Stuttering Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description An articulation disorder characterized by involuntary sound repetition and disruption or blocking of speech. (Human Disease Ontology, DOID_0060243)
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Genes

210 genes co-occuring with the disease Stuttering in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase 3.323
GNPTG N-acetylglucosamine-1-phosphate transferase, gamma subunit 3.17
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit 2.895
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits 2.885
FOXP2 forkhead box P2 2.632
SOCS3 suppressor of cytokine signaling 3 2.615
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 2.575
PVALB parvalbumin 2.494
CNTNAP2 contactin associated protein-like 2 2.213
SST somatostatin 2.121
PDE5A phosphodiesterase 5A, cGMP-specific 2.111
CALB1 calbindin 1, 28kDa 2.09
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 2.074
CALB2 calbindin 2 2.066
DRD2 dopamine receptor D2 2.052
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 1.985
ARMC3 armadillo repeat containing 3 1.981
NPY neuropeptide Y 1.865
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 1.863
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 1.857
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 1.825
KIAA0319 KIAA0319 1.819
GTPBP1 GTP binding protein 1 1.807
CELF5 CUGBP, Elav-like family member 5 1.759
SSUH2 ssu-2 homolog (C. elegans) 1.757
GP2 glycoprotein 2 (zymogen granule membrane) 1.736
LHX6 LIM homeobox 6 1.712
NASP nuclear autoantigenic sperm protein (histone-binding) 1.68
PAPOLB poly(A) polymerase beta (testis specific) 1.625
PAPOLG poly(A) polymerase gamma 1.617
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1 1.612
PAPOLA poly(A) polymerase alpha 1.606
CMIP c-Maf inducing protein 1.605
SOCS6 suppressor of cytokine signaling 6 1.589
NRXN2 neurexin 2 1.583
FURIN furin (paired basic amino acid cleaving enzyme) 1.583
CELF4 CUGBP, Elav-like family member 4 1.578
RELN reelin 1.57
OCA2 oculocutaneous albinism II 1.568
ZMAT4 zinc finger, matrin-type 4 1.549
DCDC2 doublecortin domain containing 2 1.549
NRXN1 neurexin 1 1.538
DPAGT1 dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) 1.525
MIER1 mesoderm induction early response 1, transcriptional regulator 1.523
FMR1 fragile X mental retardation 1 1.52
FOXP1 forkhead box P1 1.517
POLI polymerase (DNA directed) iota 1.513
AP1S1 adaptor-related protein complex 1, sigma 1 subunit 1.513
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 1.511
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 1.499
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 1.481
ZFX zinc finger protein, X-linked 1.462
NXF1 nuclear RNA export factor 1 1.459
OR4C3 olfactory receptor, family 4, subfamily C, member 3 1.458
PANK2 pantothenate kinase 2 1.451
TEPSIN TEPSIN adaptor related protein complex 4 accessory protein 1.451
SDF4 stromal cell derived factor 4 1.45
MROH8 maestro heat-like repeat family member 8 1.436
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 1.427
AP4M1 adaptor-related protein complex 4, mu 1 subunit 1.422
OSTF1 osteoclast stimulating factor 1 1.421
ZNF277 zinc finger protein 277 1.42
DNAAF4 dynein axonemal assembly factor 4 1.416
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 1.415
MAPT microtubule-associated protein tau 1.413
GRN granulin 1.412
TARDBP TAR DNA binding protein 1.396
LBHD2 LBH domain containing 2 1.396
VIP vasoactive intestinal peptide 1.392
ACP7 acid phosphatase 7, tartrate resistant (putative) 1.384
HAP1 huntingtin-associated protein 1 1.377
CCK cholecystokinin 1.37
PROB1 proline-rich basic protein 1 1.368
PLAT plasminogen activator, tissue 1.364
HMX3 H6 family homeobox 3 1.36
AP5M1 adaptor-related protein complex 5, mu 1 subunit 1.354
CELF3 CUGBP, Elav-like family member 3 1.354
MIS12 MIS12 kinetochore complex component 1.34
NBPF9 neuroblastoma breakpoint family, member 9 1.336
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 1.332
AP4B1 adaptor-related protein complex 4, beta 1 subunit 1.33
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 1.317
NR2F1 nuclear receptor subfamily 2, group F, member 1 1.314
CPZ carboxypeptidase Z 1.304
KIAA0319L KIAA0319-like 1.301
AP4S1 adaptor-related protein complex 4, sigma 1 subunit 1.301
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 1.294
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 1.292
SLCO6A1 solute carrier organic anion transporter family, member 6A1 1.291
SVOPL SVOP-like 1.285
HIGD1C HIG1 hypoxia inducible domain family, member 1C 1.284
ZFY zinc finger protein, Y-linked 1.283
AP1B1 adaptor-related protein complex 1, beta 1 subunit 1.279
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 1.276
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 1.269
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 1.26
NFXL1 nuclear transcription factor, X-box binding-like 1 1.259
CP ceruloplasmin (ferroxidase) 1.245
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant 1.244
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 1.242
NXT1 nuclear transport factor 2-like export factor 1 1.239
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 1.231
CHPT1 choline phosphotransferase 1 1.228
SRY sex determining region Y 1.227
HTATSF1 HIV-1 Tat specific factor 1 1.227
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific 1.226
NKX2-1 NK2 homeobox 1 1.219
NOS1 nitric oxide synthase 1 (neuronal) 1.219
AP2S1 adaptor-related protein complex 2, sigma 1 subunit 1.218
CGGBP1 CGG triplet repeat binding protein 1 1.218
ALB albumin 1.211
GSX2 GS homeobox 2 1.21
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 1.207
NLGN3 neuroligin 3 1.201
MVB12A multivesicular body subunit 12A 1.2
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) 1.198
DLX1 distal-less homeobox 1 1.195
DRD4 dopamine receptor D4 1.189
DLX5 distal-less homeobox 5 1.189
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 1.185
PABPN1 poly(A) binding protein, nuclear 1 1.174
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 1.172
DLX2 distal-less homeobox 2 1.171
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae) 1.167
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 1.155
IVNS1ABP influenza virus NS1A binding protein 1.151
CNR1 cannabinoid receptor 1 (brain) 1.148
C9ORF72 chromosome 9 open reading frame 72 1.146
NR2F2 nuclear receptor subfamily 2, group F, member 2 1.143
DRD5 dopamine receptor D5 1.142
ENDOU endonuclease, polyU-specific 1.141
TPBGL trophoblast glycoprotein-like 1.14
SNCA synuclein, alpha (non A4 component of amyloid precursor) 1.137
ERF Ets2 repressor factor 1.133
TOR1A torsin family 1, member A (torsin A) 1.128
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3 1.128
PABPC1 poly(A) binding protein, cytoplasmic 1 1.121
ERVW-1 endogenous retrovirus group W, member 1 1.119
SHF Src homology 2 domain containing F 1.118
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase) 1.116
SHANK3 SH3 and multiple ankyrin repeat domains 3 1.115
NOP9 NOP9 nucleolar protein 1.109
ERC1 ELKS/RAB6-interacting/CAST family member 1 1.108
XRN1 5'-3' exoribonuclease 1 1.106
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 1.101
MAOA monoamine oxidase A 1.1
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 1.1
SSR1 signal sequence receptor, alpha 1.098
CNTN2 contactin 2 (axonal) 1.096
APP amyloid beta (A4) precursor protein 1.096
AAGAB alpha- and gamma-adaptin binding protein 1.095
SGCE sarcoglycan, epsilon 1.092
OPRPN opiorphin prepropeptide 1.091
RTN4 reticulon 4 1.089
AK9 adenylate kinase 9 1.086
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 1.086
MYO7A myosin VIIA 1.085
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 1.085
SCN1A sodium channel, voltage gated, type I alpha subunit 1.084
UMODL1 uromodulin-like 1 1.081
PAQR5 progestin and adipoQ receptor family member V 1.081
DNAH8 dynein, axonemal, heavy chain 8 1.08
GSX1 GS homeobox 1 1.08
TMEM131 transmembrane protein 131 1.079
REP15 RAB15 effector protein 1.078
ARSA arylsulfatase A 1.078
TH tyrosine hydroxylase 1.076
TM7SF3 transmembrane 7 superfamily member 3 1.068
SPG11 spastic paraplegia 11 (autosomal recessive) 1.059
NPC1 Niemann-Pick disease, type C1 1.059
AP2A2 adaptor-related protein complex 2, alpha 2 subunit 1.058
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B 1.055
DRD1 dopamine receptor D1 1.055
CORT cortistatin 1.054
COMT catechol-O-methyltransferase 1.054
CWH43 cell wall biogenesis 43 C-terminal homolog (S. cerevisiae) 1.053
TMC6 transmembrane channel-like 6 1.052
LAS1L LAS1-like (S. cerevisiae) 1.051
REPIN1 replication initiator 1 1.049
STIM2 stromal interaction molecule 2 1.048
CRH corticotropin releasing hormone 1.048
CHAT choline O-acetyltransferase 1.043
NUP62 nucleoporin 62kDa 1.038
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 1.037
AP3S2 adaptor-related protein complex 3, sigma 2 subunit 1.036
SCN8A sodium channel, voltage gated, type VIII alpha subunit 1.033
HEMGN hemogen 1.031
CLN3 ceroid-lipofuscinosis, neuronal 3 1.029
CHMP4A charged multivesicular body protein 4A 1.029
ATG9A autophagy related 9A 1.029
TBR1 T-box, brain, 1 1.029
RTRAF RNA transcription, translation and transport factor 1.027
ATP13A2 ATPase type 13A2 1.022
MECP2 methyl CpG binding protein 2 1.021
TENT4B terminal nucleotidyltransferase 4B 1.02
ETFBKMT electron transfer flavoprotein subunit beta lysine methyltransferase 1.018
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 1.018
PLXNA2 plexin A2 1.011
IFIH1 interferon induced with helicase C domain 1 1.01
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 1.01
SCAI suppressor of cancer cell invasion 1.008
ERVFRD-1 endogenous retrovirus group FRD, member 1 1.006
ANKRD49 ankyrin repeat domain 49 1.005
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 1.005
GRIA1 glutamate receptor, ionotropic, AMPA 1 1.005
KRT76 keratin 76, type II 1.005
IFNB1 interferon, beta 1, fibroblast 1.004
SH2D3A SH2 domain containing 3A 1.002
AP1S2 adaptor-related protein complex 1, sigma 2 subunit 1.002
OXT oxytocin/neurophysin I prepropeptide 1.002