Striated Muscle Contraction Gene Set

Dataset Reactome Pathways 2024
Category structural or functional annotations
Type pathway
Description A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope. (Gene Ontology, GO_0006941)
External Link https://reactome.org/PathwayBrowser/#/R-HSA-390522
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Genes

36 proteins participating in the Striated Muscle Contraction pathway from the Reactome Pathways 2024 dataset.

Symbol Name
ACTA1 actin, alpha 1, skeletal muscle
ACTC1 actin, alpha, cardiac muscle 1
ACTN2 actinin, alpha 2
ACTN3 actinin, alpha 3 (gene/pseudogene)
DES desmin
DMD dystrophin
MYBPC1 myosin binding protein C, slow type
MYBPC2 myosin binding protein C, fast type
MYBPC3 myosin binding protein C, cardiac
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic
MYH6 myosin, heavy chain 6, cardiac muscle, alpha
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal
MYL1 myosin, light chain 1, alkali; skeletal, fast
MYL2 myosin, light chain 2, regulatory, cardiac, slow
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NEB nebulin
TCAP titin-cap
TMOD1 tropomodulin 1
TMOD2 tropomodulin 2 (neuronal)
TMOD3 tropomodulin 3 (ubiquitous)
TMOD4 tropomodulin 4 (muscle)
TNNC1 troponin C type 1 (slow)
TNNC2 troponin C type 2 (fast)
TNNI1 troponin I type 1 (skeletal, slow)
TNNI2 troponin I type 2 (skeletal, fast)
TNNI3 troponin I type 3 (cardiac)
TNNT1 troponin T type 1 (skeletal, slow)
TNNT2 troponin T type 2 (cardiac)
TNNT3 troponin T type 3 (skeletal, fast)
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TPM3 tropomyosin 3
TPM4 tropomyosin 4
TTN titin
VIM vimentin