Streptococcal tonsillitis_Tonsillar Lymphoid Tissue_GSE11494 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Diseases
Category transcriptomics
Type disease perturbation
Description disease perturbation identified as [disease]_[tissue]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE11494
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Genes

600 genes differentially expressed during Streptococcal tonsillitis_Tonsillar Lymphoid Tissue_GSE11494 disease perturbation from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.

increased expression

Symbol Name Standardized Value
RNH1 ribonuclease/angiogenin inhibitor 1 3.50866
MAPK3 mitogen-activated protein kinase 3 3.18681
FTH1 ferritin, heavy polypeptide 1 3.17114
TMEM50A transmembrane protein 50A 2.91539
DBNL drebrin-like 2.63603
MYO18A myosin XVIIIA 2.62697
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.53184
C12ORF57 chromosome 12 open reading frame 57 2.49635
MLF2 myeloid leukemia factor 2 2.48275
HMOX2 heme oxygenase 2 2.47458
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 2.45404
ADD1 adducin 1 (alpha) 2.45339
SOWAHB sosondowah ankyrin repeat domain family member B 2.43735
LASP1 LIM and SH3 protein 1 2.42684
LRP10 low density lipoprotein receptor-related protein 10 2.38007
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha 2.37744
CAPNS1 calpain, small subunit 1 2.3753
ISYNA1 inositol-3-phosphate synthase 1 2.35732
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit 2.31233
HDAC3 histone deacetylase 3 2.24352
NAA20 N(alpha)-acetyltransferase 20, NatB catalytic subunit 2.24052
MRPS17 mitochondrial ribosomal protein S17 2.2295
DPCD deleted in primary ciliary dyskinesia homolog (mouse) 2.22403
C6ORF136 chromosome 6 open reading frame 136 2.19596
ERGIC3 ERGIC and golgi 3 2.19237
CLIP4 CAP-GLY domain containing linker protein family, member 4 2.19162
KDM1A lysine (K)-specific demethylase 1A 2.15151
FNTA farnesyltransferase, CAAX box, alpha 2.15127
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme 2.12749
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa 2.10334
SURF1 surfeit 1 2.07499
PPP6C protein phosphatase 6, catalytic subunit 2.0713
SNX3 sorting nexin 3 2.05756
PGLS 6-phosphogluconolactonase 2.05177
BAG6 BCL2-associated athanogene 6 2.02052
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 1.99773
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae) 1.98506
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 1.97555
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 1.97385
SEPW1 selenoprotein W, 1 1.9614
MOCOS molybdenum cofactor sulfurase 1.95052
SNX9 sorting nexin 9 1.94748
CRIP1 cysteine-rich protein 1 (intestinal) 1.93779
HIRIP3 HIRA interacting protein 3 1.92463
DALRD3 DALR anticodon binding domain containing 3 1.92406
SH3RF1 SH3 domain containing ring finger 1 1.92395
RHOG ras homolog family member G 1.92042
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) 1.90896
VDAC2 voltage-dependent anion channel 2 1.90692
SSNA1 Sjogren syndrome nuclear autoantigen 1 1.89909
HDAC1 histone deacetylase 1 1.8922
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 1.89116
ZNF32 zinc finger protein 32 1.88343
UHRF1BP1L UHRF1 binding protein 1-like 1.87143
ADRBK1 adrenergic, beta, receptor kinase 1 1.86156
RCAN1 regulator of calcineurin 1 1.84328
PAPD4 PAP associated domain containing 4 1.84023
FAM76B family with sequence similarity 76, member B 1.83661
TRAPPC8 trafficking protein particle complex 8 1.82357
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 1.81755
TMEM5 transmembrane protein 5 1.80138
PUM1 pumilio RNA-binding family member 1 1.80114
TRIM28 tripartite motif containing 28 1.79903
ZC3H3 zinc finger CCCH-type containing 3 1.78545
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 1.77118
TJP2 tight junction protein 2 1.77099
HSPA4L heat shock 70kDa protein 4-like 1.7707
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 1.76638
STX7 syntaxin 7 1.76554
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.76354
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 1.7635
RBP1 retinol binding protein 1, cellular 1.76072
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa 1.75847
PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 1.75702
EGLN2 egl-9 family hypoxia-inducible factor 2 1.75347
RAB14 RAB14, member RAS oncogene family 1.75099
CNIH4 cornichon family AMPA receptor auxiliary protein 4 1.74489
ABHD4 abhydrolase domain containing 4 1.73538
UBE2D1 ubiquitin-conjugating enzyme E2D 1 1.7344
AMACR alpha-methylacyl-CoA racemase 1.72297
CNOT8 CCR4-NOT transcription complex, subunit 8 1.71781
NLRP3 NLR family, pyrin domain containing 3 1.7153
NAF1 nuclear assembly factor 1 ribonucleoprotein 1.71449
SCARF1 scavenger receptor class F, member 1 1.7077
SSRP1 structure specific recognition protein 1 1.70714
CTSH cathepsin H 1.69676
FAM53C family with sequence similarity 53, member C 1.6885
RPS5 ribosomal protein S5 1.68842
NUDT14 nudix (nucleoside diphosphate linked moiety X)-type motif 14 1.68303
PINK1 PTEN induced putative kinase 1 1.68171
RXRB retinoid X receptor, beta 1.68069
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 1.6804
SNX18 sorting nexin 18 1.67735
VEGFB vascular endothelial growth factor B 1.67476
MRPL14 mitochondrial ribosomal protein L14 1.67453
TJP3 tight junction protein 3 1.67246
EIF3D eukaryotic translation initiation factor 3, subunit D 1.67095
ODF3B outer dense fiber of sperm tails 3B 1.66853
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 1.66707
PIGP phosphatidylinositol glycan anchor biosynthesis, class P 1.66278
ELP5 elongator acetyltransferase complex subunit 5 1.65558
MYO19 myosin XIX 1.65006
ERP29 endoplasmic reticulum protein 29 1.64668
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent) 1.64549
RPL13 ribosomal protein L13 1.64356
XPOT exportin, tRNA 1.63634
SRSF4 serine/arginine-rich splicing factor 4 1.63433
KCTD20 potassium channel tetramerization domain containing 20 1.63388
ZNF655 zinc finger protein 655 1.63236
COL4A2 collagen, type IV, alpha 2 1.62644
ATXN7L3 ataxin 7-like 3 1.62508
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 1.6232
MIB2 mindbomb E3 ubiquitin protein ligase 2 1.62296
FOS FBJ murine osteosarcoma viral oncogene homolog 1.62173
WBP4 WW domain binding protein 4 1.62149
PPP1R35 protein phosphatase 1, regulatory subunit 35 1.61759
GPS2 G protein pathway suppressor 2 1.61459
AKIP1 A kinase (PRKA) interacting protein 1 1.61425
UQCRC1 ubiquinol-cytochrome c reductase core protein I 1.61299
IFT43 intraflagellar transport 43 1.61169
RPL24 ribosomal protein L24 1.60925
RGS3 regulator of G-protein signaling 3 1.60659
NABP2 nucleic acid binding protein 2 1.60646
USE1 unconventional SNARE in the ER 1 homolog (S. cerevisiae) 1.60641
TMEM216 transmembrane protein 216 1.6005
CBX4 chromobox homolog 4 1.6
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 1.59992
TST thiosulfate sulfurtransferase (rhodanese) 1.59313
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 1.5912
ILK integrin-linked kinase 1.58779
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 1.58523
ACVRL1 activin A receptor type II-like 1 1.58469
OAZ2 ornithine decarboxylase antizyme 2 1.57516
POLRMT polymerase (RNA) mitochondrial (DNA directed) 1.57404
PPP1R16A protein phosphatase 1, regulatory subunit 16A 1.57369
AP3M2 adaptor-related protein complex 3, mu 2 subunit 1.57313
CUL1 cullin 1 1.57133
RBM22 RNA binding motif protein 22 1.56626
SCPEP1 serine carboxypeptidase 1 1.56598
KIF9 kinesin family member 9 1.56217
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 1.5533
FBXO18 F-box protein, helicase, 18 1.54805
CDCP1 CUB domain containing protein 1 1.54632
NOSIP nitric oxide synthase interacting protein 1.54508
ANXA11 annexin A11 1.54281
ACTN4 actinin, alpha 4 1.54278
STX4 syntaxin 4 1.5414
FAM175B family with sequence similarity 175, member B 1.53524
TMEM192 transmembrane protein 192 1.53397
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 1.53336
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase 1.53277
SF3A3 splicing factor 3a, subunit 3, 60kDa 1.53037
ZFYVE9 zinc finger, FYVE domain containing 9 1.53015
CBR1 carbonyl reductase 1 1.52255
PLA2G16 phospholipase A2, group XVI 1.51061
KCTD17 potassium channel tetramerization domain containing 17 1.50731
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 1.50592
MRPL39 mitochondrial ribosomal protein L39 1.50504
KIAA1522 KIAA1522 1.50449
SLC22A18 solute carrier family 22, member 18 1.50388
RIMS4 regulating synaptic membrane exocytosis 4 1.50307
PBX1 pre-B-cell leukemia homeobox 1 1.50238
ATP6V1C2 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 1.49922
PRMT1 protein arginine methyltransferase 1 1.49908
ZNHIT1 zinc finger, HIT-type containing 1 1.4952
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 1.49359
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 1.49258
CSRP2 cysteine and glycine-rich protein 2 1.49225
LAPTM4B lysosomal protein transmembrane 4 beta 1.49158
MKNK1 MAP kinase interacting serine/threonine kinase 1 1.49116
PPP1R18 protein phosphatase 1, regulatory subunit 18 1.48774
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2 1.48374
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 1.47956
PGD phosphogluconate dehydrogenase 1.47719
CSNK2B casein kinase 2, beta polypeptide 1.47626
PLTP phospholipid transfer protein 1.45735
ACBD6 acyl-CoA binding domain containing 6 1.45586
GATAD2A GATA zinc finger domain containing 2A 1.45495
BIRC2 baculoviral IAP repeat containing 2 1.45386
LPAR6 lysophosphatidic acid receptor 6 1.45366
ZNF354B zinc finger protein 354B 1.45172
PKP3 plakophilin 3 1.44944
CBR4 carbonyl reductase 4 1.44506
TMBIM1 transmembrane BAX inhibitor motif containing 1 1.44145
C9ORF69 chromosome 9 open reading frame 69 1.4365
SLC4A2 solute carrier family 4 (anion exchanger), member 2 1.43522
CADM4 cell adhesion molecule 4 1.43507
C9ORF9 chromosome 9 open reading frame 9 1.43468
TCEA1 transcription elongation factor A (SII), 1 1.43189
IGFBP4 insulin-like growth factor binding protein 4 1.43046
TMEM176B transmembrane protein 176B 1.41952
GPX4 glutathione peroxidase 4 1.41509
RING1 ring finger protein 1 1.41497
SPSB2 splA/ryanodine receptor domain and SOCS box containing 2 1.41062
ZMYM6NB ZMYM6 neighbor 1.41016
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 1.40547
ANXA4 annexin A4 1.40521
PTDSS2 phosphatidylserine synthase 2 1.40184
IGBP1 immunoglobulin (CD79A) binding protein 1 1.4016
PRR15L proline rich 15-like 1.40067
RPS9 ribosomal protein S9 1.40025
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 1.39895
DNAAF5 dynein, axonemal, assembly factor 5 1.39651
MEAF6 MYST/Esa1-associated factor 6 1.39527
CCT4 chaperonin containing TCP1, subunit 4 (delta) 1.39523
SMAGP small cell adhesion glycoprotein 1.38275
COX4I1 cytochrome c oxidase subunit IV isoform 1 1.37935
TBC1D12 TBC1 domain family, member 12 1.37843
CCNG2 cyclin G2 1.37818
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 1.37761
UVRAG UV radiation resistance associated 1.37442
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 1.37119
PEF1 penta-EF-hand domain containing 1 1.36955
ZNF639 zinc finger protein 639 1.36886
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 1.36884
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant 1.36812
DTX3 deltex 3, E3 ubiquitin ligase 1.36276
CFAP126 cilia and flagella associated protein 126 1.36011
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 1.35919
LXN latexin 1.3578
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase) 1.35775
SERPINB11 serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene) 1.35697
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 1.35353
THEGL theg spermatid protein-like 1.35268
ZFC3H1 zinc finger, C3H1-type containing 1.35101
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 1.34785
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 1.34611
LYZ lysozyme 1.34523
C7ORF26 chromosome 7 open reading frame 26 1.34462
EIF6 eukaryotic translation initiation factor 6 1.34455
HDGFRP3 hepatoma-derived growth factor, related protein 3 1.34003
PPDPF pancreatic progenitor cell differentiation and proliferation factor 1.33907
NUAK2 NUAK family, SNF1-like kinase, 2 1.33896
APEH acylaminoacyl-peptide hydrolase 1.33667
CDHR4 cadherin-related family member 4 1.33424
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa 1.32841
CUTA cutA divalent cation tolerance homolog (E. coli) 1.32725
ANXA3 annexin A3 1.32385
ADGRL4 adhesion G protein-coupled receptor L4 1.32285
OGG1 8-oxoguanine DNA glycosylase 1.32206
TRIM62 tripartite motif containing 62 1.32172
ACBD4 acyl-CoA binding domain containing 4 1.31667
MOCS2 molybdenum cofactor synthesis 2 1.31496
RPS24 ribosomal protein S24 1.31323
SCNN1A sodium channel, non voltage gated 1 alpha subunit 1.31049
G6PD glucose-6-phosphate dehydrogenase 1.31005
GRN granulin 1.30752
TMEM98 transmembrane protein 98 1.30597
TAGLN transgelin 1.30573
NDUFA6 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa 1.30484
PRKCDBP protein kinase C, delta binding protein 1.30125
BRI3 brain protein I3 1.30119
PPP4R1 protein phosphatase 4, regulatory subunit 1 1.30034
XRN2 5'-3' exoribonuclease 2 1.29661
KLHDC10 kelch domain containing 10 1.29633
LYNX1 Ly6/neurotoxin 1 1.29474
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 1.29232
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa 1.28983
RDM1 RAD52 motif containing 1 1.28944
MXD4 MAX dimerization protein 4 1.28915
PHKG2 phosphorylase kinase, gamma 2 (testis) 1.28818
CTSZ cathepsin Z 1.28712
DGKA diacylglycerol kinase, alpha 80kDa 1.28668
SH3BP5L SH3-binding domain protein 5-like 1.28338
NICN1 nicolin 1 1.28282
C2ORF50 chromosome 2 open reading frame 50 1.27896
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 1.27855
TULP3 tubby like protein 3 1.27686
ACOT2 acyl-CoA thioesterase 2 1.27679
RTN3 reticulon 3 1.27657
ZMYND8 zinc finger, MYND-type containing 8 1.27657
ACTG1 actin gamma 1 1.27536
ISY1-RAB43 ISY1-RAB43 readthrough 1.27267
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 1.27176
HDC histidine decarboxylase 1.26451
MXI1 MAX interactor 1, dimerization protein 1.26368
SDF2 stromal cell-derived factor 2 1.26348
FBXW5 F-box and WD repeat domain containing 5 1.26123
GADD45G growth arrest and DNA-damage-inducible, gamma 1.26009
NTPCR nucleoside-triphosphatase, cancer-related 1.25867
NOC4L nucleolar complex associated 4 homolog (S. cerevisiae) 1.25249
GMPR guanosine monophosphate reductase 1.25153
DCTN2 dynactin 2 (p50) 1.25032
IRS1 insulin receptor substrate 1 1.24759
KRT18 keratin 18, type I 1.24635
MAPK13 mitogen-activated protein kinase 13 1.24356
PPP4C protein phosphatase 4, catalytic subunit 1.24155
SHKBP1 SH3KBP1 binding protein 1 1.23981
LRWD1 leucine-rich repeats and WD repeat domain containing 1 1.23945
FLCN folliculin 1.23872
ATPIF1 ATPase inhibitory factor 1 1.23804
PPT2 palmitoyl-protein thioesterase 2 1.23421
PDK3 pyruvate dehydrogenase kinase, isozyme 3 1.23116
TTC39A tetratricopeptide repeat domain 39A 1.22771
WNT11 wingless-type MMTV integration site family, member 11 1.2267
RSPH9 radial spoke head 9 homolog (Chlamydomonas) 1.22653
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) 1.22577
IFNAR1 interferon (alpha, beta and omega) receptor 1 1.22367
NIT1 nitrilase 1 1.22091
PYGO2 pygopus family PHD finger 2 1.22069

decreased expression

Symbol Name Standardized Value
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 -3.94872
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -3.79302
OAZ1 ornithine decarboxylase antizyme 1 -3.44274
GLRX2 glutaredoxin 2 -3.29845
UQCRB ubiquinol-cytochrome c reductase binding protein -3.25794
SH3BP4 SH3-domain binding protein 4 -3.2498
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -3.21918
HIAT1 hippocampus abundant transcript 1 -3.16745
ROMO1 reactive oxygen species modulator 1 -3.16413
OXCT1 3-oxoacid CoA transferase 1 -2.9108
C18ORF32 chromosome 18 open reading frame 32 -2.86322
KATNA1 katanin p60 (ATPase containing) subunit A 1 -2.85422
ZBTB11 zinc finger and BTB domain containing 11 -2.731
DHRS4 dehydrogenase/reductase (SDR family) member 4 -2.68741
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -2.68106
ALG10 ALG10, alpha-1,2-glucosyltransferase -2.67302
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 -2.67066
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 -2.67006
ERGIC2 ERGIC and golgi 2 -2.66544
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.66361
SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae) -2.65786
NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa -2.64526
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) -2.64182
LARP4 La ribonucleoprotein domain family, member 4 -2.63751
MAGT1 magnesium transporter 1 -2.63066
SERINC1 serine incorporator 1 -2.62417
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8 -2.61543
AHCY adenosylhomocysteinase -2.61204
HRSP12 heat-responsive protein 12 -2.57082
IMPAD1 inositol monophosphatase domain containing 1 -2.51477
CSNK1D casein kinase 1, delta -2.50994
NBR1 neighbor of BRCA1 gene 1 -2.50823
DYNLT3 dynein, light chain, Tctex-type 3 -2.49522
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -2.4879
MRPL48 mitochondrial ribosomal protein L48 -2.47545
BRCC3 BRCA1/BRCA2-containing complex, subunit 3 -2.46773
CCT7 chaperonin containing TCP1, subunit 7 (eta) -2.45043
CS citrate synthase -2.42815
NCOA4 nuclear receptor coactivator 4 -2.4184
RPS27L ribosomal protein S27-like -2.40799
FAF1 Fas (TNFRSF6) associated factor 1 -2.4074
MRPL12 mitochondrial ribosomal protein L12 -2.40163
CARM1 coactivator-associated arginine methyltransferase 1 -2.38709
CTAGE5 CTAGE family, member 5 -2.3809
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa -2.37682
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -2.37584
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 -2.35603
COMMD3 COMM domain containing 3 -2.35217
COPZ1 coatomer protein complex, subunit zeta 1 -2.32835
HNRNPM heterogeneous nuclear ribonucleoprotein M -2.32608
NR4A2 nuclear receptor subfamily 4, group A, member 2 -2.31563
MFAP1 microfibrillar-associated protein 1 -2.30529
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -2.28769
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 -2.27303
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa -2.26143
RHEB Ras homolog enriched in brain -2.25427
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 -2.25388
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -2.24236
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -2.2398
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) -2.2303
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like -2.22849
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -2.22134
RIPK4 receptor-interacting serine-threonine kinase 4 -2.21716
VMP1 vacuole membrane protein 1 -2.21184
TSPAN5 tetraspanin 5 -2.21029
RNF7 ring finger protein 7 -2.19723
SCAMP1 secretory carrier membrane protein 1 -2.17471
SERF2 small EDRK-rich factor 2 -2.1736
LRRC58 leucine rich repeat containing 58 -2.17254
PCNP PEST proteolytic signal containing nuclear protein -2.16094
METTL1 methyltransferase like 1 -2.15549
CDKN2AIPNL CDKN2A interacting protein N-terminal like -2.14984
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase -2.14898
TMX1 thioredoxin-related transmembrane protein 1 -2.13645
PI4K2B phosphatidylinositol 4-kinase type 2 beta -2.13024
IPO9 importin 9 -2.12623
FILIP1L filamin A interacting protein 1-like -2.12514
ETFB electron-transfer-flavoprotein, beta polypeptide -2.11782
SLC35F5 solute carrier family 35, member F5 -2.11077
NAGA N-acetylgalactosaminidase, alpha- -2.10946
NXT1 nuclear transport factor 2-like export factor 1 -2.10225
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -2.10213
RDX radixin -2.1
CHCHD1 coiled-coil-helix-coiled-coil-helix domain containing 1 -2.0929
AMD1 adenosylmethionine decarboxylase 1 -2.08544
RPS12 ribosomal protein S12 -2.07818
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 -2.07747
SMNDC1 survival motor neuron domain containing 1 -2.06997
CSDE1 cold shock domain containing E1, RNA-binding -2.06761
AASS aminoadipate-semialdehyde synthase -2.0676
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) -2.06729
TEX261 testis expressed 261 -2.06677
TMCO1 transmembrane and coiled-coil domains 1 -2.0648
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4 -2.06342
HSPD1 heat shock 60kDa protein 1 (chaperonin) -2.06041
IQGAP2 IQ motif containing GTPase activating protein 2 -2.05901
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -2.0542
SLC35B1 solute carrier family 35, member B1 -2.05098
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) -2.04395
TPD52L1 tumor protein D52-like 1 -2.04224
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 -2.03071
HIST1H2BI histone cluster 1, H2bi -2.02336
TMEM234 transmembrane protein 234 -2.01998
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa -2.01537
PPP4R2 protein phosphatase 4, regulatory subunit 2 -2.00318
HNRNPK heterogeneous nuclear ribonucleoprotein K -2.00045
GRSF1 G-rich RNA sequence binding factor 1 -1.99976
POLR2M polymerase (RNA) II (DNA directed) polypeptide M -1.99685
RFWD2 ring finger and WD repeat domain 2, E3 ubiquitin protein ligase -1.98998
ERO1L ERO1-like (S. cerevisiae) -1.98225
DCTN3 dynactin 3 (p22) -1.97023
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -1.96927
REPS1 RALBP1 associated Eps domain containing 1 -1.96677
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -1.95523
CANX calnexin -1.95368
CNBP CCHC-type zinc finger, nucleic acid binding protein -1.95144
TMEM208 transmembrane protein 208 -1.94984
MORF4L2 mortality factor 4 like 2 -1.94913
FBL fibrillarin -1.94498
MRPL50 mitochondrial ribosomal protein L50 -1.94137
MOB4 MOB family member 4, phocein -1.93741
GHITM growth hormone inducible transmembrane protein -1.93609
COX5A cytochrome c oxidase subunit Va -1.93358
HIATL1 hippocampus abundant transcript-like 1 -1.93286
MTFR1 mitochondrial fission regulator 1 -1.92968
DHRS1 dehydrogenase/reductase (SDR family) member 1 -1.92487
UBE2H ubiquitin-conjugating enzyme E2H -1.91981
GINM1 glycoprotein integral membrane 1 -1.91051
SUMO2 small ubiquitin-like modifier 2 -1.90452
IK IK cytokine, down-regulator of HLA II -1.90406
TRIT1 tRNA isopentenyltransferase 1 -1.8995
ISOC1 isochorismatase domain containing 1 -1.89828
C1GALT1C1 C1GALT1-specific chaperone 1 -1.89574
SLC38A1 solute carrier family 38, member 1 -1.89021
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -1.88935
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) -1.88729
NME1 NME/NM23 nucleoside diphosphate kinase 1 -1.87547
MRPS16 mitochondrial ribosomal protein S16 -1.87505
TMEM64 transmembrane protein 64 -1.86912
SGPP1 sphingosine-1-phosphate phosphatase 1 -1.86333
TC2N tandem C2 domains, nuclear -1.86192
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -1.86152
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) -1.86082
CHUK conserved helix-loop-helix ubiquitous kinase -1.86047
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -1.85865
ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit -1.84158
PPP1R7 protein phosphatase 1, regulatory subunit 7 -1.8384
TPST2 tyrosylprotein sulfotransferase 2 -1.83632
HTATSF1 HIV-1 Tat specific factor 1 -1.83627
STK26 serine/threonine protein kinase 26 -1.82865
C1ORF131 chromosome 1 open reading frame 131 -1.82744
VTI1B vesicle transport through interaction with t-SNAREs 1B -1.82625
ARMC8 armadillo repeat containing 8 -1.82211
SPTSSA serine palmitoyltransferase, small subunit A -1.8152
C6ORF120 chromosome 6 open reading frame 120 -1.81469
SF3B2 splicing factor 3b, subunit 2, 145kDa -1.81094
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -1.80968
SCP2 sterol carrier protein 2 -1.79876
SRSF1 serine/arginine-rich splicing factor 1 -1.78881
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase -1.78308
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 -1.78143
FBXO30 F-box protein 30 -1.78039
DENND4C DENN/MADD domain containing 4C -1.77965
MKKS McKusick-Kaufman syndrome -1.77954
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 -1.77562
C4ORF27 chromosome 4 open reading frame 27 -1.77308
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7 -1.77137
LOC100129361 -1.77062
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 -1.7704
GRWD1 glutamate-rich WD repeat containing 1 -1.77
LOH12CR1 loss of heterozygosity, 12, chromosomal region 1 -1.76891
AHCYL1 adenosylhomocysteinase-like 1 -1.76685
SERP1 stress-associated endoplasmic reticulum protein 1 -1.76458
CEP76 centrosomal protein 76kDa -1.75824
ECHDC1 ethylmalonyl-CoA decarboxylase 1 -1.75649
EIF5 eukaryotic translation initiation factor 5 -1.75117
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) -1.74737
CLCN3 chloride channel, voltage-sensitive 3 -1.74653
KCNK1 potassium channel, two pore domain subfamily K, member 1 -1.74429
HIST1H3G histone cluster 1, H3g -1.7418
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 -1.73487
MAN1C1 mannosidase, alpha, class 1C, member 1 -1.73278
DYNLRB1 dynein, light chain, roadblock-type 1 -1.71962
EIF5A eukaryotic translation initiation factor 5A -1.71651
MFSD6 major facilitator superfamily domain containing 6 -1.71087
CCT2 chaperonin containing TCP1, subunit 2 (beta) -1.71046
DPY30 dpy-30 homolog (C. elegans) -1.70021
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 -1.69864
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) -1.69756
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae) -1.69679
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide -1.69618
UQCRHL ubiquinol-cytochrome c reductase hinge protein-like -1.69592
GARS glycyl-tRNA synthetase -1.69495
CDK5RAP3 CDK5 regulatory subunit associated protein 3 -1.69489
C1ORF43 chromosome 1 open reading frame 43 -1.69457
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2 -1.69436
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -1.69293
PFKM phosphofructokinase, muscle -1.69083
WWP1 WW domain containing E3 ubiquitin protein ligase 1 -1.68617
TRIM16 tripartite motif containing 16 -1.68082
TALDO1 transaldolase 1 -1.67945
GOLGA7 golgin A7 -1.67923
RPL7 ribosomal protein L7 -1.67531
EIF4A1 eukaryotic translation initiation factor 4A1 -1.67531
CRLS1 cardiolipin synthase 1 -1.67241
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 -1.67214
RRAGC Ras-related GTP binding C -1.6702
UFSP2 UFM1-specific peptidase 2 -1.66309
SAR1B secretion associated, Ras related GTPase 1B -1.66109
AKAP5 A kinase (PRKA) anchor protein 5 -1.65585
MRPL32 mitochondrial ribosomal protein L32 -1.65179
CENPC centromere protein C -1.64992
OTUD6B OTU domain containing 6B -1.6496
SYNGR2 synaptogyrin 2 -1.6367
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -1.63651
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 -1.63623
AP4S1 adaptor-related protein complex 4, sigma 1 subunit -1.62755
ENSA endosulfine alpha -1.62719
FAM45A family with sequence similarity 45, member A -1.62671
RAB24 RAB24, member RAS oncogene family -1.62604
TM9SF3 transmembrane 9 superfamily member 3 -1.62514
MIER2 mesoderm induction early response 1, family member 2 -1.62387
MMGT1 membrane magnesium transporter 1 -1.62198
PPP1R10 protein phosphatase 1, regulatory subunit 10 -1.62102
ARL6IP4 ADP-ribosylation factor-like 6 interacting protein 4 -1.6186
USP1 ubiquitin specific peptidase 1 -1.61746
UFL1 UFM1-specific ligase 1 -1.61299
KDM4C lysine (K)-specific demethylase 4C -1.61164
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 -1.60794
DCTD dCMP deaminase -1.60643
GSTM1 glutathione S-transferase mu 1 -1.60251
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11 -1.60209
TM9SF4 transmembrane 9 superfamily protein member 4 -1.60166
AP3M1 adaptor-related protein complex 3, mu 1 subunit -1.60155
C12ORF43 chromosome 12 open reading frame 43 -1.6013
NGLY1 N-glycanase 1 -1.5999
MTMR6 myotubularin related protein 6 -1.59641
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -1.59448
PEX11A peroxisomal biogenesis factor 11 alpha -1.59398
DGCR2 DiGeorge syndrome critical region gene 2 -1.59395
HSBP1 heat shock factor binding protein 1 -1.59389
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -1.59212
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -1.58575
CNOT7 CCR4-NOT transcription complex, subunit 7 -1.58536
GNPTG N-acetylglucosamine-1-phosphate transferase, gamma subunit -1.58207
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa -1.57781
FAM46B family with sequence similarity 46, member B -1.57758
ZADH2 zinc binding alcohol dehydrogenase domain containing 2 -1.57568
CAPN7 calpain 7 -1.5753
RRAS2 related RAS viral (r-ras) oncogene homolog 2 -1.57479
SEC63 SEC63 homolog (S. cerevisiae) -1.57464
MRPL4 mitochondrial ribosomal protein L4 -1.57424
NUP50 nucleoporin 50kDa -1.57372
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -1.57296
DNAAF2 dynein, axonemal, assembly factor 2 -1.57102
TSPAN13 tetraspanin 13 -1.56741
C19ORF24 chromosome 19 open reading frame 24 -1.56473
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -1.56368
TXLNA taxilin alpha -1.56337
COPE coatomer protein complex, subunit epsilon -1.56114
RPN2 ribophorin II -1.55841
KIAA1211L KIAA1211-like -1.55502
ISCU iron-sulfur cluster assembly enzyme -1.55447
RWDD4 RWD domain containing 4 -1.55296
CD99L2 CD99 molecule-like 2 -1.55051
BCCIP BRCA2 and CDKN1A interacting protein -1.54879
GRPEL1 GrpE-like 1, mitochondrial (E. coli) -1.54848
MAPK1 mitogen-activated protein kinase 1 -1.54573
LYAR Ly1 antibody reactive -1.54367
H2AFZ H2A histone family, member Z -1.54225
ATP5F1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1 -1.54099
RPL15 ribosomal protein L15 -1.5387
ODC1 ornithine decarboxylase 1 -1.53866
AP1M2 adaptor-related protein complex 1, mu 2 subunit -1.53711
NARS asparaginyl-tRNA synthetase -1.53574
EPS8 epidermal growth factor receptor pathway substrate 8 -1.53418
TIPIN TIMELESS interacting protein -1.53318
FAM114A1 family with sequence similarity 114, member A1 -1.5316
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -1.53054
EID1 EP300 interacting inhibitor of differentiation 1 -1.529
GTF2A2 general transcription factor IIA, 2, 12kDa -1.52599
TSPYL1 TSPY-like 1 -1.52437
TIMM23 translocase of inner mitochondrial membrane 23 homolog (yeast) -1.52402
NFIB nuclear factor I/B -1.52349
IER3IP1 immediate early response 3 interacting protein 1 -1.52192
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1 -1.52159
VBP1 von Hippel-Lindau binding protein 1 -1.52139
MRPL9 mitochondrial ribosomal protein L9 -1.52056
MAP3K4 mitogen-activated protein kinase kinase kinase 4 -1.51892
AKT2 v-akt murine thymoma viral oncogene homolog 2 -1.51025
TRAPPC2 trafficking protein particle complex 2 -1.50756
NUPL1 nucleoporin like 1 -1.50344
RAB10 RAB10, member RAS oncogene family -1.50314
FAM122B family with sequence similarity 122B -1.50248
USP33 ubiquitin specific peptidase 33 -1.50112
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -1.5006
MIEN1 migration and invasion enhancer 1 -1.49857
HIBCH 3-hydroxyisobutyryl-CoA hydrolase -1.49836
QRICH1 glutamine-rich 1 -1.49753
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -1.49739
Funding