Spondyloarthropathy Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description Heterogeneous group of arthritic diseases sharing clinical and radiologic features. They are associated with the HLA-B27 ANTIGEN and some with a triggering infection. Most involve the axial joints in the SPINE, particularly the SACROILIAC JOINT, but can also involve asymmetric peripheral joints. Subsets include ANKYLOSING SPONDYLITIS; REACTIVE ARTHRITIS; PSORIATIC ARTHRITIS; and others. (Experimental Factor Ontology, EFO_0000706)
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Genes

322 genes co-occuring with the disease Spondyloarthropathy in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
CRP C-reactive protein, pentraxin-related 3.087
TNF tumor necrosis factor 2.987
IL17A interleukin 17A 2.904
HLA-B major histocompatibility complex, class I, B 2.884
ERAP1 endoplasmic reticulum aminopeptidase 1 2.84
IL23R interleukin 23 receptor 2.673
IL6 interleukin 6 2.466
IL1B interleukin 1, beta 2.42
CD4 CD4 molecule 2.394
IL22 interleukin 22 2.394
IFNG interferon, gamma 2.368
SAA2 serum amyloid A2 2.324
IL1A interleukin 1, alpha 2.305
CD8A CD8a molecule 2.304
MRAP melanocortin 2 receptor accessory protein 2.304
SAA1 serum amyloid A1 2.291
HLA-C major histocompatibility complex, class I, C 2.23
B2M beta-2-microglobulin 2.225
IL17F interleukin 17F 2.208
ERAP2 endoplasmic reticulum aminopeptidase 2 2.193
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 2.189
IL10 interleukin 10 2.166
IL23A interleukin 23, alpha subunit p19 2.118
MEFV Mediterranean fever 2.106
ACAN aggrecan 2.1
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 2.081
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 2.081
IL17RA interleukin 17 receptor A 2.072
DKK1 dickkopf WNT signaling pathway inhibitor 1 2.029
PRTN3 proteinase 3 2.013
SOST sclerostin 2.009
CREG1 cellular repressor of E1A-stimulated genes 1 1.99
NOD2 nucleotide-binding oligomerization domain containing 2 1.983
MMP3 matrix metallopeptidase 3 1.953
IL4 interleukin 4 1.949
TYK2 tyrosine kinase 2 1.948
IL2 interleukin 2 1.942
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 1.924
CXCL8 chemokine (C-X-C motif) ligand 8 1.911
HLA-A major histocompatibility complex, class I, A 1.911
CD80 CD80 molecule 1.892
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 1.884
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.86
TGFB1 transforming growth factor, beta 1 1.843
IL17RC interleukin 17 receptor C 1.841
JAK1 Janus kinase 1 1.82
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.818
IL18 interleukin 18 1.798
ALB albumin 1.792
TLR4 toll-like receptor 4 1.78
CARD9 caspase recruitment domain family, member 9 1.747
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.747
PTH parathyroid hormone 1.745
PDE4A phosphodiesterase 4A, cAMP-specific 1.735
BGLAP bone gamma-carboxyglutamate (gla) protein 1.732
JAK3 Janus kinase 3 1.731
IL1RN interleukin 1 receptor antagonist 1.721
CD163 CD163 molecule 1.719
JAK2 Janus kinase 2 1.716
IL6R interleukin 6 receptor 1.708
IL13 interleukin 13 1.681
IL25 interleukin 25 1.68
STAT4 signal transducer and activator of transcription 4 1.667
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 1.665
AGBL2 ATP/GTP binding protein-like 2 1.663
FOXP3 forkhead box P3 1.662
CCL2 chemokine (C-C motif) ligand 2 1.652
IL17D interleukin 17D 1.648
KIF21B kinesin family member 21B 1.646
KLRC4 killer cell lectin-like receptor subfamily C, member 4 1.635
CTLA4 cytotoxic T-lymphocyte-associated protein 4 1.632
CCL20 chemokine (C-C motif) ligand 20 1.631
COL2A1 collagen, type II, alpha 1 1.631
IL1R2 interleukin 1 receptor, type II 1.621
IL17RE interleukin 17 receptor E 1.62
IL17C interleukin 17C 1.615
C12ORF57 chromosome 12 open reading frame 57 1.614
DYNLT1 dynein, light chain, Tctex-type 1 1.613
ANKH ANKH inorganic pyrophosphate transport regulator 1.611
IFNA1 interferon, alpha 1 1.597
ANTXR2 anthrax toxin receptor 2 1.595
CCR6 chemokine (C-C motif) receptor 6 1.594
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 1.591
CD68 CD68 molecule 1.588
IL12RB1 interleukin 12 receptor, beta 1 1.588
TLR2 toll-like receptor 2 1.588
CCRL2 chemokine (C-C motif) receptor-like 2 1.585
CD28 CD28 molecule 1.582
IL15 interleukin 15 1.58
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.58
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 1.567
IL17B interleukin 17B 1.565
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 1.546
AGBL3 ATP/GTP binding protein-like 3 1.54
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 1.54
IL12RB2 interleukin 12 receptor, beta 2 1.54
IL26 interleukin 26 1.531
HGD homogentisate 1,2-dioxygenase 1.53
RORC RAR-related orphan receptor C 1.529
BMP2 bone morphogenetic protein 2 1.528
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 1.51
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 1.505
TBX21 T-box 21 1.504
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.498
ICAM1 intercellular adhesion molecule 1 1.492
IL7 interleukin 7 1.492
RUNX2 runt-related transcription factor 2 1.489
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 1.487
IL1R1 interleukin 1 receptor, type I 1.487
LTA lymphotoxin alpha 1.487
CARD14 caspase recruitment domain family, member 14 1.484
CD86 CD86 molecule 1.481
CXCL10 chemokine (C-X-C motif) ligand 10 1.463
IL36R interleukin 36 receptor 1.454
TAPBP TAP binding protein (tapasin) 1.448
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 1.443
NLRP3 NLR family, pyrin domain containing 3 1.441
CD69 CD69 molecule 1.44
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 1.436
STAT1 signal transducer and activator of transcription 1, 91kDa 1.434
IL36RN interleukin 36 receptor antagonist 1.433
CLEC7A C-type lectin domain family 7, member A 1.429
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 1.427
IL5 interleukin 5 1.426
UBAC2 UBA domain containing 2 1.42
LPIN2 lipin 2 1.416
MMP13 matrix metallopeptidase 13 1.404
MMP1 matrix metallopeptidase 1 1.402
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.402
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 1.4
IL7R interleukin 7 receptor 1.399
CD40 CD40 molecule, TNF receptor superfamily member 5 1.398
ACE angiotensin I converting enzyme 1.396
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.392
RUNX3 runt-related transcription factor 3 1.386
CAMP cathelicidin antimicrobial peptide 1.385
IL19 interleukin 19 1.38
MPO myeloperoxidase 1.38
TRAF3IP2 TRAF3 interacting protein 2 1.379
IL33 interleukin 33 1.378
CTSK cathepsin K 1.367
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 1.36
CD40LG CD40 ligand 1.36
TNIP1 TNFAIP3 interacting protein 1 1.359
VCAM1 vascular cell adhesion molecule 1 1.357
SYNJ2BP synaptojanin 2 binding protein 1.356
CD1D CD1d molecule 1.354
HP haptoglobin 1.352
ALPL alkaline phosphatase, liver/bone/kidney 1.344
TLR9 toll-like receptor 9 1.341
IL1F10 interleukin 1 family, member 10 (theta) 1.341
ACP5 acid phosphatase 5, tartrate resistant 1.341
COMP cartilage oligomeric matrix protein 1.335
INS insulin 1.333
RBP3 retinol binding protein 3, interstitial 1.332
SELE selectin E 1.329
IL24 interleukin 24 1.329
NELFCD negative elongation factor complex member C/D 1.325
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 1.321
IL9 interleukin 9 1.316
KLRB1 killer cell lectin-like receptor subfamily B, member 1 1.314
PTPRC protein tyrosine phosphatase, receptor type, C 1.311
JUN jun proto-oncogene 1.309
IL17RD interleukin 17 receptor D 1.307
SP7 Sp7 transcription factor 1.303
IFNB1 interferon, beta 1, fibroblast 1.302
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 1.29
CCL5 chemokine (C-C motif) ligand 5 1.284
MYD88 myeloid differentiation primary response 88 1.277
MMP9 matrix metallopeptidase 9 1.276
GPR65 G protein-coupled receptor 65 1.272
CCL3 chemokine (C-C motif) ligand 3 1.267
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 1.264
CD19 CD19 molecule 1.263
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.261
TLR7 toll-like receptor 7 1.259
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.259
TRADD TNFRSF1A-associated via death domain 1.254
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 1.254
CXCL9 chemokine (C-X-C motif) ligand 9 1.253
CD1C CD1c molecule 1.245
SAA2-SAA4 SAA2-SAA4 readthrough 1.243
CXCR3 chemokine (C-X-C motif) receptor 3 1.243
CKB creatine kinase, brain 1.243
NOG noggin 1.241
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.24
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.239
PTGER4 prostaglandin E receptor 4 (subtype EP4) 1.239
CKMT1B creatine kinase, mitochondrial 1B 1.238
SRSF6 serine/arginine-rich splicing factor 6 1.235
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 1.234
CKM creatine kinase, muscle 1.233
CCR1 chemokine (C-C motif) receptor 1 1.232
SELL selectin L 1.231
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 1.23
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2 1.23
CLEC2A C-type lectin domain family 2, member A 1.222
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 1.222
CCR7 chemokine (C-C motif) receptor 7 1.21
S100A9 S100 calcium binding protein A9 1.209
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.208
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 1.208
IL17RB interleukin 17 receptor B 1.204
LEP leptin 1.204
GIMAP2 GTPase, IMAP family member 2 1.202
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 1.201
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 1.2
NCAM1 neural cell adhesion molecule 1 1.199
CD83 CD83 molecule 1.196
PRF1 perforin 1 (pore forming protein) 1.195
IL2RA interleukin 2 receptor, alpha 1.195
TRIM21 tripartite motif containing 21 1.193
PTPN2 protein tyrosine phosphatase, non-receptor type 2 1.192
SAA4 serum amyloid A4, constitutive 1.189
EDNRA endothelin receptor type A 1.187
CSF3 colony stimulating factor 3 (granulocyte) 1.186
BMP7 bone morphogenetic protein 7 1.185
LCE3B late cornified envelope 3B 1.183
HLA-E major histocompatibility complex, class I, E 1.181
PADI4 peptidyl arginine deiminase, type IV 1.178
BMP6 bone morphogenetic protein 6 1.174
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 1.173
ADA adenosine deaminase 1.171
C3 complement component 3 1.171
MADCAM1 mucosal vascular addressin cell adhesion molecule 1 1.171
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 1.163
FN1 fibronectin 1 1.163
CD27 CD27 molecule 1.16
STAT5A signal transducer and activator of transcription 5A 1.153
BMP4 bone morphogenetic protein 4 1.153
STAT5B signal transducer and activator of transcription 5B 1.15
CD1B CD1b molecule 1.15
CD1E CD1e molecule 1.15
HLA-G major histocompatibility complex, class I, G 1.143
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 1.142
ECM1 extracellular matrix protein 1 1.135
F2 coagulation factor II (thrombin) 1.131
SUN3 Sad1 and UNC84 domain containing 3 1.127
ADAM17 ADAM metallopeptidase domain 17 1.118
F3 coagulation factor III (thromboplastin, tissue factor) 1.116
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 1.115
TAC1 tachykinin, precursor 1 1.113
CXCL12 chemokine (C-X-C motif) ligand 12 1.112
CCL4 chemokine (C-C motif) ligand 4 1.111
SOX9 SRY (sex determining region Y)-box 9 1.11
PXDN peroxidasin 1.109
THY1 Thy-1 cell surface antigen 1.108
SPP1 secreted phosphoprotein 1 1.107
IGF1 insulin-like growth factor 1 (somatomedin C) 1.105
PXDNL peroxidasin-like 1.104
XBP1 X-box binding protein 1 1.101
HLA-F major histocompatibility complex, class I, F 1.098
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 1.097
KLRK1 killer cell lectin-like receptor subfamily K, member 1 1.094
LNPEP leucyl/cystinyl aminopeptidase 1.093
IL11 interleukin 11 1.09
IL18R1 interleukin 18 receptor 1 1.087
TLR5 toll-like receptor 5 1.086
CD1A CD1a molecule 1.085
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.085
IL20RA interleukin 20 receptor, alpha 1.082
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) 1.08
TOR1A torsin family 1, member A (torsin A) 1.078
TLR3 toll-like receptor 3 1.077
IRF5 interferon regulatory factor 5 1.076
CLEC2D C-type lectin domain family 2, member D 1.074
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 1.073
RETNLB resistin like beta 1.073
CD276 CD276 molecule 1.071
HSPA1L heat shock 70kDa protein 1-like 1.069
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 1.068
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.066
LCE3C late cornified envelope 3C 1.063
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta 1.061
HPD 4-hydroxyphenylpyruvate dioxygenase 1.06
CXCR5 chemokine (C-X-C motif) receptor 5 1.059
NCR2 natural cytotoxicity triggering receptor 2 1.059
IL2RB interleukin 2 receptor, beta 1.057
S100A12 S100 calcium binding protein A12 1.055
IL20RB interleukin 20 receptor beta 1.052
IL37 interleukin 37 1.051
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 1.047
CD38 CD38 molecule 1.044
LRP5 low density lipoprotein receptor-related protein 5 1.04
MNDA myeloid cell nuclear differentiation antigen 1.039
LCN2 lipocalin 2 1.038
SH2B3 SH2B adaptor protein 3 1.037
PRDM1 PR domain containing 1, with ZNF domain 1.036
IL32 interleukin 32 1.036
CSF1 colony stimulating factor 1 (macrophage) 1.035
TIMP1 TIMP metallopeptidase inhibitor 1 1.034
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) 1.033
CXCL13 chemokine (C-X-C motif) ligand 13 1.031
SOCS1 suppressor of cytokine signaling 1 1.031
IRF4 interferon regulatory factor 4 1.03
CXCR4 chemokine (C-X-C motif) receptor 4 1.03
CCR2 chemokine (C-C motif) receptor 2 1.028
OSM oncostatin M 1.027
EXOC3L1 exocyst complex component 3-like 1 1.026
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 1.026
RETN resistin 1.026
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 1.022
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 1.021
CLEC2B C-type lectin domain family 2, member B 1.02
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.02
LCE3A late cornified envelope 3A 1.019
MMP2 matrix metallopeptidase 2 1.019
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 1.018
ACTB actin, beta 1.016
CD2 CD2 molecule 1.016
ACKR2 atypical chemokine receptor 2 1.015
IDO1 indoleamine 2,3-dioxygenase 1 1.014
IFNA2 interferon, alpha 2 1.013
IRAK1 interleukin-1 receptor-associated kinase 1 1.012
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 1.011
IL22RA1 interleukin 22 receptor, alpha 1 1.009
GDF5 growth differentiation factor 5 1.007
GIMAP4 GTPase, IMAP family member 4 1.006
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 1.006
IFNLR1 interferon, lambda receptor 1 1.003
ENO1 enolase 1, (alpha) 1.001
IFIH1 interferon induced with helicase C domain 1 1.001