Stroke Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A sudden, nonconvulsive loss of neurologic function due to an ischemic or hemorrhagic intracranial vascular event. In general, cerebrovascular accidents are classified by anatomic location in the brain, vascular distribution, etiology, age of the affected individual, and hemorrhagic vs. nonhemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)|A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)|A sudden, nonconvulsive loss of neurologic function due to an ischemic or hemorrhagic intracranial vascular event. In general, cerebrovascular accidents are classified by anatomic location in the brain, vascular distribution, etiology, age of the affected individual, and hemorrhagic vs. nonhemorrhagic nature (MeSH).|A sudden loss of neurological function secondary to hemorrhage or ischemia in the brain parenchyma due to a vascular event.|Tissue NECROSIS in any area of the brain, including the CEREBRAL HEMISPHERES, the CEREBELLUM, and the BRAIN STEM. Brain infarction is the result of a cascade of events initiated by inadequate blood flow through the brain that is followed by HYPOXIA and HYPOGLYCEMIA in brain tissue. Damage may be temporary, permanent, selective or pan-necrosis. (Experimental Factor Ontology, EFO_0000712)
External Link https://www.disgenet.org/browser/0/1/0/C1857287
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Genes

25 genes associated with the disease Stroke in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ACE angiotensin I converting enzyme
ACE2 angiotensin I converting enzyme 2
CCL11 chemokine (C-C motif) ligand 11
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CST3 cystatin C
HP haptoglobin
IFNB1 interferon, beta 1, fibroblast
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL6 interleukin 6
KALRN kalirin, RhoGEF kinase
MMP2 matrix metallopeptidase 2
MMRN1 multimerin 1
MPO myeloperoxidase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH3 notch 3
PCSK9 proprotein convertase subtilisin/kexin type 9
PLAT plasminogen activator, tissue
PLG plasminogen
POU2F3 POU class 2 homeobox 3
TEK TEK tyrosine kinase, endothelial
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TREX1 three prime repair exonuclease 1