Spondylosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description An bone structure disease that involves degeneration between vertebra located_in vertebral column. (Human Disease Ontology, DOID_2247)
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Genes

134 genes co-occuring with the disease Spondylosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
HTRA1 HtrA serine peptidase 1 2.263
BMP2 bone morphogenetic protein 2 2.175
ACAN aggrecan 2.103
CRP C-reactive protein, pentraxin-related 2.003
LAPTM4A lysosomal protein transmembrane 4 alpha 2.002
GDF5 growth differentiation factor 5 1.866
TNF tumor necrosis factor 1.817
TAC1 tachykinin, precursor 1 1.814
IL1B interleukin 1, beta 1.809
IL6 interleukin 6 1.774
NOTCH3 notch 3 1.762
LIPN lipase, family member N 1.755
TGFB1 transforming growth factor, beta 1 1.698
MMP13 matrix metallopeptidase 13 1.667
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 1.629
NGF nerve growth factor (beta polypeptide) 1.6
NIPAL1 NIPA-like domain containing 1 1.578
MKX mohawk homeobox 1.576
PTH parathyroid hormone 1.574
CKM creatine kinase, muscle 1.56
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 1.555
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.547
CKMT1B creatine kinase, mitochondrial 1B 1.546
CKB creatine kinase, brain 1.543
COL2A1 collagen, type II, alpha 1 1.511
MMP3 matrix metallopeptidase 3 1.501
LRP5 low density lipoprotein receptor-related protein 5 1.5
ALB albumin 1.492
BGLAP bone gamma-carboxyglutamate (gla) protein 1.477
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 1.468
INS insulin 1.427
COL4A1 collagen, type IV, alpha 1 1.423
IGF1 insulin-like growth factor 1 (somatomedin C) 1.413
WIZ widely interspaced zinc finger motifs 1.407
CCDC91 coiled-coil domain containing 91 1.395
SOX9 SRY (sex determining region Y)-box 9 1.39
CNGA1 cyclic nucleotide gated channel alpha 1 1.382
BMP6 bone morphogenetic protein 6 1.375
BSPRY B-box and SPRY domain containing 1.374
CTSA cathepsin A 1.369
SPAST spastin 1.368
BCL2 B-cell CLL/lymphoma 2 1.351
C3ORF49 chromosome 3 open reading frame 49 1.333
PAX1 paired box 1 1.331
TNMD tenomodulin 1.33
COL4A2 collagen, type IV, alpha 2 1.316
F2 coagulation factor II (thrombin) 1.315
PLAC9 placenta-specific 9 1.307
OAF OAF homolog (Drosophila) 1.3
IL1A interleukin 1, alpha 1.299
BMP4 bone morphogenetic protein 4 1.299
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.298
LRRC45 leucine rich repeat containing 45 1.291
VCAN versican 1.291
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.284
TBPL1 TBP-like 1 1.277
RUNX2 runt-related transcription factor 2 1.274
TRPV1 transient receptor potential cation channel, subfamily V, member 1 1.261
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase 1.26
BAX BCL2-associated X protein 1.255
BGN biglycan 1.245
KL klotho 1.242
BDNF brain-derived neurotrophic factor 1.241
TIAM2 T-cell lymphoma invasion and metastasis 2 1.235
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.234
FGF2 fibroblast growth factor 2 (basic) 1.232
CXCL8 chemokine (C-X-C motif) ligand 8 1.231
IL10 interleukin 10 1.23
ENO2 enolase 2 (gamma, neuronal) 1.226
BMP7 bone morphogenetic protein 7 1.22
FMOD fibromodulin 1.218
COL11A1 collagen, type XI, alpha 1 1.216
ASPN asporin 1.199
CLNK cytokine-dependent hematopoietic cell linker 1.189
TIMP1 TIMP metallopeptidase inhibitor 1 1.188
COL1A1 collagen, type I, alpha 1 1.182
SOX5 SRY (sex determining region Y)-box 5 1.178
JUN jun proto-oncogene 1.174
BAHCC1 BAH domain and coiled-coil containing 1 1.173
POMC proopiomelanocortin 1.171
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.168
TARDBP TAR DNA binding protein 1.161
COL9A2 collagen, type IX, alpha 2 1.159
ACE angiotensin I converting enzyme 1.15
NEFH neurofilament, heavy polypeptide 1.142
PRG4 proteoglycan 4 1.139
CYREN cell cycle regulator of NHEJ 1.134
PXDNL peroxidasin-like 1.133
DCN decorin 1.133
PXDN peroxidasin 1.131
FUS FUS RNA binding protein 1.129
PCSK5 proprotein convertase subtilisin/kexin type 5 1.129
GDF6 growth differentiation factor 6 1.129
TRIM14 tripartite motif containing 14 1.129
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 1.123
ARHGAP28 Rho GTPase activating protein 28 1.122
S100B S100 calcium binding protein B 1.12
SOST sclerostin 1.112
C9ORF72 chromosome 9 open reading frame 72 1.107
CAPS calcyphosine 1.1
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 1.098
MOG myelin oligodendrocyte glycoprotein 1.097
TMTC1 transmembrane and tetratricopeptide repeat containing 1 1.093
APOE apolipoprotein E 1.088
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 1.075
GLA galactosidase, alpha 1.075
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 1.074
SPP1 secreted phosphoprotein 1 1.072
COL1A2 collagen, type I, alpha 2 1.071
ZBTB7C zinc finger and BTB domain containing 7C 1.07
IL17A interleukin 17A 1.068
KNG1 kininogen 1 1.06
SOD1 superoxide dismutase 1, soluble 1.058
ELN elastin 1.058
FBN1 fibrillin 1 1.055
APLNR apelin receptor 1.052
PRSS1 protease, serine, 1 (trypsin 1) 1.051
FN1 fibronectin 1 1.048
QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 1.038
APP amyloid beta (A4) precursor protein 1.037
NOTO notochord homeobox 1.035
SOX6 SRY (sex determining region Y)-box 6 1.035
ACP5 acid phosphatase 5, tartrate resistant 1.034
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 1.032
FGF9 fibroblast growth factor 9 1.032
IHH indian hedgehog 1.03
NEFL neurofilament, light polypeptide 1.03
CDH22 cadherin 22, type 2 1.026
FGF4 fibroblast growth factor 4 1.026
TNXB tenascin XB 1.022
F3 coagulation factor III (thromboplastin, tissue factor) 1.021
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.015
ERCC1 excision repair cross-complementation group 1 1.009
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3 1.001