa | -0.58 |
| ZBTB25 | zinc finger and BTB domain containing 25 | -0.58 |
| BORCS5 | BLOC-1 related complex subunit 5 | -0.53 |
| CDK7 | cyclin-dependent kinase 7 | -0.52 |
| CD63 | CD63 molecule | -0.52 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | -0.51 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | -0.47 |
| BBS10 | Bardet-Biedl syndrome 10 | -0.45 |
| MID1IP1 | MID1 interacting protein 1 | -0.45 |
| MT1F | metallothionein 1F | -0.45 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | -0.44 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -0.44 |
| HRH1 | histamine receptor H1 | -0.44 |
| ACTBL2 | actin, beta-like 2 | -0.44 |
| TM7SF3 | transmembrane 7 superfamily member 3 | -0.44 |
| BBS4 | Bardet-Biedl syndrome 4 | -0.43 |
| GTF2H3 | general transcription factor IIH, polypeptide 3, 34kDa | -0.4 |
| RNF170 | ring finger protein 170 | -0.4 |
| TRIM62 | tripartite motif containing 62 | -0.4 |
| DCAF5 | DDB1 and CUL4 associated factor 5 | -0.4 |
| SNRPD3 | small nuclear ribonucleoprotein D3 polypeptide 18kDa | -0.39 |
| SESN1 | sestrin 1 | -0.39 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.39 |
| FSIP2 | fibrous sheath interacting protein 2 | -0.39 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | -0.39 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.39 |
| LMBRD1 | LMBR1 domain containing 1 | -0.39 |
| LSM10 | LSM10, U7 small nuclear RNA associated | -0.39 |
| RNF149 | ring finger protein 149 | -0.39 |
| FBXW2 | F-box and WD repeat domain containing 2 | -0.38 |
| SLC22A23 | solute carrier family 22, member 23 | -0.38 |
| SLC16A6 | solute carrier family 16, member 6 | -0.38 |
| CCNH | cyclin H | -0.38 |
| APOBEC3G | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | -0.37 |
| NADSYN1 | NAD synthetase 1 | -0.37 |
| NCOA4 | nuclear receptor coactivator 4 | -0.37 |
| LYSMD3 | LysM, putative peptidoglycan-binding, domain containing 3 | -0.37 |
| SLC17A5 | solute carrier family 17 (acidic sugar transporter), member 5 | -0.37 |
| RNF19B | ring finger protein 19B | -0.37 |
| LYRM1 | LYR motif containing 1 | -0.36 |
| MYBPC1 | myosin binding protein C, slow type | -0.36 |
| ZCCHC10 | zinc finger, CCHC domain containing 10 | -0.36 |
| SNRPA | small nuclear ribonucleoprotein polypeptide A | -0.36 |
| CELSR2 | cadherin, EGF LAG seven-pass G-type receptor 2 | -0.36 |
| TVP23C | trans-golgi network vesicle protein 23 homolog C (S. cerevisiae) | -0.36 |
| CCPG1 | cell cycle progression 1 | -0.35 |
| C15ORF40 | chromosome 15 open reading frame 40 | -0.35 |
| C19ORF54 | chromosome 19 open reading frame 54 | -0.35 |
| CST6 | cystatin E/M | -0.35 |
| GTF2H2 | general transcription factor IIH, polypeptide 2, 44kDa | -0.35 |
| SBSN | suprabasin | -0.34 |
| SNRPB | small nuclear ribonucleoprotein polypeptides B and B1 | -0.34 |
| MRNIP | MRN complex interacting protein | -0.34 |
| FHIT | fragile histidine triad | -0.34 |
| KLF3 | Kruppel-like factor 3 (basic) | -0.34 |
| MGAT4B | mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B | -0.33 |
| TMEM41B | transmembrane protein 41B | -0.33 |
| NOMO1 | NODAL modulator 1 | -0.33 |
| ATP7B | ATPase, Cu++ transporting, beta polypeptide | -0.33 |
| MT-ND5 | NADH dehydrogenase, subunit 5 (complex I) | -0.33 |
| CLN3 | ceroid-lipofuscinosis, neuronal 3 | -0.33 |
| TAPT1 | transmembrane anterior posterior transformation 1 | -0.33 |
| HEXIM2 | hexamethylene bis-acetamide inducible 2 | -0.33 |
| RNF146 | ring finger protein 146 | -0.32 |
| S100A5 | S100 calcium binding protein A5 | -0.32 |
| AZI2 | 5-azacytidine induced 2 | -0.32 |
| PEX16 | peroxisomal biogenesis factor 16 | -0.32 |
| GDF15 | growth differentiation factor 15 | -0.32 |
| ZNF623 | zinc finger protein 623 | -0.32 |
| APOE | apolipoprotein E | -0.32 |
| RHOD | ras homolog family member D | -0.31 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.31 |
| CDA | cytidine deaminase | -0.31 |
| ZNF414 | zinc finger protein 414 | -0.31 |
| DCBLD1 | discoidin, CUB and LCCL domain containing 1 | -0.31 |
| AREG | amphiregulin | -0.31 |
| PCBD2 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 | -0.31 |
| TECPR1 | tectonin beta-propeller repeat containing 1 | -0.3 |
| ELL3 | elongation factor RNA polymerase II-like 3 | -0.3 |
| PRKD1 | protein kinase D1 | -0.3 |
| ONECUT2 | one cut homeobox 2 | -0.3 |
| ADGRG1 | adhesion G protein-coupled receptor G1 | -0.3 |
| DUSP4 | dual specificity phosphatase 4 | -0.3 |
| CLDN3 | claudin 3 | -0.29 |
| IGSF8 | immunoglobulin superfamily, member 8 | -0.29 |
| C15ORF61 | chromosome 15 open reading frame 61 | -0.29 |
| PCYT1A | phosphate cytidylyltransferase 1, choline, alpha | -0.29 |
| PCYT1B | phosphate cytidylyltransferase 1, choline, beta | -0.29 |
| SREBF1 | sterol regulatory element binding transcription factor 1 | -0.29 |
